EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000056586 (Gene tree)
Gene ID: 54542
Gene Symbol: RC3H2
Alias: FLJ20301|FLJ20713|RNF164|MNAB
Full Name: ring finger and CCCH-type domains 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 60,786 bases
Position: chr9:122,844,556-122,905,341
Accession: 21461
RBP type: canonical RBP
Summary: (Ring Finger And CCCH-Type Domains 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include mRNA binding. An important paralog of this gene is RC3H1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000335150	zf-CCCH	PF00642.24	1.7e-06	1	1
ENSP00000411767	zf-CCCH	PF00642.24	4.6e-06	1	1
ENSP00000349783	zf-CCCH	PF00642.24	5.5e-06	1	1
ENSP00000362774	zf-CCCH	PF00642.24	5.5e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26489670	New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.	Sci Rep	2015 Oct 22	Zhang Q	doi: 10.1038/srep15660.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000478216	RC3H2-208	547	-	-	- (aa)	-	-
ENST00000335387	RC3H2-201	3081	-	ENSP00000335150	506 (aa)	-	A6NHN2
ENST00000498479	RC3H2-210	5746	-	ENSP00000474709	478 (aa)	-	Q9HBD1
ENST00000495727	RC3H2-209	420	-	-	- (aa)	-	-
ENST00000357244	RC3H2-202	3991	-	ENSP00000349783	1191 (aa)	-	Q9HBD1
ENST00000471874	RC3H2-207	749	-	ENSP00000474148	218 (aa)	-	Q9HBD1
ENST00000398671	RC3H2-204	666	-	ENSP00000381663	111 (aa)	-	Q4VXB2
ENST00000423239	RC3H2-205	3623	-	ENSP00000411767	1064 (aa)	-	Q9HBD1
ENST00000373670	RC3H2-203	9248	-	ENSP00000362774	1191 (aa)	-	Q9HBD1
ENST00000454740	RC3H2-206	923	-	ENSP00000398081	188 (aa)	-	H0Y5D9

Gene Model

Click here to download ENSG00000056586's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000056586's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000056586	RC3H2	94	83.223	ENSG00000135870	RC3H1	96	52.323

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000056586	RC3H2	94	87.751	ENSAPOG00000002117	rc3h2	93	56.806	Acanthochromis_polyacanthus
ENSG00000056586	RC3H2	100	98.153	ENSAMEG00000006498	RC3H2	100	98.153	Ailuropoda_melanoleuca
ENSG00000056586	RC3H2	93	86.486	ENSACIG00000005206	rc3h2	99	84.416	Amphilophus_citrinellus
ENSG00000056586	RC3H2	92	87.783	ENSAOCG00000007724	rc3h2	98	86.245	Amphiprion_ocellaris
ENSG00000056586	RC3H2	92	87.755	ENSAOCG00000019780	-	98	86.117	Amphiprion_ocellaris
ENSG00000056586	RC3H2	94	87.528	ENSAPEG00000007757	rc3h2	93	56.719	Amphiprion_percula
ENSG00000056586	RC3H2	94	86.414	ENSATEG00000019414	rc3h2	91	56.322	Anabas_testudineus
ENSG00000056586	RC3H2	95	98.896	ENSAPLG00000013920	RC3H2	100	90.460	Anas_platyrhynchos
ENSG00000056586	RC3H2	100	99.582	ENSANAG00000030862	RC3H2	100	99.582	Aotus_nancymaae
ENSG00000056586	RC3H2	95	84.946	ENSACLG00000023136	rc3h2	92	55.362	Astatotilapia_calliptera
ENSG00000056586	RC3H2	94	85.333	ENSAMXG00000006778	rc3h2	88	57.548	Astyanax_mexicanus
ENSG00000056586	RC3H2	100	97.229	ENSBTAG00000023867	RC3H2	100	97.229	Bos_taurus
ENSG00000056586	RC3H2	100	99.582	ENSCJAG00000020050	RC3H2	100	99.582	Callithrix_jacchus
ENSG00000056586	RC3H2	92	100.000	ENSCAFG00000032522	-	100	100.000	Canis_familiaris
ENSG00000056586	RC3H2	100	99.582	ENSCAFG00020015288	RC3H2	100	99.582	Canis_lupus_dingo
ENSG00000056586	RC3H2	100	97.313	ENSCHIG00000019319	RC3H2	100	97.313	Capra_hircus
ENSG00000056586	RC3H2	91	79.896	ENSCAPG00000017086	RC3H2	93	80.339	Cavia_aperea
ENSG00000056586	RC3H2	100	97.145	ENSCPOG00000008511	RC3H2	100	97.145	Cavia_porcellus
ENSG00000056586	RC3H2	100	99.582	ENSCCAG00000001404	RC3H2	100	99.582	Cebus_capucinus
ENSG00000056586	RC3H2	100	100.000	ENSCATG00000036655	RC3H2	100	100.000	Cercocebus_atys
ENSG00000056586	RC3H2	100	97.229	ENSCLAG00000013261	RC3H2	100	97.229	Chinchilla_lanigera
ENSG00000056586	RC3H2	95	98.324	ENSCSAG00000013416	RC3H2	100	99.529	Chlorocebus_sabaeus
ENSG00000056586	RC3H2	95	98.896	ENSCPBG00000009811	RC3H2	100	89.038	Chrysemys_picta_bellii
ENSG00000056586	RC3H2	100	100.000	ENSCANG00000043140	RC3H2	100	100.000	Colobus_angolensis_palliatus
ENSG00000056586	RC3H2	100	94.878	ENSCGRG00001010006	Rc3h2	100	94.291	Cricetulus_griseus_chok1gshd
ENSG00000056586	RC3H2	95	99.338	ENSCGRG00000009255	Rc3h2	100	94.628	Cricetulus_griseus_crigri
ENSG00000056586	RC3H2	95	86.062	ENSCSEG00000017460	rc3h2	96	55.526	Cynoglossus_semilaevis
ENSG00000056586	RC3H2	94	86.192	ENSCVAG00000012202	rc3h2	90	56.901	Cyprinodon_variegatus
ENSG00000056586	RC3H2	95	84.735	ENSDARG00000063050	rc3h2	96	54.554	Danio_rerio
ENSG00000056586	RC3H2	100	96.306	ENSDNOG00000014557	RC3H2	100	96.306	Dasypus_novemcinctus
ENSG00000056586	RC3H2	100	96.809	ENSDORG00000006398	Rc3h2	100	96.809	Dipodomys_ordii
ENSG00000056586	RC3H2	100	95.130	ENSEASG00005020897	RC3H2	100	95.130	Equus_asinus_asinus
ENSG00000056586	RC3H2	100	98.153	ENSECAG00000022176	RC3H2	100	98.153	Equus_caballus
ENSG00000056586	RC3H2	95	87.611	ENSELUG00000006105	rc3h2	93	57.414	Esox_lucius
ENSG00000056586	RC3H2	100	97.817	ENSFCAG00000007375	RC3H2	100	97.817	Felis_catus
ENSG00000056586	RC3H2	95	98.675	ENSFALG00000002011	RC3H2	100	90.377	Ficedula_albicollis
ENSG00000056586	RC3H2	100	97.649	ENSFDAG00000012477	RC3H2	100	97.649	Fukomys_damarensis
ENSG00000056586	RC3H2	94	87.082	ENSFHEG00000012272	rc3h2	93	55.368	Fundulus_heteroclitus
ENSG00000056586	RC3H2	59	82.143	ENSGMOG00000016709	-	100	51.450	Gadus_morhua
ENSG00000056586	RC3H2	95	98.896	ENSGALG00000001253	RC3H2	100	90.377	Gallus_gallus
ENSG00000056586	RC3H2	95	85.841	ENSGAFG00000007679	rc3h2	96	54.610	Gambusia_affinis
ENSG00000056586	RC3H2	92	86.878	ENSGACG00000017369	rc3h2	100	86.878	Gasterosteus_aculeatus
ENSG00000056586	RC3H2	95	99.117	ENSGAGG00000018295	RC3H2	100	89.121	Gopherus_agassizii
ENSG00000056586	RC3H2	100	99.791	ENSGGOG00000017062	RC3H2	100	99.791	Gorilla_gorilla
ENSG00000056586	RC3H2	95	87.389	ENSHBUG00000003976	rc3h2	92	56.085	Haplochromis_burtoni
ENSG00000056586	RC3H2	100	98.745	ENSHGLG00000012014	-	100	98.745	Heterocephalus_glaber_female
ENSG00000056586	RC3H2	100	97.315	ENSHGLG00100018015	RC3H2	100	97.315	Heterocephalus_glaber_male
ENSG00000056586	RC3H2	94	83.742	ENSHCOG00000003006	rc3h2	87	57.905	Hippocampus_comes
ENSG00000056586	RC3H2	95	83.407	ENSIPUG00000021433	rc3h2	90	57.069	Ictalurus_punctatus
ENSG00000056586	RC3H2	100	97.817	ENSSTOG00000010655	RC3H2	100	97.817	Ictidomys_tridecemlineatus
ENSG00000056586	RC3H2	100	96.982	ENSJJAG00000022376	Rc3h2	100	96.982	Jaculus_jaculus
ENSG00000056586	RC3H2	95	85.619	ENSKMAG00000010936	rc3h2	91	58.062	Kryptolebias_marmoratus
ENSG00000056586	RC3H2	95	93.598	ENSLOCG00000002894	rc3h2	94	62.282	Lepisosteus_oculatus
ENSG00000056586	RC3H2	100	96.054	ENSLAFG00000003521	RC3H2	100	96.054	Loxodonta_africana
ENSG00000056586	RC3H2	100	100.000	ENSMFAG00000035621	RC3H2	100	100.000	Macaca_fascicularis
ENSG00000056586	RC3H2	100	100.000	ENSMMUG00000021134	RC3H2	100	100.000	Macaca_mulatta
ENSG00000056586	RC3H2	100	99.580	ENSMNEG00000031599	RC3H2	100	99.580	Macaca_nemestrina
ENSG00000056586	RC3H2	100	100.000	ENSMLEG00000033809	RC3H2	100	100.000	Mandrillus_leucophaeus
ENSG00000056586	RC3H2	92	87.528	ENSMAMG00000009119	rc3h2	93	87.528	Mastacembelus_armatus
ENSG00000056586	RC3H2	95	87.389	ENSMZEG00005017019	rc3h2	92	55.703	Maylandia_zebra
ENSG00000056586	RC3H2	95	98.462	ENSMGAG00000007984	RC3H2	100	90.393	Meleagris_gallopavo
ENSG00000056586	RC3H2	95	87.151	ENSMAUG00000003117	Rc3h2	95	89.791	Mesocricetus_auratus
ENSG00000056586	RC3H2	100	99.372	ENSMICG00000003227	RC3H2	100	99.372	Microcebus_murinus
ENSG00000056586	RC3H2	100	95.298	ENSMOCG00000009592	Rc3h2	100	95.298	Microtus_ochrogaster
ENSG00000056586	RC3H2	96	85.777	ENSMMOG00000021305	rc3h2	90	87.082	Mola_mola
ENSG00000056586	RC3H2	95	99.117	ENSMODG00000019725	RC3H2	79	93.594	Monodelphis_domestica
ENSG00000056586	RC3H2	92	86.364	ENSMALG00000017885	rc3h2	96	83.731	Monopterus_albus
ENSG00000056586	RC3H2	100	98.745	MGP_CAROLIEiJ_G0023516	Rc3h2	100	98.745	Mus_caroli
ENSG00000056586	RC3H2	100	98.326	ENSMUSG00000075376	Rc3h2	100	98.326	Mus_musculus
ENSG00000056586	RC3H2	100	98.745	MGP_PahariEiJ_G0024969	Rc3h2	100	98.745	Mus_pahari
ENSG00000056586	RC3H2	100	98.536	MGP_SPRETEiJ_G0024436	Rc3h2	100	98.536	Mus_spretus
ENSG00000056586	RC3H2	100	97.313	ENSMPUG00000014141	RC3H2	100	97.313	Mustela_putorius_furo
ENSG00000056586	RC3H2	100	96.477	ENSMLUG00000013992	RC3H2	100	96.477	Myotis_lucifugus
ENSG00000056586	RC3H2	100	95.825	ENSNGAG00000009763	-	100	95.825	Nannospalax_galili
ENSG00000056586	RC3H2	95	87.389	ENSNBRG00000009276	rc3h2	92	55.908	Neolamprologus_brichardi
ENSG00000056586	RC3H2	100	100.000	ENSNLEG00000017204	RC3H2	100	100.000	Nomascus_leucogenys
ENSG00000056586	RC3H2	89	98.462	ENSMEUG00000001299	-	64	99.209	Notamacropus_eugenii
ENSG00000056586	RC3H2	95	91.620	ENSOPRG00000000135	RC3H2	93	93.038	Ochotona_princeps
ENSG00000056586	RC3H2	100	98.745	ENSODEG00000005918	-	100	98.745	Octodon_degus
ENSG00000056586	RC3H2	94	87.973	ENSONIG00000003945	rc3h2	100	58.605	Oreochromis_niloticus
ENSG00000056586	RC3H2	95	99.117	ENSOANG00000008194	RC3H2	100	93.148	Ornithorhynchus_anatinus
ENSG00000056586	RC3H2	100	97.901	ENSOCUG00000008804	RC3H2	100	97.901	Oryctolagus_cuniculus
ENSG00000056586	RC3H2	94	87.528	ENSORLG00000010018	rc3h2	92	56.156	Oryzias_latipes
ENSG00000056586	RC3H2	94	87.528	ENSORLG00020013257	rc3h2	92	56.256	Oryzias_latipes_hni
ENSG00000056586	RC3H2	94	87.528	ENSORLG00015001525	rc3h2	92	56.256	Oryzias_latipes_hsok
ENSG00000056586	RC3H2	94	87.528	ENSOMEG00000023540	rc3h2	93	55.565	Oryzias_melastigma
ENSG00000056586	RC3H2	100	98.069	ENSOGAG00000010678	RC3H2	100	98.069	Otolemur_garnettii
ENSG00000056586	RC3H2	100	97.481	ENSOARG00000013965	RC3H2	100	97.481	Ovis_aries
ENSG00000056586	RC3H2	100	99.791	ENSPPAG00000036013	RC3H2	100	99.791	Pan_paniscus
ENSG00000056586	RC3H2	100	98.069	ENSPPRG00000008698	RC3H2	100	98.069	Panthera_pardus
ENSG00000056586	RC3H2	100	98.069	ENSPTIG00000014257	RC3H2	100	98.069	Panthera_tigris_altaica
ENSG00000056586	RC3H2	100	99.791	ENSPTRG00000021339	RC3H2	100	99.791	Pan_troglodytes
ENSG00000056586	RC3H2	100	97.817	ENSPANG00000025840	RC3H2	100	97.817	Papio_anubis
ENSG00000056586	RC3H2	95	89.183	ENSPKIG00000021910	rc3h2	90	60.107	Paramormyrops_kingsleyae
ENSG00000056586	RC3H2	95	98.896	ENSPSIG00000005393	RC3H2	100	89.456	Pelodiscus_sinensis
ENSG00000056586	RC3H2	93	86.682	ENSPMGG00000023963	rc3h2	99	82.452	Periophthalmus_magnuspinnatus
ENSG00000056586	RC3H2	100	95.550	ENSPEMG00000023441	Rc3h2	100	95.550	Peromyscus_maniculatus_bairdii
ENSG00000056586	RC3H2	95	99.338	ENSPCIG00000025559	RC3H2	100	94.304	Phascolarctos_cinereus
ENSG00000056586	RC3H2	95	86.062	ENSPFOG00000019699	rc3h2	100	57.685	Poecilia_formosa
ENSG00000056586	RC3H2	95	85.619	ENSPLAG00000005799	rc3h2	90	63.172	Poecilia_latipinna
ENSG00000056586	RC3H2	95	86.062	ENSPMEG00000014187	rc3h2	93	54.513	Poecilia_mexicana
ENSG00000056586	RC3H2	95	86.062	ENSPREG00000008979	rc3h2	91	55.433	Poecilia_reticulata
ENSG00000056586	RC3H2	95	91.620	ENSPCAG00000010154	RC3H2	86	90.103	Procavia_capensis
ENSG00000056586	RC3H2	95	84.946	ENSPNYG00000012063	rc3h2	92	55.362	Pundamilia_nyererei
ENSG00000056586	RC3H2	95	86.283	ENSPNAG00000017502	rc3h2	88	58.537	Pygocentrus_nattereri
ENSG00000056586	RC3H2	100	95.634	ENSRNOG00000009196	Rc3h2	100	95.634	Rattus_norvegicus
ENSG00000056586	RC3H2	100	100.000	ENSRBIG00000032579	RC3H2	100	100.000	Rhinopithecus_bieti
ENSG00000056586	RC3H2	100	100.000	ENSRROG00000043784	RC3H2	100	100.000	Rhinopithecus_roxellana
ENSG00000056586	RC3H2	100	99.372	ENSSBOG00000029100	RC3H2	100	99.372	Saimiri_boliviensis_boliviensis
ENSG00000056586	RC3H2	95	99.338	ENSSHAG00000007498	RC3H2	100	92.977	Sarcophilus_harrisii
ENSG00000056586	RC3H2	92	90.023	ENSSFOG00015000964	rc3h2	91	90.023	Scleropages_formosus
ENSG00000056586	RC3H2	95	86.062	ENSSMAG00000020048	rc3h2	93	56.140	Scophthalmus_maximus
ENSG00000056586	RC3H2	95	86.947	ENSSDUG00000016022	rc3h2	93	56.830	Seriola_dumerili
ENSG00000056586	RC3H2	95	86.947	ENSSLDG00000016070	rc3h2	93	56.392	Seriola_lalandi_dorsalis
ENSG00000056586	RC3H2	100	95.634	ENSSARG00000012329	RC3H2	100	95.634	Sorex_araneus
ENSG00000056586	RC3H2	95	97.788	ENSSPUG00000001457	RC3H2	100	87.646	Sphenodon_punctatus
ENSG00000056586	RC3H2	94	87.751	ENSSPAG00000005233	rc3h2	93	56.195	Stegastes_partitus
ENSG00000056586	RC3H2	100	99.163	ENSSSCG00000005575	RC3H2	100	97.567	Sus_scrofa
ENSG00000056586	RC3H2	95	98.896	ENSTGUG00000006889	-	100	90.544	Taeniopygia_guttata
ENSG00000056586	RC3H2	92	86.199	ENSTRUG00000003364	rc3h2	100	86.199	Takifugu_rubripes
ENSG00000056586	RC3H2	96	83.080	ENSTNIG00000004942	rc3h2	100	58.759	Tetraodon_nigroviridis
ENSG00000056586	RC3H2	95	98.455	ENSTBEG00000009622	RC3H2	86	98.611	Tupaia_belangeri
ENSG00000056586	RC3H2	95	99.338	ENSTTRG00000016954	RC3H2	94	98.535	Tursiops_truncatus
ENSG00000056586	RC3H2	100	97.985	ENSUAMG00000015355	RC3H2	100	97.985	Ursus_americanus
ENSG00000056586	RC3H2	100	99.791	ENSUMAG00000003161	RC3H2	100	99.791	Ursus_maritimus
ENSG00000056586	RC3H2	100	97.565	ENSVPAG00000005994	RC3H2	100	97.565	Vicugna_pacos
ENSG00000056586	RC3H2	100	97.313	ENSVVUG00000009519	RC3H2	100	97.313	Vulpes_vulpes
ENSG00000056586	RC3H2	94	86.414	ENSXCOG00000005002	rc3h2	99	84.165	Xiphophorus_couchianus
ENSG00000056586	RC3H2	94	86.860	ENSXMAG00000001724	rc3h2	90	56.506	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000209	protein polyubiquitination	26489670.	IDA	Process
GO:0000209	protein polyubiquitination	24448648.	IMP	Process
GO:0000932	P-body	-	IEA	Component
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0001782	B cell homeostasis	-	IEA	Process
GO:0003677	DNA binding	10938276.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003725	double-stranded RNA binding	26489670.	IDA	Function
GO:0003729	mRNA binding	-	IEA	Function
GO:0004842	ubiquitin-protein transferase activity	24448648.26489670.	IDA	Function
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0009791	post-embryonic development	-	IEA	Process
GO:0009986	cell surface	10938276.	IDA	Component
GO:0010608	posttranscriptional regulation of gene expression	-	IEA	Process
GO:0016020	membrane	10938276.	IDA	Component
GO:0035264	multicellular organism growth	-	IEA	Process
GO:0035613	RNA stem-loop binding	26249698.26489670.	IDA	Function
GO:0042098	T cell proliferation	-	IEA	Process
GO:0043029	T cell homeostasis	-	IEA	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0048286	lung alveolus development	-	IEA	Process
GO:0048535	lymph node development	-	IEA	Process
GO:0048536	spleen development	-	IEA	Process
GO:0050852	T cell receptor signaling pathway	-	ISS	Process
GO:0060173	limb development	-	IEA	Process
GO:0061470	T follicular helper cell differentiation	-	IEA	Process
GO:1901224	positive regulation of NIK/NF-kappaB signaling	-	IEA	Process
GO:2000320	negative regulation of T-helper 17 cell differentiation	-	ISS	Process
GO:2000628	regulation of miRNA metabolic process	-	ISS	Process