EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000054654 (Gene tree)
Gene ID: 23224
Gene Symbol: SYNE2
Alias: SYNE-2|DKFZP434H2235|Nesprin-2|NUANCE|NUA|KIAA1011|Nesp2
Full Name: spectrin repeat containing nuclear envelope protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 373,864 bases
Position: chr14:63,852,586-64,226,449
Accession: 17084
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000554805	SYNE2-213	3481	-	-	- (aa)	-	-
ENST00000554997	SYNE2-215	711	-	-	- (aa)	-	-
ENST00000557024	SYNE2-224	998	-	-	- (aa)	-	-
ENST00000554584	SYNE2-212	20508	-	ENSP00000452570	6818 (aa)	-	G3V5X4
ENST00000557005	SYNE2-223	5804	-	-	- (aa)	-	-
ENST00000557060	SYNE2-225	3203	-	-	- (aa)	-	-
ENST00000555002	SYNE2-216	11532	-	ENSP00000450831	3541 (aa)	-	A0A0C4DGK3
ENST00000555022	SYNE2-217	3396	-	-	- (aa)	-	-
ENST00000557307	SYNE2-227	526	-	-	- (aa)	-	-
ENST00000553289	SYNE2-208	5261	-	ENSP00000451184	607 (aa)	-	G3V3D4
ENST00000553801	SYNE2-211	536	-	ENSP00000492590	16 (aa)	-	A0A1W2PS37
ENST00000554928	SYNE2-214	1048	-	-	- (aa)	-	-
ENST00000553455	SYNE2-210	674	-	ENSP00000452434	214 (aa)	-	G3V5N1
ENST00000553308	SYNE2-209	557	-	-	- (aa)	-	-
ENST00000357395	SYNE2-203	21555	-	ENSP00000349969	6824 (aa)	-	A0A0A0MRE3
ENST00000341472	SYNE2-201	1132	-	ENSP00000344528	285 (aa)	-	Q8WXH0
ENST00000358025	SYNE2-204	21842	XM_005267454	ENSP00000350719	6907 (aa)	XP_005267511	Q8WXH0
ENST00000556342	SYNE2-221	572	-	-	- (aa)	-	-
ENST00000557084	SYNE2-226	689	-	ENSP00000450789	199 (aa)	-	G3V2Q0
ENST00000344113	SYNE2-202	21777	XM_005267458	ENSP00000341781	6885 (aa)	XP_005267515	Q8WXH0
ENST00000394768	SYNE2-205	11095	-	-	- (aa)	-	-
ENST00000556725	SYNE2-222	672	-	-	- (aa)	-	-
ENST00000555612	SYNE2-220	6766	-	ENSP00000451972	1127 (aa)	-	G3V4T3
ENST00000458046	SYNE2-207	2669	XM_017021103	ENSP00000391937	556 (aa)	XP_016876592	Q8WXH0
ENST00000441438	SYNE2-206	3084	-	-	- (aa)	-	-
ENST00000555323	SYNE2-219	389	-	-	- (aa)	-	-
ENST00000555241	SYNE2-218	665	-	ENSP00000492588	99 (aa)	-	A0A1W2PRN9
ENST00000639659	SYNE2-228	1290	-	ENSP00000492333	429 (aa)	-	Q8WXH0

Gene Model

Click here to download ENSG00000054654's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000054654	Hemoglobin A, Glycosylated	5.6370000E-005	19875614
ENSG00000054654	Lymphocyte Count	9.357e-005	-
ENSG00000054654	Lymphocyte Count	9.631e-005	-
ENSG00000054654	Lymphocyte Count	8.561e-005	-
ENSG00000054654	Neutrophils	4.82e-005	-
ENSG00000054654	Neutrophils	5.818e-005	-
ENSG00000054654	Neutrophils	4.424e-005	-
ENSG00000054654	Child Development Disorders, Pervasive	3.9570000E-007	-
ENSG00000054654	Child Development Disorders, Pervasive	2.8275000E-007	-
ENSG00000054654	Autistic Disorder	4.0461000E-006	-
ENSG00000054654	Autistic Disorder	3.6392000E-006	-
ENSG00000054654	Child Development Disorders, Pervasive	6.9518000E-006	-
ENSG00000054654	Child Development Disorders, Pervasive	2.3881000E-006	-
ENSG00000054654	Child Development Disorders, Pervasive	1.9115000E-005	-
ENSG00000054654	Autistic Disorder	1.5146000E-005	-
ENSG00000054654	Child Development Disorders, Pervasive	8.4024000E-006	-
ENSG00000054654	Child Development Disorders, Pervasive	1.0223000E-005	-
ENSG00000054654	Child Development Disorders, Pervasive	9.7627000E-006	-
ENSG00000054654	Child Development Disorders, Pervasive	1.0578000E-005	-
ENSG00000054654	Child Development Disorders, Pervasive	1.6068000E-005	-
ENSG00000054654	Child Development Disorders, Pervasive	5.5000000E-005	-
ENSG00000054654	Child Development Disorders, Pervasive	4.5000000E-005	-
ENSG00000054654	Myocardial Infarction	2.2360000E-005	-
ENSG00000054654	Myocardial Infarction	1.7400000E-005	-
ENSG00000054654	Myocardial Infarction	2.0030000E-005	-
ENSG00000054654	Myocardial Infarction	1.7960000E-005	-
ENSG00000054654	Myocardial Infarction	2.4020000E-005	-
ENSG00000054654	Myocardial Infarction	2.4230000E-005	-
ENSG00000054654	Myocardial Infarction	2.3310000E-005	-
ENSG00000054654	Myocardial Infarction	1.7630000E-005	-
ENSG00000054654	Myocardial Infarction	2.3890000E-005	-
ENSG00000054654	Myocardial Infarction	1.7950000E-005	-
ENSG00000054654	Myocardial Infarction	1.8200000E-005	-
ENSG00000054654	Myocardial Infarction	1.3620000E-005	-
ENSG00000054654	Myocardial Infarction	2.3430000E-005	-
ENSG00000054654	Myocardial Infarction	2.2750000E-005	-
ENSG00000054654	Myocardial Infarction	1.5100000E-005	-
ENSG00000054654	Myocardial Infarction	2.4590000E-005	-
ENSG00000054654	Myocardial Infarction	1.4340000E-005	-
ENSG00000054654	Myocardial Infarction	1.5170000E-005	-
ENSG00000054654	Myocardial Infarction	2.3260000E-005	-
ENSG00000054654	Myocardial Infarction	1.0810000E-005	-
ENSG00000054654	Myocardial Infarction	9.2370000E-006	-
ENSG00000054654	Myocardial Infarction	2.0770000E-005	-
ENSG00000054654	Myocardial Infarction	2.5970000E-005	-
ENSG00000054654	Atrial Fibrillation	6E-13	22544366

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000054654	rs2738413	14	64213242	A	Atrial fibrillation	30061737	[1.07-1.10]	1.08	EFO_0000275
ENSG00000054654	rs1152595	14	64208263	T	Educational attainment (MTAG)	30038396	[0.0061-0.0111] unit decrease	0.0086	EFO_0004784
ENSG00000054654	rs1152591	14	64214130	A	Atrial fibrillation	28416818	[1.06-1.13]	1.09	EFO_0000275
ENSG00000054654	rs2738413	14	64213242	A	Atrial fibrillation	29892015	[1.07-1.1]	1.08	EFO_0000275
ENSG00000054654	rs2738413	14	64213242	A	Atrial fibrillation	29892015	[1.06-1.1]	1.08	EFO_0000275
ENSG00000054654	rs1152591	14	64214130	A	Atrial fibrillation	22544366	[1.09-1.17]	1.13	EFO_0000275
ENSG00000054654	rs915057	14	64219489	G	Depression	29700475	[1.02-1.04]	1.0309278	EFO_0003761
ENSG00000054654	rs2357176	14	63942595	?	Nevus count or cutaneous melanoma	30429480			EFO_0004632\|EFO_0000389
ENSG00000054654	rs10873172	14	63923312	G	Blond vs. brown/black hair color	30531825	NR	1.068	EFO_0003924
ENSG00000054654	rs148114281	14	64160241	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000054654	rs10873172	14	63923312	?	Hair color	30595370			EFO_0007822

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000054654's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000054654	SYNE2	100	98.990	ENSMUSG00000063450	Syne2	100	96.396	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003779	actin binding	-	ISS	Function
GO:0005515	protein binding	15671068.18396275.22555292.22632968.23414517.24880667.26506308.	IPI	Function
GO:0005634	nucleus	12118075.	IDA	Component
GO:0005635	nuclear envelope	15671068.	IDA	Component
GO:0005640	nuclear outer membrane	-	IEA	Component
GO:0005654	nucleoplasm	-	IEA	Component
GO:0005737	cytoplasm	12118075.15671068.	IDA	Component
GO:0005739	mitochondrion	15671068.	IDA	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005925	focal adhesion	15671068.	IDA	Component
GO:0007097	nuclear migration	20724637.	IMP	Process
GO:0010457	centriole-centriole cohesion	21873635.	IBA	Process
GO:0016021	integral component of membrane	-	IEA	Component
GO:0016235	aggresome	-	IDA	Component
GO:0016529	sarcoplasmic reticulum	15671068.	IDA	Component
GO:0021817	nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration	-	IEA	Process
GO:0030018	Z disc	15671068.	IDA	Component
GO:0030335	positive regulation of cell migration	-	ISS	Process
GO:0031022	nuclear migration along microfilament	-	ISS	Process
GO:0031258	lamellipodium membrane	15671068.	IDA	Component
GO:0031527	filopodium membrane	15671068.	IDA	Component
GO:0031965	nuclear membrane	-	IDA	Component
GO:0031981	nuclear lumen	15671068.	IDA	Component
GO:0033017	sarcoplasmic reticulum membrane	-	IEA	Component
GO:0034993	meiotic nuclear membrane microtubule tethering complex	18396275.	IDA	Component
GO:0045111	intermediate filament cytoskeleton	-	IDA	Component
GO:0051015	actin filament binding	-	IEA	Function
GO:0051642	centrosome localization	20724637.	IMP	Process
GO:0070062	extracellular exosome	18570454.	HDA	Component
GO:0090286	cytoskeletal anchoring at nuclear membrane	18396275.	IDA	Process
GO:1902017	regulation of cilium assembly	-	IEA	Process