EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Description

Ensembl ID: ENSG00000055208 (Gene tree)
Gene ID: 23118
Gene Symbol: TAB2
Alias: KIAA0733|MAP3K7IP2
Full Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 193,690 bases
Position: chr6:149,217,924-149,411,613
Accession: 17075
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
14633996	Tab2 is a novel conserved RNA binding protein required for translation of the chloroplast psaB mRNA.	EMBO J	2003 Dec 1	Dauvillee D	-
15590691	Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.	J Biol Chem	2005 Feb 25	Singhirunnusorn P	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000461481	TAB2-202	524	-	-	- (aa)	-	-
ENST00000367456	TAB2-201	4553	XM_011535633	ENSP00000356426	693 (aa)	XP_011533935	Q9NYJ8
ENST00000484505	TAB2-204	493	-	-	- (aa)	-	-
ENST00000606797	TAB2-207	677	-	ENSP00000475580	33 (aa)	-	U3KQ62
ENST00000636456	TAB2-208	3092	-	ENSP00000490379	409 (aa)	-	A0A1B0GV57
ENST00000606202	TAB2-206	648	-	ENSP00000476139	130 (aa)	-	U3KQR0
ENST00000637181	TAB2-209	4230	-	ENSP00000490618	693 (aa)	-	Q9NYJ8
ENST00000538427	TAB2-205	4240	XM_017010591	ENSP00000445752	693 (aa)	XP_016866080	Q9NYJ8
ENST00000470466	TAB2-203	4199	-	ENSP00000432709	536 (aa)	-	Q9NYJ8

Gene Model

Click here to download ENSG00000055208's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000055208	rs7758080	6	149255943	G	Crohn's disease	26192919	[1.05-1.1]	1.0790637	EFO_0000384
ENSG00000055208	rs7758080	6	149255943	G	Inflammatory bowel disease	26192919	[1.04-1.08]	1.0597305	EFO_0003767
ENSG00000055208	rs9485372	6	149287738	G	Breast cancer	22383897	[1.09-1.15]	1.11	EFO_0000305
ENSG00000055208	rs727979	6	149272784	?	Hemostatic factors and hematological phenotypes	17903294			EFO_0004305
ENSG00000055208	rs9485372	6	149287738	G	Breast cancer	29059683	[1.02-1.08] (Oncoarray)	1.0416667	EFO_0000305
ENSG00000055208	rs35409891	6	149265193	C	Breast cancer	29059683	[0.031-0.061] unit decrease	0.0457	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000055208's network

* RBP PPI network refers to all genes directly bind to RBP

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17158449	TAK1-dependent signaling requires functional interaction with TAB2/TAB3.	J Biol Chem	2007 Feb 9	Besse A	-
22660635	The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.	Nat Med	2012 Jul	Zhu S	doi: 10.1038/nm.2815.
27992601	A Novel Functional Domain of Tab2 Involved in the Interaction with Estrogen Receptor Alpha in Breast Cancer Cells.	PLoS One	2016 Dec 19	Reineri S	doi: 10.1371/journal.pone.0168639

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	149378211	Missense_Mutation	NA	G99V	0.1
BLCA	chr6	149369994	5'UTR	novel		0.18
BLCA	chr6	149379102	Missense_Mutation	NA	G396A	0.19
BLCA	chr6	149409701	Missense_Mutation	NA	E688D	0.25
BLCA	chr6	149379484	Silent	NA	L523L	0.51
BLCA	chr6	149379269	Nonsense_Mutation	NA	R452*	0.31
BLCA	chr6	149397639	Missense_Mutation	novel	L547F	0.16
BLCA	chr6	149379042	Missense_Mutation	rs760538795	T376M	0.28
BLCA	chr6	149378919	Missense_Mutation	NA	R335T	0.41
BLCA	chr6	149397736	Frame_Shift_Ins	novel	*R579Sfs12**	0.04
BLCA	chr6	149397737	In_Frame_Ins	novel	R579_S580insNKNL	0.04
BRCA	chr6	149378222	Frame_Shift_Ins	novel	*T104Nfs5**	0.24
BRCA	chr6	149378843	Missense_Mutation	NA	S310G	0.13
BRCA	chr6	149409870	3'UTR	novel		0.3
BRCA	chr6	149411330	3'UTR	novel		0.23
BRCA	chr6	149378269	Silent	rs148722166	N118N	0.39
BRCA	chr6	149410440	3'UTR	novel		0.27
CESC	chr6	149398053	Missense_Mutation	NA	Q617E	0.19
CESC	chr6	149411016	3'UTR	novel		0.39
CESC	chr6	149379156	Missense_Mutation	rs775633022	G414A	0.21
CESC	chr6	149378433	Missense_Mutation	NA	R173T	0.61
CESC	chr6	149411162	3'UTR	novel		0.38
COAD	chr6	149369928	5'UTR	novel		0.76
COAD	chr6	149399105	Splice_Region	novel	G620G	0.25
COAD	chr6	149370032	Frame_Shift_Del	novel	*L13Yfs48**	0.43
COAD	chr6	149378928	Missense_Mutation	NA	S338Y	0.34
COAD	chr6	149378248	Missense_Mutation	novel	Q111H	0.07
COAD	chr6	149379060	Missense_Mutation	rs532837920	R382H	0.32
COAD	chr6	149378661	Missense_Mutation	NA	Q249R	0.41
COAD	chr6	149378288	Missense_Mutation	rs374508964	E125K	0.19
COAD	chr6	149378840	Missense_Mutation	novel	H309N	0.06
COAD	chr6	149397720	Nonsense_Mutation	NA	R574*	0.21
COAD	chr6	149379319	Silent	rs138678250	V468V	0.33
COAD	chr6	149379387	Missense_Mutation	novel	L491R	0.14
COAD	chr6	149398047	Missense_Mutation	novel	L615I	0.05
COAD	chr6	149409684	Missense_Mutation	NA	R683C	0.35
COAD	chr6	149409856	3'UTR	novel		0.17
COAD	chr6	149378542	Missense_Mutation	novel	Q209H	0.21
GBM	chr6	149378679	Missense_Mutation	rs748656776	P255L	0.1
GBM	chr6	149379328	Silent	novel	N471N	0.08
GBM	chr6	149378275	Silent	rs765640727	E120E	0.74
GBM	chr6	149409596	Silent	rs111920140	K653K	0.38
HNSC	chr6	149379255	Missense_Mutation	novel	S447F	0.25
HNSC	chr6	149370046	Nonsense_Mutation	novel	R17*	0.1
HNSC	chr6	149378814	Missense_Mutation	novel	S300L	0.1
HNSC	chr6	149398027	Missense_Mutation	rs746984589	C608Y	0.26
KIRC	chr6	149378735	Frame_Shift_Ins	novel	*N274Ifs30**	0.2
KIRC	chr6	149370059	Missense_Mutation	NA	P21R	0.65
LGG	chr6	149378763	Missense_Mutation	novel	V283G	0.12
LGG	chr6	149397639	Missense_Mutation	novel	L547F	0.36
LIHC	chr6	149379433	Silent	novel	L506L	0.3
LIHC	chr6	149378467	Frame_Shift_Ins	novel	*I185Nfs6**	0.35
LUAD	chr6	149409576	Splice_Site	NA	X647_splice	0.18
LUAD	chr6	149379491	Nonsense_Mutation	NA	G526*	0.29
LUAD	chr6	149378874	Missense_Mutation	NA	G320V	0.27
LUAD	chr6	149379020	Missense_Mutation	novel	I369V	0.11
LUAD	chr6	149379169	Silent	rs371956282	A418A	0.23
LUAD	chr6	149378473	Missense_Mutation	NA	Q186H	0.4
LUAD	chr6	149409630	Missense_Mutation	novel	G665R	0.18
LUAD	chr6	149409729	3'UTR	rs755917762		0.33
LUAD	chr6	149378840	Missense_Mutation	NA	H309D	0.2
LUSC	chr6	149379470	Missense_Mutation	novel	E519K	0.27
LUSC	chr6	149379295	Silent	rs150699204	T460T	0.25
LUSC	chr6	149378827	Silent	NA	S304S	0.49
LUSC	chr6	149378847	Missense_Mutation	novel	Q311R	0.17
LUSC	chr6	149397684	Missense_Mutation	novel	K562E	0.25
OV	chr6	149378238	Missense_Mutation	novel	S108T	0.04
OV	chr6	149379057	Missense_Mutation	novel	S381F	0.04
PAAD	chr6	149378706	Missense_Mutation	novel	P264H	0.17
PCPG	chr6	149397737	Missense_Mutation	novel	R579S	0.05
PRAD	chr6	149378821	In_Frame_Del	novel	S304_S310del	0.13
PRAD	chr6	149378685	Missense_Mutation	novel	T257I	0.4
PRAD	chr6	149379133	Silent	NA	T406T	0.37
READ	chr6	149378526	Missense_Mutation	NA	V204E	0.41
READ	chr6	149370070	Missense_Mutation	rs747627781	E25K	0.44
SKCM	chr6	149378430	Missense_Mutation	NA	P172L	0.29
SKCM	chr6	149378315	Missense_Mutation	novel	P134S	0.42
SKCM	chr6	149378349	Missense_Mutation	rs778012324	S145F	0.92
SKCM	chr6	149399111	Silent	NA	H622H	0.44
SKCM	chr6	149378480	Missense_Mutation	rs754720551	R189C	0.51
SKCM	chr6	149370058	Missense_Mutation	rs756714260	P21S	0.5
SKCM	chr6	149379392	Missense_Mutation	NA	H493Y	0.25
SKCM	chr6	149409782	3'UTR	novel		0.29
SKCM	chr6	149378944	Silent	novel	S343S	0.26
SKCM	chr6	149378945	Missense_Mutation	novel	S344P	0.27
SKCM	chr6	149378135	Missense_Mutation	NA	H74Y	0.38
SKCM	chr6	149370057	Silent	NA	F20F	0.51
SKCM	chr6	149399178	Missense_Mutation	NA	P645S	0.31
SKCM	chr6	149378832	Missense_Mutation	novel	S306Y	0.24
STAD	chr6	149398057	Missense_Mutation	NA	A618V	0.26
STAD	chr6	149378523	Missense_Mutation	NA	P203L	0.05
STAD	chr6	149379131	Missense_Mutation	NA	T406A	0.11
STAD	chr6	149379492	Missense_Mutation	novel	G526E	0.08
STAD	chr6	149378028	Missense_Mutation	NA	N38I	0.38
STAD	chr6	149409795	3'UTR	novel		0.31
STAD	chr6	149379120	Missense_Mutation	NA	R402Q	0.45
TGCT	chr6	149378703	Missense_Mutation	novel	N263S	0.19
THYM	chr6	149411016	3'UTR	novel		0.34
UCEC	chr6	149398059	Nonsense_Mutation	NA	R619*	0.33
UCEC	chr6	149411608	3'UTR	novel		0.42
UCEC	chr6	149379282	Missense_Mutation	novel	T456I	0.14
UCEC	chr6	149411196	3'UTR	novel		0.34
UCEC	chr6	149411138	3'UTR	novel		0.13
UCEC	chr6	149378224	Silent	novel	L103L	0.17
UCEC	chr6	149409631	Missense_Mutation	novel	G665V	0.47
UCEC	chr6	149378928	Missense_Mutation	NA	S338Y	0.49
UCEC	chr6	149379360	Missense_Mutation	novel	S482F	0.36
UCEC	chr6	149397760	Missense_Mutation	novel	P587H	0.38
UCEC	chr6	149409946	3'UTR	novel		0.43
UCEC	chr6	149378228	Missense_Mutation	rs748152528	H105Y	0.51
UCEC	chr6	149379087	Missense_Mutation	novel	A391V	0.18
UCEC	chr6	149379240	Missense_Mutation	NA	A442V	0.14
UCEC	chr6	149397995	Missense_Mutation	NA	S597R	0.18
UCEC	chr6	149379165	Missense_Mutation	rs147099781	A417V	0.1
UCEC	chr6	149378480	Missense_Mutation	rs754720551	R189C	0.2
UCEC	chr6	149378078	Missense_Mutation	NA	Y55H	0.53
UCEC	chr6	149409949	3'UTR	novel		0.48
UCEC	chr6	149379101	Nonsense_Mutation	novel	G396*	0.61
UCEC	chr6	149410098	3'UTR	novel		0.42
UCEC	chr6	149378954	Nonsense_Mutation	novel	R347*	0.38
UCEC	chr6	149378167	Silent	novel	S84S	0.16
UCEC	chr6	149378300	Missense_Mutation	novel	A129S	0.31
UCEC	chr6	149379100	Silent	novel	T395T	0.3
UCEC	chr6	149379477	Missense_Mutation	rs768565483	R521L	0.32
UCEC	chr6	149411016	3'UTR	novel		0.33
UCEC	chr6	149397666	Frame_Shift_Del	NA	*K557Sfs5**	0.48
UCEC	chr6	149370089	Missense_Mutation	novel	C31Y	0.3
UCEC	chr6	149379333	Missense_Mutation	NA	P473L	0.34
UCEC	chr6	149378186	Nonsense_Mutation	NA	G91*	0.04
UCEC	chr6	149378477	Missense_Mutation	NA	G188C	0.38
UCEC	chr6	149410906	3'UTR	novel		0.55
UCEC	chr6	149378465	Missense_Mutation	novel	N184D	0.22
UCEC	chr6	149379140	Missense_Mutation	novel	I409V	0.41
UCEC	chr6	149411554	3'UTR	novel		0.33
UCEC	chr6	149409926	3'UTR	novel		0.23
UCEC	chr6	149411016	3'UTR	novel		0.35
UCEC	chr6	149411016	3'UTR	novel		0.3
UCEC	chr6	149379359	Missense_Mutation	novel	S482P	0.33
UCEC	chr6	149410088	3'UTR	novel		0.28
UCEC	chr6	149410232	3'UTR	novel		0.42
UCEC	chr6	149379236	Nonsense_Mutation	novel	R441*	0.49
UCEC	chr6	149409754	3'UTR	novel		0.45
UCEC	chr6	149409881	3'UTR	novel		0.4
UCEC	chr6	149397724	Missense_Mutation	NA	R575M	0.35
UCEC	chr6	149379955	Intron	novel		0.4
UCEC	chr6	149379031	Silent	NA	S372S	0.37
UCEC	chr6	149410560	3'UTR	rs538961888		0.29
UCEC	chr6	149409782	3'UTR	novel		0.24
UCEC	chr6	149369995	5'UTR	novel		0.27
UCEC	chr6	149378496	Missense_Mutation	novel	S194Y	0.05
UCEC	chr6	149378817	Missense_Mutation	NA	S301F	0.3
UCEC	chr6	149379303	Missense_Mutation	NA	T463I	0.12
UCEC	chr6	149378169	Frame_Shift_Del	novel	*N86Hfs10**	0.47
UCEC	chr6	149378939	Missense_Mutation	rs761260364	R342C	0.23
UCEC	chr6	149379192	Missense_Mutation	novel	V426A	0.11
UCEC	chr6	149410888	3'UTR	NA		0.44
UCEC	chr6	149378782	Silent	novel	S289S	0.28
UCEC	chr6	149410888	3'UTR	NA		0.36
UCEC	chr6	149378919	Missense_Mutation	novel	R335I	0.06
UCEC	chr6	149379269	Nonsense_Mutation	NA	R452*	0.34
UCEC	chr6	149378195	Nonsense_Mutation	NA	G94*	0.26
UCEC	chr6	149378087	Missense_Mutation	novel	G58R	0.28
UCEC	chr6	149378393	Missense_Mutation	novel	G160S	0.27
UCEC	chr6	149379955	Intron	novel		0.45
UCEC	chr6	149411016	3'UTR	novel		0.29
UCEC	chr6	149369985	5'UTR	rs765241830		0.35
UCEC	chr6	149378594	Nonsense_Mutation	novel	R227*	0.33
UCEC	chr6	149378928	Missense_Mutation	NA	S338Y	0.31
UCEC	chr6	149409651	Missense_Mutation	rs771448294	A672T	0.46
UCEC	chr6	149410345	3'UTR	novel		0.33
UCEC	chr6	149411604	3'UTR	novel		0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3505	0.00027473
KIRC	DEL	0.2443	7.439e-11
KIRP	DEL	0.1042	0.054498
LGG	DEL	0.1442	0.0054594
MESO	DEL	0.4483	0.05642
PAAD	DEL	0.375	0.11274
SARC	AMP	0.2568	5.3375e-09
SKCM	DEL	0.5504	1.5442e-06
THYM	DEL	0.1463	0.10691
UVM	DEL	0.275	0.0054289

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0012	Kaplan-Meier Survival Analysis
SKCM	0.00013	Kaplan-Meier Survival Analysis
LUSC	0.0028	Kaplan-Meier Survival Analysis
BRCA	0.016	Kaplan-Meier Survival Analysis
KIRP	0.026	Kaplan-Meier Survival Analysis
COAD	0.023	Kaplan-Meier Survival Analysis
PAAD	0.035	Kaplan-Meier Survival Analysis
CESC	0.013	Kaplan-Meier Survival Analysis
READ	0.027	Kaplan-Meier Survival Analysis
UCEC	0.0077	Kaplan-Meier Survival Analysis
OV	0.039	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742