EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000051341 (Gene tree)
Gene ID: 10721
Gene Symbol: POLQ
Alias: POLH
Full Name: DNA polymerase theta
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 115,222 bases
Position: chr3:121,431,420-121,546,641
Accession: 9186
RBP type: canonical RBP
Summary: POLQ (DNA Polymerase Theta) is a Protein Coding gene. Diseases associated with POLQ include Interdigitating Dendritic Cell Sarcoma and Histiocytic And Dendritic Cell Cancer. Among its related pathways are DNA Double-Strand Break Repair and Cell Cycle Control of Chromosomal Replication. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and damaged DNA binding. An important paralog of this gene is ASCC3.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000264233	DEAD	PF00270.29	2e-16	1	1
ENSP00000481120	DEAD	PF00270.29	2.2e-16	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000474243	POLQ-202	613	-	-	- (aa)	-	-
ENST00000264233	POLQ-201	8775	XM_011512343	ENSP00000264233	2590 (aa)	XP_011510645	O75417
ENST00000621776	POLQ-204	9055	-	ENSP00000481120	2725 (aa)	-	A0A087WXL3
ENST00000488282	POLQ-203	839	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000051341's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000051341	Autistic Disorder	3.0673000E-005	-
ENSG00000051341	Autistic Disorder	3.0673000E-005	-
ENSG00000051341	Multiple Myeloma	2E-6	23502783

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000051341	rs6800901	3	121435346	A	Multiple myeloma (IgH translocation)	23502783	[1.17-1.47]	1.31	EFO_0001378

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000051341's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000051341	POLQ	65	67.577	ENSAPOG00000008650	polq	61	67.577	Acanthochromis_polyacanthus
ENSG00000051341	POLQ	100	81.661	ENSAMEG00000014870	POLQ	100	81.518	Ailuropoda_melanoleuca
ENSG00000051341	POLQ	65	68.794	ENSAOCG00000005817	polq	75	68.794	Amphiprion_ocellaris
ENSG00000051341	POLQ	65	68.625	ENSAPEG00000020432	polq	75	68.625	Amphiprion_percula
ENSG00000051341	POLQ	98	55.360	ENSAPLG00000014869	POLQ	100	55.521	Anas_platyrhynchos
ENSG00000051341	POLQ	83	69.066	ENSACAG00000011574	POLQ	92	69.066	Anolis_carolinensis
ENSG00000051341	POLQ	98	84.267	ENSANAG00000024407	POLQ	99	84.267	Aotus_nancymaae
ENSG00000051341	POLQ	65	67.198	ENSACLG00000013865	polq	59	67.352	Astatotilapia_calliptera
ENSG00000051341	POLQ	75	63.934	ENSAMXG00000004839	polq	82	63.934	Astyanax_mexicanus
ENSG00000051341	POLQ	100	79.692	ENSBTAG00000001920	POLQ	100	85.468	Bos_taurus
ENSG00000051341	POLQ	51	33.296	WBGene00020964	polq-1	72	33.182	Caenorhabditis_elegans
ENSG00000051341	POLQ	100	90.720	ENSCJAG00000008508	POLQ	100	90.720	Callithrix_jacchus
ENSG00000051341	POLQ	71	78.032	ENSCAFG00000011479	POLQ	99	78.032	Canis_familiaris
ENSG00000051341	POLQ	100	79.215	ENSCAFG00020005928	POLQ	100	79.292	Canis_lupus_dingo
ENSG00000051341	POLQ	100	79.900	ENSCHIG00000013841	POLQ	100	79.900	Capra_hircus
ENSG00000051341	POLQ	79	82.410	ENSTSYG00000009550	POLQ	97	81.836	Carlito_syrichta
ENSG00000051341	POLQ	86	95.329	ENSCCAG00000026574	POLQ	99	95.329	Cebus_capucinus
ENSG00000051341	POLQ	100	94.875	ENSCATG00000014007	POLQ	100	93.782	Cercocebus_atys
ENSG00000051341	POLQ	100	77.136	ENSCLAG00000008388	POLQ	100	77.136	Chinchilla_lanigera
ENSG00000051341	POLQ	100	91.276	ENSCSAG00000007239	POLQ	100	91.188	Chlorocebus_sabaeus
ENSG00000051341	POLQ	78	94.483	ENSCHOG00000005999	POLQ	79	94.483	Choloepus_hoffmanni
ENSG00000051341	POLQ	98	57.246	ENSCPBG00000001827	POLQ	99	57.539	Chrysemys_picta_bellii
ENSG00000051341	POLQ	98	94.879	ENSCANG00000032946	POLQ	98	94.879	Colobus_angolensis_palliatus
ENSG00000051341	POLQ	90	85.116	ENSCGRG00001013184	Polq	100	83.256	Cricetulus_griseus_chok1gshd
ENSG00000051341	POLQ	90	85.116	ENSCGRG00000001328	Polq	100	83.256	Cricetulus_griseus_crigri
ENSG00000051341	POLQ	69	59.879	ENSCSEG00000005068	polq	62	59.879	Cynoglossus_semilaevis
ENSG00000051341	POLQ	64	67.206	ENSCVAG00000019651	polq	76	67.206	Cyprinodon_variegatus
ENSG00000051341	POLQ	78	68.409	ENSDARG00000044622	polq	69	68.409	Danio_rerio
ENSG00000051341	POLQ	99	79.502	ENSDNOG00000009810	POLQ	100	79.208	Dasypus_novemcinctus
ENSG00000051341	POLQ	89	89.100	ENSDORG00000002416	Polq	100	87.442	Dipodomys_ordii
ENSG00000051341	POLQ	64	43.133	FBgn0002905	mus308	73	43.148	Drosophila_melanogaster
ENSG00000051341	POLQ	95	82.962	ENSETEG00000002958	POLQ	96	82.962	Echinops_telfairi
ENSG00000051341	POLQ	57	43.390	ENSEBUG00000007484	POLQ	55	44.313	Eptatretus_burgeri
ENSG00000051341	POLQ	100	79.815	ENSEASG00005014326	POLQ	99	76.390	Equus_asinus_asinus
ENSG00000051341	POLQ	100	83.608	ENSECAG00000014314	POLQ	100	83.608	Equus_caballus
ENSG00000051341	POLQ	83	89.344	ENSEEUG00000001047	POLQ	83	89.344	Erinaceus_europaeus
ENSG00000051341	POLQ	52	71.127	ENSELUG00000018460	polq	85	71.127	Esox_lucius
ENSG00000051341	POLQ	100	81.200	ENSFCAG00000023397	POLQ	100	81.200	Felis_catus
ENSG00000051341	POLQ	96	54.112	ENSFALG00000005269	POLQ	100	54.034	Ficedula_albicollis
ENSG00000051341	POLQ	100	76.559	ENSFDAG00000013705	POLQ	100	76.559	Fukomys_damarensis
ENSG00000051341	POLQ	64	66.894	ENSFHEG00000009685	polq	61	66.894	Fundulus_heteroclitus
ENSG00000051341	POLQ	73	65.000	ENSGMOG00000003509	polq	78	65.041	Gadus_morhua
ENSG00000051341	POLQ	89	66.959	ENSGALG00000014924	POLQ	95	66.708	Gallus_gallus
ENSG00000051341	POLQ	64	65.188	ENSGAFG00000004642	polq	68	63.736	Gambusia_affinis
ENSG00000051341	POLQ	65	65.774	ENSGACG00000016100	polq	96	66.479	Gasterosteus_aculeatus
ENSG00000051341	POLQ	99	56.050	ENSGAGG00000013573	POLQ	98	56.302	Gopherus_agassizii
ENSG00000051341	POLQ	92	98.145	ENSGGOG00000011565	POLQ	99	98.145	Gorilla_gorilla
ENSG00000051341	POLQ	64	68.787	ENSHBUG00000002672	polq	75	68.787	Haplochromis_burtoni
ENSG00000051341	POLQ	93	87.634	ENSHGLG00000012935	POLQ	99	80.601	Heterocephalus_glaber_female
ENSG00000051341	POLQ	100	77.033	ENSHGLG00100013873	POLQ	100	77.033	Heterocephalus_glaber_male
ENSG00000051341	POLQ	83	62.710	ENSIPUG00000001045	polq	75	62.160	Ictalurus_punctatus
ENSG00000051341	POLQ	100	81.394	ENSSTOG00000009954	POLQ	100	81.202	Ictidomys_tridecemlineatus
ENSG00000051341	POLQ	64	67.654	ENSKMAG00000000050	polq	79	62.234	Kryptolebias_marmoratus
ENSG00000051341	POLQ	84	68.939	ENSLOCG00000005709	polq	81	68.939	Lepisosteus_oculatus
ENSG00000051341	POLQ	85	75.966	ENSLAFG00000011574	POLQ	100	75.587	Loxodonta_africana
ENSG00000051341	POLQ	100	95.341	ENSMFAG00000001627	POLQ	100	95.341	Macaca_fascicularis
ENSG00000051341	POLQ	100	95.495	ENSMMUG00000007973	POLQ	100	95.495	Macaca_mulatta
ENSG00000051341	POLQ	100	95.341	ENSMNEG00000035186	POLQ	100	94.652	Macaca_nemestrina
ENSG00000051341	POLQ	91	91.163	ENSMLEG00000032728	POLQ	98	91.163	Mandrillus_leucophaeus
ENSG00000051341	POLQ	65	67.540	ENSMAMG00000000877	polq	59	67.540	Mastacembelus_armatus
ENSG00000051341	POLQ	64	68.639	ENSMZEG00005021576	polq	74	68.639	Maylandia_zebra
ENSG00000051341	POLQ	78	49.587	ENSMGAG00000014264	POLQ	100	49.490	Meleagris_gallopavo
ENSG00000051341	POLQ	99	85.875	ENSMICG00000049493	POLQ	99	85.352	Microcebus_murinus
ENSG00000051341	POLQ	90	86.047	ENSMOCG00000016969	Polq	100	84.651	Microtus_ochrogaster
ENSG00000051341	POLQ	65	67.417	ENSMMOG00000007373	polq	82	67.494	Mola_mola
ENSG00000051341	POLQ	98	62.297	ENSMODG00000018252	POLQ	100	62.312	Monodelphis_domestica
ENSG00000051341	POLQ	64	67.045	ENSMALG00000007491	polq	58	67.045	Monopterus_albus
ENSG00000051341	POLQ	99	72.724	MGP_CAROLIEiJ_G0020725	Polq	100	79.070	Mus_caroli
ENSG00000051341	POLQ	99	72.319	ENSMUSG00000034206	Polq	100	79.070	Mus_musculus
ENSG00000051341	POLQ	99	72.501	MGP_PahariEiJ_G0016426	Polq	100	80.930	Mus_pahari
ENSG00000051341	POLQ	100	72.990	MGP_SPRETEiJ_G0021625	Polq	100	80.465	Mus_spretus
ENSG00000051341	POLQ	96	81.085	ENSMPUG00000004980	POLQ	100	81.085	Mustela_putorius_furo
ENSG00000051341	POLQ	96	80.589	ENSMLUG00000007687	POLQ	100	80.589	Myotis_lucifugus
ENSG00000051341	POLQ	100	76.287	ENSNGAG00000024216	Polq	100	82.326	Nannospalax_galili
ENSG00000051341	POLQ	95	95.589	ENSNLEG00000005179	POLQ	100	95.589	Nomascus_leucogenys
ENSG00000051341	POLQ	70	80.909	ENSMEUG00000005314	-	69	81.944	Notamacropus_eugenii
ENSG00000051341	POLQ	82	91.803	ENSOPRG00000006048	POLQ	82	91.803	Ochotona_princeps
ENSG00000051341	POLQ	94	89.179	ENSODEG00000007851	POLQ	96	89.179	Octodon_degus
ENSG00000051341	POLQ	75	68.521	ENSONIG00000008937	polq	82	68.602	Oreochromis_niloticus
ENSG00000051341	POLQ	66	68.737	ENSOANG00000004437	-	92	67.917	Ornithorhynchus_anatinus
ENSG00000051341	POLQ	100	79.300	ENSOCUG00000008077	POLQ	100	79.146	Oryctolagus_cuniculus
ENSG00000051341	POLQ	62	67.975	ENSORLG00015004392	polq	68	67.975	Oryzias_latipes_hsok
ENSG00000051341	POLQ	65	66.067	ENSOMEG00000012947	polq	62	66.067	Oryzias_melastigma
ENSG00000051341	POLQ	100	80.831	ENSOGAG00000015795	POLQ	100	80.831	Otolemur_garnettii
ENSG00000051341	POLQ	100	79.380	ENSOARG00000020009	POLQ	99	77.228	Ovis_aries
ENSG00000051341	POLQ	100	99.037	ENSPPAG00000027313	POLQ	100	99.037	Pan_paniscus
ENSG00000051341	POLQ	100	81.986	ENSPPRG00000007014	POLQ	100	81.986	Panthera_pardus
ENSG00000051341	POLQ	100	80.584	ENSPTIG00000017074	POLQ	100	80.584	Panthera_tigris_altaica
ENSG00000051341	POLQ	100	99.037	ENSPTRG00000015276	POLQ	100	99.037	Pan_troglodytes
ENSG00000051341	POLQ	100	95.222	ENSPANG00000000759	POLQ	100	94.660	Papio_anubis
ENSG00000051341	POLQ	83	67.423	ENSPKIG00000015375	polq	86	67.423	Paramormyrops_kingsleyae
ENSG00000051341	POLQ	99	57.471	ENSPSIG00000013657	POLQ	100	57.764	Pelodiscus_sinensis
ENSG00000051341	POLQ	100	73.182	ENSPEMG00000017429	Polq	100	73.067	Peromyscus_maniculatus_bairdii
ENSG00000051341	POLQ	64	67.503	ENSPFOG00000019624	polq	70	65.897	Poecilia_formosa
ENSG00000051341	POLQ	51	67.122	ENSPLAG00000022900	polq	56	65.677	Poecilia_latipinna
ENSG00000051341	POLQ	64	67.389	ENSPREG00000006445	polq	64	63.399	Poecilia_reticulata
ENSG00000051341	POLQ	100	97.144	ENSPPYG00000013498	POLQ	100	97.144	Pongo_abelii
ENSG00000051341	POLQ	90	90.844	ENSPCOG00000024680	POLQ	99	90.564	Propithecus_coquereli
ENSG00000051341	POLQ	100	75.048	ENSPVAG00000003165	POLQ	100	73.966	Pteropus_vampyrus
ENSG00000051341	POLQ	71	69.213	ENSPNAG00000003089	polq	66	69.213	Pygocentrus_nattereri
ENSG00000051341	POLQ	99	71.567	ENSRNOG00000002471	Polq	100	71.785	Rattus_norvegicus
ENSG00000051341	POLQ	100	95.110	ENSRBIG00000023391	POLQ	100	96.471	Rhinopithecus_bieti
ENSG00000051341	POLQ	100	95.033	ENSRROG00000045280	POLQ	100	95.033	Rhinopithecus_roxellana
ENSG00000051341	POLQ	98	63.306	ENSSHAG00000006984	POLQ	100	63.190	Sarcophilus_harrisii
ENSG00000051341	POLQ	84	67.916	ENSSFOG00015013674	polq	68	70.270	Scleropages_formosus
ENSG00000051341	POLQ	64	66.895	ENSSMAG00000011427	polq	60	66.970	Scophthalmus_maximus
ENSG00000051341	POLQ	65	65.475	ENSSDUG00000022307	polq	77	65.475	Seriola_dumerili
ENSG00000051341	POLQ	65	66.442	ENSSLDG00000024994	polq	76	66.442	Seriola_lalandi_dorsalis
ENSG00000051341	POLQ	91	93.220	ENSSARG00000001970	POLQ	91	93.220	Sorex_araneus
ENSG00000051341	POLQ	88	78.151	ENSSPUG00000004529	POLQ	94	74.778	Sphenodon_punctatus
ENSG00000051341	POLQ	65	68.565	ENSSPAG00000021010	polq	73	68.565	Stegastes_partitus
ENSG00000051341	POLQ	100	80.015	ENSSSCG00000036613	POLQ	100	80.015	Sus_scrofa
ENSG00000051341	POLQ	91	66.310	ENSTGUG00000013371	-	94	66.310	Taeniopygia_guttata
ENSG00000051341	POLQ	85	85.632	ENSTTRG00000001348	POLQ	84	85.632	Tursiops_truncatus
ENSG00000051341	POLQ	100	81.440	ENSUMAG00000025251	POLQ	99	81.440	Ursus_maritimus
ENSG00000051341	POLQ	95	89.474	ENSVVUG00000022390	POLQ	100	89.474	Vulpes_vulpes
ENSG00000051341	POLQ	84	73.055	ENSXETG00000009913	polq	88	68.141	Xenopus_tropicalis
ENSG00000051341	POLQ	64	67.008	ENSXMAG00000012597	polq	63	65.457	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000724	double-strand break repair via homologous recombination	-	TAS	Process
GO:0003682	chromatin binding	25642963.	IDA	Function
GO:0003684	damaged DNA binding	10395804.	TAS	Function
GO:0003887	DNA-directed DNA polymerase activity	14576298.25643323.	IDA	Function
GO:0003887	DNA-directed DNA polymerase activity	22135286.	IMP	Function
GO:0005515	protein binding	25642963.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006261	DNA-dependent DNA replication	21873635.	IBA	Process
GO:0006281	DNA repair	10395804.	TAS	Process
GO:0006284	base-excision repair	19188258.	IDA	Process
GO:0006302	double-strand break repair	22135286.	IDA	Process
GO:0006974	cellular response to DNA damage stimulus	25642963.25643323.	IDA	Process
GO:0016446	somatic hypermutation of immunoglobulin genes	-	ISS	Process
GO:0043142	single-stranded DNA-dependent ATPase activity	14576298.	IDA	Function
GO:0051260	protein homooligomerization	25643323.	IDA	Process
GO:0051575	5'-deoxyribose-5-phosphate lyase activity	19188258.	IDA	Function
GO:0071897	DNA biosynthetic process	-	IEA	Process
GO:0097681	double-strand break repair via alternative nonhomologous end joining	25643323.	IDA	Process
GO:2000042	negative regulation of double-strand break repair via homologous recombination	25642963.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
14735462	DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers.	Int J Cancer	2004 Mar	Kawamura K	-
30099721	A case of interdigitating dendritic cell sarcoma studied by whole-exome sequencing.	Genes Genomics	2018 Dec	Hong KH	doi: 10.1007/s13258-018-0724-y
29509408	DNA Polymerase θ Increases Mutational Rates in Mitochondrial DNA.	ACS Chem Biol	2018 Apr 20	Wisnovsky S	doi: 10.1021/acschembio.8b00072
20700469	Overexpression of POLQ confers a poor prognosis in early breast cancer patients.	Oncotarget	2010 Jul	Higgins GS	-
25642963	Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.	Nature	2015 Feb 12	Ceccaldi R	doi: 10.1038/nature14184
25409685	A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.	BMC Cancer	2014 Nov 19	Brandalize AP	doi: 10.1186/1471-2407-14-850.
25417172	Single-nucleotide polymorphisms in DNA bypass polymerase genes and association with breast cancer and breast cancer subtypes among African Americans and Whites.	Breast Cancer Res Treat	2015 Jan	Family L	doi: 10.1007/s10549-014-3203-4
20624954	DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.	Proc Natl Acad Sci U S A	2010 Jul 27	Lemee F	doi: 10.1073/pnas.0910759107

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr3	121545792	Missense_Mutation	novel	A29D	0.31
BLCA	chr3	121488211	Missense_Mutation	novel	D1574H	0.39
BLCA	chr3	121483555	Missense_Mutation	novel	S1934C	0.18
BLCA	chr3	121490182	Missense_Mutation	rs149007312	E917K	0.48
BLCA	chr3	121541352	Silent	novel	L157L	0.3
BLCA	chr3	121483452	Missense_Mutation	novel	I1968M	0.05
BLCA	chr3	121488642	Nonsense_Mutation	rs377402875	L1430*	0.65
BLCA	chr3	121488642	Frame_Shift_Del	NA	L1430*	0.09
BLCA	chr3	121533033	Nonsense_Mutation	NA	S306*	0.3	DEAD
BLCA	chr3	121546611	5'Flank	novel		0.35
BLCA	chr3	121489122	Frame_Shift_Del	novel	*P1270Hfs17**	0.04
BLCA	chr3	121496841	Nonsense_Mutation	novel	Q749*	0.07
BLCA	chr3	121487833	Missense_Mutation	novel	E1700Q	0.5
BLCA	chr3	121512019	Missense_Mutation	novel	I493M	0.15
BLCA	chr3	121509703	Missense_Mutation	novel	G606A	0.16
BLCA	chr3	121473428	Missense_Mutation	rs767522841	K2155N	0.49
BLCA	chr3	121529642	Splice_Region	novel		0.09
BLCA	chr3	121488027	Nonsense_Mutation	NA	S1635*	0.28
BLCA	chr3	121489239	Nonsense_Mutation	NA	S1231*	0.2
BLCA	chr3	121539543	Frame_Shift_Del	novel	*M172Tfs24**	0.21
BLCA	chr3	121487555	Silent	novel	G1792G	0.29
BLCA	chr3	121432980	Missense_Mutation	novel	F2533V	0.19
BLCA	chr3	121545896	5'UTR	novel		0.09
BLCA	chr3	121496814	Missense_Mutation	novel	Y758H	0.65
BLCA	chr3	121488188	Silent	rs759732692	K1581K	0.25
BLCA	chr3	121496810	Missense_Mutation	novel	A759G	0.06
BLCA	chr3	121488511	Missense_Mutation	NA	E1474K	0.16
BLCA	chr3	121544729	Missense_Mutation	NA	S114L	0.16
BLCA	chr3	121510091	Nonsense_Mutation	novel	W588*	0.13
BLCA	chr3	121460181	Missense_Mutation	rs769839271	H2341Y	0.53
BLCA	chr3	121468376	Missense_Mutation	NA	I2258M	0.36
BLCA	chr3	121493599	Missense_Mutation	novel	L801V	0.35
BLCA	chr3	121476725	Missense_Mutation	novel	R2074C	0.35
BLCA	chr3	121436168	Silent	novel	F2499F	0.23
BLCA	chr3	121481608	Missense_Mutation	NA	Q2059E	0.53
BLCA	chr3	121449412	Silent	NA	I2389I	0.4
BLCA	chr3	121468339	Missense_Mutation	novel	Q2271E	0.3
BLCA	chr3	121432292	3'UTR	novel		0.21
BRCA	chr3	121529766	Missense_Mutation	NA	L329F	0.25	DEAD
BRCA	chr3	121488707	Silent	rs778061468	D1408D	0.31
BRCA	chr3	121489239	Frame_Shift_Ins	novel	*S1231Lfs10**	0.04
BRCA	chr3	121510123	Nonsense_Mutation	NA	Q578*	0.21
BRCA	chr3	121498562	Missense_Mutation	novel	E690K	0.37
BRCA	chr3	121440047	Missense_Mutation	NA	G2445V	0.3
BRCA	chr3	121498620	Silent	NA	F670F	0.17
BRCA	chr3	121483433	Missense_Mutation	novel	L1975F	0.05
BRCA	chr3	121488462	Missense_Mutation	NA	L1490P	0.11
BRCA	chr3	121498642	Missense_Mutation	NA	T663S	0.19
BRCA	chr3	121487374	Missense_Mutation	novel	S1853T	0.48
BRCA	chr3	121488493	Nonsense_Mutation	NA	E1480*	0.16
BRCA	chr3	121488168	Missense_Mutation	NA	P1588L	0.16
BRCA	chr3	121489239	Frame_Shift_Ins	novel	*S1231Yfs15**	0.07
BRCA	chr3	121488285	Nonsense_Mutation	novel	*T1549Kfs2**	0.08
BRCA	chr3	121487952	Missense_Mutation	NA	S1660L	0.11
BRCA	chr3	121529785	Missense_Mutation	novel	E323G	0.26	DEAD
BRCA	chr3	121432305	Nonstop_Mutation	NA	2591Sext4	0.48
BRCA	chr3	121519996	Missense_Mutation	NA	S448Y	0.33
BRCA	chr3	121468402	Missense_Mutation	novel	Q2250K	0.06
CESC	chr3	121490352	Missense_Mutation	NA	R860Q	0.37
CESC	chr3	121488079	Frame_Shift_Ins	novel	*S1618Ifs20**	0.23
CESC	chr3	121544729	Missense_Mutation	NA	S114L	0.15
CESC	chr3	121541472	In_Frame_Ins	novel	A119_G120insSQSA	0.06
CESC	chr3	121541474	Missense_Mutation	novel	T117A	0.03
CESC	chr3	121472065	Nonsense_Mutation	NA	Q2215*	0.47
CESC	chr3	121476587	Missense_Mutation	NA	L2120V	0.28
CESC	chr3	121449375	Frame_Shift_Del	novel	*M2402Wfs26**	0.06
CESC	chr3	121489065	Missense_Mutation	novel	S1289Y	0.07
CESC	chr3	121431929	3'UTR	rs571530580		0.5
CESC	chr3	121490361	Missense_Mutation	rs751166841	R857H	0.35
CESC	chr3	121467528	Missense_Mutation	NA	P2320T	0.41
CESC	chr3	121539498	Missense_Mutation	novel	C189Y	0.38
CESC	chr3	121489239	Nonsense_Mutation	NA	S1231*	0.13
CESC	chr3	121522009	Missense_Mutation	NA	H417D	0.29
CESC	chr3	121472010	Missense_Mutation	NA	S2233L	0.33
CESC	chr3	121489996	Missense_Mutation	NA	E979K	0.1
CESC	chr3	121488115	Nonsense_Mutation	NA	Q1606*	0.31
CESC	chr3	121489826	Missense_Mutation	NA	M1035I	0.23
COAD	chr3	121460134	Silent	NA	A2356A	0.22
COAD	chr3	121520086	Splice_Region	rs779959046		0.33
COAD	chr3	121487760	Missense_Mutation	novel	K1724T	0.36
COAD	chr3	121487893	Missense_Mutation	NA	E1680K	0.16
COAD	chr3	121488326	Frame_Shift_Del	novel	*K1535Nfs4**	0.38
COAD	chr3	121490352	Missense_Mutation	NA	R860Q	0.39
COAD	chr3	121467633	Frame_Shift_Del	novel	*Y2285Ifs7**	0.44
COAD	chr3	121489847	Silent	NA	L1028L	0.37
COAD	chr3	121487575	Missense_Mutation	novel	S1786R	0.29
COAD	chr3	121488642	Frame_Shift_Del	NA	L1430*	0.28
COAD	chr3	121490263	Missense_Mutation	novel	D890N	0.35
COAD	chr3	121489893	Missense_Mutation	novel	K1013T	0.06
COAD	chr3	121490352	Missense_Mutation	NA	R860Q	0.34
COAD	chr3	121432339	Missense_Mutation	rs375979324	A2580T	0.12
COAD	chr3	121472025	Missense_Mutation	novel	R2228I	0.3
COAD	chr3	121472119	Missense_Mutation	NA	I2197L	0.47
COAD	chr3	121539556	Missense_Mutation	novel	G170S	0.07
COAD	chr3	121520086	Splice_Region	rs779959046		0.3
COAD	chr3	121493637	Missense_Mutation	NA	G788D	0.16
COAD	chr3	121519976	Missense_Mutation	NA	R455C	0.22
COAD	chr3	121481775	Missense_Mutation	rs773624174	P2003L	0.25
COAD	chr3	121544798	Frame_Shift_Del	NA	*K91Rfs21**	0.27
COAD	chr3	121489528	Missense_Mutation	NA	E1135K	0.11
COAD	chr3	121481656	Nonsense_Mutation	rs762108057	R2043*	0.39
COAD	chr3	121489044	Missense_Mutation	novel	G1296D	0.34
COAD	chr3	121467585	Nonsense_Mutation	novel	E2301*	0.44
COAD	chr3	121436268	Missense_Mutation	rs367989768	R2466H	0.34
COAD	chr3	121498621	Frame_Shift_Del	NA	*F670Sfs11**	0.33
COAD	chr3	121468387	Missense_Mutation	NA	D2255N	0.1
COAD	chr3	121488780	Missense_Mutation	rs749686819	A1384V	0.19
COAD	chr3	121468313	Silent	novel	P2279P	0.35
COAD	chr3	121529754	Silent	rs770350964	T333T	0.53
COAD	chr3	121544798	Frame_Shift_Del	NA	*K91Rfs21**	0.49
COAD	chr3	121488642	Frame_Shift_Del	NA	L1430*	0.39
COAD	chr3	121483528	Missense_Mutation	NA	D1943G	0.26
COAD	chr3	121487867	Missense_Mutation	NA	K1688N	0.1
COAD	chr3	121488328	Missense_Mutation	NA	K1535Q	0.08
COAD	chr3	121488848	Missense_Mutation	NA	Q1361H	0.23
COAD	chr3	121489460	Missense_Mutation	NA	K1157N	0.1
COAD	chr3	121519939	Missense_Mutation	rs761630032	R467Q	0.19
COAD	chr3	121539465	Missense_Mutation	rs747882906	R200H	0.07
COAD	chr3	121440026	Missense_Mutation	novel	G2452E	0.18
COAD	chr3	121468354	Missense_Mutation	rs768809386	E2266K	0.33
COAD	chr3	121490352	Missense_Mutation	NA	R860Q	0.32
COAD	chr3	121485120	Silent	NA	T1898T	0.24
COAD	chr3	121510233	Missense_Mutation	rs769203695	G541D	0.34
COAD	chr3	121432358	Silent	novel	K2573K	0.06
COAD	chr3	121432359	Nonsense_Mutation	novel	K2573delinsR*	0.06
COAD	chr3	121489021	Missense_Mutation	novel	K1304E	0.05
COAD	chr3	121489022	Frame_Shift_Ins	novel	*K1304Lfs11**	0.06
COAD	chr3	121510219	Frame_Shift_Ins	novel	*T546Sfs41**	0.05
COAD	chr3	121493508	Missense_Mutation	rs756028056	V831A	0.42
COAD	chr3	121520086	Splice_Region	rs779959046		0.32
COAD	chr3	121436171	Silent	novel	T2498T	0.15
COAD	chr3	121436179	Frame_Shift_Del	novel	*H2496Tfs59**	0.11
COAD	chr3	121472162	Splice_Region	rs201717586	D2182D	0.23
DLBC	chr3	121483561	Missense_Mutation	novel	P1932L	0.2
ESCA	chr3	121481812	Missense_Mutation	novel	V1991M	0.17
ESCA	chr3	121511993	Nonsense_Mutation	novel	S502*	0.25
ESCA	chr3	121488961	Missense_Mutation	novel	L1324V	0.3
ESCA	chr3	121489061	Silent	novel	R1290R	0.16
ESCA	chr3	121511922	Missense_Mutation	novel	E526K	0.2
ESCA	chr3	121489666	Missense_Mutation	novel	T1089P	0.34
ESCA	chr3	121460164	Silent	novel	R2346R	0.17
ESCA	chr3	121431853	3'UTR	novel		0.32
ESCA	chr3	121489274	Silent	NA	P1219P	0.4
ESCA	chr3	121490365	Missense_Mutation	rs200486636	R856C	0.46
ESCA	chr3	121460135	Missense_Mutation	novel	A2356V	0.41
GBM	chr3	121490352	Missense_Mutation	NA	R860Q	0.47
GBM	chr3	121476632	Missense_Mutation	novel	I2105L	0.04
GBM	chr3	121510185	Missense_Mutation	novel	T557I	0.07
GBM	chr3	121488075	Missense_Mutation	NA	K1619T	0.39
GBM	chr3	121487982	Missense_Mutation	novel	S1650F	0.41
GBM	chr3	121488642	Nonsense_Mutation	rs377402875	L1430*	0.21
GBM	chr3	121533087	Missense_Mutation	rs200236939	R288H	0.46	DEAD
GBM	chr3	121473454	Frame_Shift_Del	novel	*R2147Efs3**	0.07
GBM	chr3	121488936	Missense_Mutation	novel	I1332R	0.03
GBM	chr3	121489106	Missense_Mutation	novel	F1275L	0.11
GBM	chr3	121487410	Missense_Mutation	novel	I1841L	0.05
GBM	chr3	121493608	Silent	NA	R798R	0.36
GBM	chr3	121483507	Missense_Mutation	novel	S1950Y	0.27
GBM	chr3	121511897	Missense_Mutation	NA	A534G	0.09
GBM	chr3	121487336	Silent	novel	S1865S	0.05
GBM	chr3	121489147	Missense_Mutation	novel	T1262P	0.06
HNSC	chr3	121489998	Missense_Mutation	novel	Q978R	0.27
HNSC	chr3	121440060	Missense_Mutation	novel	Q2441E	0.3
HNSC	chr3	121487517	Missense_Mutation	novel	S1805L	0.23
HNSC	chr3	121487412	Missense_Mutation	novel	F1840Y	0.11
HNSC	chr3	121483461	Frame_Shift_Del	novel	*I1964Tfs31**	0.13
HNSC	chr3	121481775	Missense_Mutation	rs773624174	P2003L	0.12
HNSC	chr3	121489060	Missense_Mutation	novel	L1291V	0.24
HNSC	chr3	121490407	Missense_Mutation	novel	A842S	0.06
HNSC	chr3	121487552	Silent	novel	F1793F	0.08
HNSC	chr3	121488850	Nonsense_Mutation	NA	Q1361*	0.13
HNSC	chr3	121490202	Missense_Mutation	novel	S910L	0.16
HNSC	chr3	121476649	Missense_Mutation	novel	C2099F	0.29
HNSC	chr3	121481634	Frame_Shift_Del	novel	*R2045Hfs25**	0.17
HNSC	chr3	121487841	Missense_Mutation	novel	S1697F	0.35
HNSC	chr3	121539537	Missense_Mutation	novel	S176C	0.3
HNSC	chr3	121488404	Missense_Mutation	novel	M1509I	0.22
HNSC	chr3	121489149	Missense_Mutation	novel	R1261K	0.2
HNSC	chr3	121467543	Nonsense_Mutation	rs765178927	R2315*	0.3
HNSC	chr3	121489345	Missense_Mutation	novel	L1196V	0.04
HNSC	chr3	121489752	Missense_Mutation	novel	S1060F	0.07
HNSC	chr3	121541414	Silent	novel	R137R	0.21
HNSC	chr3	121489626	Missense_Mutation	novel	S1102C	0.31
HNSC	chr3	121432962	Missense_Mutation	NA	H2539Y	0.52
HNSC	chr3	121488680	Silent	novel	F1417F	0.15
HNSC	chr3	121488011	Silent	novel	P1640P	0.2
KIRC	chr3	121519869	Splice_Site	novel	X488_splice	0.05
KIRC	chr3	121489326	Missense_Mutation	NA	E1202A	0.16
KIRC	chr3	121468429	Nonsense_Mutation	rs369712134	R2241*	0.33
KIRC	chr3	121489699	Missense_Mutation	NA	C1078S	0.18
KIRP	chr3	121449419	Missense_Mutation	NA	Y2387C	0.49
KIRP	chr3	121541415	Missense_Mutation	NA	M136I	0.28
KIRP	chr3	121498480	Missense_Mutation	NA	K717T	0.53
KIRP	chr3	121541441	Missense_Mutation	NA	L128F	0.18
LAML	chr3	121533007	Missense_Mutation	novel	P315A	0.06	DEAD
LAML	chr3	121496830	Missense_Mutation	novel	Q752H	0.08
LGG	chr3	121433002	Missense_Mutation	rs750113313	M2525I	0.11
LGG	chr3	121467541	Silent	NA	R2315R	0.43
LGG	chr3	121545886	5'UTR	novel		0.1
LGG	chr3	121440041	Missense_Mutation	rs760099812	R2447H	0.37
LGG	chr3	121488745	Missense_Mutation	novel	G1396C	0.08
LGG	chr3	121436152	Silent	novel	R2505R	0.24
LGG	chr3	121539545	In_Frame_Ins	novel	G173_S174insNHN	0.1
LIHC	chr3	121533009	Missense_Mutation	NA	E314G	0.46	DEAD
LIHC	chr3	121460217	Missense_Mutation	NA	A2329S	0.16
LIHC	chr3	121545852	Missense_Mutation	novel	K9I	0.29
LIHC	chr3	121489495	Missense_Mutation	rs751919003	V1146M	0.38
LIHC	chr3	121544746	Silent	NA	G108G	0.43
LIHC	chr3	121489835	Silent	novel	S1032S	0.16
LIHC	chr3	121488810	Missense_Mutation	NA	P1374L	0.12
LIHC	chr3	121481790	Missense_Mutation	novel	P1998L	0.25
LIHC	chr3	121496853	Missense_Mutation	novel	R745S	0.41
LIHC	chr3	121545757	Missense_Mutation	novel	P41T	0.29
LIHC	chr3	121489301	Silent	NA	Q1210Q	0.44
LIHC	chr3	121467587	Missense_Mutation	novel	E2300V	0.35
LIHC	chr3	121533142	Missense_Mutation	novel	N270Y	0.25	DEAD
LIHC	chr3	121537209	Splice_Site	novel	X211_splice	0.5
LIHC	chr3	121440055	Frame_Shift_Del	novel	*T2442Nfs6**	0.43
LIHC	chr3	121490162	Missense_Mutation	novel	F923L	0.18
LIHC	chr3	121487834	Silent	novel	N1699N	0.48
LIHC	chr3	121449321	Missense_Mutation	novel	Y2420N	0.46
LIHC	chr3	121510117	Missense_Mutation	novel	G580R	0.31
LIHC	chr3	121481775	Missense_Mutation	rs773624174	P2003L	0.36
LIHC	chr3	121539579	Missense_Mutation	novel	Q162R	0.39
LUAD	chr3	121511886	Splice_Site	NA	X537_splice	0.08
LUAD	chr3	121481586	Missense_Mutation	novel	K2066M	0.12
LUAD	chr3	121489702	Missense_Mutation	NA	L1077V	0.68
LUAD	chr3	121488442	Missense_Mutation	novel	D1497Y	0.7
LUAD	chr3	121481794	Missense_Mutation	NA	D1997Y	0.3
LUAD	chr3	121489084	Nonsense_Mutation	NA	E1283*	0.32
LUAD	chr3	121487385	Missense_Mutation	rs376715818	R1849Q	0.22
LUAD	chr3	121529675	Missense_Mutation	novel	E360Q	0.14	DEAD
LUAD	chr3	121485153	Missense_Mutation	novel	D1887E	0.13
LUAD	chr3	121489885	Missense_Mutation	NA	V1016F	0.27
LUAD	chr3	121489824	Missense_Mutation	NA	S1036N	0.06
LUAD	chr3	121488499	Missense_Mutation	NA	V1478F	0.21
LUAD	chr3	121432270	3'UTR	rs574058342		0.29
LUAD	chr3	121488039	Missense_Mutation	NA	W1631S	0.29
LUAD	chr3	121529755	Missense_Mutation	novel	T333K	0.22	DEAD
LUAD	chr3	121545848	Silent	NA	R10R	0.22
LUAD	chr3	121488124	Missense_Mutation	NA	Q1603E	0.24
LUAD	chr3	121440028	Silent	novel	P2451P	0.16
LUAD	chr3	121488067	Missense_Mutation	novel	G1622W	0.2
LUAD	chr3	121487601	Missense_Mutation	novel	P1777H	0.36
LUAD	chr3	121490402	Silent	NA	R843R	0.25
LUAD	chr3	121498590	Missense_Mutation	NA	M680I	0.09
LUAD	chr3	121537197	Missense_Mutation	NA	V215L	0.08
LUAD	chr3	121539498	Missense_Mutation	NA	C189F	0.4
LUAD	chr3	121468308	Missense_Mutation	rs146701093	G2281V	0.24
LUAD	chr3	121493607	Missense_Mutation	NA	R798P	0.55
LUAD	chr3	121440028	Silent	novel	P2451P	0.15
LUAD	chr3	121510053	Missense_Mutation	rs758650458	S601I	0.27
LUAD	chr3	121490229	Missense_Mutation	NA	C901F	0.46
LUAD	chr3	121512019	Silent	NA	I493I	0.18
LUAD	chr3	121432933	Missense_Mutation	novel	E2548D	0.57
LUAD	chr3	121487532	Missense_Mutation	NA	S1800I	0.1
LUAD	chr3	121433006	Missense_Mutation	novel	G2524V	0.26
LUAD	chr3	121488039	Missense_Mutation	novel	W1631L	0.39
LUAD	chr3	121488041	Silent	novel	I1630I	0.39
LUAD	chr3	121483394	Missense_Mutation	NA	D1988H	0.14
LUAD	chr3	121520019	Missense_Mutation	novel	L440F	0.12
LUAD	chr3	121489072	Missense_Mutation	NA	N1287Y	0.28
LUAD	chr3	121460112	Missense_Mutation	novel	A2364S	0.16
LUAD	chr3	121488339	Missense_Mutation	novel	D1531V	0.77
LUAD	chr3	121539500	Silent	rs774704896	V188V	0.12
LUAD	chr3	121533020	Silent	novel	V310V	0.34
LUAD	chr3	121489118	Silent	novel	S1271S	0.08
LUSC	chr3	121510051	Missense_Mutation	NA	D602Y	0.28
LUSC	chr3	121496811	Frame_Shift_Del	novel	*Y758Rfs36**	0.32
LUSC	chr3	121493586	Missense_Mutation	novel	Q805L	0.26
LUSC	chr3	121476683	Missense_Mutation	novel	E2088Q	0.26
LUSC	chr3	121489835	Silent	novel	S1032S	0.23
LUSC	chr3	121498577	Missense_Mutation	NA	E685K	0.2
LUSC	chr3	121440002	Missense_Mutation	novel	R2460L	0.34
LUSC	chr3	121476704	Nonsense_Mutation	novel	Q2081*	0.1
LUSC	chr3	121511927	Missense_Mutation	NA	G524A	0.16
LUSC	chr3	121496888	Missense_Mutation	novel	P733L	0.12
LUSC	chr3	121487387	Silent	novel	K1848K	0.1
LUSC	chr3	121488635	Silent	rs148117258	K1432K	0.46
LUSC	chr3	121490157	Missense_Mutation	novel	S925F	0.08
LUSC	chr3	121436266	Missense_Mutation	novel	Q2467E	0.07
LUSC	chr3	121487574	Frame_Shift_Del	novel	*S1786Ifs30**	0.23
LUSC	chr3	121489456	Missense_Mutation	novel	R1159G	0.28
LUSC	chr3	121487443	Missense_Mutation	novel	V1830L	0.39
LUSC	chr3	121498492	Frame_Shift_Del	novel	*M713Rfs14**	0.16
LUSC	chr3	121509605	Missense_Mutation	NA	M639L	0.23
LUSC	chr3	121533092	Missense_Mutation	novel	D286E	0.21	DEAD
LUSC	chr3	121488048	Missense_Mutation	NA	S1628L	0.07
LUSC	chr3	121498572	Silent	novel	L686L	0.21
LUSC	chr3	121449377	Missense_Mutation	novel	Q2401R	0.24
LUSC	chr3	121472010	Missense_Mutation	NA	S2233L	0.43
LUSC	chr3	121498490	Missense_Mutation	NA	A714S	0.75
LUSC	chr3	121498491	Missense_Mutation	NA	M713I	0.75
LUSC	chr3	121436152	Nonsense_Mutation	rs147692745	R2505*	0.16
LUSC	chr3	121433024	Missense_Mutation	novel	R2518L	0.31
LUSC	chr3	121488496	Missense_Mutation	rs149344067	P1479S	0.09
LUSC	chr3	121487923	Nonsense_Mutation	novel	R1670*	0.35
LUSC	chr3	121489549	Missense_Mutation	novel	L1128V	0.29
LUSC	chr3	121510121	Missense_Mutation	rs535880169	Q578H	0.43
LUSC	chr3	121487432	Missense_Mutation	NA	D1833E	0.2
LUSC	chr3	121490032	Missense_Mutation	NA	S967G	0.23
LUSC	chr3	121432950	Silent	NA	L2543L	0.1
LUSC	chr3	121487539	Missense_Mutation	NA	P1798S	0.4
LUSC	chr3	121487567	Silent	NA	G1788G	0.14
LUSC	chr3	121488641	Frame_Shift_Ins	rs755281591	*L1430Ffs5**	0.16
LUSC	chr3	121489885	Missense_Mutation	NA	V1016F	0.12
LUSC	chr3	121520003	Missense_Mutation	rs369056683	L446V	0.18
LUSC	chr3	121481655	Missense_Mutation	NA	R2043L	0.15
LUSC	chr3	121488166	Missense_Mutation	novel	R1589G	0.18
LUSC	chr3	121481581	Missense_Mutation	NA	N2068D	0.35
LUSC	chr3	121433016	Missense_Mutation	novel	K2521E	0.29
LUSC	chr3	121487396	Silent	novel	R1845R	0.22
LUSC	chr3	121519939	Missense_Mutation	rs761630032	R467Q	0.43
OV	chr3	121509689	Missense_Mutation	NA	P611A	0.35
OV	chr3	121487983	Missense_Mutation	novel	S1650P	0.33
OV	chr3	121460228	Nonsense_Mutation	novel	S2325*	0.06
OV	chr3	121488554	Silent	NA	I1459I	0.5
OV	chr3	121468315	Missense_Mutation	NA	P2279S	0.36
OV	chr3	121498550	Missense_Mutation	novel	L694M	0.04
OV	chr3	121467522	Missense_Mutation	NA	P2322A	0.31
OV	chr3	121546417	5'Flank	novel		0.07
PAAD	chr3	121537203	Missense_Mutation	novel	V213M	0.15
PAAD	chr3	121539465	Missense_Mutation	rs747882906	R200H	0.16
PRAD	chr3	121546426	5'Flank	novel		0.07
PRAD	chr3	121488641	Frame_Shift_Ins	rs755281591	*L1430Ffs5**	0.19
PRAD	chr3	121544811	In_Frame_Ins	novel	S86_F87insISTATN	0.05
PRAD	chr3	121544813	In_Frame_Ins	novel	H85_S86insT	0.04
PRAD	chr3	121473399	Missense_Mutation	NA	I2165N	0.07
PRAD	chr3	121487508	Missense_Mutation	NA	L1808S	0.06
PRAD	chr3	121509696	Silent	novel	V608V	0.18
PRAD	chr3	121533095	Silent	rs556803867	T285T	0.2
PRAD	chr3	121490145	Missense_Mutation	NA	S929T	0.1
PRAD	chr3	121489541	Silent	rs779774025	N1130N	0.26
PRAD	chr3	121490132	Frame_Shift_Del	NA	*K933Nfs2**	0.43
READ	chr3	121488055	Missense_Mutation	NA	N1626H	0.24
READ	chr3	121489740	Missense_Mutation	NA	R1064K	0.25
READ	chr3	121489211	Silent	novel	I1240I	0.06
READ	chr3	121489097	Silent	novel	S1278S	0.07
READ	chr3	121487564	Missense_Mutation	novel	S1789R	0.05
READ	chr3	121511892	Missense_Mutation	rs758335813	L536V	0.27
READ	chr3	121532993	Silent	NA	V319V	0.18
READ	chr3	121432026	3'UTR	novel		0.86
READ	chr3	121483439	Missense_Mutation	novel	I1973L	0.46
READ	chr3	121488929	Silent	novel	Q1334Q	0.41
READ	chr3	121489836	Missense_Mutation	novel	S1032L	0.44
READ	chr3	121509587	Nonsense_Mutation	novel	E645*	0.05
READ	chr3	121522102	Nonsense_Mutation	rs776837608	E386*	0.39	DEAD
READ	chr3	121546520	5'Flank	novel		0.45
READ	chr3	121487922	Missense_Mutation	NA	R1670K	0.3
READ	chr3	121488398	Missense_Mutation	novel	E1511D	0.29
SARC	chr3	121546631	5'Flank	novel		0.4
SARC	chr3	121449357	Missense_Mutation	novel	D2408Y	0.27
SARC	chr3	121485142	Missense_Mutation	novel	P1891L	0.57
SKCM	chr3	121467566	Missense_Mutation	rs752041083	G2307E	0.46
SKCM	chr3	121520027	Missense_Mutation	rs146111884	R438W	0.34
SKCM	chr3	121496869	Silent	NA	Q739Q	0.32
SKCM	chr3	121488238	Nonsense_Mutation	NA	Q1565*	0.4
SKCM	chr3	121546474	5'Flank	novel		0.31
SKCM	chr3	121487850	Missense_Mutation	NA	S1694L	0.17
SKCM	chr3	121510125	Missense_Mutation	NA	V577A	0.11
SKCM	chr3	121481571	Splice_Site	novel	X2071_splice	0.38
SKCM	chr3	121460059	Missense_Mutation	NA	Q2381H	0.29
SKCM	chr3	121488811	Missense_Mutation	novel	P1374S	0.22
SKCM	chr3	121546452	5'Flank	novel		0.2
SKCM	chr3	121489940	Missense_Mutation	NA	N997K	0.25
SKCM	chr3	121489566	Missense_Mutation	NA	C1122F	0.13
SKCM	chr3	121485143	Missense_Mutation	NA	P1891S	0.12
SKCM	chr3	121522009	Missense_Mutation	NA	H417Y	1
SKCM	chr3	121487657	Silent	novel	N1758N	0.33
SKCM	chr3	121488712	Missense_Mutation	novel	V1407I	0.39
SKCM	chr3	121490011	Nonsense_Mutation	novel	Q974*	0.32
SKCM	chr3	121490012	Silent	novel	F973F	0.32
SKCM	chr3	121460051	Missense_Mutation	novel	Q2384R	0.81
SKCM	chr3	121490237	Nonsense_Mutation	novel	W898*	0.24
SKCM	chr3	121488766	Missense_Mutation	NA	H1389Y	0.37
SKCM	chr3	121546501	5'Flank	novel		0.38
SKCM	chr3	121487844	Missense_Mutation	NA	S1696F	0.22
SKCM	chr3	121546376	5'Flank	novel		0.3
SKCM	chr3	121490184	Missense_Mutation	NA	S916F	0.17
SKCM	chr3	121472016	Missense_Mutation	NA	P2231L	0.45
SKCM	chr3	121489401	Missense_Mutation	NA	S1177L	0.45
SKCM	chr3	121496889	Missense_Mutation	rs769353243	P733S	0.37
SKCM	chr3	121533047	Silent	NA	S301S	0.29
SKCM	chr3	121488027	Missense_Mutation	novel	S1635L	0.4
SKCM	chr3	121460102	Missense_Mutation	NA	K2367T	0.47
SKCM	chr3	121489813	Nonsense_Mutation	rs764050733	R1040*	0.29
SKCM	chr3	121488243	Missense_Mutation	NA	S1563F	0.22
SKCM	chr3	121545767	Silent	NA	S37S	0.26
SKCM	chr3	121488877	Missense_Mutation	novel	G1352R	0.35
SKCM	chr3	121541389	Missense_Mutation	NA	P145L	0.36
SKCM	chr3	121522030	Missense_Mutation	NA	P410S	0.08
SKCM	chr3	121489843	Missense_Mutation	NA	F1030I	0.27
SKCM	chr3	121496871	Nonsense_Mutation	novel	Q739*	0.34
SKCM	chr3	121488891	Missense_Mutation	NA	T1347I	0.22
SKCM	chr3	121432285	3'UTR	novel		0.41
SKCM	chr3	121489813	Nonsense_Mutation	rs764050733	R1040*	0.2
SKCM	chr3	121537163	Missense_Mutation	rs771235928	R226Q	0.39
SKCM	chr3	121545916	5'UTR	novel		0.15
SKCM	chr3	121485130	Missense_Mutation	novel	C1895S	0.21
SKCM	chr3	121533048	Missense_Mutation	NA	S301F	0.22	DEAD
SKCM	chr3	121476726	Silent	NA	F2073F	0.31
SKCM	chr3	121488391	Missense_Mutation	NA	P1514S	0.29
SKCM	chr3	121488202	Missense_Mutation	NA	P1577S	0.25
SKCM	chr3	121520063	Missense_Mutation	novel	D426N	0.43
SKCM	chr3	121509575	Missense_Mutation	NA	H649Y	0.11
SKCM	chr3	121544775	Missense_Mutation	NA	C99R	0.33
SKCM	chr3	121496924	Missense_Mutation	NA	T721I	0.16
SKCM	chr3	121432344	Missense_Mutation	NA	I2578K	0.18
SKCM	chr3	121489884	Missense_Mutation	rs781652004	V1016A	0.05
STAD	chr3	121520075	Frame_Shift_Del	novel	*T421Lfs29**	0.25
STAD	chr3	121490030	Silent	novel	S967S	0.16
STAD	chr3	121533130	Missense_Mutation	rs767741010	V274M	0.37	DEAD
STAD	chr3	121468366	Missense_Mutation	novel	T2262A	0.05
STAD	chr3	121537180	Missense_Mutation	novel	M220I	0.11
STAD	chr3	121488642	Frame_Shift_Del	NA	L1430*	0.42
STAD	chr3	121533033	Missense_Mutation	NA	S306L	0.07	DEAD
STAD	chr3	121488641	Frame_Shift_Ins	rs755281591	*L1430Ffs5**	0.19
STAD	chr3	121460170	Silent	NA	H2344H	0.21
STAD	chr3	121487763	Missense_Mutation	rs748483271	R1723H	0.11
STAD	chr3	121489088	Silent	NA	Q1281Q	0.25
STAD	chr3	121487538	Missense_Mutation	NA	P1798H	0.28
STAD	chr3	121541388	Silent	NA	P145P	0.39
STAD	chr3	121488703	Missense_Mutation	NA	L1410M	0.31
STAD	chr3	121512028	Splice_Region	rs778193670	G490G	0.33
STAD	chr3	121496853	Missense_Mutation	rs373455498	R745C	0.41
STAD	chr3	121519960	Missense_Mutation	rs763394640	R460Q	0.35
STAD	chr3	121539563	Silent	NA	K167K	0.38
STAD	chr3	121546527	5'Flank	novel		0.28
STAD	chr3	121433024	Missense_Mutation	rs200303341	R2518Q	0.22
STAD	chr3	121493687	Nonsense_Mutation	novel	W771*	0.45
STAD	chr3	121522071	Missense_Mutation	novel	R396H	0.36	DEAD
STAD	chr3	121539502	Missense_Mutation	novel	V188I	0.44
STAD	chr3	121473459	Frame_Shift_Del	novel	*P2145Qfs5**	0.2
STAD	chr3	121544825	Missense_Mutation	NA	E82V	0.06
STAD	chr3	121490223	Missense_Mutation	novel	L903R	0.34
STAD	chr3	121529678	Nonsense_Mutation	rs779818079	R359*	0.23	DEAD
STAD	chr3	121519915	Missense_Mutation	NA	K475M	0.13
STAD	chr3	121509600	Missense_Mutation	NA	K640N	0.14
STAD	chr3	121488418	Frame_Shift_Ins	novel	*P1505Ifs3**	0.12
STAD	chr3	121439991	Splice_Site	novel	X2463_splice	0.13
STAD	chr3	121541429	Missense_Mutation	rs201454367	R132W	0.04
STAD	chr3	121440030	Missense_Mutation	NA	P2451S	0.18
STAD	chr3	121539470	Silent	NA	I198I	0.39
STAD	chr3	121460069	Missense_Mutation	NA	L2378P	0.28
STAD	chr3	121487440	Missense_Mutation	rs772328819	A1831T	0.26
STAD	chr3	121440007	Silent	NA	P2458P	0.39
STAD	chr3	121510220	Silent	NA	S545S	0.36
STAD	chr3	121529643	Splice_Site	NA	X370_splice	0.1
STAD	chr3	121432921	Silent	NA	V2552V	0.06
STAD	chr3	121520048	Missense_Mutation	NA	A431P	0.27
STAD	chr3	121468312	Missense_Mutation	NA	M2280V	0.18
STAD	chr3	121509645	Silent	NA	P625P	0.21
STAD	chr3	121488281	Silent	NA	C1550C	0.15
STAD	chr3	121544725	Splice_Site	NA	X115_splice	0.23
STAD	chr3	121488642	Frame_Shift_Del	NA	L1430*	0.21
STAD	chr3	121488642	Frame_Shift_Del	NA	L1430*	0.3
STAD	chr3	121481590	Nonsense_Mutation	NA	Q2065*	0.12
STAD	chr3	121510056	Missense_Mutation	NA	A600V	0.1
STAD	chr3	121539547	Missense_Mutation	novel	G173S	0.36
THCA	chr3	121493688	Frame_Shift_Ins	novel	*W771Yfs36**	0.07
THCA	chr3	121511973	Nonsense_Mutation	novel	Q509*	0.16
THCA	chr3	121487387	Silent	novel	K1848K	0.15
THCA	chr3	121487522	Frame_Shift_Ins	novel	*S1803Rfs32**	0.05
THCA	chr3	121489382	Nonsense_Mutation	novel	*M1184Ifs2**	0.03
THCA	chr3	121489526	In_Frame_Ins	novel	E1135delinsDVTTDCFTG	0.05
THCA	chr3	121545944	5'UTR	novel		0.44
THYM	chr3	121489801	Missense_Mutation	rs201749749	R1044C	0.08
THYM	chr3	121489747	Missense_Mutation	novel	A1062T	0.22
UCEC	chr3	121460145	Missense_Mutation	NA	N2353H	0.29
UCEC	chr3	121432250	3'UTR	novel		0.35
UCEC	chr3	121510224	Missense_Mutation	NA	A544G	0.32
UCEC	chr3	121433024	Missense_Mutation	rs200303341	R2518Q	0.25
UCEC	chr3	121490352	Missense_Mutation	NA	R860Q	0.33
UCEC	chr3	121481720	Missense_Mutation	novel	E2021D	0.29
UCEC	chr3	121488443	Silent	NA	D1496D	0.31
UCEC	chr3	121488343	Missense_Mutation	NA	E1530K	0.57
UCEC	chr3	121488612	Missense_Mutation	NA	S1440L	0.12
UCEC	chr3	121467565	Silent	novel	G2307G	0.35
UCEC	chr3	121489288	Missense_Mutation	novel	E1215K	0.45
UCEC	chr3	121489982	Silent	novel	C983C	0.2
UCEC	chr3	121490329	Missense_Mutation	novel	K868Q	0.3
UCEC	chr3	121496875	Silent	novel	I737I	0.47
UCEC	chr3	121498591	Missense_Mutation	novel	M680T	0.25
UCEC	chr3	121541456	Missense_Mutation	novel	L123V	0.22
UCEC	chr3	121472142	Missense_Mutation	NA	A2189V	0.26
UCEC	chr3	121489960	Missense_Mutation	rs752913920	R991W	0.46
UCEC	chr3	121509677	Missense_Mutation	novel	G615R	0.12
UCEC	chr3	121487893	Nonsense_Mutation	NA	E1680*	0.43
UCEC	chr3	121487429	Missense_Mutation	novel	Q1834H	0.26
UCEC	chr3	121498547	Missense_Mutation	novel	A695T	0.06
UCEC	chr3	121532996	Missense_Mutation	novel	Q318H	0.57	DEAD
UCEC	chr3	121546511	5'Flank	novel		0.34
UCEC	chr3	121436122	Nonsense_Mutation	novel	G2515*	0.32
UCEC	chr3	121519972	Missense_Mutation	rs375295723	R456H	0.42
UCEC	chr3	121498605	Missense_Mutation	novel	K675N	0.48
UCEC	chr3	121522102	Nonsense_Mutation	rs776837608	E386*	0.61	DEAD
UCEC	chr3	121544726	Splice_Site	novel	X115_splice	0.42
UCEC	chr3	121493660	Missense_Mutation	NA	Q780H	0.14
UCEC	chr3	121476545	Missense_Mutation	rs148445441	A2134T	0.1
UCEC	chr3	121489774	Missense_Mutation	NA	D1053N	0.17
UCEC	chr3	121544832	Missense_Mutation	NA	V80L	0.35
UCEC	chr3	121440070	Silent	rs763663799	D2437D	0.33
UCEC	chr3	121489783	Nonsense_Mutation	rs747386606	R1050*	0.37
UCEC	chr3	121468387	Missense_Mutation	novel	D2255Y	0.11
UCEC	chr3	121509608	Missense_Mutation	novel	A638S	0.06
UCEC	chr3	121489664	Silent	novel	T1089T	0.22
UCEC	chr3	121511915	Missense_Mutation	novel	T528I	0.2
UCEC	chr3	121511900	Missense_Mutation	rs375451342	R533Q	0.39
UCEC	chr3	121489082	Missense_Mutation	novel	E1283D	0.5
UCEC	chr3	121488145	Missense_Mutation	NA	P1596A	0.28
UCEC	chr3	121488496	Missense_Mutation	NA	P1479A	0.28
UCEC	chr3	121537163	Missense_Mutation	rs771235928	R226Q	0.25
UCEC	chr3	121460111	Missense_Mutation	novel	A2364E	0.08
UCEC	chr3	121432066	3'UTR	novel		0.59
UCEC	chr3	121488574	Nonsense_Mutation	novel	E1453*	0.35
UCEC	chr3	121431663	3'UTR	novel		0.31
UCEC	chr3	121487758	Nonsense_Mutation	novel	E1725*	0.41
UCEC	chr3	121490033	Silent	novel	T966T	0.33
UCEC	chr3	121449413	Missense_Mutation	novel	I2389T	0.38
UCEC	chr3	121487758	Nonsense_Mutation	novel	E1725*	0.37
UCEC	chr3	121432115	3'UTR	novel		0.38
UCEC	chr3	121487763	Missense_Mutation	rs748483271	R1723H	0.18
UCEC	chr3	121489323	Missense_Mutation	novel	Q1203P	0.47
UCEC	chr3	121529677	Missense_Mutation	rs755957380	R359Q	0.39	DEAD
UCEC	chr3	121483494	Missense_Mutation	novel	K1954N	0.59
UCEC	chr3	121488099	Missense_Mutation	novel	Q1611R	0.07
UCEC	chr3	121489664	Silent	novel	T1089T	0.22
UCEC	chr3	121489793	Silent	novel	K1046K	0.53
UCEC	chr3	121488800	Silent	rs757369707	A1377A	0.34
UCEC	chr3	121440085	Missense_Mutation	novel	K2432N	0.53
UCEC	chr3	121485170	Missense_Mutation	novel	E1882K	0.57
UCEC	chr3	121488929	Missense_Mutation	novel	Q1334H	0.4
UCEC	chr3	121496907	Missense_Mutation	novel	D727Y	0.39
UCEC	chr3	121498627	Missense_Mutation	rs747642530	R668Q	0.54
UCEC	chr3	121509585	Missense_Mutation	novel	E645D	0.34
UCEC	chr3	121533156	Missense_Mutation	novel	S265I	0.38	DEAD
UCEC	chr3	121541348	Splice_Site	rs140109548	X158_splice	0.46
UCEC	chr3	121487954	Missense_Mutation	novel	K1659N	0.5
UCEC	chr3	121432258	3'UTR	novel		0.39
UCEC	chr3	121487471	Silent	novel	S1820S	0.05
UCEC	chr3	121449373	Missense_Mutation	novel	M2402I	0.77
UCEC	chr3	121488662	Missense_Mutation	NA	L1423F	0.46
UCEC	chr3	121489740	Missense_Mutation	novel	R1064I	0.28
UCEC	chr3	121509597	Silent	novel	G641G	0.44
UCEC	chr3	121489030	Missense_Mutation	novel	N1301H	0.34
UCEC	chr3	121489673	Missense_Mutation	novel	E1086D	0.51
UCEC	chr3	121510162	Nonsense_Mutation	NA	E565*	0.52
UCEC	chr3	121485144	Silent	novel	F1890F	0.3
UCEC	chr3	121509671	Missense_Mutation	novel	A617T	0.26
UCEC	chr3	121488848	Missense_Mutation	NA	Q1361H	0.24
UCEC	chr3	121489257	Missense_Mutation	novel	S1225N	0.07
UCEC	chr3	121546380	5'Flank	novel		0.27
UCEC	chr3	121476665	Missense_Mutation	novel	F2094I	0.43
UCEC	chr3	121544860	Silent	rs368265969	L70L	0.04
UCEC	chr3	121460116	Silent	novel	I2362I	0.18
UCEC	chr3	121432932	Nonsense_Mutation	NA	E2549*	0.36
UCEC	chr3	121481734	Missense_Mutation	NA	L2017I	0.36
UCEC	chr3	121431770	3'UTR	novel		0.36
UCEC	chr3	121431895	3'UTR	novel		0.44
UCEC	chr3	121493642	Silent	rs778716268	T786T	0.36
UCEC	chr3	121431954	3'UTR	novel		0.43
UCEC	chr3	121440094	Missense_Mutation	novel	E2429D	0.44
UCEC	chr3	121468323	Missense_Mutation	rs758239782	G2276D	0.38
UCEC	chr3	121533167	Silent	rs374632964	I261I	0.37
UCEC	chr3	121498558	Missense_Mutation	NA	E691A	0.16
UCEC	chr3	121488642	Frame_Shift_Del	NA	L1430*	0.33
UCEC	chr3	121468381	Nonsense_Mutation	novel	E2257*	0.08
UCEC	chr3	121487919	Missense_Mutation	novel	K1671T	0.08
UCEC	chr3	121488188	Missense_Mutation	NA	K1581N	0.29
UCEC	chr3	121537132	Missense_Mutation	NA	K236N	0.34	DEAD
UCEC	chr3	121488642	Frame_Shift_Del	NA	L1430*	0.43
UCEC	chr3	121546380	5'Flank	novel		0.28
UCEC	chr3	121436263	Missense_Mutation	novel	A2468S	0.24
UCEC	chr3	121488724	In_Frame_Ins	novel	S1402_D1403insSENII	0.05
UCEC	chr3	121481731	Missense_Mutation	NA	P2018T	0.26
UCEC	chr3	121460095	Silent	NA	I2369I	0.18
UCEC	chr3	121436219	Silent	novel	K2482K	0.04
UCEC	chr3	121510178	Silent	NA	L559L	0.27
UCEC	chr3	121473432	Missense_Mutation	novel	S2154N	0.31
UCEC	chr3	121481616	Missense_Mutation	novel	S2056Y	0.38
UCEC	chr3	121498663	Missense_Mutation	novel	P656H	0.5
UCEC	chr3	121488542	Silent	novel	P1463P	0.07
UCEC	chr3	121436236	Missense_Mutation	novel	A2477T	0.38
UCEC	chr3	121432932	Nonsense_Mutation	NA	E2549*	0.52
UCEC	chr3	121539565	Missense_Mutation	NA	K167Q	0.38
UCEC	chr3	121545742	Missense_Mutation	novel	G46C	0.56
UCEC	chr3	121488856	Missense_Mutation	NA	V1359I	0.36
UCEC	chr3	121489211	Silent	NA	I1240I	0.35
UCEC	chr3	121490352	Missense_Mutation	NA	R860Q	0.26
UCEC	chr3	121529690	Missense_Mutation	novel	D355Y	0.07	DEAD
UCEC	chr3	121489556	Missense_Mutation	novel	N1125K	0.05
UCEC	chr3	121489558	Frame_Shift_Ins	novel	*N1125Pfs13**	0.05
UCEC	chr3	121533152	Frame_Shift_Ins	novel	*T267Mfs29**	0.01	DEAD
UCEC	chr3	121529759	Nonsense_Mutation	NA	E332*	0.15	DEAD
UCEC	chr3	121489028	Silent	novel	N1301N	0.45
UCEC	chr3	121489801	Missense_Mutation	rs201749749	R1044C	0.21
UCEC	chr3	121498627	Missense_Mutation	rs747642530	R668Q	0.2
UCEC	chr3	121529644	Splice_Site	novel	X370_splice	0.21
UCEC	chr3	121496895	Nonsense_Mutation	novel	E731*	0.42
UCEC	chr3	121498631	Missense_Mutation	novel	Y667H	0.36
UCEC	chr3	121432319	Missense_Mutation	novel	K2586N	0.06
UCEC	chr3	121467586	Missense_Mutation	NA	E2300D	0.17
UCEC	chr3	121519939	Missense_Mutation	rs761630032	R467Q	0.32
UCEC	chr3	121544743	Missense_Mutation	rs142782936	K109N	0.33
UCEC	chr3	121489745	Silent	rs751377736	A1062A	0.26
UCEC	chr3	121539451	Missense_Mutation	novel	N205H	0.43
UCEC	chr3	121431919	3'UTR	novel		0.33
UCEC	chr3	121488555	Missense_Mutation	novel	I1459T	0.25
UCEC	chr3	121489272	Missense_Mutation	rs746582878	C1220Y	0.27
UCEC	chr3	121489756	Missense_Mutation	NA	D1059Y	0.21
UCEC	chr3	121511900	Missense_Mutation	rs375451342	R533Q	0.37
UCS	chr3	121472138	Silent	novel	L2190L	0.35
UCS	chr3	121488944	Missense_Mutation	rs751763795	E1329D	0.33
UCS	chr3	121541372	Nonsense_Mutation	novel	K151*	0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	AMP	0.1109	0.005341
GBM	DEL	0.0867	0.00094652
KIRC	DEL	0.2045	0.11092
LGG	DEL	0.0604	0.04374
READ	AMP	0.1636	0.02906

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0029	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.00049	Kaplan-Meier Survival Analysis
SARC	0.015	Kaplan-Meier Survival Analysis
MESO	0.00013	Kaplan-Meier Survival Analysis
ACC	0.00013	Kaplan-Meier Survival Analysis
PRAD	0.032	Kaplan-Meier Survival Analysis
LUSC	0.048	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.00012	Kaplan-Meier Survival Analysis
PCPG	0.034	Kaplan-Meier Survival Analysis
READ	0.0046	Kaplan-Meier Survival Analysis
KICH	0.0051	Kaplan-Meier Survival Analysis
UCEC	0.00011	Kaplan-Meier Survival Analysis
LIHC	0.00014	Kaplan-Meier Survival Analysis
CHOL	0.028	Kaplan-Meier Survival Analysis
LUAD	0.00028	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742