EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000057294 (Gene tree)
Gene ID: 5318
Gene Symbol: PKP2
Alias: N
Full Name: plakophilin 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 106,102 bases
Position: chr12:32,790,745-32,896,846
Accession: 9024
RBP type: non-canonical RBP
Summary: This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25225333	Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.	Mol Cell Biol	2014 Dec 1	Fischer-Keso R	doi: 10.1128/MCB.00766-14

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000546769	PKP2-205	782	-	-	- (aa)	-	-
ENST00000546741	PKP2-204	1563	-	ENSP00000481383	36 (aa)	-	A0A087WXY2
ENST00000340811	PKP2-202	4302	-	ENSP00000342800	837 (aa)	-	Q99959
ENST00000546498	PKP2-203	589	-	-	- (aa)	-	-
ENST00000552612	PKP2-207	901	-	-	- (aa)	-	-
ENST00000070846	PKP2-201	4241	-	ENSP00000070846	881 (aa)	-	Q99959
ENST00000549461	PKP2-206	566	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000057294's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000057294	Platelet Function Tests	1.7890500E-005	-
ENSG00000057294	Platelet Function Tests	1.0843100E-005	-
ENSG00000057294	Platelet Function Tests	1.0843100E-005	-
ENSG00000057294	Platelet Function Tests	1.6594600E-005	-
ENSG00000057294	Platelet Function Tests	1.1731400E-005	-
ENSG00000057294	Lithium	1.3910400E-005	-
ENSG00000057294	Body Composition	3E-6	23251661
ENSG00000057294	Periodontitis	1E-8	26962152
ENSG00000057294	Tooth	1E-8	26962152
ENSG00000057294	Body Composition	9E-6	23251661
ENSG00000057294	Body Composition	3E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000057294	rs6488099	12	32882549	?	Periodontal disease-related phenotypes	26962152	[0.19-0.39] unit increase	0.29	EFO_0000649\|EFO_0007780
ENSG00000057294	rs1454933	12	32864109	C	Obesity-related traits	23251661	[NR] kcal/d increase	0.04	EFO_0005106
ENSG00000057294	rs1454933	12	32864109	C	Obesity-related traits	23251661	[NR] kg/y increase	0.03	EFO_0005106
ENSG00000057294	rs1454933	12	32864109	C	Obesity-related traits	23251661	[NR] kcal/d increase	0.04	EFO_0005106
ENSG00000057294	rs12809354	12	32825503	C	Atrial fibrillation	30061737	[1.05-1.09]	1.07	EFO_0000275
ENSG00000057294	rs1454934	12	32820006	T	Prevalent atrial fibrillation	28416818	1.1-1.22	1.16	EFO_0000275
ENSG00000057294	rs12809354	12	32825503	C	Atrial fibrillation	29892015	[1.06-1.11]	1.08	EFO_0000275
ENSG00000057294	rs12809354	12	32825503	C	Atrial fibrillation	29892015	[1.07-1.11]	1.09	EFO_0000275

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000057294's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000057294	PKP2	100	78.375	ENSMUSG00000041957	Pkp2	100	78.495	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001533	cornified envelope	-	TAS	Component
GO:0002159	desmosome assembly	18474624.	IMP	Process
GO:0005080	protein kinase C binding	21873635.	IBA	Function
GO:0005080	protein kinase C binding	18474624.	IPI	Function
GO:0005515	protein binding	10852826.25416956.28169297.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	8922383.	NAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005882	intermediate filament	21873635.	IBA	Component
GO:0005882	intermediate filament	-	ISS	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	20859650.23863954.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005911	cell-cell junction	21873635.	IBA	Component
GO:0005911	cell-cell junction	-	ISS	Component
GO:0005912	adherens junction	-	ISS	Component
GO:0005913	cell-cell adherens junction	21873635.	IBA	Component
GO:0007043	cell-cell junction assembly	21873635.	IBA	Process
GO:0007507	heart development	21873635.	IBA	Process
GO:0007507	heart development	-	ISS	Process
GO:0010765	positive regulation of sodium ion transport	-	ISS	Process
GO:0014704	intercalated disc	21873635.	IBA	Component
GO:0014704	intercalated disc	22781308.	IDA	Component
GO:0014704	intercalated disc	-	ISS	Component
GO:0016021	integral component of membrane	8922383.	TAS	Component
GO:0017080	sodium channel regulator activity	-	ISS	Function
GO:0019215	intermediate filament binding	21873635.	IBA	Function
GO:0019215	intermediate filament binding	10852826.	IDA	Function
GO:0030054	cell junction	-	IDA	Component
GO:0030057	desmosome	-	ISS	Component
GO:0030057	desmosome	8922383.	NAS	Component
GO:0031424	keratinization	-	TAS	Process
GO:0034334	adherens junction maintenance	21873635.	IBA	Process
GO:0044325	ion channel binding	-	ISS	Function
GO:0045110	intermediate filament bundle assembly	21873635.	IBA	Process
GO:0045110	intermediate filament bundle assembly	18474624.	IMP	Process
GO:0045294	alpha-catenin binding	21873635.	IBA	Function
GO:0045294	alpha-catenin binding	23136403.	IPI	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045296	cadherin binding	21873635.	IBA	Function
GO:0048496	maintenance of animal organ identity	22889254.	IMP	Process
GO:0055010	ventricular cardiac muscle tissue morphogenesis	22889254.	IMP	Process
GO:0060090	molecular adaptor activity	21873635.	IBA	Function
GO:0060090	molecular adaptor activity	18474624.	IMP	Function
GO:0070268	cornification	-	TAS	Process
GO:0072659	protein localization to plasma membrane	21873635.	IBA	Process
GO:0072659	protein localization to plasma membrane	23863954.	IMP	Process
GO:0086002	cardiac muscle cell action potential involved in contraction	22889254.	IMP	Process
GO:0086005	ventricular cardiac muscle cell action potential	22889254.	IMP	Process
GO:0086019	cell-cell signaling involved in cardiac conduction	21873635.	IBA	Process
GO:0086019	cell-cell signaling involved in cardiac conduction	22889254.	IMP	Process
GO:0086064	cell communication by electrical coupling involved in cardiac conduction	-	ISS	Process
GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	22889254.	IMP	Process
GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	22889254.	IC	Function
GO:0086091	regulation of heart rate by cardiac conduction	17980246.22889254.	IMP	Process
GO:0098609	cell-cell adhesion	21873635.	IBA	Process
GO:0098609	cell-cell adhesion	-	ISS	Process
GO:0098609	cell-cell adhesion	8922383.	NAS	Process
GO:0098911	regulation of ventricular cardiac muscle cell action potential	22889254.	IMP	Process
GO:1990124	messenger ribonucleoprotein complex	25225333.	IDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24276085	The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy.	Circ Res	2014 Jan 31	Chen SN	doi: 10.1161/CIRCRESAHA.114.302810
21947748	Expression of Plakophilins (PKP1, PKP2, and PKP3) in breast cancers.	Med Oncol	2012 Sep	Demirag GG	doi: 10.1007/s12032-011-0071-1
22119253	Up-regulation of plakophilin-2 and Down-regulation of plakophilin-3 are correlated with invasiveness in bladder cancer.	Urology	2012 Jan	Takahashi H	doi: 10.1016/j.urology.2011.08.049
29044515	The human PKP2/plakophilin-2 gene is induced by Wnt/β-catenin in normal and colon cancer-associated fibroblasts.	Int J Cancer	2018 Feb 15	Niell N	doi: 10.1002/ijc.31104

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	32843273	Silent	rs377424658	G473G	0.43
BLCA	chr12	32802420	Missense_Mutation	novel	S761F	0.12
BLCA	chr12	32878402	Missense_Mutation	novel	H160Y	0.1
BLCA	chr12	32877877	Missense_Mutation	novel	E335K	0.21
BLCA	chr12	32796290	Missense_Mutation	novel	T770S	0.45
BLCA	chr12	32821366	Missense_Mutation	NA	G712E	0.15
BLCA	chr12	32796113	Missense_Mutation	rs151264959	D829N	0.45
BLCA	chr12	32869044	Missense_Mutation	NA	M351I	0.52
BLCA	chr12	32824143	Missense_Mutation	rs558637427	A570T	0.36
BLCA	chr12	32802557	Splice_Site	NA	X716_splice	0.15
BLCA	chr12	32878208	Silent	novel	G224G	0.86
BLCA	chr12	32843244	Missense_Mutation	novel	T483S	0.23
BRCA	chr12	32796292	Missense_Mutation	NA	E769G	0.18
BRCA	chr12	32878407	Missense_Mutation	rs397517027	R158K	0.08
BRCA	chr12	32802409	Missense_Mutation	rs368986542	E765Q	0.09
BRCA	chr12	32802552	Missense_Mutation	rs144018320	P717L	0.29
BRCA	chr12	32802443	Silent	NA	L753L	0.24
BRCA	chr12	32802409	Nonsense_Mutation	NA	E765*	0.26
BRCA	chr12	32841168	Missense_Mutation	NA	K516N	0.27
BRCA	chr12	32878495	Frame_Shift_Del	novel	*Q129Sfs13**	0.33
BRCA	chr12	32869033	Missense_Mutation	rs370868564	R355Q	0.1
CESC	chr12	32822502	Missense_Mutation	NA	G646R	0.16
CESC	chr12	32792667	Missense_Mutation	rs727505312	E852K	0.34
CESC	chr12	32877963	Missense_Mutation	novel	P306L	0.1
CESC	chr12	32878360	Missense_Mutation	novel	A174S	0.49
COAD	chr12	32878065	Missense_Mutation	NA	R272M	0.33
COAD	chr12	32869034	Missense_Mutation	novel	R355G	0.2
COAD	chr12	32841191	Missense_Mutation	NA	L509V	0.34
COAD	chr12	32868960	Silent	rs754927123	H379H	0.36
COAD	chr12	32878245	Missense_Mutation	novel	R212H	0.19
COAD	chr12	32878283	Silent	NA	I199I	0.57
COAD	chr12	32878158	Missense_Mutation	novel	L241R	0.26
COAD	chr12	32802450	Missense_Mutation	NA	S751L	0.44
COAD	chr12	32796148	Missense_Mutation	novel	G817E	0.05
COAD	chr12	32841161	Missense_Mutation	rs751517092	M519V	0.33
COAD	chr12	32792259	3'UTR	novel		0.44
COAD	chr12	32792308	3'UTR	novel		0.26
COAD	chr12	32850776	Frame_Shift_Del	novel	*K456Nfs3**	0.41
COAD	chr12	32850846	Missense_Mutation	novel	V433A	0.14
ESCA	chr12	32824126	Silent	rs760093803	A575A	0.14
ESCA	chr12	32822577	Missense_Mutation	novel	E621Q	0.08
GBM	chr12	32841030	Splice_Region	novel	L562L	0.04
GBM	chr12	32824111	Silent	rs397517006	D580D	0.42
GBM	chr12	32802436	Missense_Mutation	novel	L756M	0.22
GBM	chr12	32877867	Missense_Mutation	NA	T338I	0.27
GBM	chr12	32792343	3'UTR	novel		0.22
GBM	chr12	32821431	Silent	rs538127756	I690I	0.14
GBM	chr12	32850833	Missense_Mutation	novel	N437K	0.45
GBM	chr12	32879027	Missense_Mutation	NA	L77F	0.38
GBM	chr12	32796232	Missense_Mutation	rs543233804	I789T	0.19
GBM	chr12	32878954	Missense_Mutation	rs149542398	R101H	0.41
HNSC	chr12	32878485	Missense_Mutation	novel	S132F	0.2
HNSC	chr12	32843217	Missense_Mutation	novel	T492R	0.58
HNSC	chr12	32878157	Silent	novel	L241L	0.15
KIRC	chr12	32796213	Silent	NA	A795A	0.48
KIRC	chr12	32824045	Missense_Mutation	NA	K602N	0.19
KIRP	chr12	32878955	Missense_Mutation	rs796827562	R101C	0.06
KIRP	chr12	32850782	Silent	novel	T454T	0.23
LAML	chr12	32878441	Nonsense_Mutation	novel	R147*	0.07
LAML	chr12	32841201	Silent	novel	L505L	0.13
LAML	chr12	32850773	Silent	novel	Q457Q	0.08
LGG	chr12	32878954	Missense_Mutation	rs149542398	R101H	0.08
LGG	chr12	32877909	Missense_Mutation	novel	A324E	0.44
LGG	chr12	32878491	Missense_Mutation	novel	Y130C	0.05
LGG	chr12	32821482	Silent	rs368325383	G673G	0.24
LGG	chr12	32878075	Missense_Mutation	rs757285245	G269R	0.16
LIHC	chr12	32878409	Silent	NA	E157E	0.12
LIHC	chr12	32879030	Missense_Mutation	novel	N76H	0.26
LIHC	chr12	32877954	Missense_Mutation	novel	A309V	0.29
LUAD	chr12	32821524	Nonsense_Mutation	NA	Y659*	0.12
LUAD	chr12	32802441	Missense_Mutation	NA	R754K	0.13
LUAD	chr12	32869014	Silent	novel	E361E	0.11
LUAD	chr12	32850829	Missense_Mutation	NA	V439I	0.61
LUAD	chr12	32796197	Missense_Mutation	novel	N801D	0.29
LUAD	chr12	32878020	Missense_Mutation	novel	R287M	0.09
LUAD	chr12	32796169	Missense_Mutation	NA	A810V	0.12
LUAD	chr12	32824071	Missense_Mutation	rs727503371	I594V	0.1
LUAD	chr12	32850822	Missense_Mutation	NA	R441L	0.42
LUAD	chr12	32878512	Nonsense_Mutation	novel	W123*	0.27
LUAD	chr12	32796175	Missense_Mutation	NA	Q808R	0.18
LUAD	chr12	32796276	Missense_Mutation	NA	L774F	0.13
LUAD	chr12	32824101	Missense_Mutation	novel	D584Y	0.16
LUAD	chr12	32878186	Missense_Mutation	NA	D232N	0.16
LUAD	chr12	32792405	3'UTR	novel		0.13
LUAD	chr12	32822506	Missense_Mutation	NA	S644R	0.1
LUAD	chr12	32878132	Missense_Mutation	novel	R250G	0.3
LUAD	chr12	32896593	Frame_Shift_Ins	novel	*G47Rfs39**	0.45
LUAD	chr12	32896596	Frame_Shift_Del	novel	*R46Afs66**	0.45
LUAD	chr12	32878931	Missense_Mutation	novel	D109Y	0.64
LUAD	chr12	32879001	Missense_Mutation	NA	E85D	0.1
LUAD	chr12	32822501	Missense_Mutation	novel	G646A	0.12
LUAD	chr12	32878129	Missense_Mutation	NA	S251C	0.41
LUAD	chr12	32824081	Silent	NA	V590V	0.1
LUAD	chr12	32878454	Missense_Mutation	novel	R142S	0.2
LUAD	chr12	32878455	Missense_Mutation	NA	R142M	0.2
LUAD	chr12	32821371	Silent	rs371089832	T710T	0.68
LUAD	chr12	32878947	Frame_Shift_Ins	novel	*V104Cfs3**	0.31
LUAD	chr12	32822465	Splice_Site	novel	X657_splice	0.27
LUAD	chr12	32879034	Splice_Site	novel	X75_splice	0.21
LUAD	chr12	32792410	3'UTR	novel		0.11
LUAD	chr12	32850862	Missense_Mutation	NA	D428H	0.33
LUAD	chr12	32878455	Missense_Mutation	novel	R142K	0.19
LUAD	chr12	32821476	Silent	novel	E675E	0.26
LUAD	chr12	32850850	Nonsense_Mutation	novel	E432*	0.09
LUSC	chr12	32821520	Missense_Mutation	novel	D661N	0.47
LUSC	chr12	32879032	Missense_Mutation	novel	G75V	0.17
LUSC	chr12	32843186	Missense_Mutation	novel	Q502H	0.31
LUSC	chr12	32878923	Silent	novel	L111L	0.26
LUSC	chr12	32877875	Missense_Mutation	novel	E335D	0.21
LUSC	chr12	32878411	Missense_Mutation	novel	E157Q	0.25
LUSC	chr12	32868984	Silent	NA	S371S	0.21
LUSC	chr12	32821394	Missense_Mutation	novel	L703V	0.36
LUSC	chr12	32802478	Missense_Mutation	novel	D742Y	0.14
LUSC	chr12	32877930	Missense_Mutation	rs775318947	A317V	0.52
LUSC	chr12	32878269	Missense_Mutation	NA	R204L	0.56
LUSC	chr12	32878377	Missense_Mutation	novel	Y168C	0.25
LUSC	chr12	32843303	Silent	NA	V463V	0.05
LUSC	chr12	32822520	Missense_Mutation	NA	D640N	0.04
LUSC	chr12	32822593	Silent	novel	S615S	0.09
LUSC	chr12	32792460	Missense_Mutation	NA	S870R	0.28
OV	chr12	32822558	Missense_Mutation	NA	S627F	0.09
OV	chr12	32878243	Missense_Mutation	NA	H213Y	0.12
PAAD	chr12	32878398	Missense_Mutation	rs775789180	Y161C	0.05
PAAD	chr12	32850851	Missense_Mutation	novel	L431F	0.2
PAAD	chr12	32878245	Missense_Mutation	novel	R212H	0.17
PRAD	chr12	32822511	Missense_Mutation	NA	K643E	0.09
READ	chr12	32878192	Missense_Mutation	rs543281875	V230I	0.16
READ	chr12	32792279	3'UTR	novel		0.45
READ	chr12	32824127	Missense_Mutation	novel	A575V	0.4
READ	chr12	32878229	Nonsense_Mutation	NA	Y217*	0.43
SARC	chr12	32824144	Silent	rs780049494	G569G	0.24
SARC	chr12	32822599	Missense_Mutation	novel	N613K	0.12
SARC	chr12	32821498	Missense_Mutation	novel	K668R	0.27
SKCM	chr12	32821502	Missense_Mutation	NA	E667K	0.31
SKCM	chr12	32841066	Silent	NA	L550L	0.32
SKCM	chr12	32869062	Splice_Region	NA	G345G	0.31
SKCM	chr12	32824111	Silent	rs397517006	D580D	0.18
SKCM	chr12	32850795	Missense_Mutation	novel	R450K	0.45
SKCM	chr12	32843251	Missense_Mutation	NA	P481S	0.21
SKCM	chr12	32878516	Missense_Mutation	rs759377911	R122C	0.37
SKCM	chr12	32792422	3'UTR	novel		0.44
SKCM	chr12	32802520	Missense_Mutation	NA	E728K	0.3
SKCM	chr12	32843311	Missense_Mutation	NA	H461Y	0.27
SKCM	chr12	32868928	Missense_Mutation	novel	R390K	0.3
SKCM	chr12	32878206	Missense_Mutation	novel	S225F	0.32
SKCM	chr12	32878283	Silent	NA	I199I	0.31
SKCM	chr12	32850961	Missense_Mutation	rs761238380	R395C	0.29
SKCM	chr12	32879027	Missense_Mutation	NA	L77F	0.18
SKCM	chr12	32841162	Silent	NA	L518L	0.49
SKCM	chr12	32877950	Silent	NA	V310V	0.94
SKCM	chr12	32878067	Silent	NA	V271V	0.44
SKCM	chr12	32878034	Silent	novel	Q282Q	0.49
SKCM	chr12	32878970	Missense_Mutation	NA	D96N	0.23
SKCM	chr12	32802432	Missense_Mutation	NA	S757F	0.31
SKCM	chr12	32822479	Silent	NA	R653R	0.18
SKCM	chr12	32824123	Missense_Mutation	NA	M576I	0.31
SKCM	chr12	32843244	Missense_Mutation	NA	T483I	0.5
SKCM	chr12	32850964	Missense_Mutation	NA	L394F	0.29
SKCM	chr12	32877973	Missense_Mutation	NA	E303K	0.08
SKCM	chr12	32878283	Silent	NA	I199I	0.25
SKCM	chr12	32879032	Missense_Mutation	rs267603443	G75E	0.12
SKCM	chr12	32841038	Missense_Mutation	rs777207291	G560R	0.28
SKCM	chr12	32879006	Missense_Mutation	rs756468173	P84S	0.29
SKCM	chr12	32841114	Silent	NA	P534P	0.51
SKCM	chr12	32802483	Missense_Mutation	novel	V740A	0.32
SKCM	chr12	32878450	Missense_Mutation	novel	P144S	0.35
SKCM	chr12	32878976	Missense_Mutation	novel	E94K	0.28
SKCM	chr12	32878956	Silent	novel	G100G	0.09
SKCM	chr12	32841065	Missense_Mutation	rs763427502	D551N	0.58
SKCM	chr12	32796263	Missense_Mutation	NA	P779S	0.41
SKCM	chr12	32841066	Silent	NA	L550L	0.4
SKCM	chr12	32796293	Missense_Mutation	novel	E769K	0.32
SKCM	chr12	32877998	Silent	NA	S294S	0.22
SKCM	chr12	32878948	Missense_Mutation	NA	P103L	0.24
SKCM	chr12	32878294	Missense_Mutation	rs748957791	R196C	0.35
SKCM	chr12	32821461	Silent	rs138495471	S680S	0.29
SKCM	chr12	32822584	Silent	NA	L618L	0.25
SKCM	chr12	32843216	Silent	rs140301552	T492T	0.62
SKCM	chr12	32878471	Missense_Mutation	rs781739949	E137K	0.22
SKCM	chr12	32877956	Silent	NA	V308V	0.51
SKCM	chr12	32792437	Missense_Mutation	NA	S878F	0.1
SKCM	chr12	32792387	3'UTR	novel		0.57
SKCM	chr12	32877867	Missense_Mutation	NA	T338I	0.32
SKCM	chr12	32841074	Missense_Mutation	NA	G548S	0.22
SKCM	chr12	32879032	Missense_Mutation	rs267603443	G75E	0.14
SKCM	chr12	32792382	3'UTR	novel		0.08
SKCM	chr12	32796282	Frame_Shift_Del	novel	*K768Rfs8**	0.13
SKCM	chr12	32878970	Missense_Mutation	NA	D96N	0.25
SKCM	chr12	32796285	Silent	NA	L771L	0.35
SKCM	chr12	32802440	Silent	NA	R754R	0.37
SKCM	chr12	32792481	Silent	rs777477467	K863K	0.48
SKCM	chr12	32878970	Missense_Mutation	NA	D96N	0.31
SKCM	chr12	32792481	Silent	rs777477467	K863K	0.43
SKCM	chr12	32878442	Silent	NA	R146R	0.17
SKCM	chr12	32796256	Missense_Mutation	NA	T781R	0.26
SKCM	chr12	32877899	Silent	novel	G327G	0.12
SKCM	chr12	32878195	Missense_Mutation	NA	T229S	0.26
SKCM	chr12	32878016	Silent	NA	S288S	0.7
SKCM	chr12	32843222	Silent	NA	R490R	0.38
SKCM	chr12	32850961	Missense_Mutation	rs761238380	R395C	0.13
SKCM	chr12	32878029	Missense_Mutation	novel	R284K	0.14
SKCM	chr12	32878433	Silent	NA	E149E	0.12
SKCM	chr12	32878306	Missense_Mutation	novel	P192S	0.31
SKCM	chr12	32802440	Silent	NA	R754R	0.36
SKCM	chr12	32821502	Missense_Mutation	NA	E667K	0.51
SKCM	chr12	32878229	Silent	NA	Y217Y	0.16
SKCM	chr12	32878063	Missense_Mutation	rs765756156	P273S	0.35
SKCM	chr12	32821502	Missense_Mutation	NA	E667K	0.37
SKCM	chr12	32792343	3'UTR	novel		0.67
SKCM	chr12	32878970	Missense_Mutation	NA	D96N	0.32
SKCM	chr12	32850961	Missense_Mutation	rs761238380	R395C	0.12
SKCM	chr12	32868990	Silent	NA	R369R	0.39
SKCM	chr12	32792382	3'UTR	novel		0.19
SKCM	chr12	32792698	Silent	rs772225819	S841S	0.47
SKCM	chr12	32878283	Silent	NA	I199I	0.38
SKCM	chr12	32878283	Silent	NA	I199I	0.3
SKCM	chr12	32878283	Silent	NA	I199I	0.18
SKCM	chr12	32850871	Missense_Mutation	novel	E425K	0.26
SKCM	chr12	32792436	Silent	rs763095604	S878S	0.27
SKCM	chr12	32822479	Silent	NA	R653R	0.34
SKCM	chr12	32792667	Missense_Mutation	rs727505312	E852K	0.56
SKCM	chr12	32802440	Silent	NA	R754R	0.3
SKCM	chr12	32824148	Missense_Mutation	novel	A568V	0.2
SKCM	chr12	32868935	Missense_Mutation	rs766209297	R388W	0.58
SKCM	chr12	32878468	Missense_Mutation	novel	E138K	0.52
STAD	chr12	32843273	Silent	rs377424658	G473G	0.15
STAD	chr12	32878192	Missense_Mutation	rs543281875	V230I	0.29
STAD	chr12	32878327	Missense_Mutation	rs571569344	R185W	0.06
STAD	chr12	32821482	Silent	rs368325383	G673G	0.35
STAD	chr12	32824144	Silent	rs780049494	G569G	0.14
STAD	chr12	32877955	Missense_Mutation	rs761677945	A309T	0.33
STAD	chr12	32841025	Splice_Region	novel		0.1
STAD	chr12	32878103	In_Frame_Del	novel	E259del	0.24
STAD	chr12	32792698	Silent	rs772225819	S841S	0.52
STAD	chr12	32877980	Silent	rs140235564	T300T	0.26
STAD	chr12	32796114	Silent	rs727504509	G828G	0.34
STAD	chr12	32878166	Silent	rs727503372	P238P	0.26
STAD	chr12	32878092	Missense_Mutation	rs543758984	T263M	0.31
STAD	chr12	32821481	Missense_Mutation	rs143038626	V674M	0.29
STAD	chr12	32877905	Silent	rs369921166	A325A	0.18
UCEC	chr12	32841155	Missense_Mutation	rs775192286	T521A	0.4
UCEC	chr12	32822537	Missense_Mutation	novel	N634S	0.34
UCEC	chr12	32878295	Silent	novel	A195A	0.05
UCEC	chr12	32802422	Silent	novel	L760L	0.07
UCEC	chr12	32841164	Missense_Mutation	novel	L518I	0.3
UCEC	chr12	32792402	3'UTR	rs371003054		0.22
UCEC	chr12	32879025	Silent	novel	L77L	0.18
UCEC	chr12	32796170	Missense_Mutation	rs779956129	A810T	0.43
UCEC	chr12	32796251	Missense_Mutation	novel	P783T	0.4
UCEC	chr12	32792308	3'UTR	novel		0.38
UCEC	chr12	32802400	Splice_Region	novel		0.08
UCEC	chr12	32792058	3'UTR	novel		0.83
UCEC	chr12	32821482	Silent	rs368325383	G673G	0.21
UCEC	chr12	32792648	In_Frame_Ins	novel	K858delinsTEIE	0.04
UCEC	chr12	32796114	Silent	rs727504509	G828G	0.48
UCEC	chr12	32792270	3'UTR	novel		0.24
UCEC	chr12	32878090	Missense_Mutation	NA	A264T	0.34
UCEC	chr12	32878364	Silent	novel	S172S	0.26
UCEC	chr12	32821512	Silent	rs760434776	P663P	0.36
UCEC	chr12	32878051	Silent	novel	L277L	0.37
UCEC	chr12	32878321	Missense_Mutation	rs200095747	A187T	0.35
UCEC	chr12	32877979	Silent	NA	L301L	0.45
UCEC	chr12	32843251	Missense_Mutation	NA	P481S	0.5
UCEC	chr12	32824151	Missense_Mutation	novel	S567Y	0.36
UCEC	chr12	32792268	3'UTR	novel		0.57
UCEC	chr12	32878484	Frame_Shift_Ins	novel	*Q133Dfs11**	0.09
UCEC	chr12	32802423	Missense_Mutation	NA	L760R	0.5
UCEC	chr12	32802424	Missense_Mutation	novel	L760I	0.35
UCEC	chr12	32821359	Silent	novel	G714G	0.19
UCEC	chr12	32878269	Missense_Mutation	rs755215178	R204H	0.34
UCEC	chr12	32868998	Missense_Mutation	novel	P367S	0.35
UCEC	chr12	32843203	Nonsense_Mutation	rs151212477	R497*	0.5
UCEC	chr12	32877908	Silent	rs142636176	A324A	0.41
UCEC	chr12	32877969	Missense_Mutation	novel	A304V	0.11
UCEC	chr12	32821518	Silent	rs752732048	D661D	0.55
UCEC	chr12	32878194	Missense_Mutation	novel	T229I	0.46
UCEC	chr12	32841206	Splice_Site	rs779082302	X504_splice	0.22
UCEC	chr12	32878327	Missense_Mutation	rs571569344	R185W	0.17
UCEC	chr12	32877980	Silent	rs140235564	T300T	0.27
UCEC	chr12	32796164	Missense_Mutation	rs200947767	D812N	0.38
UCEC	chr12	32792648	In_Frame_Ins	novel	K858delinsTEIE	0.05
UCEC	chr12	32822571	Missense_Mutation	novel	P623T	0.05
UCEC	chr12	32796164	Missense_Mutation	rs200947767	D812N	0.52
UCEC	chr12	32821418	Missense_Mutation	rs199583774	R695C	0.38
UCEC	chr12	32822534	Missense_Mutation	rs755076586	R635Q	0.55
UCEC	chr12	32850769	Missense_Mutation	novel	T459A	0.46
UCEC	chr12	32878388	Silent	rs747582030	S164S	0.74
UCEC	chr12	32792648	In_Frame_Ins	novel	K858delinsTEIE	0.04
UCEC	chr12	32822522	Missense_Mutation	NA	T639I	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	DEL	0.103	0.064633

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00037	Kaplan-Meier Survival Analysis
STAD	0.0019	Kaplan-Meier Survival Analysis
MESO	0.024	Kaplan-Meier Survival Analysis
ACC	0.0047	Kaplan-Meier Survival Analysis
KIRP	0.016	Kaplan-Meier Survival Analysis
COAD	0.0046	Kaplan-Meier Survival Analysis
PAAD	0.0095	Kaplan-Meier Survival Analysis
READ	0.0041	Kaplan-Meier Survival Analysis
LGG	0.014	Kaplan-Meier Survival Analysis
THCA	0.046	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0016	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742