EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000054267 (Gene tree)
Gene ID: 51742
Gene Symbol: ARID4B
Alias: BCAA|BRCAA1|SAP180|RBP1L1
Full Name: AT-rich interaction domain 4B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 196,665 bases
Position: chr1:235,131,634-235,328,298
Accession: 15550
RBP type: canonical RBP
Summary: This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000264183	Tudor-knot	PF11717.8	3.7e-11	1	1
ENSP00000355562	Tudor-knot	PF11717.8	3.7e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000264183	ARID4B-201	4995	XM_006711781	ENSP00000264183	1312 (aa)	XP_006711844	Q4LE39
ENST00000462969	ARID4B-207	273	-	-	- (aa)	-	-
ENST00000418304	ARID4B-204	1759	-	ENSP00000391497	483 (aa)	-	X6RCR8
ENST00000444620	ARID4B-206	1660	-	ENSP00000416063	553 (aa)	-	H0Y7Y8
ENST00000491632	ARID4B-212	3823	-	-	- (aa)	-	-
ENST00000366603	ARID4B-203	5946	-	ENSP00000355562	1312 (aa)	-	Q4LE39
ENST00000474401	ARID4B-210	578	-	-	- (aa)	-	-
ENST00000349213	ARID4B-202	5811	XM_024447626	ENSP00000264184	1226 (aa)	XP_024303394	Q4LE39
ENST00000466653	ARID4B-208	2315	-	-	- (aa)	-	-
ENST00000421364	ARID4B-205	5151	-	ENSP00000394663	1153 (aa)	-	Q4LE39
ENST00000494543	ARID4B-213	453	-	-	- (aa)	-	-
ENST00000474953	ARID4B-211	3463	-	ENSP00000420620	696 (aa)	-	H7C5R6
ENST00000471257	ARID4B-209	4195	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000054267's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000054267	Child Development Disorders, Pervasive	5.7000000E-005	-
ENSG00000054267	Child Development Disorders, Pervasive	7.2000000E-005	-
ENSG00000054267	Child Development Disorders, Pervasive	6.7000000E-005	-
ENSG00000054267	Child Development Disorders, Pervasive	2.1000000E-005	-
ENSG00000054267	Child Development Disorders, Pervasive	5.5000000E-005	-
ENSG00000054267	Child Development Disorders, Pervasive	4.2000000E-005	-
ENSG00000054267	Child Development Disorders, Pervasive	6.4000000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000054267's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000054267	ARID4B	85	75.728	ENSAPOG00000010823	tomm20a	87	75.728	Acanthochromis_polyacanthus
ENSG00000054267	ARID4B	99	96.266	ENSAMEG00000008801	ARID4B	100	93.450	Ailuropoda_melanoleuca
ENSG00000054267	ARID4B	88	73.058	ENSACIG00000006313	tomm20a	98	72.330	Amphilophus_citrinellus
ENSG00000054267	ARID4B	85	75.485	ENSAOCG00000003330	tomm20a	87	75.485	Amphiprion_ocellaris
ENSG00000054267	ARID4B	85	75.485	ENSAPEG00000024018	tomm20a	100	49.525	Amphiprion_percula
ENSG00000054267	ARID4B	94	69.414	ENSATEG00000014930	tomm20a	55	42.112	Anabas_testudineus
ENSG00000054267	ARID4B	99	82.992	ENSAPLG00000004422	ARID4B	100	77.410	Anas_platyrhynchos
ENSG00000054267	ARID4B	98	80.625	ENSACAG00000001289	ARID4B	100	73.565	Anolis_carolinensis
ENSG00000054267	ARID4B	100	98.137	ENSANAG00000038088	ARID4B	100	97.869	Aotus_nancymaae
ENSG00000054267	ARID4B	89	64.146	ENSACLG00000023521	tomm20a	98	64.146	Astatotilapia_calliptera
ENSG00000054267	ARID4B	72	96.429	ENSAMXG00000003657	tomm20a	86	67.952	Astyanax_mexicanus
ENSG00000054267	ARID4B	100	96.687	ENSBTAG00000000222	ARID4B	100	91.400	Bos_taurus
ENSG00000054267	ARID4B	100	97.282	ENSCJAG00000018055	ARID4B	100	96.954	Callithrix_jacchus
ENSG00000054267	ARID4B	100	96.894	ENSCAFG00000011439	ARID4B	100	93.836	Canis_familiaris
ENSG00000054267	ARID4B	98	96.211	ENSCAFG00020027130	ARID4B	99	93.492	Canis_lupus_dingo
ENSG00000054267	ARID4B	99	89.916	ENSCHIG00000020742	ARID4B	100	89.748	Capra_hircus
ENSG00000054267	ARID4B	100	96.480	ENSTSYG00000010028	ARID4B	100	94.440	Carlito_syrichta
ENSG00000054267	ARID4B	99	95.634	ENSCPOG00000034766	ARID4B	100	91.857	Cavia_porcellus
ENSG00000054267	ARID4B	100	98.344	ENSCCAG00000021520	ARID4B	100	97.869	Cebus_capucinus
ENSG00000054267	ARID4B	100	99.172	ENSCATG00000042166	ARID4B	100	98.554	Cercocebus_atys
ENSG00000054267	ARID4B	100	97.101	ENSCLAG00000003255	ARID4B	100	94.521	Chinchilla_lanigera
ENSG00000054267	ARID4B	100	99.172	ENSCSAG00000010069	ARID4B	100	98.706	Chlorocebus_sabaeus
ENSG00000054267	ARID4B	85	97.368	ENSCHOG00000001152	ARID4B	74	100.000	Choloepus_hoffmanni
ENSG00000054267	ARID4B	100	78.887	ENSCPBG00000004501	ARID4B	100	78.307	Chrysemys_picta_bellii
ENSG00000054267	ARID4B	100	98.712	ENSCANG00000027498	ARID4B	93	98.569	Colobus_angolensis_palliatus
ENSG00000054267	ARID4B	100	94.203	ENSCGRG00001014397	Arid4b	100	90.881	Cricetulus_griseus_chok1gshd
ENSG00000054267	ARID4B	99	94.179	ENSCGRG00000004910	Arid4b	100	90.868	Cricetulus_griseus_crigri
ENSG00000054267	ARID4B	89	75.061	ENSCSEG00000012928	tomm20a	87	73.850	Cynoglossus_semilaevis
ENSG00000054267	ARID4B	91	73.397	ENSDARG00000090656	tomm20a	87	73.634	Danio_rerio
ENSG00000054267	ARID4B	97	91.867	ENSDNOG00000005711	ARID4B	100	93.540	Dasypus_novemcinctus
ENSG00000054267	ARID4B	99	95.842	ENSDORG00000006422	Arid4b	100	92.536	Dipodomys_ordii
ENSG00000054267	ARID4B	92	90.701	ENSETEG00000005596	ARID4B	92	91.555	Echinops_telfairi
ENSG00000054267	ARID4B	99	97.297	ENSEASG00005000677	ARID4B	99	93.211	Equus_asinus_asinus
ENSG00000054267	ARID4B	99	97.505	ENSECAG00000017836	ARID4B	99	94.432	Equus_caballus
ENSG00000054267	ARID4B	83	97.222	ENSEEUG00000005378	ARID4B	86	97.222	Erinaceus_europaeus
ENSG00000054267	ARID4B	100	97.101	ENSFCAG00000030096	ARID4B	100	92.542	Felis_catus
ENSG00000054267	ARID4B	99	83.469	ENSFALG00000013548	ARID4B	98	78.912	Ficedula_albicollis
ENSG00000054267	ARID4B	99	96.674	ENSFDAG00000014194	ARID4B	100	94.127	Fukomys_damarensis
ENSG00000054267	ARID4B	85	74.757	ENSFHEG00000003798	tomm20a	86	75.243	Fundulus_heteroclitus
ENSG00000054267	ARID4B	94	69.978	ENSGMOG00000018747	tomm20a	78	72.993	Gadus_morhua
ENSG00000054267	ARID4B	86	74.519	ENSGACG00000004298	tomm20a	87	73.077	Gasterosteus_aculeatus
ENSG00000054267	ARID4B	99	78.031	ENSGAGG00000020544	ARID4B	98	76.568	Gopherus_agassizii
ENSG00000054267	ARID4B	100	99.793	ENSGGOG00000022080	ARID4B	100	99.543	Gorilla_gorilla
ENSG00000054267	ARID4B	89	74.757	ENSHBUG00000020369	tomm20a	67	74.757	Haplochromis_burtoni
ENSG00000054267	ARID4B	100	96.480	ENSHGLG00000012546	ARID4B	100	94.068	Heterocephalus_glaber_female
ENSG00000054267	ARID4B	100	96.480	ENSHGLG00100015436	ARID4B	100	94.068	Heterocephalus_glaber_male
ENSG00000054267	ARID4B	91	73.366	ENSHCOG00000010376	tomm20a	95	73.544	Hippocampus_comes
ENSG00000054267	ARID4B	91	71.498	ENSIPUG00000014234	arid4b	87	71.498	Ictalurus_punctatus
ENSG00000054267	ARID4B	100	95.445	ENSSTOG00000002810	ARID4B	100	93.541	Ictidomys_tridecemlineatus
ENSG00000054267	ARID4B	99	92.083	ENSJJAG00000021368	Arid4b	100	87.671	Jaculus_jaculus
ENSG00000054267	ARID4B	89	54.265	ENSKMAG00000010987	tomm20a	98	52.370	Kryptolebias_marmoratus
ENSG00000054267	ARID4B	87	76.247	ENSLOCG00000015899	tomm20a	100	54.227	Lepisosteus_oculatus
ENSG00000054267	ARID4B	99	96.667	ENSLAFG00000014295	ARID4B	100	92.912	Loxodonta_africana
ENSG00000054267	ARID4B	100	99.379	ENSMFAG00000044016	ARID4B	100	98.630	Macaca_fascicularis
ENSG00000054267	ARID4B	100	99.379	ENSMMUG00000007141	ARID4B	100	98.630	Macaca_mulatta
ENSG00000054267	ARID4B	100	99.379	ENSMNEG00000014840	ARID4B	100	98.629	Macaca_nemestrina
ENSG00000054267	ARID4B	99	99.370	ENSMLEG00000033583	ARID4B	100	98.623	Mandrillus_leucophaeus
ENSG00000054267	ARID4B	85	75.485	ENSMAMG00000017134	tomm20a	85	75.485	Mastacembelus_armatus
ENSG00000054267	ARID4B	89	74.515	ENSMZEG00005009879	tomm20a	67	74.515	Maylandia_zebra
ENSG00000054267	ARID4B	99	81.633	ENSMGAG00000011896	ARID4B	100	79.289	Meleagris_gallopavo
ENSG00000054267	ARID4B	100	97.930	ENSMICG00000016358	ARID4B	100	96.505	Microcebus_murinus
ENSG00000054267	ARID4B	84	75.303	ENSMMOG00000000561	tomm20a	69	74.272	Mola_mola
ENSG00000054267	ARID4B	100	91.097	ENSMODG00000008417	ARID4B	100	85.997	Monodelphis_domestica
ENSG00000054267	ARID4B	85	74.272	ENSMALG00000005205	tomm20a	67	74.272	Monopterus_albus
ENSG00000054267	ARID4B	100	93.789	MGP_CAROLIEiJ_G0018236	Arid4b	100	89.202	Mus_caroli
ENSG00000054267	ARID4B	100	93.168	ENSMUSG00000039219	Arid4b	100	88.669	Mus_musculus
ENSG00000054267	ARID4B	99	94.191	MGP_PahariEiJ_G0019286	Arid4b	100	89.278	Mus_pahari
ENSG00000054267	ARID4B	100	93.168	MGP_SPRETEiJ_G0019094	Arid4b	100	88.593	Mus_spretus
ENSG00000054267	ARID4B	100	97.101	ENSMPUG00000002906	ARID4B	100	92.542	Mustela_putorius_furo
ENSG00000054267	ARID4B	99	94.802	ENSMLUG00000016232	ARID4B	100	91.476	Myotis_lucifugus
ENSG00000054267	ARID4B	100	92.547	ENSNGAG00000014629	Arid4b	100	88.956	Nannospalax_galili
ENSG00000054267	ARID4B	89	73.479	ENSNBRG00000019684	tomm20a	98	73.479	Neolamprologus_brichardi
ENSG00000054267	ARID4B	100	99.172	ENSNLEG00000002665	ARID4B	100	99.163	Nomascus_leucogenys
ENSG00000054267	ARID4B	100	96.894	ENSODEG00000005373	ARID4B	100	93.303	Octodon_degus
ENSG00000054267	ARID4B	99	96.881	ENSOCUG00000006605	ARID4B	100	94.360	Oryctolagus_cuniculus
ENSG00000054267	ARID4B	94	70.087	ENSORLG00000012510	tomm20a	89	57.021	Oryzias_latipes
ENSG00000054267	ARID4B	91	74.279	ENSORLG00020013988	tomm20a	72	73.976	Oryzias_latipes_hni
ENSG00000054267	ARID4B	91	74.879	ENSORLG00015022835	tomm20a	72	74.576	Oryzias_latipes_hsok
ENSG00000054267	ARID4B	86	75.240	ENSOMEG00000000521	tomm20a	100	57.368	Oryzias_melastigma
ENSG00000054267	ARID4B	99	92.181	ENSOGAG00000012476	ARID4B	90	88.824	Otolemur_garnettii
ENSG00000054267	ARID4B	100	96.074	ENSOARG00000003481	ARID4B	97	90.847	Ovis_aries
ENSG00000054267	ARID4B	100	99.586	ENSPPAG00000031651	ARID4B	100	99.315	Pan_paniscus
ENSG00000054267	ARID4B	100	97.101	ENSPPRG00000013739	ARID4B	100	92.542	Panthera_pardus
ENSG00000054267	ARID4B	100	97.101	ENSPTIG00000012520	ARID4B	100	90.563	Panthera_tigris_altaica
ENSG00000054267	ARID4B	99	93.174	ENSPTRG00000048786	-	95	99.460	Pan_troglodytes
ENSG00000054267	ARID4B	100	99.586	ENSPTRG00000002129	ARID4B	100	99.543	Pan_troglodytes
ENSG00000054267	ARID4B	99	98.283	ENSPANG00000013611	ARID4B	100	98.171	Papio_anubis
ENSG00000054267	ARID4B	93	78.459	ENSPSIG00000011632	ARID4B	99	77.958	Pelodiscus_sinensis
ENSG00000054267	ARID4B	73	42.830	ENSPMGG00000001596	tomm20a	73	73.563	Periophthalmus_magnuspinnatus
ENSG00000054267	ARID4B	100	90.890	ENSPCIG00000029756	ARID4B	100	85.616	Phascolarctos_cinereus
ENSG00000054267	ARID4B	89	74.519	ENSPFOG00000019430	tomm20a	85	74.279	Poecilia_formosa
ENSG00000054267	ARID4B	85	75.728	ENSPLAG00000010554	tomm20a	55	41.238	Poecilia_latipinna
ENSG00000054267	ARID4B	85	71.625	ENSPMEG00000003093	tomm20a	53	41.284	Poecilia_mexicana
ENSG00000054267	ARID4B	85	75.243	ENSPREG00000007996	tomm20a	86	75.728	Poecilia_reticulata
ENSG00000054267	ARID4B	100	99.379	ENSPPYG00000000098	ARID4B	100	99.086	Pongo_abelii
ENSG00000054267	ARID4B	100	97.723	ENSPCOG00000024328	ARID4B	100	96.654	Propithecus_coquereli
ENSG00000054267	ARID4B	100	96.480	ENSPVAG00000015159	ARID4B	94	95.265	Pteropus_vampyrus
ENSG00000054267	ARID4B	85	69.324	ENSPNYG00000013988	tomm20a	92	69.756	Pundamilia_nyererei
ENSG00000054267	ARID4B	91	73.522	ENSPNAG00000000523	tomm20a	81	72.340	Pygocentrus_nattereri
ENSG00000054267	ARID4B	99	79.658	ENSRNOG00000016391	LOC100912163	97	87.391	Rattus_norvegicus
ENSG00000054267	ARID4B	99	94.253	ENSRBIG00000042029	ARID4B	100	89.787	Rhinopithecus_bieti
ENSG00000054267	ARID4B	100	98.965	ENSRROG00000045203	ARID4B	100	98.706	Rhinopithecus_roxellana
ENSG00000054267	ARID4B	99	90.956	ENSSBOG00000020196	ARID4B	100	97.527	Saimiri_boliviensis_boliviensis
ENSG00000054267	ARID4B	100	92.340	ENSSHAG00000015214	ARID4B	100	86.798	Sarcophilus_harrisii
ENSG00000054267	ARID4B	98	33.923	ENSSFOG00015008923	tomm20a	86	45.975	Scleropages_formosus
ENSG00000054267	ARID4B	94	68.352	ENSSFOG00015000132	arid4b	55	57.584	Scleropages_formosus
ENSG00000054267	ARID4B	86	72.837	ENSSMAG00000010430	tomm20a	86	72.596	Scophthalmus_maximus
ENSG00000054267	ARID4B	89	75.243	ENSSDUG00000003019	tomm20a	87	74.760	Seriola_dumerili
ENSG00000054267	ARID4B	100	80.448	ENSSPUG00000015466	ARID4B	98	76.626	Sphenodon_punctatus
ENSG00000054267	ARID4B	94	70.022	ENSSPAG00000007358	tomm20a	67	75.485	Stegastes_partitus
ENSG00000054267	ARID4B	100	96.687	ENSSSCG00000010156	ARID4B	100	92.922	Sus_scrofa
ENSG00000054267	ARID4B	99	84.265	ENSTGUG00000010246	ARID4B	100	78.799	Taeniopygia_guttata
ENSG00000054267	ARID4B	98	38.571	ENSTRUG00000002893	tomm20a	85	45.253	Takifugu_rubripes
ENSG00000054267	ARID4B	97	86.938	ENSTBEG00000003961	ARID4B	80	85.439	Tupaia_belangeri
ENSG00000054267	ARID4B	100	95.031	ENSTTRG00000002228	ARID4B	100	91.775	Tursiops_truncatus
ENSG00000054267	ARID4B	99	92.759	ENSUMAG00000006905	ARID4B	100	92.361	Ursus_maritimus
ENSG00000054267	ARID4B	100	95.238	ENSVPAG00000006841	ARID4B	69	94.000	Vicugna_pacos
ENSG00000054267	ARID4B	99	93.857	ENSVVUG00000008154	ARID4B	99	93.446	Vulpes_vulpes
ENSG00000054267	ARID4B	99	73.950	ENSXETG00000024651	arid4b	89	72.899	Xenopus_tropicalis
ENSG00000054267	ARID4B	85	75.485	ENSXMAG00000006538	tomm20a	55	42.021	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0003674	molecular_function	-	ND	Function
GO:0005515	protein binding	20195357.	IPI	Function
GO:0005575	cellular_component	-	ND	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006349	regulation of gene expression by genetic imprinting	-	IEA	Process
GO:0006357	regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0007283	spermatogenesis	-	IEA	Process
GO:0008150	biological_process	-	ND	Process
GO:0034773	histone H4-K20 trimethylation	-	IEA	Process
GO:0036124	histone H3-K9 trimethylation	-	IEA	Process
GO:0044212	transcription regulatory region DNA binding	21873635.	IBA	Function
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0097368	establishment of Sertoli cell barrier	-	IEA	Process