EuRBPDB

Description

Ensembl ID: ENSG00000055483 (Gene tree)
Gene ID: 57602
Gene Symbol: USP36
Alias: KIAA1453|FLJ12851
Full Name: ubiquitin specific peptidase 36
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 54,061 bases
Position: chr17:78,787,381-78,841,441
Accession: 20062
RBP type: non-canonical RBP
Summary: This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31268153	Hydroxychloroquine enhances the antitumor effects of BC001 in gastric cancer.	Int J Oncol	2019 Jun 12	Wang W	doi: 10.3892/ijo.2019.4824

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000592326	USP36-223	406	-	-	- (aa)	-	-
ENST00000586066	USP36-204	960	-	ENSP00000466567	259 (aa)	-	K7EMM6
ENST00000591942	USP36-220	564	-	ENSP00000475654	61 (aa)	-	U3KQ92
ENST00000587010	USP36-207	607	-	ENSP00000465679	71 (aa)	-	K7EKL7
ENST00000586896	USP36-206	696	-	ENSP00000467951	159 (aa)	-	K7EQS0
ENST00000587379	USP36-208	606	-	ENSP00000464886	24 (aa)	-	K7EIT7
ENST00000312010	USP36-201	5234	XM_005257542	ENSP00000310590	1123 (aa)	XP_005257599	Q9P275
ENST00000588365	USP36-212	546	-	ENSP00000465183	52 (aa)	-	K7EJI3
ENST00000590546	USP36-218	1771	-	ENSP00000467682	285 (aa)	-	Q8IXW9
ENST00000589424	USP36-216	970	-	ENSP00000466187	234 (aa)	-	K7ELR5
ENST00000589254	USP36-215	565	-	-	- (aa)	-	-
ENST00000592907	USP36-224	543	-	-	- (aa)	-	-
ENST00000590312	USP36-217	549	-	-	- (aa)	-	-
ENST00000449938	USP36-202	1647	XM_011525071	ENSP00000401119	548 (aa)	XP_011523373	E9PEW0
ENST00000542802	USP36-203	6063	XM_017024901	ENSP00000441214	1123 (aa)	XP_016880390	Q9P275
ENST00000591052	USP36-219	427	-	ENSP00000468356	11 (aa)	-	K7ERP8
ENST00000592275	USP36-222	594	-	ENSP00000466212	80 (aa)	-	K7ELT3
ENST00000587783	USP36-209	679	-	ENSP00000468194	66 (aa)	-	K7ERC1
ENST00000592231	USP36-221	2479	-	ENSP00000465698	69 (aa)	-	K7EKN3
ENST00000586531	USP36-205	898	-	ENSP00000467520	179 (aa)	-	K7EPT1
ENST00000588467	USP36-213	589	-	-	- (aa)	-	-
ENST00000588086	USP36-210	3187	-	ENSP00000468549	961 (aa)	-	A0A075B784
ENST00000588130	USP36-211	602	-	ENSP00000464746	101 (aa)	-	K7EIH0
ENST00000589225	USP36-214	5885	-	ENSP00000467280	1123 (aa)	-	Q9P275

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000055483	Parkinson Disease	3.555749E-6	17052657
ENSG00000055483	Child Development Disorders, Pervasive	3.7567400E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000055483	rs900348	17	78837347	C	Heel bone mineral density	30598549	[0.0094-0.0187] unit decrease	0.0140938	EFO_0009270
ENSG00000055483	rs12942645	17	78808234	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000055483	rs1044486	17	78796097	?	Cardiovascular disease	30595370			EFO_0000319
ENSG00000055483	rs7218605	17	78815721	T	Systolic blood pressure	30578418	[0.12-0.25] mmHg decrease	0.1822	EFO_0006335
ENSG00000055483	rs8073626	17	78794197	C	Systolic blood pressure	27841878	unit increase	0.217	EFO_0006335
ENSG00000055483	rs8073626	17	78794197	C	Pulse pressure	27841878	unit increase	0.122	EFO_0005763

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000055483	USP36	99	91.429	ENSMUSG00000033909	Usp36	100	72.896	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004197	cysteine-type endopeptidase activity	21873635.	IBA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	21873635.	IBA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	14715245.	IDA	Function
GO:0005515	protein binding	25775507.27445338.	IPI	Function
GO:0005730	nucleolus	19208757.25775507.	IDA	Component
GO:0005737	cytoplasm	27445338.	IDA	Component
GO:0006511	ubiquitin-dependent protein catabolic process	-	IEA	Process
GO:0007000	nucleolus organization	19208757.	IDA	Process
GO:0007000	nucleolus organization	-	ISS	Process
GO:0016242	negative regulation of macroautophagy	22622177.	IMP	Process
GO:0016578	histone deubiquitination	29274341.	IMP	Process
GO:0016579	protein deubiquitination	21873635.	IBA	Process
GO:0016579	protein deubiquitination	14715245.19208757.25775507.	IDA	Process
GO:0016579	protein deubiquitination	27445338.	IMP	Process
GO:0016607	nuclear speck	-	IDA	Component
GO:0031647	regulation of protein stability	27445338.	IMP	Process
GO:0042981	regulation of apoptotic process	21873635.	IBA	Process
GO:0050821	protein stabilization	-	ISS	Process
GO:1903146	regulation of autophagy of mitochondrion	24912190.	HMP	Process
GO:1903955	positive regulation of protein targeting to mitochondrion	24912190.	HMP	Process
GO:2000232	regulation of rRNA processing	19208757.	IDA	Process
GO:2000232	regulation of rRNA processing	-	ISS	Process