EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000055917 (Gene tree)
Gene ID: 23369
Gene Symbol: PUM2
Alias: PUMH2|KIAA0235
Full Name: pumilio RNA binding family member 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 103,544 bases
Position: chr2:20,248,691-20,352,234
Accession: 14958
RBP type: canonical RBP
Summary: This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000409905	PUF	PF00806.19	4.8e-74	1	8
ENSP00000409905	PUF	PF00806.19	4.8e-74	2	8
ENSP00000409905	PUF	PF00806.19	4.8e-74	3	8
ENSP00000409905	PUF	PF00806.19	4.8e-74	4	8
ENSP00000409905	PUF	PF00806.19	4.8e-74	5	8
ENSP00000409905	PUF	PF00806.19	4.8e-74	6	8
ENSP00000409905	PUF	PF00806.19	4.8e-74	7	8
ENSP00000409905	PUF	PF00806.19	4.8e-74	8	8
ENSP00000326746	PUF	PF00806.19	8.3e-74	1	8
ENSP00000326746	PUF	PF00806.19	8.3e-74	2	8
ENSP00000326746	PUF	PF00806.19	8.3e-74	3	8
ENSP00000326746	PUF	PF00806.19	8.3e-74	4	8
ENSP00000326746	PUF	PF00806.19	8.3e-74	5	8
ENSP00000326746	PUF	PF00806.19	8.3e-74	6	8
ENSP00000326746	PUF	PF00806.19	8.3e-74	7	8
ENSP00000326746	PUF	PF00806.19	8.3e-74	8	8
ENSP00000354370	PUF	PF00806.19	1.8e-73	1	8
ENSP00000354370	PUF	PF00806.19	1.8e-73	2	8
ENSP00000354370	PUF	PF00806.19	1.8e-73	3	8
ENSP00000354370	PUF	PF00806.19	1.8e-73	4	8
ENSP00000354370	PUF	PF00806.19	1.8e-73	5	8
ENSP00000354370	PUF	PF00806.19	1.8e-73	6	8
ENSP00000354370	PUF	PF00806.19	1.8e-73	7	8
ENSP00000354370	PUF	PF00806.19	1.8e-73	8	8
ENSP00000338173	PUF	PF00806.19	2.9e-73	1	8
ENSP00000338173	PUF	PF00806.19	2.9e-73	2	8
ENSP00000338173	PUF	PF00806.19	2.9e-73	3	8
ENSP00000338173	PUF	PF00806.19	2.9e-73	4	8
ENSP00000338173	PUF	PF00806.19	2.9e-73	5	8
ENSP00000338173	PUF	PF00806.19	2.9e-73	6	8
ENSP00000338173	PUF	PF00806.19	2.9e-73	7	8
ENSP00000338173	PUF	PF00806.19	2.9e-73	8	8
ENSP00000385992	PUF	PF00806.19	2.9e-73	1	8
ENSP00000385992	PUF	PF00806.19	2.9e-73	2	8
ENSP00000385992	PUF	PF00806.19	2.9e-73	3	8
ENSP00000385992	PUF	PF00806.19	2.9e-73	4	8
ENSP00000385992	PUF	PF00806.19	2.9e-73	5	8
ENSP00000385992	PUF	PF00806.19	2.9e-73	6	8
ENSP00000385992	PUF	PF00806.19	2.9e-73	7	8
ENSP00000385992	PUF	PF00806.19	2.9e-73	8	8

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21865157	Translational regulation of acetylcholinesterase by the RNA-binding protein Pumilio-2 at the neuromuscular synapse.	J Biol Chem	2011 Oct 21	Marrero E	doi: 10.1074/jbc.M111.285510
21397187	Alternate modes of cognate RNA recognition by human PUMILIO proteins.	Structure	2011 Mar 9	Lu G	doi: 10.1016/j.str.2010.12.019.
28977511	Towards enhanced and interpretable clustering/classification in integrative genomics.	Nucleic Acids Res	2017 Nov 16	Lu YY	doi: 10.1093/nar/gkx767.
22902294	An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells.	Cell Stem Cell	2012 Oct 5	Vessey JP	doi: 10.1016/j.stem.2012.06.010
16775137	Dendritic localization of the translational repressor Pumilio 2 and its contribution to dendritic stress granules.	J Neurosci	2006 Jun 14	Vessey JP	-
18599029	Assembly and regulation of acetylcholinesterase at the vertebrate neuromuscular junction.	Chem Biol Interact	2008 Sep 25	Rotundo RL	doi: 10.1016/j.cbi.2008.05.025
23776146	Specificity factors in cytoplasmic polyadenylation.	Wiley Interdiscip Rev RNA	2013 Jul-Aug	Charlesworth A	doi: 10.1002/wrna.1171.
28138061	Pseudouridine and N6-methyladenosine modifications weaken PUF protein/RNA interactions.	RNA	2017 May	Vaidyanathan PP	doi: 10.1261/rna.060053.116
30084199	RNA-binding protein PUM2 suppresses osteosarcoma progression via partly and competitively binding to STARD13 3'UTR with miRNAs.	Cell Prolif	2018 Dec	Hu R	doi: 10.1111/cpr.12508
30909144	RNA binding protein PUM2 promotes the stemness of breast cancer cells via competitively binding to neuropilin-1 (NRP-1) mRNA with miR-376a.	Biomed Pharmacother	2019 Jun	Zhang L	doi: 10.1016/j.biopha.2019.108772
12667987	Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors.	Blood Cells Mol Dis	2003 Jan-Feb	Spassov DS	-
12511597	Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.	Proc Natl Acad Sci U S A	2003 Jan 21	Moore FL	-
12459267	Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.	Gene	2002 Oct 16	Spassov DS	-
11780640	PUM2, a novel murine puf protein, and its consensus RNA-binding site.	RNA	2001 Dec	White EK	-
15617101	P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA.	J Cell Physiol	2005 Jul	Scott RE	-
19540345	Structure and RNA binding of the mouse Pumilio-2 Puf domain.	J Struct Biol	2009 Sep	Jenkins HT	doi: 10.1016/j.jsb.2009.06.007
22955276	Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs.	J Biol Chem	2012 Oct 19	Van Etten J	doi: 10.1074/jbc.M112.373522
18089289	Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population.	Dev Biol	2008 Jan 15	Lolicato F	-
17768378	The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye.	Mol Vis	2007 Aug 10	Raji B	-
17474090	Identification and gene expression profiling of the Pum1 and Pum2 members of the Pumilio family in the chicken.	Mol Reprod Dev	2008 Jan	Lee JY	-
21589936	A translational regulator, PUM2, promotes both protein stability and kinase activity of Aurora-A.	PLoS One	2011 May 11	Huang YH	doi: 10.1371/journal.pone.0019718.
25151966	miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer.	Oncogene	2015 Jun	Fernandez S	doi: 10.1038/onc.2014.267
27157388	NORAD: Defender of the Genome.	Trends Genet	2016 Jul	Ventura A	doi: 10.1016/j.tig.2016.04.002
26808677	Translational Control of UIS4 Protein of the Host-Parasite Interface Is Mediated by the RNA Binding Protein Puf2 in Plasmodium berghei Sporozoites.	PLoS One	2016 Jan 25	Silva PA	doi: 10.1371/journal.pone.0147940
26379701	mRNA fragments in in vitro culture media are associated with bovine preimplantation embryonic development.	Front Genet	2015 Aug 24	Kropp J	doi: 10.3389/fgene.2015.00273
29046322	Pumilio2-deficient mice show a predisposition for epilepsy.	Dis Model Mech	2017 Nov 1	Follwaczny P	doi: 10.1242/dmm.029678
29165587	Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.	Nucleic Acids Res	2018 Jan 9	Bohn JA	doi: 10.1093/nar/gkx1120.
29395907	A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification.	Neuron	2018 Feb 7	Zahr SK	doi: 10.1016/j.neuron.2017.12.045
29448111	In silico screening of proteins targeting circulating miRNAs for improved diagnosis of multiple myeloma.	Biochem Biophys Res Commun	2018 Mar 4	Suyal S	doi: 10.1016/j.bbrc.2018.02.103
30181804	Pumilio2 regulates synaptic plasticity via translational repression of synaptic receptors in mice.	Oncotarget	2018 Jan 30	Dong H	doi: 10.18632/oncotarget.24345
30256721	Essential requirement of mammalian Pumilio family in embryonic development.	Mol Biol Cell	2018 Nov 26	Lin K	doi: 10.1091/mbc.E18-06-0369
30316580	Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins.	Trends Genet	2018 Dec	Goldstrohm AC	doi: 10.1016/j.tig.2018.09.006
30642763	The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.	Mol Cell	2019 Feb 21	D'Amico D	doi: 10.1016/j.molcel.2018.11.034
30787206	PUM2 Promotes Glioblastoma Cell Proliferation and Migration via Repressing BTG1 Expression.	Cell Struct Funct	2019	Wang Y	doi: 10.1247/csf.18030.
30811992	Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b.	Cell Rep	2019 Feb 26	Lin K	doi: 10.1016/j.celrep.2019.01.111.
30824182	Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA/NF-kB pathway.	Biochem Biophys Res Commun	2019 Apr 9	Zhang X	doi: 10.1016/j.bbrc.2019.02.082
31284728	Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins.	Circulation	2019 Jul 9	Chothani S	doi: 10.1161/CIRCULATIONAHA.119.039596
31078383	A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.	Mol Cell	2019 Jun 6	Jarmoskaite I	doi: 10.1016/j.molcel.2019.04.012
15607425	Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind.	Genomics	2005 Jan	Fox M	-
29722104	Long noncoding RNA NORAD regulates transforming growth factor-β signaling and epithelial-to-mesenchymal transition-like phenotype.	Cancer Sci	2018 Jul	Kawasaki N	doi: 10.1111/cas.13626
30914482	Demonstration of protein cooperativity mediated by RNA structure using the human protein PUM2.	RNA	2019 Jun	Becker WR	doi: 10.1261/rna.068585.118

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000442400	PUM2-210	955	-	ENSP00000387399	293 (aa)	-	C9JW01
ENST00000420234	PUM2-205	562	-	-	- (aa)	-	-
ENST00000424110	PUM2-206	546	-	ENSP00000395098	34 (aa)	-	C9JE24
ENST00000403432	PUM2-204	3594	XM_011532719	ENSP00000385992	1064 (aa)	XP_011531021	Q8TB72
ENST00000361078	PUM2-203	6251	XM_011532723	ENSP00000354370	1008 (aa)	XP_011531025	Q8TB72
ENST00000338086	PUM2-202	6112	XM_005262607	ENSP00000338173	1064 (aa)	XP_005262664	Q8TB72
ENST00000319801	PUM2-201	6002	XM_017003715	ENSP00000326746	929 (aa)	XP_016859204	A0A0A0MR59
ENST00000440577	PUM2-209	4352	-	ENSP00000409905	876 (aa)	-	A0A0C4DG68
ENST00000429419	PUM2-207	547	-	ENSP00000396727	40 (aa)	-	F8WD57
ENST00000432105	PUM2-208	584	-	ENSP00000408384	35 (aa)	-	F2Z366
ENST00000446940	PUM2-211	525	-	ENSP00000413515	35 (aa)	-	F2Z366

Gene Model

Click here to download ENSG00000055917's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000055917	Myocardial Infarction	4.4292985E-005	-
ENSG00000055917	Attention Deficit Disorder with Hyperactivity	4.1600000E-005	18937294

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000055917's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000055917	PUM2	100	89.320	ENSG00000134644	PUM1	95	87.354

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000055917	PUM2	89	91.198	ENSAPOG00000015756	pum2	100	81.723	Acanthochromis_polyacanthus
ENSG00000055917	PUM2	100	100.000	ENSAMEG00000002823	PUM2	100	98.223	Ailuropoda_melanoleuca
ENSG00000055917	PUM2	100	76.471	ENSACIG00000010646	pum2	98	84.330	Amphilophus_citrinellus
ENSG00000055917	PUM2	100	76.471	ENSAOCG00000016619	pum2	87	75.971	Amphiprion_ocellaris
ENSG00000055917	PUM2	89	91.198	ENSAPEG00000019924	pum2	100	81.723	Amphiprion_percula
ENSG00000055917	PUM2	100	76.471	ENSATEG00000015030	pum2	90	77.214	Anabas_testudineus
ENSG00000055917	PUM2	100	93.360	ENSAPLG00000010496	PUM2	90	92.958	Anas_platyrhynchos
ENSG00000055917	PUM2	99	97.066	ENSACAG00000010491	PUM2	100	92.394	Anolis_carolinensis
ENSG00000055917	PUM2	100	100.000	ENSANAG00000021807	PUM2	100	99.531	Aotus_nancymaae
ENSG00000055917	PUM2	100	76.471	ENSACLG00000022532	pum2	89	77.072	Astatotilapia_calliptera
ENSG00000055917	PUM2	100	100.000	ENSBTAG00000011155	PUM2	100	98.317	Bos_taurus
ENSG00000055917	PUM2	100	100.000	ENSCJAG00000007450	PUM2	100	99.437	Callithrix_jacchus
ENSG00000055917	PUM2	100	100.000	ENSCAFG00000003839	PUM2	100	98.499	Canis_familiaris
ENSG00000055917	PUM2	100	98.515	ENSCAFG00020025689	PUM2	100	97.097	Canis_lupus_dingo
ENSG00000055917	PUM2	100	100.000	ENSCHIG00000022180	PUM2	100	98.405	Capra_hircus
ENSG00000055917	PUM2	100	100.000	ENSTSYG00000014463	PUM2	100	98.685	Carlito_syrichta
ENSG00000055917	PUM2	100	86.329	ENSCAPG00000016888	PUM2	96	98.958	Cavia_aperea
ENSG00000055917	PUM2	100	100.000	ENSCPOG00000031996	PUM2	100	97.753	Cavia_porcellus
ENSG00000055917	PUM2	100	100.000	ENSCCAG00000037035	PUM2	100	99.785	Cebus_capucinus
ENSG00000055917	PUM2	100	100.000	ENSCATG00000043826	PUM2	100	99.677	Cercocebus_atys
ENSG00000055917	PUM2	100	100.000	ENSCLAG00000006048	PUM2	100	98.311	Chinchilla_lanigera
ENSG00000055917	PUM2	100	100.000	ENSCSAG00000008087	PUM2	100	99.624	Chlorocebus_sabaeus
ENSG00000055917	PUM2	100	100.000	ENSCHOG00000004575	PUM2	86	98.276	Choloepus_hoffmanni
ENSG00000055917	PUM2	100	93.011	ENSCPBG00000019966	PUM2	94	92.473	Chrysemys_picta_bellii
ENSG00000055917	PUM2	100	100.000	ENSCANG00000032797	PUM2	100	99.570	Colobus_angolensis_palliatus
ENSG00000055917	PUM2	100	100.000	ENSCGRG00001025023	Pum2	100	97.840	Cricetulus_griseus_chok1gshd
ENSG00000055917	PUM2	100	100.000	ENSCGRG00000001580	Pum2	100	97.840	Cricetulus_griseus_crigri
ENSG00000055917	PUM2	97	84.257	ENSCSEG00000020899	pum2	89	77.689	Cynoglossus_semilaevis
ENSG00000055917	PUM2	100	79.412	ENSCVAG00000002426	pum2	100	76.077	Cyprinodon_variegatus
ENSG00000055917	PUM2	100	76.471	ENSDARG00000061040	pum2	79	91.304	Danio_rerio
ENSG00000055917	PUM2	100	97.059	ENSDNOG00000006733	PUM2	100	93.520	Dasypus_novemcinctus
ENSG00000055917	PUM2	100	100.000	ENSDORG00000011453	Pum2	100	92.056	Dipodomys_ordii
ENSG00000055917	PUM2	91	98.932	ENSETEG00000017683	PUM2	85	98.932	Echinops_telfairi
ENSG00000055917	PUM2	77	76.427	ENSEBUG00000014828	pum2	93	62.625	Eptatretus_burgeri
ENSG00000055917	PUM2	100	74.710	ENSEBUG00000004435	pum2	91	86.019	Eptatretus_burgeri
ENSG00000055917	PUM2	100	100.000	ENSEASG00005009429	PUM2	100	98.311	Equus_asinus_asinus
ENSG00000055917	PUM2	100	100.000	ENSECAG00000021930	PUM2	100	98.317	Equus_caballus
ENSG00000055917	PUM2	100	100.000	ENSEEUG00000003224	-	80	91.787	Erinaceus_europaeus
ENSG00000055917	PUM2	100	72.947	ENSELUG00000014997	pum2	90	75.160	Esox_lucius
ENSG00000055917	PUM2	100	100.000	ENSFCAG00000027520	PUM2	100	98.499	Felis_catus
ENSG00000055917	PUM2	97	98.457	ENSFALG00000001759	PUM2	100	93.709	Ficedula_albicollis
ENSG00000055917	PUM2	100	100.000	ENSFDAG00000019685	PUM2	100	97.378	Fukomys_damarensis
ENSG00000055917	PUM2	99	91.443	ENSFHEG00000021596	pum2	100	81.933	Fundulus_heteroclitus
ENSG00000055917	PUM2	100	79.412	ENSGMOG00000006903	pum2	100	74.013	Gadus_morhua
ENSG00000055917	PUM2	100	93.954	ENSGALG00000016481	PUM2	100	93.427	Gallus_gallus
ENSG00000055917	PUM2	96	91.463	ENSGAFG00000013691	pum2	100	82.180	Gambusia_affinis
ENSG00000055917	PUM2	100	76.471	ENSGACG00000009670	pum2	100	74.770	Gasterosteus_aculeatus
ENSG00000055917	PUM2	100	93.558	ENSGAGG00000020698	PUM2	100	92.770	Gopherus_agassizii
ENSG00000055917	PUM2	100	100.000	ENSGGOG00000011374	PUM2	100	99.892	Gorilla_gorilla
ENSG00000055917	PUM2	100	86.076	ENSHBUG00000016453	pum2	90	70.853	Haplochromis_burtoni
ENSG00000055917	PUM2	100	96.230	ENSHGLG00000007892	PUM2	100	95.865	Heterocephalus_glaber_female
ENSG00000055917	PUM2	100	95.549	ENSHGLG00100015510	PUM2	100	95.220	Heterocephalus_glaber_male
ENSG00000055917	PUM2	99	91.443	ENSHCOG00000010119	pum2	90	76.710	Hippocampus_comes
ENSG00000055917	PUM2	100	100.000	ENSSTOG00000006262	PUM2	100	98.780	Ictidomys_tridecemlineatus
ENSG00000055917	PUM2	99	99.270	ENSJJAG00000020969	Pum2	100	98.036	Jaculus_jaculus
ENSG00000055917	PUM2	100	76.471	ENSKMAG00000017216	pum2	82	85.371	Kryptolebias_marmoratus
ENSG00000055917	PUM2	96	90.998	ENSLBEG00000020488	pum2	82	85.590	Labrus_bergylta
ENSG00000055917	PUM2	100	91.176	ENSLACG00000008723	PUM2	89	90.476	Latimeria_chalumnae
ENSG00000055917	PUM2	100	88.235	ENSLOCG00000017196	pum2	89	86.598	Lepisosteus_oculatus
ENSG00000055917	PUM2	100	100.000	ENSLAFG00000009278	PUM2	100	97.477	Loxodonta_africana
ENSG00000055917	PUM2	100	100.000	ENSMFAG00000000492	PUM2	100	99.570	Macaca_fascicularis
ENSG00000055917	PUM2	100	100.000	ENSMMUG00000023181	PUM2	100	99.531	Macaca_mulatta
ENSG00000055917	PUM2	100	100.000	ENSMNEG00000039659	PUM2	100	99.531	Macaca_nemestrina
ENSG00000055917	PUM2	100	100.000	ENSMLEG00000039243	PUM2	100	99.677	Mandrillus_leucophaeus
ENSG00000055917	PUM2	100	76.471	ENSMAMG00000006121	pum2	90	77.151	Mastacembelus_armatus
ENSG00000055917	PUM2	100	76.471	ENSMZEG00005000791	pum2	89	77.214	Maylandia_zebra
ENSG00000055917	PUM2	100	93.855	ENSMGAG00000014040	PUM2	100	93.427	Meleagris_gallopavo
ENSG00000055917	PUM2	100	100.000	ENSMAUG00000000311	Pum2	100	97.938	Mesocricetus_auratus
ENSG00000055917	PUM2	100	100.000	ENSMICG00000011647	PUM2	100	99.343	Microcebus_murinus
ENSG00000055917	PUM2	100	100.000	ENSMOCG00000013663	Pum2	100	97.751	Microtus_ochrogaster
ENSG00000055917	PUM2	100	74.078	ENSMMOG00000002975	pum2	100	75.414	Mola_mola
ENSG00000055917	PUM2	100	100.000	ENSMODG00000009811	PUM2	100	90.968	Monodelphis_domestica
ENSG00000055917	PUM2	91	90.954	ENSMALG00000022313	pum2	100	82.143	Monopterus_albus
ENSG00000055917	PUM2	100	100.000	MGP_CAROLIEiJ_G0017603	Pum2	99	99.511	Mus_caroli
ENSG00000055917	PUM2	100	100.000	ENSMUSG00000020594	Pum2	100	97.470	Mus_musculus
ENSG00000055917	PUM2	100	100.000	MGP_PahariEiJ_G0029361	Pum2	100	97.936	Mus_pahari
ENSG00000055917	PUM2	100	100.000	MGP_SPRETEiJ_G0018447	Pum2	100	97.527	Mus_spretus
ENSG00000055917	PUM2	100	100.000	ENSMPUG00000013734	PUM2	100	98.499	Mustela_putorius_furo
ENSG00000055917	PUM2	100	100.000	ENSMLUG00000007362	PUM2	100	97.566	Myotis_lucifugus
ENSG00000055917	PUM2	100	97.059	ENSNGAG00000016239	-	67	75.147	Nannospalax_galili
ENSG00000055917	PUM2	100	100.000	ENSNGAG00000016665	-	100	98.030	Nannospalax_galili
ENSG00000055917	PUM2	100	76.471	ENSNBRG00000020737	pum2	100	66.325	Neolamprologus_brichardi
ENSG00000055917	PUM2	100	100.000	ENSNLEG00000002509	PUM2	100	99.677	Nomascus_leucogenys
ENSG00000055917	PUM2	100	100.000	ENSMEUG00000016567	PUM2	93	89.577	Notamacropus_eugenii
ENSG00000055917	PUM2	100	82.253	ENSOPRG00000001963	PUM2	100	78.018	Ochotona_princeps
ENSG00000055917	PUM2	100	100.000	ENSODEG00000007823	PUM2	100	97.563	Octodon_degus
ENSG00000055917	PUM2	100	76.471	ENSONIG00000006119	pum2	90	77.306	Oreochromis_niloticus
ENSG00000055917	PUM2	100	100.000	ENSOCUG00000017908	PUM2	100	98.405	Oryctolagus_cuniculus
ENSG00000055917	PUM2	100	79.412	ENSORLG00000012611	pum2	94	75.556	Oryzias_latipes
ENSG00000055917	PUM2	91	90.931	ENSORLG00020014452	pum2	94	75.661	Oryzias_latipes_hni
ENSG00000055917	PUM2	100	79.412	ENSORLG00015009427	pum2	90	74.908	Oryzias_latipes_hsok
ENSG00000055917	PUM2	100	83.403	ENSOMEG00000005889	pum2	100	82.143	Oryzias_melastigma
ENSG00000055917	PUM2	100	100.000	ENSOGAG00000002187	PUM2	94	98.536	Otolemur_garnettii
ENSG00000055917	PUM2	100	100.000	ENSOARG00000017236	PUM2	100	98.221	Ovis_aries
ENSG00000055917	PUM2	100	100.000	ENSPPAG00000023095	PUM2	100	99.892	Pan_paniscus
ENSG00000055917	PUM2	100	100.000	ENSPPRG00000021443	PUM2	100	98.515	Panthera_pardus
ENSG00000055917	PUM2	100	100.000	ENSPTIG00000018982	PUM2	100	98.499	Panthera_tigris_altaica
ENSG00000055917	PUM2	100	100.000	ENSPTRG00000011692	PUM2	100	99.892	Pan_troglodytes
ENSG00000055917	PUM2	100	100.000	ENSPANG00000009393	PUM2	100	100.000	Papio_anubis
ENSG00000055917	PUM2	97	87.879	ENSPKIG00000023195	pum2	94	76.496	Paramormyrops_kingsleyae
ENSG00000055917	PUM2	99	97.800	ENSPSIG00000011626	PUM2	88	93.052	Pelodiscus_sinensis
ENSG00000055917	PUM2	96	90.709	ENSPMGG00000016123	pum2	94	75.899	Periophthalmus_magnuspinnatus
ENSG00000055917	PUM2	100	100.000	ENSPEMG00000008357	Pum2	100	97.376	Peromyscus_maniculatus_bairdii
ENSG00000055917	PUM2	100	80.000	ENSPMAG00000007038	pum2	88	84.652	Petromyzon_marinus
ENSG00000055917	PUM2	100	100.000	ENSPCIG00000022139	PUM2	100	89.851	Phascolarctos_cinereus
ENSG00000055917	PUM2	100	79.412	ENSPFOG00000019208	pum2	90	75.248	Poecilia_formosa
ENSG00000055917	PUM2	100	79.412	ENSPLAG00000001826	pum2	94	77.225	Poecilia_latipinna
ENSG00000055917	PUM2	100	79.412	ENSPMEG00000015766	pum2	90	76.916	Poecilia_mexicana
ENSG00000055917	PUM2	100	79.412	ENSPREG00000006905	pum2	94	77.037	Poecilia_reticulata
ENSG00000055917	PUM2	100	100.000	ENSPPYG00000012617	PUM2	100	99.624	Pongo_abelii
ENSG00000055917	PUM2	100	100.000	ENSPCAG00000008001	PUM2	70	100.000	Procavia_capensis
ENSG00000055917	PUM2	100	99.247	ENSPCOG00000019636	PUM2	100	99.050	Propithecus_coquereli
ENSG00000055917	PUM2	100	96.101	ENSPVAG00000002920	PUM2	100	92.674	Pteropus_vampyrus
ENSG00000055917	PUM2	100	76.471	ENSPNYG00000022901	pum2	89	77.072	Pundamilia_nyererei
ENSG00000055917	PUM2	100	79.412	ENSPNAG00000008025	pum2	98	76.004	Pygocentrus_nattereri
ENSG00000055917	PUM2	100	100.000	ENSRNOG00000006180	Pum2	100	97.280	Rattus_norvegicus
ENSG00000055917	PUM2	100	100.000	ENSRBIG00000044880	PUM2	100	99.604	Rhinopithecus_bieti
ENSG00000055917	PUM2	100	100.000	ENSSBOG00000022007	PUM2	100	99.678	Saimiri_boliviensis_boliviensis
ENSG00000055917	PUM2	100	100.000	ENSSHAG00000002778	PUM2	100	88.745	Sarcophilus_harrisii
ENSG00000055917	PUM2	98	86.768	ENSSFOG00015003476	pum2	84	87.636	Scleropages_formosus
ENSG00000055917	PUM2	100	76.471	ENSSMAG00000018236	pum2	100	67.279	Scophthalmus_maximus
ENSG00000055917	PUM2	94	74.227	ENSSDUG00000001800	pum2	87	77.113	Seriola_dumerili
ENSG00000055917	PUM2	100	76.471	ENSSLDG00000000981	pum2	90	76.866	Seriola_lalandi_dorsalis
ENSG00000055917	PUM2	100	100.000	ENSSARG00000010992	PUM2	86	89.875	Sorex_araneus
ENSG00000055917	PUM2	100	94.549	ENSSPUG00000017012	PUM2	99	93.081	Sphenodon_punctatus
ENSG00000055917	PUM2	89	91.198	ENSSPAG00000022948	pum2	100	81.723	Stegastes_partitus
ENSG00000055917	PUM2	100	100.000	ENSSSCG00000008600	PUM2	100	98.611	Sus_scrofa
ENSG00000055917	PUM2	100	94.153	ENSTGUG00000013149	PUM2	100	93.709	Taeniopygia_guttata
ENSG00000055917	PUM2	100	76.471	ENSTRUG00000018167	pum2	90	72.426	Takifugu_rubripes
ENSG00000055917	PUM2	100	73.529	ENSTNIG00000003116	pum2	90	75.668	Tetraodon_nigroviridis
ENSG00000055917	PUM2	86	99.187	ENSTBEG00000008729	PUM2	86	99.187	Tupaia_belangeri
ENSG00000055917	PUM2	100	100.000	ENSTTRG00000004887	PUM2	100	97.753	Tursiops_truncatus
ENSG00000055917	PUM2	79	98.413	ENSUAMG00000008120	PUM2	98	98.413	Ursus_americanus
ENSG00000055917	PUM2	100	100.000	ENSUMAG00000023198	PUM2	100	98.499	Ursus_maritimus
ENSG00000055917	PUM2	100	100.000	ENSVPAG00000005056	PUM2	100	98.126	Vicugna_pacos
ENSG00000055917	PUM2	100	100.000	ENSVVUG00000014829	PUM2	100	98.593	Vulpes_vulpes
ENSG00000055917	PUM2	100	82.857	ENSXETG00000008903	pum2	90	80.988	Xenopus_tropicalis
ENSG00000055917	PUM2	94	74.043	ENSXCOG00000002556	pum2	87	77.249	Xiphophorus_couchianus
ENSG00000055917	PUM2	96	91.463	ENSXMAG00000017682	pum2	94	77.331	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	26724866.	IDA	Function
GO:0003730	mRNA 3'-UTR binding	18776931.	IDA	Function
GO:0005515	protein binding	12511597.19168546.21800163.22190034.23125361.25340845.	IPI	Function
GO:0005829	cytosol	-	IDA	Component
GO:0006417	regulation of translation	-	IEA	Process
GO:0010494	cytoplasmic stress granule	25340845.	IDA	Component
GO:0010494	cytoplasmic stress granule	-	ISS	Component
GO:0010608	posttranscriptional regulation of gene expression	25100735.	IDA	Process
GO:0010608	posttranscriptional regulation of gene expression	28431233.	IMP	Process
GO:0031965	nuclear membrane	-	IDA	Component
GO:0034063	stress granule assembly	-	IEA	Process
GO:0035196	production of miRNAs involved in gene silencing by miRNA	28431233.	IMP	Process
GO:0035198	miRNA binding	28431233.	IDA	Function
GO:0043488	regulation of mRNA stability	26724866.	IDA	Process
GO:0048471	perinuclear region of cytoplasm	19168546.	IDA	Component
GO:0051983	regulation of chromosome segregation	26724866.	IDA	Process
GO:0060964	regulation of gene silencing by miRNA	18776931.	TAS	Process
GO:1900246	positive regulation of RIG-I signaling pathway	25340845.	IDA	Process
GO:2000637	positive regulation of gene silencing by miRNA	22345517.	IMP	Process