EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000052126 (Gene tree)
Gene ID: 54477
Gene Symbol: PLEKHA5
Alias: PEPP2|KIAA1686|FLJ10667
Full Name: pleckstrin homology domain containing A5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 246,709 bases
Position: chr12:19,129,692-19,376,400
Accession: 30036
RBP type: non-canonical RBP
Summary: (Pleckstrin Homology Domain Containing A5) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3-phosphate binding and phosphatidylinositol-3,5-bisphosphate binding. An important paralog of this gene is PLEKHA7.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000538972	PLEKHA5-214	2072	-	ENSP00000443553	397 (aa)	-	H0YGJ6
ENST00000510738	PLEKHA5-204	2534	-	-	- (aa)	-	-
ENST00000537027	PLEKHA5-208	427	-	-	- (aa)	-	-
ENST00000538305	PLEKHA5-211	633	-	ENSP00000446308	118 (aa)	-	F5H1X3
ENST00000538677	PLEKHA5-212	557	-	ENSP00000441777	135 (aa)	-	H0YG48
ENST00000534979	PLEKHA5-205	428	-	-	- (aa)	-	-
ENST00000538714	PLEKHA5-213	6487	XM_006719091	ENSP00000439673	1174 (aa)	XP_006719154	Q9HAU0
ENST00000299275	PLEKHA5-201	4238	XM_005253400	ENSP00000299275	1116 (aa)	XP_005253457	Q9HAU0
ENST00000540972	PLEKHA5-216	1954	-	ENSP00000439396	76 (aa)	XP_016874992	Q9HAU0
ENST00000539256	PLEKHA5-215	3357	-	ENSP00000440611	874 (aa)	-	A0JP02
ENST00000429027	PLEKHA5-203	4762	XM_006719096	ENSP00000404296	1282 (aa)	XP_006719159	Q9HAU0
ENST00000424268	PLEKHA5-202	4391	XM_017019497	ENSP00000400411	1098 (aa)	XP_016874986	Q9HAU0
ENST00000536974	PLEKHA5-207	3139	-	ENSP00000440371	977 (aa)	-	B4DJX4
ENST00000538034	PLEKHA5-209	453	-	-	- (aa)	-	-
ENST00000535357	PLEKHA5-206	597	-	-	- (aa)	-	-
ENST00000538068	PLEKHA5-210	901	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000052126's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000052126	Body Mass Index	4.13150138250935E-5	17903300
ENSG00000052126	Body Mass Index	1.36759712285303E-5	17903300
ENSG00000052126	Body Mass Index	2.75289443319401E-5	17903300
ENSG00000052126	Body Height	6.12351203499464E-5	17903300
ENSG00000052126	Body Height	8.08049766047127E-5	17903300
ENSG00000052126	Body Weight	1.76169194411743E-6	17903300
ENSG00000052126	Body Mass Index	1.92860456922538E-5	17903300
ENSG00000052126	Body Mass Index	4.02668970961868E-6	17903300
ENSG00000052126	Body Mass Index	1.85220982192981E-5	17903300
ENSG00000052126	Body Mass Index	2.02605443348284E-5	17903300
ENSG00000052126	Body Weight	1.30601465345088E-7	17903300
ENSG00000052126	Body Weight	2.28985647536195E-6	17903300
ENSG00000052126	Body Weight	5.41479146789304E-7	17903300
ENSG00000052126	Body Weight	1.9746646853399E-6	17903300
ENSG00000052126	Body Weight	4.68154600323329E-8	17903300
ENSG00000052126	Body Weight	2.71829117448215E-7	17903300
ENSG00000052126	Body Weight	6.06817240537306E-6	17903300
ENSG00000052126	Body Weight	1.49109341827103E-5	17903300
ENSG00000052126	Body Weight	1.61059601495982E-6	17903300
ENSG00000052126	Body Weight	7.40137817251735E-5	17903300
ENSG00000052126	Body Weight	2.26693455903071E-7	17903300
ENSG00000052126	Body Weight	5.97572552053577E-7	17903300
ENSG00000052126	Body Weight	4.66111793851419E-5	17903300
ENSG00000052126	Body Mass Index	4.58170185810982E-5	17903300
ENSG00000052126	Body Weight	7.30888620575288E-5	17903300
ENSG00000052126	Body Weight	1.62517905613471E-5	17903300
ENSG00000052126	Body Weight	2.9798605373945E-5	17903300
ENSG00000052126	Body Weight	8.38922377239488E-5	17903300
ENSG00000052126	Platelet Function Tests	8.3200000E-006	-
ENSG00000052126	Platelet Function Tests	1.0125200E-005	-
ENSG00000052126	Platelet Function Tests	1.0075735E-007	-
ENSG00000052126	S-(3-hydroxypropyl)cysteine N-acetate	9E-8	26053186
ENSG00000052126	Smoking	9E-8	26053186
ENSG00000052126	Gastrointestinal Microbiome	1E-8	27694959

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000052126	rs10743315	12	19316144	A	Gut microbiota (bacterial taxa)	27694959	NR Z-score decrease	5.6769347	EFO_0007874
ENSG00000052126	rs143970033	12	19368705	?	3-hydroxypropylmercapturic acid levels in smokers	26053186	[NR] unit increase	1.0142	EFO_0004318\|EFO_0007014
ENSG00000052126	rs11044463	12	19250055	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000052126's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	16713569.25416956.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0008150	biological_process	-	ND	Process
GO:0010314	phosphatidylinositol-5-phosphate binding	-	IEA	Function
GO:0014069	postsynaptic density	-	IEA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0032266	phosphatidylinositol-3-phosphate binding	-	IEA	Function
GO:0061458	reproductive system development	-	IEA	Process
GO:0070273	phosphatidylinositol-4-phosphate binding	-	IEA	Function
GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	-	IEA	Function
GO:0098978	glutamatergic synapse	-	IEA	Component