EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000052749 (Gene tree)
Gene ID: 23223
Gene Symbol: RRP12
Alias: KIAA0690
Full Name: ribosomal RNA processing 12 homolog
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 69,719 bases
Position: chr10:97,356,358-97,426,076
Accession: 29100
RBP type: canonical RBP
Summary: (Ribosomal RNA Processing 12 Homolog) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000324315	NUC173	PF08161.12	2.1e-74	1	1
ENSP00000414863	NUC173	PF08161.12	2.4e-74	1	1
ENSP00000360031	NUC173	PF08161.12	2.5e-74	1	1
ENSP00000446184	NUC173	PF08161.12	2.5e-74	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000622320	RRP12-215	543	-	ENSP00000482139	32 (aa)	-	A0A087WYW2
ENST00000490815	RRP12-209	529	-	-	- (aa)	-	-
ENST00000370992	RRP12-202	4425	XM_011539556	ENSP00000360031	1297 (aa)	XP_011537858	Q5JTH9
ENST00000465394	RRP12-205	652	-	-	- (aa)	-	-
ENST00000414986	RRP12-203	4242	-	ENSP00000414863	1236 (aa)	-	Q5JTH9
ENST00000491313	RRP12-210	1919	-	-	- (aa)	-	-
ENST00000487612	RRP12-208	459	-	ENSP00000483365	106 (aa)	-	A0A087X0G0
ENST00000621606	RRP12-214	886	-	-	- (aa)	-	-
ENST00000618765	RRP12-212	833	-	ENSP00000484474	176 (aa)	-	A0A087X1U8
ENST00000479317	RRP12-206	411	-	-	- (aa)	-	-
ENST00000479481	RRP12-207	3271	-	-	- (aa)	-	-
ENST00000439965	RRP12-204	545	-	ENSP00000401102	64 (aa)	-	H7C1M8
ENST00000315563	RRP12-201	4038	-	ENSP00000324315	1197 (aa)	-	Q5JTH9
ENST00000536831	RRP12-211	4476	-	ENSP00000446184	1297 (aa)	-	Q5JTH9
ENST00000619048	RRP12-213	509	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000052749's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000052749	Child Development Disorders, Pervasive	2.0115000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000052749	rs11189181	10	97384397	G	Monocyte count	27863252	[0.034-0.049] unit increase	0.04169618	EFO_0005091
ENSG00000052749	rs7903847	10	97395225	C	Granulocyte percentage of myeloid white cells	27863252	[0.017-0.033] unit decrease	0.02538068	EFO_0007997
ENSG00000052749	rs61863818	10	97376646	T	Monocyte percentage of white cells	27863252	[0.025-0.041] unit increase	0.03332382	EFO_0007989

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000052749's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000052749	RRP12	98	79.365	ENSAPOG00000013355	rrp12	99	62.414	Acanthochromis_polyacanthus
ENSG00000052749	RRP12	100	100.000	ENSAMEG00000000134	RRP12	98	95.395	Ailuropoda_melanoleuca
ENSG00000052749	RRP12	100	76.562	ENSACIG00000022673	rrp12	99	63.218	Amphilophus_citrinellus
ENSG00000052749	RRP12	98	79.365	ENSAOCG00000016149	rrp12	99	63.720	Amphiprion_ocellaris
ENSG00000052749	RRP12	98	79.365	ENSAPEG00000016023	rrp12	99	62.855	Amphiprion_percula
ENSG00000052749	RRP12	100	76.562	ENSATEG00000022627	rrp12	97	75.000	Anabas_testudineus
ENSG00000052749	RRP12	97	66.271	ENSAPLG00000014387	RRP12	100	66.350	Anas_platyrhynchos
ENSG00000052749	RRP12	100	78.125	ENSACAG00000002175	RRP12	99	66.334	Anolis_carolinensis
ENSG00000052749	RRP12	100	98.438	ENSANAG00000037485	RRP12	100	96.302	Aotus_nancymaae
ENSG00000052749	RRP12	100	75.000	ENSACLG00000007354	rrp12	99	63.154	Astatotilapia_calliptera
ENSG00000052749	RRP12	100	77.966	ENSAMXG00000012852	rrp12	98	69.143	Astyanax_mexicanus
ENSG00000052749	RRP12	100	96.875	ENSBTAG00000002191	RRP12	100	90.776	Bos_taurus
ENSG00000052749	RRP12	93	31.618	WBGene00021595	Y46E12BL.2	89	31.618	Caenorhabditis_elegans
ENSG00000052749	RRP12	88	95.764	ENSCJAG00000016549	-	100	95.833	Callithrix_jacchus
ENSG00000052749	RRP12	100	100.000	ENSCAFG00000009043	RRP12	100	91.699	Canis_familiaris
ENSG00000052749	RRP12	100	100.000	ENSCAFG00020005991	RRP12	100	91.699	Canis_lupus_dingo
ENSG00000052749	RRP12	100	96.875	ENSCHIG00000011876	RRP12	100	87.538	Capra_hircus
ENSG00000052749	RRP12	76	82.927	ENSTSYG00000030210	-	100	88.269	Carlito_syrichta
ENSG00000052749	RRP12	96	81.070	ENSCAPG00000008991	RRP12	98	80.911	Cavia_aperea
ENSG00000052749	RRP12	100	96.875	ENSCPOG00000004215	RRP12	99	89.591	Cavia_porcellus
ENSG00000052749	RRP12	76	94.852	ENSCCAG00000033123	-	83	94.852	Cebus_capucinus
ENSG00000052749	RRP12	100	96.875	ENSCCAG00000024088	RRP12	100	97.198	Cebus_capucinus
ENSG00000052749	RRP12	100	100.000	ENSCATG00000045310	RRP12	100	90.293	Cercocebus_atys
ENSG00000052749	RRP12	100	90.625	ENSCLAG00000003753	RRP12	99	89.514	Chinchilla_lanigera
ENSG00000052749	RRP12	88	97.472	ENSCSAG00000005877	RRP12	100	97.472	Chlorocebus_sabaeus
ENSG00000052749	RRP12	100	100.000	ENSCHOG00000003095	-	60	95.385	Choloepus_hoffmanni
ENSG00000052749	RRP12	93	82.432	ENSCPBG00000011935	RRP12	89	82.432	Chrysemys_picta_bellii
ENSG00000052749	RRP12	69	38.921	ENSCSAVG00000006059	-	99	38.740	Ciona_savignyi
ENSG00000052749	RRP12	100	100.000	ENSCANG00000031653	RRP12	100	98.026	Colobus_angolensis_palliatus
ENSG00000052749	RRP12	91	90.128	ENSCGRG00001004338	Rrp12	100	89.787	Cricetulus_griseus_chok1gshd
ENSG00000052749	RRP12	100	89.595	ENSCGRG00000011965	Rrp12	100	88.290	Cricetulus_griseus_crigri
ENSG00000052749	RRP12	100	78.462	ENSCSEG00000007799	rrp12	92	72.727	Cynoglossus_semilaevis
ENSG00000052749	RRP12	100	76.705	ENSCVAG00000003418	rrp12	92	76.316	Cyprinodon_variegatus
ENSG00000052749	RRP12	100	76.136	ENSDARG00000022410	rrp12	97	67.816	Danio_rerio
ENSG00000052749	RRP12	100	96.875	ENSDNOG00000005120	RRP12	99	88.574	Dasypus_novemcinctus
ENSG00000052749	RRP12	100	96.875	ENSDORG00000009199	Rrp12	99	91.063	Dipodomys_ordii
ENSG00000052749	RRP12	98	35.366	FBgn0030504	CG2691	95	34.940	Drosophila_melanogaster
ENSG00000052749	RRP12	97	93.548	ENSETEG00000002455	RRP12	93	76.750	Echinops_telfairi
ENSG00000052749	RRP12	88	67.857	ENSEBUG00000006555	rrp12	98	69.388	Eptatretus_burgeri
ENSG00000052749	RRP12	100	96.875	ENSEASG00005008693	RRP12	100	92.225	Equus_asinus_asinus
ENSG00000052749	RRP12	100	96.875	ENSECAG00000010892	RRP12	100	92.138	Equus_caballus
ENSG00000052749	RRP12	100	100.000	ENSEEUG00000005447	-	70	72.634	Erinaceus_europaeus
ENSG00000052749	RRP12	100	79.688	ENSELUG00000010510	rrp12	97	69.792	Esox_lucius
ENSG00000052749	RRP12	100	100.000	ENSFCAG00000028639	RRP12	100	94.737	Felis_catus
ENSG00000052749	RRP12	93	87.671	ENSFALG00000008458	RRP12	92	87.671	Ficedula_albicollis
ENSG00000052749	RRP12	100	96.875	ENSFDAG00000019108	RRP12	95	89.977	Fukomys_damarensis
ENSG00000052749	RRP12	100	78.125	ENSFHEG00000004148	rrp12	99	58.276	Fundulus_heteroclitus
ENSG00000052749	RRP12	100	74.432	ENSGMOG00000004188	rrp12	92	73.684	Gadus_morhua
ENSG00000052749	RRP12	100	77.528	ENSGALG00000041331	RRP12	96	71.952	Gallus_gallus
ENSG00000052749	RRP12	100	76.562	ENSGAFG00000009038	rrp12	92	75.000	Gambusia_affinis
ENSG00000052749	RRP12	100	72.727	ENSGACG00000007175	rrp12	92	71.711	Gasterosteus_aculeatus
ENSG00000052749	RRP12	100	75.978	ENSGAGG00000019169	RRP12	96	76.023	Gopherus_agassizii
ENSG00000052749	RRP12	100	100.000	ENSGGOG00000014850	RRP12	100	99.383	Gorilla_gorilla
ENSG00000052749	RRP12	100	75.000	ENSHBUG00000023527	rrp12	99	63.154	Haplochromis_burtoni
ENSG00000052749	RRP12	100	96.875	ENSHGLG00000016772	RRP12	99	89.831	Heterocephalus_glaber_female
ENSG00000052749	RRP12	100	96.875	ENSHGLG00100015110	RRP12	99	89.831	Heterocephalus_glaber_male
ENSG00000052749	RRP12	100	76.562	ENSHCOG00000019519	rrp12	97	74.342	Hippocampus_comes
ENSG00000052749	RRP12	100	76.705	ENSIPUG00000000311	RRP12	99	61.231	Ictalurus_punctatus
ENSG00000052749	RRP12	100	100.000	ENSSTOG00000006515	RRP12	100	91.911	Ictidomys_tridecemlineatus
ENSG00000052749	RRP12	96	90.162	ENSJJAG00000000110	Rrp12	99	89.856	Jaculus_jaculus
ENSG00000052749	RRP12	100	78.125	ENSKMAG00000020621	rrp12	97	75.658	Kryptolebias_marmoratus
ENSG00000052749	RRP12	100	75.000	ENSLBEG00000015335	rrp12	92	73.684	Labrus_bergylta
ENSG00000052749	RRP12	100	81.250	ENSLACG00000016633	RRP12	72	76.623	Latimeria_chalumnae
ENSG00000052749	RRP12	98	79.365	ENSLOCG00000003846	rrp12	97	65.934	Lepisosteus_oculatus
ENSG00000052749	RRP12	100	100.000	ENSLAFG00000015965	RRP12	99	91.154	Loxodonta_africana
ENSG00000052749	RRP12	100	100.000	ENSMFAG00000041558	RRP12	100	97.843	Macaca_fascicularis
ENSG00000052749	RRP12	100	100.000	ENSMMUG00000019634	RRP12	100	97.843	Macaca_mulatta
ENSG00000052749	RRP12	100	100.000	ENSMNEG00000036759	RRP12	100	97.368	Macaca_nemestrina
ENSG00000052749	RRP12	100	100.000	ENSMLEG00000041317	RRP12	100	97.746	Mandrillus_leucophaeus
ENSG00000052749	RRP12	93	82.432	ENSMAMG00000002964	rrp12	92	82.432	Mastacembelus_armatus
ENSG00000052749	RRP12	100	75.000	ENSMZEG00005003241	rrp12	99	63.308	Maylandia_zebra
ENSG00000052749	RRP12	100	69.555	ENSMGAG00000009829	RRP12	100	69.479	Meleagris_gallopavo
ENSG00000052749	RRP12	100	96.875	ENSMAUG00000020743	Rrp12	100	86.133	Mesocricetus_auratus
ENSG00000052749	RRP12	100	100.000	ENSMICG00000007624	RRP12	100	92.533	Microcebus_murinus
ENSG00000052749	RRP12	100	93.750	ENSMOCG00000006753	Rrp12	99	89.977	Microtus_ochrogaster
ENSG00000052749	RRP12	100	76.562	ENSMMOG00000010708	rrp12	99	62.337	Mola_mola
ENSG00000052749	RRP12	100	85.938	ENSMODG00000004315	RRP12	99	79.012	Monodelphis_domestica
ENSG00000052749	RRP12	100	73.295	ENSMALG00000016560	rrp12	97	71.711	Monopterus_albus
ENSG00000052749	RRP12	100	96.875	MGP_CAROLIEiJ_G0022957	Rrp12	99	88.829	Mus_caroli
ENSG00000052749	RRP12	100	96.875	ENSMUSG00000035049	Rrp12	99	90.131	Mus_musculus
ENSG00000052749	RRP12	100	96.875	MGP_PahariEiJ_G0014447	Rrp12	99	89.977	Mus_pahari
ENSG00000052749	RRP12	100	96.875	MGP_SPRETEiJ_G0023878	Rrp12	99	90.131	Mus_spretus
ENSG00000052749	RRP12	100	100.000	ENSMPUG00000017046	RRP12	100	91.014	Mustela_putorius_furo
ENSG00000052749	RRP12	100	100.000	ENSMLUG00000017160	RRP12	100	92.402	Myotis_lucifugus
ENSG00000052749	RRP12	100	96.875	ENSNGAG00000024144	Rrp12	99	89.977	Nannospalax_galili
ENSG00000052749	RRP12	100	75.000	ENSNBRG00000009987	rrp12	95	74.026	Neolamprologus_brichardi
ENSG00000052749	RRP12	100	100.000	ENSNLEG00000013762	RRP12	100	97.368	Nomascus_leucogenys
ENSG00000052749	RRP12	98	78.894	ENSMEUG00000003185	RRP12	99	73.709	Notamacropus_eugenii
ENSG00000052749	RRP12	100	95.312	ENSOPRG00000005001	RRP12	94	87.601	Ochotona_princeps
ENSG00000052749	RRP12	100	90.909	ENSODEG00000016439	RRP12	99	87.741	Octodon_degus
ENSG00000052749	RRP12	100	76.562	ENSONIG00000009528	rrp12	99	63.538	Oreochromis_niloticus
ENSG00000052749	RRP12	100	81.921	ENSOANG00000006560	RRP12	99	73.062	Ornithorhynchus_anatinus
ENSG00000052749	RRP12	100	96.875	ENSOCUG00000005662	RRP12	100	91.834	Oryctolagus_cuniculus
ENSG00000052749	RRP12	100	78.125	ENSORLG00000008688	rrp12	99	64.652	Oryzias_latipes
ENSG00000052749	RRP12	100	76.562	ENSORLG00020002355	rrp12	99	64.167	Oryzias_latipes_hni
ENSG00000052749	RRP12	100	78.125	ENSORLG00015006709	rrp12	99	64.049	Oryzias_latipes_hsok
ENSG00000052749	RRP12	100	78.125	ENSOMEG00000002609	rrp12	99	64.720	Oryzias_melastigma
ENSG00000052749	RRP12	100	93.750	ENSOGAG00000001626	RRP12	99	90.253	Otolemur_garnettii
ENSG00000052749	RRP12	100	96.875	ENSOARG00000009681	RRP12	100	89.102	Ovis_aries
ENSG00000052749	RRP12	100	100.000	ENSPPAG00000043885	RRP12	99	99.342	Pan_paniscus
ENSG00000052749	RRP12	100	100.000	ENSPPRG00000002029	RRP12	100	94.079	Panthera_pardus
ENSG00000052749	RRP12	100	100.000	ENSPTIG00000004428	RRP12	100	94.079	Panthera_tigris_altaica
ENSG00000052749	RRP12	100	100.000	ENSPTRG00000002806	RRP12	99	99.342	Pan_troglodytes
ENSG00000052749	RRP12	100	100.000	ENSPANG00000021360	RRP12	100	97.689	Papio_anubis
ENSG00000052749	RRP12	100	78.125	ENSPKIG00000016516	rrp12	98	68.824	Paramormyrops_kingsleyae
ENSG00000052749	RRP12	100	76.562	ENSPMGG00000020217	rrp12	92	75.000	Periophthalmus_magnuspinnatus
ENSG00000052749	RRP12	100	93.750	ENSPEMG00000008437	Rrp12	99	89.676	Peromyscus_maniculatus_bairdii
ENSG00000052749	RRP12	100	65.625	ENSPMAG00000007493	rrp12	97	55.682	Petromyzon_marinus
ENSG00000052749	RRP12	100	84.375	ENSPCIG00000002157	RRP12	95	84.564	Phascolarctos_cinereus
ENSG00000052749	RRP12	100	77.273	ENSPFOG00000014975	rrp12	92	76.316	Poecilia_formosa
ENSG00000052749	RRP12	100	76.705	ENSPLAG00000009840	rrp12	92	75.658	Poecilia_latipinna
ENSG00000052749	RRP12	100	77.273	ENSPMEG00000021871	rrp12	92	76.316	Poecilia_mexicana
ENSG00000052749	RRP12	100	77.273	ENSPREG00000020950	rrp12	92	76.316	Poecilia_reticulata
ENSG00000052749	RRP12	100	100.000	ENSPPYG00000002528	RRP12	100	96.610	Pongo_abelii
ENSG00000052749	RRP12	100	100.000	ENSPCAG00000008967	RRP12	94	94.915	Procavia_capensis
ENSG00000052749	RRP12	100	100.000	ENSPCOG00000014009	RRP12	100	93.421	Propithecus_coquereli
ENSG00000052749	RRP12	100	96.875	ENSPVAG00000003370	RRP12	100	86.692	Pteropus_vampyrus
ENSG00000052749	RRP12	100	75.000	ENSPNYG00000009451	rrp12	99	63.308	Pundamilia_nyererei
ENSG00000052749	RRP12	100	77.841	ENSPNAG00000007658	rrp12	97	68.966	Pygocentrus_nattereri
ENSG00000052749	RRP12	100	95.312	ENSRNOG00000048495	Rrp12	100	89.291	Rattus_norvegicus
ENSG00000052749	RRP12	100	100.000	ENSRBIG00000021296	RRP12	100	98.026	Rhinopithecus_bieti
ENSG00000052749	RRP12	100	100.000	ENSRROG00000032482	RRP12	100	98.026	Rhinopithecus_roxellana
ENSG00000052749	RRP12	100	96.071	ENSSBOG00000030992	RRP12	100	96.211	Saimiri_boliviensis_boliviensis
ENSG00000052749	RRP12	100	85.938	ENSSHAG00000018275	RRP12	99	78.180	Sarcophilus_harrisii
ENSG00000052749	RRP12	100	76.705	ENSSFOG00015016400	rrp12	92	75.658	Scleropages_formosus
ENSG00000052749	RRP12	100	75.000	ENSSMAG00000004047	rrp12	92	73.684	Scophthalmus_maximus
ENSG00000052749	RRP12	100	75.568	ENSSDUG00000022871	rrp12	99	62.750	Seriola_dumerili
ENSG00000052749	RRP12	100	75.568	ENSSLDG00000003038	rrp12	92	74.342	Seriola_lalandi_dorsalis
ENSG00000052749	RRP12	97	96.774	ENSSARG00000000157	-	81	89.908	Sorex_araneus
ENSG00000052749	RRP12	100	72.626	ENSSPUG00000012221	RRP12	99	69.172	Sphenodon_punctatus
ENSG00000052749	RRP12	100	78.125	ENSSPAG00000002261	rrp12	99	63.413	Stegastes_partitus
ENSG00000052749	RRP12	100	93.750	ENSSSCG00000010514	RRP12	99	89.923	Sus_scrofa
ENSG00000052749	RRP12	89	69.157	ENSTGUG00000009711	RRP12	100	68.810	Taeniopygia_guttata
ENSG00000052749	RRP12	100	75.568	ENSTRUG00000012017	rrp12	99	59.353	Takifugu_rubripes
ENSG00000052749	RRP12	100	79.688	ENSTNIG00000016522	rrp12	92	76.316	Tetraodon_nigroviridis
ENSG00000052749	RRP12	83	91.586	ENSTBEG00000004907	RRP12	80	91.667	Tupaia_belangeri
ENSG00000052749	RRP12	100	96.875	ENSTTRG00000009878	RRP12	95	94.079	Tursiops_truncatus
ENSG00000052749	RRP12	100	100.000	ENSUAMG00000009092	RRP12	100	91.558	Ursus_americanus
ENSG00000052749	RRP12	100	89.753	ENSUMAG00000021621	RRP12	100	88.249	Ursus_maritimus
ENSG00000052749	RRP12	100	100.000	ENSVVUG00000023168	RRP12	99	91.550	Vulpes_vulpes
ENSG00000052749	RRP12	100	78.125	ENSXETG00000003430	rrp12	92	75.163	Xenopus_tropicalis
ENSG00000052749	RRP12	100	77.273	ENSXCOG00000012082	rrp12	89	76.316	Xiphophorus_couchianus
ENSG00000052749	RRP12	100	76.705	ENSXMAG00000013498	rrp12	92	76.316	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005730	nucleolus	-	IDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0031965	nuclear membrane	-	IEA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr10	97366520	Missense_Mutation	novel	R1106L	0.19
ACC	chr10	97401339	5'UTR	novel		0.14
ACC	chr10	97369508	Missense_Mutation	rs370226569	V958M	0.38
ACC	chr10	97385949	Silent	rs377580724	H354H	0.62
BLCA	chr10	97380866	Missense_Mutation	novel	S489F	0.24	NUC173
BLCA	chr10	97401220	Silent	NA	S4S	0.27
BLCA	chr10	97363851	Splice_Region	novel		0.43
BLCA	chr10	97400457	Missense_Mutation	rs367633522	E73K	0.5
BLCA	chr10	97370547	Missense_Mutation	novel	T866I	0.25
BLCA	chr10	97370176	Missense_Mutation	novel	E930K	0.25
BLCA	chr10	97388266	Missense_Mutation	rs756146657	T335A	0.42
BLCA	chr10	97366144	Missense_Mutation	NA	D1161N	0.27
BLCA	chr10	97379372	Silent	rs369210999	I573I	0.12
BLCA	chr10	97388593	Missense_Mutation	NA	S262L	0.16
BLCA	chr10	97388525	Missense_Mutation	novel	A285T	0.08
BLCA	chr10	97363866	Silent	NA	V1185V	0.19
BLCA	chr10	97373681	Silent	novel	F640F	0.14
BLCA	chr10	97373726	Silent	NA	L625L	0.73
BLCA	chr10	97370756	Missense_Mutation	rs754064680	S848L	0.43
BLCA	chr10	97400477	Missense_Mutation	rs577455394	S66F	0.2
BLCA	chr10	97396274	Missense_Mutation	novel	E133K	0.31
BRCA	chr10	97370953	Silent	novel	S824S	0.18
BRCA	chr10	97373847	Missense_Mutation	rs202239906	D616N	0.09	NUC173
BRCA	chr10	97381721	Silent	novel	S438S	0.26
BRCA	chr10	97401278	5'UTR	novel		0.46
BRCA	chr10	97400457	Missense_Mutation	rs367633522	E73K	0.08
BRCA	chr10	97370501	Silent	rs767203074	L881L	0.24
BRCA	chr10	97366794	Missense_Mutation	NA	E1055Q	0.45
BRCA	chr10	97401256	5'UTR	novel		0.33
BRCA	chr10	97400396	Missense_Mutation	NA	G93D	0.27
BRCA	chr10	97372798	Silent	NA	V729V	0.27
BRCA	chr10	97381424	Silent	rs752269038	S460S	0.32
BRCA	chr10	97367293	Intron	novel		0.28
CESC	chr10	97388530	Missense_Mutation	novel	S283Y	0.32
CESC	chr10	97400457	Missense_Mutation	rs367633522	E73K	0.21
CESC	chr10	97370500	Missense_Mutation	novel	V882L	0.42
CESC	chr10	97401333	5'UTR	novel		0.56
CESC	chr10	97371127	Intron	novel		0.21
CESC	chr10	97400505	Missense_Mutation	novel	K57Q	0.32
CESC	chr10	97373166	Missense_Mutation	NA	K687N	0.38
CESC	chr10	97366195	Missense_Mutation	NA	H1144D	0.24
COAD	chr10	97373664	Missense_Mutation	rs776080417	T646M	0.42	NUC173
COAD	chr10	97396277	Missense_Mutation	novel	T132A	0.23
COAD	chr10	97381748	Silent	novel	S429S	0.08
COAD	chr10	97370483	Silent	novel	A887A	0.28
COAD	chr10	97370269	Silent	NA	L899L	0.32
COAD	chr10	97356983	3'UTR	novel		0.3
COAD	chr10	97388342	Silent	rs145461858	T309T	0.33
COAD	chr10	97357144	Nonsense_Mutation	NA	R1282*	0.32
COAD	chr10	97370730	Missense_Mutation	novel	A857T	0.51
COAD	chr10	97390486	Silent	NA	G230G	0.52
COAD	chr10	97369509	Silent	rs150017845	D957D	0.28
COAD	chr10	97372037	Intron	novel		0.17
COAD	chr10	97373099	Missense_Mutation	rs201494564	R710C	0.16
COAD	chr10	97370515	Missense_Mutation	rs201584883	A877T	0.23
COAD	chr10	97396264	Missense_Mutation	NA	R136H	0.52
COAD	chr10	97366500	Missense_Mutation	rs138766679	G1113S	0.55
COAD	chr10	97373847	Missense_Mutation	rs202239906	D616N	0.29	NUC173
DLBC	chr10	97370920	Splice_Region	rs769496404		0.25
ESCA	chr10	97366111	Missense_Mutation	novel	K1172Q	0.34
GBM	chr10	97396238	Missense_Mutation	novel	T145S	0.27
GBM	chr10	97366765	Missense_Mutation	NA	E1064D	0.67
GBM	chr10	97401343	5'UTR	novel		0.19
GBM	chr10	97380886	Silent	novel	K482K	0.18
GBM	chr10	97381728	Missense_Mutation	NA	T436M	0.44
GBM	chr10	97370535	Missense_Mutation	rs771713481	S870L	0.09
GBM	chr10	97358975	Nonsense_Mutation	novel	K1226*	0.05
GBM	chr10	97380799	Splice_Region	novel	K511K	0.16
HNSC	chr10	97372087	Missense_Mutation	rs762952867	R777W	0.21
HNSC	chr10	97371001	Silent	novel	L808L	0.2
HNSC	chr10	97388312	Silent	rs182185024	P319P	0.14
HNSC	chr10	97360576	Missense_Mutation	rs116818150	E1204K	0.37
HNSC	chr10	97388342	Silent	rs145461858	T309T	0.1
HNSC	chr10	97360576	Missense_Mutation	rs116818150	E1204K	0.08
KIRC	chr10	97360619	Splice_Site	NA	X1190_splice	0.26
KIRC	chr10	97357119	Missense_Mutation	NA	N1290S	0.2
KIRC	chr10	97370922	Splice_Site	novel	X834_splice	0.29
KIRP	chr10	97400316	Missense_Mutation	NA	A120T	0.29
KIRP	chr10	97357102	Nonsense_Mutation	rs371319861	R1296*	0.47
KIRP	chr10	97360557	Frame_Shift_Del	novel	*P1210Lfs33**	0.51
KIRP	chr10	97360561	Missense_Mutation	rs370146748	P1209S	0.52
KIRP	chr10	97381728	Missense_Mutation	NA	T436M	0.48
LAML	chr10	97379336	Frame_Shift_Ins	novel	*T586Hfs9**	0.12	NUC173
LAML	chr10	97366592	Missense_Mutation	NA	D1082G	0.05
LGG	chr10	97401177	Missense_Mutation	novel	K19E	0.34
LGG	chr10	97373176	Missense_Mutation	rs182519643	R684H	0.35
LGG	chr10	97385232	Missense_Mutation	novel	E381G	0.07
LGG	chr10	97357070	3'UTR	novel		0.07
LIHC	chr10	97372141	Missense_Mutation	novel	A759P	0.21
LIHC	chr10	97401334	5'UTR	novel		0.42
LUAD	chr10	97401283	5'UTR	rs573285534		0.1
LUAD	chr10	97370249	Silent	NA	L905L	0.3
LUAD	chr10	97367114	Missense_Mutation	NA	L992V	0.73
LUAD	chr10	97367177	Intron	novel		0.22
LUAD	chr10	97385213	Silent	NA	L387L	0.17
LUAD	chr10	97366232	Splice_Region	novel	A1131A	0.35
LUAD	chr10	97385204	Missense_Mutation	NA	W390C	0.19
LUAD	chr10	97357179	Missense_Mutation	rs560000334	Q1270R	0.17
LUAD	chr10	97390468	Silent	novel	Q236Q	0.29
LUAD	chr10	97379717	Silent	novel	A529A	0.31
LUAD	chr10	97366758	Missense_Mutation	novel	Q1067E	0.06
LUAD	chr10	97388511	Silent	novel	I289I	0.27
LUAD	chr10	97401318	5'UTR	novel		0.19
LUAD	chr10	97373883	Missense_Mutation	NA	A604S	0.44	NUC173
LUAD	chr10	97366529	Missense_Mutation	NA	Q1103R	0.25
LUSC	chr10	97380865	Silent	rs775808485	S489S	0.28
LUSC	chr10	97371107	Intron	novel		0.38
LUSC	chr10	97371108	Intron	novel		0.38
LUSC	chr10	97379318	Silent	novel	P591P	0.39
LUSC	chr10	97401191	Missense_Mutation	novel	K14M	0.1
LUSC	chr10	97366780	Missense_Mutation	novel	E1059D	0.27
LUSC	chr10	97381749	Missense_Mutation	rs142406474	S429L	0.1
LUSC	chr10	97358596	Silent	rs751509031	K1244K	0.23
LUSC	chr10	97381753	Missense_Mutation	novel	H428D	0.16
LUSC	chr10	97370527	Missense_Mutation	rs145302632	A873T	0.78
LUSC	chr10	97363886	Missense_Mutation	novel	A1179S	0.41
LUSC	chr10	97390812	Missense_Mutation	novel	S188C	0.14
LUSC	chr10	97401101	Missense_Mutation	novel	R44L	0.37
LUSC	chr10	97366500	Missense_Mutation	rs138766679	G1113C	0.39
LUSC	chr10	97373854	Silent	novel	K613K	0.11
LUSC	chr10	97400413	Silent	novel	L87L	0.17
LUSC	chr10	97390743	Missense_Mutation	novel	R211Q	0.2
LUSC	chr10	97373615	Nonsense_Mutation	novel	C662*	0.23	NUC173
OV	chr10	97366797	Missense_Mutation	novel	E1054K	0.15
OV	chr10	97373122	Missense_Mutation	novel	A702E	0.1
OV	chr10	97390815	Missense_Mutation	NA	F187Y	0.12
OV	chr10	97357078	3'UTR	novel		0.34
OV	chr10	97357122	Missense_Mutation	novel	K1289R	0.04
OV	chr10	97385977	Missense_Mutation	NA	A345G	0.47
OV	chr10	97388319	Missense_Mutation	novel	C317F	0.26
OV	chr10	97381465	Missense_Mutation	rs762936931	V447M	0.27
OV	chr10	97366817	Missense_Mutation	novel	A1047G	0.05
OV	chr10	97381728	Missense_Mutation	NA	T436M	0.2
OV	chr10	97379294	Missense_Mutation	novel	K599N	0.16	NUC173
OV	chr10	97366885	Silent	novel	L1024L	0.05
OV	chr10	97366886	Missense_Mutation	novel	L1024S	0.05
OV	chr10	97379692	Nonsense_Mutation	novel	*A538Ffs2**	0.43	NUC173
PRAD	chr10	97373155	Missense_Mutation	NA	P691L	0.21
PRAD	chr10	97373718	Missense_Mutation	rs762139875	G628E	0.34	NUC173
PRAD	chr10	97381466	Silent	rs766302067	C446C	0.25
SARC	chr10	97358547	Missense_Mutation	novel	L1261I	0.2
SARC	chr10	97401358	5'UTR	novel		0.13
SARC	chr10	97372091	Silent	novel	T775T	0.13
SARC	chr10	97371107	Intron	novel		0.61
SARC	chr10	97366062	Intron	novel		0.25
SKCM	chr10	97367161	Intron	novel		0.37
SKCM	chr10	97388264	Silent	NA	T335T	0.25
SKCM	chr10	97367087	Missense_Mutation	NA	R1001C	0.19
SKCM	chr10	97370722	Silent	novel	I859I	0.76
SKCM	chr10	97401351	5'UTR	novel		0.44
SKCM	chr10	97390428	Missense_Mutation	NA	P250S	0.14
SKCM	chr10	97379728	Missense_Mutation	NA	P526S	0.19	NUC173
SKCM	chr10	97366763	Missense_Mutation	novel	P1065L	0.32
SKCM	chr10	97393734	Silent	NA	S160S	0.26
SKCM	chr10	97401351	5'UTR	novel		0.27
SKCM	chr10	97396265	Missense_Mutation	NA	R136C	0.81
SKCM	chr10	97366561	Silent	NA	S1092S	0.45
SKCM	chr10	97367051	Missense_Mutation	rs750620077	R1013C	0.24
SKCM	chr10	97372132	Missense_Mutation	NA	P762S	0.23
SKCM	chr10	97366882	Silent	rs776364835	P1025P	0.69
SKCM	chr10	97388372	Silent	NA	K299K	0.2
SKCM	chr10	97401330	5'UTR	novel		0.35
SKCM	chr10	97381477	Silent	NA	L443L	0.65
SKCM	chr10	97379739	Missense_Mutation	NA	S522F	0.24	NUC173
SKCM	chr10	97379721	Missense_Mutation	NA	T528K	0.8	NUC173
SKCM	chr10	97401330	5'UTR	novel		0.78
SKCM	chr10	97366521	Missense_Mutation	NA	R1106W	0.45
SKCM	chr10	97366768	Silent	NA	E1063E	0.32
SKCM	chr10	97401351	5'UTR	novel		0.53
SKCM	chr10	97390479	Missense_Mutation	rs376656308	V233M	0.52
SKCM	chr10	97401330	5'UTR	novel		0.5
SKCM	chr10	97393723	Missense_Mutation	novel	L164P	0.45
STAD	chr10	97379746	Missense_Mutation	rs781471005	R520C	0.4	NUC173
STAD	chr10	97366454	Missense_Mutation	NA	R1128Q	0.21
STAD	chr10	97357108	Missense_Mutation	novel	D1294Y	0.25
STAD	chr10	97358586	Missense_Mutation	NA	P1248S	0.25
STAD	chr10	97381737	Missense_Mutation	NA	T433I	0.36
STAD	chr10	97371006	Missense_Mutation	rs766446844	A807T	0.52
STAD	chr10	97366783	Silent	rs759507422	E1058E	0.27
STAD	chr10	97373133	Silent	novel	G698G	0.18
STAD	chr10	97381714	Splice_Site	NA	X440_splice	0.18
STAD	chr10	97390502	Missense_Mutation	NA	D225V	0.11
STAD	chr10	97366592	Missense_Mutation	NA	D1082G	0.18
STAD	chr10	97385232	Missense_Mutation	NA	E381A	0.08
STAD	chr10	97357174	Nonsense_Mutation	novel	Q1272*	0.34
STAD	chr10	97370986	Silent	NA	H813H	0.14
STAD	chr10	97380808	Silent	NA	V508V	0.72
STAD	chr10	97379326	Missense_Mutation	NA	F589V	0.1	NUC173
STAD	chr10	97367092	Missense_Mutation	NA	H999L	0.22
STAD	chr10	97373192	Missense_Mutation	rs746700980	R679C	0.2
STAD	chr10	97388521	Missense_Mutation	NA	K286R	0.22
STAD	chr10	97357101	Missense_Mutation	NA	R1296Q	0.27
STAD	chr10	97373848	Silent	rs200667236	Y615Y	0.19
THCA	chr10	97372037	Intron	novel		0.12
THCA	chr10	97401098	Missense_Mutation	novel	P45L	0.24
UCEC	chr10	97388279	Silent	novel	L330L	0.21
UCEC	chr10	97371922	Intron	novel		0.27
UCEC	chr10	97388313	Missense_Mutation	rs145670609	P319L	0.47
UCEC	chr10	97367099	Missense_Mutation	rs773783036	R997W	0.21
UCEC	chr10	97373692	Missense_Mutation	novel	A637T	0.08	NUC173
UCEC	chr10	97371069	Missense_Mutation	novel	G786W	0.11
UCEC	chr10	97357144	Nonsense_Mutation	NA	R1282*	0.47
UCEC	chr10	97379350	Nonsense_Mutation	rs375227694	R581*	0.42	NUC173
UCEC	chr10	97366491	Missense_Mutation	novel	E1116K	0.26
UCEC	chr10	97379351	Silent	rs768624455	T580T	0.48
UCEC	chr10	97381771	Missense_Mutation	novel	T422P	0.22
UCEC	chr10	97373098	Missense_Mutation	rs771627474	R710H	0.28
UCEC	chr10	97388266	Missense_Mutation	NA	T335P	0.35
UCEC	chr10	97357051	3'UTR	novel		0.18
UCEC	chr10	97366549	Missense_Mutation	NA	E1096D	0.15
UCEC	chr10	97367301	Intron	novel		0.5
UCEC	chr10	97370732	Missense_Mutation	NA	T856N	0.2
UCEC	chr10	97370792	Missense_Mutation	rs560486956	R836H	0.45
UCEC	chr10	97373154	Silent	rs749300280	P691P	0.31
UCEC	chr10	97373127	Silent	NA	P700P	0.18
UCEC	chr10	97366500	Missense_Mutation	rs138766679	G1113S	0.35
UCEC	chr10	97357088	3'UTR	rs771851759		0.19
UCEC	chr10	97401253	5'UTR	novel		0.07
UCEC	chr10	97373880	Nonsense_Mutation	novel	Q605*	0.16	NUC173
UCEC	chr10	97357024	3'UTR	novel		0.37
UCEC	chr10	97373591	Silent	novel	T670T	0.1
UCEC	chr10	97379371	Nonsense_Mutation	rs762556732	R574*	0.19	NUC173
UCEC	chr10	97379721	Missense_Mutation	novel	T528M	0.22	NUC173
UCEC	chr10	97369566	Silent	NA	S938S	0.24
UCEC	chr10	97372120	Missense_Mutation	NA	E766K	0.38
UCEC	chr10	97401147	Missense_Mutation	novel	A29T	0.31
UCEC	chr10	97367087	Missense_Mutation	NA	R1001C	0.24
UCEC	chr10	97370466	Missense_Mutation	rs781271284	S893L	0.53
UCEC	chr10	97385248	Missense_Mutation	rs751778020	D376N	0.54
UCEC	chr10	97366829	Missense_Mutation	NA	K1043R	0.36
UCEC	chr10	97371924	Intron	novel		0.42
UCEC	chr10	97401200	Missense_Mutation	novel	V11G	0.35
UCEC	chr10	97370462	Silent	novel	N894N	0.21
UCEC	chr10	97373155	Missense_Mutation	NA	P691L	0.37
UCEC	chr10	97379633	Silent	novel	G557G	0.23
UCEC	chr10	97393727	Missense_Mutation	novel	S163P	0.14
UCEC	chr10	97357021	3'UTR	novel		0.45
UCEC	chr10	97357186	Missense_Mutation	novel	K1268Q	0.33
UCEC	chr10	97372092	Missense_Mutation	novel	T775I	0.39
UCEC	chr10	97390519	Silent	novel	T219T	0.48
UCEC	chr10	97358989	Missense_Mutation	novel	R1221H	0.35
UCEC	chr10	97369452	Silent	rs547972049	A976A	0.48
UCEC	chr10	97372026	Intron	novel		0.39
UCEC	chr10	97388505	Missense_Mutation	novel	E291D	0.46
UCEC	chr10	97358541	Missense_Mutation	rs781057741	R1263C	0.28
UCEC	chr10	97381400	Silent	rs751344563	V468V	0.28
UCEC	chr10	97366565	Missense_Mutation	novel	R1091I	0.55
UCEC	chr10	97366117	Missense_Mutation	novel	G1170C	0.23
UCEC	chr10	97358967	Missense_Mutation	NA	M1228I	0.15
UCEC	chr10	97373604	Missense_Mutation	rs552818559	R666H	0.24	NUC173
UCEC	chr10	97373833	Nonsense_Mutation	NA	W620*	0.46	NUC173
UCEC	chr10	97400410	Silent	rs762289811	T88T	0.23
UCEC	chr10	97401092	Splice_Site	NA	X47_splice	0.39
UCEC	chr10	97369469	Missense_Mutation	novel	T971A	0.31
UCEC	chr10	97390762	Missense_Mutation	rs769264384	G205S	0.36
UCEC	chr10	97366123	Missense_Mutation	novel	E1168Q	0.06
UCEC	chr10	97366849	Silent	novel	R1036R	0.14
UCEC	chr10	97370528	Silent	rs367843722	G872G	0.09
UCEC	chr10	97372120	Missense_Mutation	NA	E766K	0.4
UCEC	chr10	97357177	Missense_Mutation	novel	G1271R	0.23
UCEC	chr10	97396243	Missense_Mutation	rs559101512	T143M	0.17
UCEC	chr10	97373166	Missense_Mutation	novel	K687N	0.31
UCEC	chr10	97373126	Missense_Mutation	rs143637567	V701M	0.41
UCEC	chr10	97358585	Missense_Mutation	novel	P1248L	0.45
UCEC	chr10	97369452	Silent	rs547972049	A976A	0.41
UCEC	chr10	97370958	Missense_Mutation	novel	D823N	0.43
UCEC	chr10	97401343	5'UTR	novel		0.32
UVM	chr10	97390465	Silent	novel	V237V	0.11

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
CHOL	DEL	0.2222	0.048655
COAD	DEL	0.1752	9.4741e-07
MESO	DEL	0.2759	0.00015289
OV	DEL	0.3903	5.3759e-12
PAAD	DEL	0.1304	0.169
READ	DEL	0.2364	0.014135
THCA	DEL	0.016	0.011063
THYM	DEL	0.0325	0.10563
UCS	DEL	0.2857	0.1218

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.032	Kaplan-Meier Survival Analysis
SARC	0.038	Kaplan-Meier Survival Analysis
MESO	0.00048	Kaplan-Meier Survival Analysis
ACC	0.00018	Kaplan-Meier Survival Analysis
SKCM	0.02	Kaplan-Meier Survival Analysis
KIRP	0.044	Kaplan-Meier Survival Analysis
COAD	0.0085	Kaplan-Meier Survival Analysis
BLCA	0.018	Kaplan-Meier Survival Analysis
READ	0.043	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.016	Kaplan-Meier Survival Analysis
LGG	0.0011	Kaplan-Meier Survival Analysis
THCA	0.043	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742