EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000055130 (Gene tree)
Gene ID: 8454
Gene Symbol: CUL1
Alias: N
Full Name: cullin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 103,197 bases
Position: chr7:148,697,914-148,801,110
Accession: 2551
RBP type: non-canonical RBP
Summary: (Cullin 1) is a Protein Coding gene. Diseases associated with CUL1 include Vaccinia and Weaver Syndrome. Among its related pathways are Apoptosis-related network due to altered Notch3 in ovarian cancer and Signaling by NOTCH1. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is CUL2.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31309752	[Identification of differentially expressed genes in peripheral blood mononuclear cells of patients with hepatocellular carcinoma and its regulatory network analysis].	Zhejiang Da Xue Xue Bao Yi Xue Ban	2019 Apr 25	Lun Y	-
16036220	CAND1 enhances deneddylation of CUL1 by COP9 signalosome.	Biochem Biophys Res Commun	2005 Sep 2	Min KW	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000325222	CUL1-201	3064	XM_011516629	ENSP00000326804	776 (aa)	XP_011514931	Q13616
ENST00000602748	CUL1-203	3054	XM_005250060	ENSP00000473318	776 (aa)	XP_005250117	Q13616
ENST00000617797	CUL1-204	2508	-	ENSP00000482123	752 (aa)	-	A0A0C4DGX4
ENST00000409469	CUL1-202	2857	XM_011516630	ENSP00000387160	776 (aa)	XP_011514932	Q13616

Gene Model

Click here to download ENSG00000055130's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04120	Ubiquitin mediated proteolysis	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa04310	Wnt signaling pathway	KEGG
hsa04340	Hedgehog signaling pathway	KEGG
hsa04350	TGF-beta signaling pathway	KEGG
hsa04710	Circadian rhythm	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG
hsa05200	Pathways in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000055130	Platelet Function Tests	1.2048700E-005	-
ENSG00000055130	Inflammatory Bowel Diseases	3E-10	28067908
ENSG00000055130	Crohn Disease	6E-7	28067908

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000055130	rs73745348	7	148725247	?	Mononucleosis	28928442	[0.53-1.55] unit decrease	1.0415	EFO_0008403
ENSG00000055130	rs243505	7	148738247	A	Inflammatory bowel disease	28067908	1.06-1.11	1.08	EFO_0003767
ENSG00000055130	rs243505	7	148738247	?	Crohn's disease	28067908			EFO_0000384

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000055130's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000055130	CUL1	98	62.773	FBgn0015509	Cul1	99	62.773	Drosophila_melanogaster
ENSG00000055130	CUL1	98	31.802	YDL132W		99	31.802	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000082	G1/S transition of mitotic cell cycle	8681378.	TAS	Process
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0005515	protein binding	11961546.12504025.12504026.12609982.14685242.15537541.16051867.16278047.16861300.16880511.17290223.17318178.17914462.18203720.18239684.18264111.18274552.18354482.18644861.18667692.18723677.18775313.18805092.18818696.18826954.18929646.19615732.19713960.19945379.20399188.20596027.20708156.21102408.21765416.21778237.22466964.22479149.22632967.22660580.23108047.23452855.23452856.23563313.23776465.24076655.24794231.24949976.25241761.25435324.25609649.27705803.28007894.29149593.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006511	ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0006513	protein monoubiquitination	-	IEA	Process
GO:0006879	cellular iron ion homeostasis	-	TAS	Process
GO:0007050	cell cycle arrest	8681378.	TAS	Process
GO:0008283	cell proliferation	-	IEA	Process
GO:0008285	negative regulation of cell proliferation	8681378.	TAS	Process
GO:0009887	animal organ morphogenesis	-	IEA	Process
GO:0010265	SCF complex assembly	-	TAS	Process
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0016055	Wnt signaling pathway	-	TAS	Process
GO:0016567	protein ubiquitination	15103331.	IDA	Process
GO:0019005	SCF ubiquitin ligase complex	21873635.	IBA	Component
GO:0019005	SCF ubiquitin ligase complex	11956208.15103331.16880511.20596027.21572392.21725316.23263282.25585578.28007894.	IDA	Component
GO:0019005	SCF ubiquitin ligase complex	-	ISS	Component
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	15103331.	IDA	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	ISS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0031461	cullin-RING ubiquitin ligase complex	21873635.	IBA	Component
GO:0031461	cullin-RING ubiquitin ligase complex	22405651.	IDA	Component
GO:0031625	ubiquitin protein ligase binding	21873635.	IBA	Function
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0051403	stress-activated MAPK cascade	-	TAS	Process
GO:0061630	ubiquitin protein ligase activity	21873635.	IBA	Function
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0097193	intrinsic apoptotic signaling pathway	8681378.	TAS	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	12628165.	IPI	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24819753	Aberrant expression pattern and location of cullin 1 are associated with the development of papillary carcinoma in thyroid and cyclin D1 expression.	Endocr Pathol	2014 Sep	Do SI	doi: 10.1007/s12022-014-9321-z.
19679553	Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels.	Cancer Res	2009 Aug 15	Korzeniewski N	doi: 10.1158/0008-5472.CAN-09-1284.
27542266	DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage.	Oncotarget	2016 Sep 6	Zhang S	doi: 10.18632/oncotarget.11302.
23592700	Cullin1 is a novel marker of poor prognosis and a potential therapeutic target in human breast cancer.	Ann Oncol	2013 Aug	Bai J	doi: 10.1093/annonc/mdt147
19349673	Expression of ubiquitin and cullin-1 and its clinicopathological significance in benign and malignant lesions of the lung.	Zhong Nan Da Xue Xue Bao Yi Xue Ban	2009 Mar	Peng Z	-
24767980	High expression of Cullin1 indicates poor prognosis for NSCLC patients.	Pathol Res Pract	2014 Jul	Xu M	doi: 10.1016/j.prp.2014.01.015
25973042	Cullin-1 promotes cell proliferation via cell cycle regulation and is a novel in prostate cancer.	Int J Clin Exp Pathol	2015 Feb 1	Jiang H	-
21190721	Overexpression of Cullin1 is associated with poor prognosis of patients with gastric cancer.	Hum Pathol	2011 Mar	Bai J	doi: 10.1016/j.humpath.2010.09.003
28269751	Synergistic efficacy of Cullin1 and MMP-2 expressions in diagnosis and prognosis of colorectal cancer.	Cancer Biomark	2017	Deng J	doi: 10.3233/CBM-160341.
28560438	Synergistic role of Cul1 and c-Myc: Prognostic and predictive biomarkers in colorectal cancer.	Oncol Rep	2017 Jul	Wang W	doi: 10.3892/or.2017.5671

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr7	148787094	Missense_Mutation	NA	E485K	0.32
BLCA	chr7	148766645	Missense_Mutation	NA	E292K	0.21
BLCA	chr7	148784037	Missense_Mutation	NA	E420K	0.36
BLCA	chr7	148760346	Silent	novel	L213L	0.1
BLCA	chr7	148792740	Missense_Mutation	novel	Q607H	0.31
BLCA	chr7	148786579	Missense_Mutation	novel	E443K	0.23
BLCA	chr7	148767616	Splice_Region	novel		0.18
BLCA	chr7	148787088	Missense_Mutation	NA	D483N	0.21
BLCA	chr7	148787088	Missense_Mutation	NA	D483N	0.59
BLCA	chr7	148753996	Missense_Mutation	novel	T54S	0.19
BLCA	chr7	148787094	Missense_Mutation	NA	E485K	0.27
BLCA	chr7	148799333	Missense_Mutation	novel	G732D	0.13
BLCA	chr7	148760455	Nonsense_Mutation	NA	E250*	0.31
BLCA	chr7	148730244	Missense_Mutation	NA	R41K	0.13
BLCA	chr7	148798582	Missense_Mutation	novel	R681G	0.32
BLCA	chr7	148800511	Missense_Mutation	novel	D754N	0.33
BLCA	chr7	148792730	Missense_Mutation	novel	S604L	0.63
BLCA	chr7	148790313	Missense_Mutation	NA	E560K	0.32
BLCA	chr7	148787094	Missense_Mutation	NA	E485K	0.7
BLCA	chr7	148787088	Missense_Mutation	NA	D483N	0.52
BLCA	chr7	148792740	Silent	novel	Q607Q	0.5
BLCA	chr7	148787088	Missense_Mutation	NA	D483N	0.15
BRCA	chr7	148766626	Silent	NA	D285D	0.24
BRCA	chr7	148757103	Missense_Mutation	NA	R146C	0.24
BRCA	chr7	148790346	Missense_Mutation	NA	A571P	0.19
BRCA	chr7	148788626	Missense_Mutation	novel	L517V	0.07
BRCA	chr7	148789812	Missense_Mutation	novel	A554S	0.08
BRCA	chr7	148798651	Missense_Mutation	novel	E704Q	0.28
BRCA	chr7	148760428	Missense_Mutation	NA	E241Q	0.21
BRCA	chr7	148788632	Missense_Mutation	novel	E519K	0.1
CESC	chr7	148786564	Missense_Mutation	novel	E438Q	0.09
CESC	chr7	148799295	Missense_Mutation	novel	M719I	0.78
CESC	chr7	148786567	Missense_Mutation	NA	E439K	0.3
CESC	chr7	148787094	Missense_Mutation	NA	E485K	0.24
CESC	chr7	148790365	Missense_Mutation	NA	R577Q	0.19
CESC	chr7	148784047	Missense_Mutation	novel	A423D	0.29
CESC	chr7	148789817	Silent	novel	L555L	0.33
CESC	chr7	148799340	Silent	novel	V734V	0.18
CESC	chr7	148787094	Missense_Mutation	NA	E485K	0.35
CESC	chr7	148760444	Missense_Mutation	NA	R246T	0.3
CESC	chr7	148760430	Missense_Mutation	novel	E241D	0.45
CESC	chr7	148787057	Silent	novel	K472K	0.52
COAD	chr7	148786586	Frame_Shift_Del	NA	*L446Ifs3**	0.4
COAD	chr7	148790377	Missense_Mutation	novel	W581L	0.42
COAD	chr7	148790417	Nonsense_Mutation	NA	C594*	0.38
COAD	chr7	148798006	Missense_Mutation	NA	L673I	0.34
COAD	chr7	148730127	Missense_Mutation	rs746247997	S2L	0.13
COAD	chr7	148730136	Missense_Mutation	rs748809924	R5Q	0.46
COAD	chr7	148783813	Missense_Mutation	novel	D372H	0.08
COAD	chr7	148800541	Nonsense_Mutation	NA	R764*	0.18
COAD	chr7	148799323	Nonsense_Mutation	NA	Q729*	0.31
COAD	chr7	148757104	Missense_Mutation	NA	R146H	0.34
COAD	chr7	148799335	Missense_Mutation	rs762885752	E733K	0.32
COAD	chr7	148787038	Missense_Mutation	novel	Y466S	0.33
COAD	chr7	148797823	Silent	rs145563536	A637A	0.3
COAD	chr7	148783821	Frame_Shift_Ins	NA	*Y377Ifs12**	0.28
COAD	chr7	148792760	Missense_Mutation	novel	Y614C	0.07
COAD	chr7	148792725	Splice_Site	novel	X603_splice	0.48
COAD	chr7	148760464	Nonsense_Mutation	NA	Q253*	0.21
COAD	chr7	148760440	Missense_Mutation	novel	T245A	0.35
DLBC	chr7	148757011	Missense_Mutation	novel	V115A	0.35
ESCA	chr7	148783822	Frame_Shift_Del	novel	*K376Nfs6**	0.23
ESCA	chr7	148800553	Missense_Mutation	novel	E768K	0.56
GBM	chr7	148790322	Missense_Mutation	novel	Y563N	0.07
GBM	chr7	148730201	Missense_Mutation	novel	G27S	0.22
GBM	chr7	148800594	3'UTR	novel		0.16
GBM	chr7	148789801	Missense_Mutation	rs17855577	S550F	0.2
GBM	chr7	148798593	Frame_Shift_Del	novel	*N685Mfs4**	0.27
GBM	chr7	148760460	Missense_Mutation	NA	F251L	0.45
GBM	chr7	148787069	Missense_Mutation	NA	H476Q	0.32
GBM	chr7	148760365	Missense_Mutation	NA	A220T	0.3
HNSC	chr7	148730179	Silent	novel	Q19Q	0.27
HNSC	chr7	148787094	Missense_Mutation	NA	E485K	0.79
HNSC	chr7	148754071	Missense_Mutation	novel	G79E	0.16
HNSC	chr7	148788579	Missense_Mutation	novel	T501I	0.21
HNSC	chr7	148766645	Missense_Mutation	NA	E292K	0.19
HNSC	chr7	148799313	Silent	novel	L725L	0.37
HNSC	chr7	148789824	Missense_Mutation	novel	E558K	0.14
HNSC	chr7	148759593	Missense_Mutation	novel	E194K	0.33
HNSC	chr7	148786567	Missense_Mutation	NA	E439K	0.34
HNSC	chr7	148788574	Missense_Mutation	novel	E499D	0.33
KIRC	chr7	148789807	Frame_Shift_Del	novel	*T552Nfs28**	0.3
KIRC	chr7	148757124	Nonsense_Mutation	NA	R153*	0.14
KIRP	chr7	148787107	Missense_Mutation	novel	I489S	0.36
KIRP	chr7	148799284	Missense_Mutation	NA	V716M	0.35
LAML	chr7	148757089	Missense_Mutation	NA	N141S	0.61
LAML	chr7	148760430	Missense_Mutation	NA	E241D	0.3
LGG	chr7	148753993	Missense_Mutation	NA	C53Y	0.38
LIHC	chr7	148787015	Silent	novel	D458D	0.4
LIHC	chr7	148787016	Missense_Mutation	novel	K459E	0.4
LUAD	chr7	148787030	Missense_Mutation	novel	Q463H	0.23
LUAD	chr7	148767628	Missense_Mutation	novel	R321L	0.14
LUAD	chr7	148787023	Missense_Mutation	NA	V461G	0.13
LUAD	chr7	148730196	Missense_Mutation	NA	R25I	0.15
LUAD	chr7	148789795	Missense_Mutation	NA	Q548P	0.25
LUAD	chr7	148783995	Missense_Mutation	NA	N406H	0.36
LUAD	chr7	148759321	Missense_Mutation	novel	W167C	0.14
LUAD	chr7	148800517	Missense_Mutation	NA	L756V	0.19
LUAD	chr7	148757035	Missense_Mutation	novel	W123L	0.33
LUAD	chr7	148757036	Missense_Mutation	novel	W123C	0.33
LUAD	chr7	148800523	Missense_Mutation	NA	E758Q	0.2
LUAD	chr7	148783993	Missense_Mutation	rs772237633	N405S	0.33
LUAD	chr7	148730134	Silent	NA	T4T	0.15
LUAD	chr7	148799288	Missense_Mutation	novel	R717T	0.24
LUAD	chr7	148766609	Missense_Mutation	NA	H280Y	0.05
LUSC	chr7	148766637	Missense_Mutation	NA	R289K	0.5
LUSC	chr7	148766561	Missense_Mutation	novel	A264S	0.2
LUSC	chr7	148786553	Missense_Mutation	novel	S434F	0.23
LUSC	chr7	148787094	Missense_Mutation	NA	E485K	0.19
LUSC	chr7	148788670	Silent	rs764878022	L531L	0.15
LUSC	chr7	148730230	Missense_Mutation	novel	S36R	0.19
LUSC	chr7	148786577	Missense_Mutation	novel	L442R	0.22
LUSC	chr7	148789758	Missense_Mutation	novel	S536G	0.1
LUSC	chr7	148783793	Missense_Mutation	novel	M365T	0.48
LUSC	chr7	148767698	Silent	novel	I344I	0.07
LUSC	chr7	148787094	Missense_Mutation	NA	E485K	0.76
OV	chr7	148757100	Missense_Mutation	novel	V145F	0.1
OV	chr7	148800531	Missense_Mutation	novel	E760D	0.07
OV	chr7	148789819	Missense_Mutation	NA	P556L	0.16
OV	chr7	148754074	Missense_Mutation	novel	G80E	0.06
OV	chr7	148799386	Missense_Mutation	novel	K750E	0.09
OV	chr7	148790348	Silent	novel	A571A	0.07
OV	chr7	148787010	Missense_Mutation	NA	E457Q	0.33
PAAD	chr7	148787094	Missense_Mutation	NA	E485K	0.06
PAAD	chr7	148730206	Silent	novel	I28I	0.05
PAAD	chr7	148757001	Missense_Mutation	novel	D112N	0.2
PCPG	chr7	148730206	Missense_Mutation	novel	I28M	0.06
PRAD	chr7	148730153	Missense_Mutation	novel	G11S	0.42
PRAD	chr7	148760378	Missense_Mutation	novel	T224M	0.35
READ	chr7	148757118	Missense_Mutation	NA	E151K	0.21
READ	chr7	148757031	Nonsense_Mutation	novel	Q122*	0.33
READ	chr7	148730102	5'UTR	novel		0.53
READ	chr7	148757104	Missense_Mutation	NA	R146H	0.11
SARC	chr7	148797812	Missense_Mutation	novel	D634H	0.54
SARC	chr7	148766571	Missense_Mutation	novel	R267H	0.21
SARC	chr7	148792730	Missense_Mutation	novel	S604L	0.24
SKCM	chr7	148759623	Missense_Mutation	NA	V204I	0.49
SKCM	chr7	148784035	Missense_Mutation	NA	P419L	0.16
SKCM	chr7	148766656	Silent	novel	L295L	0.51
SKCM	chr7	148797989	Missense_Mutation	NA	T667I	0.38
SKCM	chr7	148800568	Missense_Mutation	rs143079007	S773G	0.22
SKCM	chr7	148789779	Missense_Mutation	NA	G543R	0.48
SKCM	chr7	148766725	Splice_Site	novel	X318_splice	0.16
SKCM	chr7	148730052	5'UTR	novel		0.3
SKCM	chr7	148730182	Silent	NA	I20I	0.21
SKCM	chr7	148798651	Missense_Mutation	novel	E704K	0.22
SKCM	chr7	148787108	Silent	NA	I489I	0.36
STAD	chr7	148730217	Missense_Mutation	NA	Y32C	0.15
STAD	chr7	148787087	Silent	rs774670924	D482D	0.12
STAD	chr7	148792775	Missense_Mutation	NA	A619V	0.25
STAD	chr7	148792759	Missense_Mutation	NA	Y614H	0.09
STAD	chr7	148730159	Missense_Mutation	NA	K13Q	0.64
STAD	chr7	148767684	Missense_Mutation	NA	L340V	0.34
STAD	chr7	148790375	Silent	rs764499381	T580T	0.37
STAD	chr7	148759302	Splice_Site	NA	X162_splice	0.25
STAD	chr7	148800560	Missense_Mutation	NA	D770G	0.07
STAD	chr7	148788651	Missense_Mutation	NA	L525S	0.3
STAD	chr7	148798661	Missense_Mutation	NA	R707H	0.38
STAD	chr7	148756982	Splice_Site	novel	X106_splice	0.17
STAD	chr7	148788593	Missense_Mutation	novel	R506S	0.17
STAD	chr7	148799276	Missense_Mutation	NA	A713V	0.25
STAD	chr7	148800523	Missense_Mutation	NA	E758Q	0.37
STAD	chr7	148788565	Silent	rs750560055	C496C	0.23
STAD	chr7	148787032	Missense_Mutation	NA	K464T	0.1
STAD	chr7	148760439	Frame_Shift_Ins	novel	*E259Dfs6**	0.54
STAD	chr7	148730096	5'UTR	novel		0.27
STAD	chr7	148788594	Missense_Mutation	NA	R506H	0.24
STAD	chr7	148759356	Splice_Site	NA	X178_splice	0.21
STAD	chr7	148787101	Missense_Mutation	NA	S487N	0.19
STAD	chr7	148792758	Silent	rs761975125	Q613Q	0.3
STAD	chr7	148757103	Missense_Mutation	NA	R146C	0.08
STAD	chr7	148757106	Missense_Mutation	NA	R147C	0.23
STAD	chr7	148767674	Frame_Shift_Ins	novel	*L339Tfs8**	0.13
STAD	chr7	148759637	Splice_Region	rs144866150	Y208Y	0.26
THCA	chr7	148730015	5'UTR	novel		0.43
UCEC	chr7	148757103	Missense_Mutation	NA	R146C	0.36
UCEC	chr7	148766706	Missense_Mutation	novel	D312G	0.31
UCEC	chr7	148798008	Silent	novel	L673L	0.3
UCEC	chr7	148800989	3'UTR	novel		0.43
UCEC	chr7	148766627	Missense_Mutation	NA	E286K	0.18
UCEC	chr7	148797850	Silent	rs529529570	S646S	0.46
UCEC	chr7	148789823	Silent	NA	S557S	0.41
UCEC	chr7	148800883	3'UTR	novel		0.32
UCEC	chr7	148798650	Silent	rs375091492	I703I	0.33
UCEC	chr7	148798647	Silent	NA	N702N	0.18
UCEC	chr7	148790334	Missense_Mutation	NA	T567A	0.47
UCEC	chr7	148797849	Missense_Mutation	NA	S646L	0.04
UCEC	chr7	148786595	Missense_Mutation	NA	Q448R	0.14
UCEC	chr7	148787094	Missense_Mutation	NA	E485K	0.41
UCEC	chr7	148757144	Silent	novel	I159I	0.27
UCEC	chr7	148766653	Silent	novel	V294V	0.27
UCEC	chr7	148757121	Nonsense_Mutation	novel	G152*	0.41
UCEC	chr7	148759558	Missense_Mutation	novel	A182V	0.41
UCEC	chr7	148799293	Missense_Mutation	novel	M719V	0.36
UCEC	chr7	148789777	Missense_Mutation	novel	S542F	0.33
UCEC	chr7	148798650	Silent	rs375091492	I703I	0.37
UCEC	chr7	148800739	3'UTR	novel		0.34
UCEC	chr7	148790374	Missense_Mutation	rs758702023	T580M	0.3
UCEC	chr7	148783837	Missense_Mutation	novel	L380M	0.36
UCEC	chr7	148760413	Frame_Shift_Del	novel	*L237Wfs25**	0.49
UCEC	chr7	148757047	Missense_Mutation	NA	R127Q	0.31
UCEC	chr7	148788606	Missense_Mutation	NA	D510G	0.12
UCEC	chr7	148792766	Missense_Mutation	NA	T616M	0.38
UCEC	chr7	148783822	Frame_Shift_Del	novel	*K376Nfs6**	0.14
UCEC	chr7	148788565	Silent	rs750560055	C496C	0.38
UCEC	chr7	148797849	Missense_Mutation	NA	S646L	0.39
UCEC	chr7	148798612	Missense_Mutation	novel	E691K	0.41
UCEC	chr7	148799334	Silent	rs565504382	G732G	0.48
UCEC	chr7	148800789	3'UTR	novel		0.36
UCEC	chr7	148800790	3'UTR	rs748356931		0.28
UCEC	chr7	148754032	Missense_Mutation	NA	G66V	0.34
UCEC	chr7	148729971	5'UTR	novel		0.39
UCEC	chr7	148797849	Missense_Mutation	NA	S646L	0.41
UCEC	chr7	148784050	Missense_Mutation	novel	R424Q	0.27
UCEC	chr7	148787088	Missense_Mutation	NA	D483N	0.29
UCEC	chr7	148797849	Missense_Mutation	NA	S646L	0.45
UCEC	chr7	148798650	Silent	rs375091492	I703I	0.41
UCEC	chr7	148800883	3'UTR	rs577115013		0.32
UCEC	chr7	148800883	3'UTR	rs577115013		0.18
UCEC	chr7	148754143	Missense_Mutation	novel	L103P	0.11
UCEC	chr7	148799334	Silent	rs565504382	G732G	0.19
UCEC	chr7	148730234	Missense_Mutation	NA	A38T	0.37
UCEC	chr7	148788613	Silent	rs372179870	G512G	0.08
UCEC	chr7	148788557	Nonsense_Mutation	novel	Q494*	0.42
UCEC	chr7	148757149	Missense_Mutation	NA	S161L	0.49
UCEC	chr7	148800525	Missense_Mutation	NA	E758D	0.31
UCEC	chr7	148790353	Missense_Mutation	rs142906551	R573H	0.46
UCEC	chr7	148800783	3'UTR	novel		0.3
UCEC	chr7	148800670	3'UTR	novel		0.25
UCEC	chr7	148730102	5'UTR	novel		0.3
UCEC	chr7	148788653	Missense_Mutation	novel	T526A	0.41
UCEC	chr7	148789809	Missense_Mutation	novel	F553L	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0667	0.12261
CESC	DEL	0.1763	0.0016147
DLBC	DEL	0.125	0.03486
HNSC	DEL	0.1973	1.1399e-22
KIRC	AMP	0.2898	0.075418
LAML	DEL	0.1309	3.4101e-05
LGG	AMP	0.3119	1.5525e-07
LIHC	DEL	0.0811	0.24831
OV	AMP	0.4853	1.5763e-13
PAAD	DEL	0.0652	0.049388
TGCT	DEL	0.0733	0.11738
THCA	DEL	0.002	0.27619
UCEC	DEL	0.102	0.0001859
UCS	DEL	0.3214	0.10142

Survival Analysis

Cancer	P-value	Q-value
SARC	0.037	Kaplan-Meier Survival Analysis
MESO	0.018	Kaplan-Meier Survival Analysis
ACC	0.019	Kaplan-Meier Survival Analysis
HNSC	0.041	Kaplan-Meier Survival Analysis
KIRP	0.013	Kaplan-Meier Survival Analysis
BLCA	0.00054	Kaplan-Meier Survival Analysis
LAML	0.0022	Kaplan-Meier Survival Analysis
KICH	0.047	Kaplan-Meier Survival Analysis
GBM	0.0037	Kaplan-Meier Survival Analysis
LIHC	0.0034	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0095	Kaplan-Meier Survival Analysis
OV	0.016	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742