EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000057608 (Gene tree)
Gene ID: 2665
Gene Symbol: GDI2
Alias: RABGDIB
Full Name: GDP dissociation inhibitor 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 76,910 bases
Position: chr10:5,765,223-5,842,132
Accession: 4227
RBP type: non-canonical RBP
Summary: GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000418688	GDI2-204	636	-	ENSP00000394177	155 (aa)	-	Q5SX86
ENST00000456041	GDI2-206	918	-	ENSP00000401733	263 (aa)	-	Q5SX87
ENST00000608581	GDI2-208	634	-	ENSP00000476707	130 (aa)	-	V9GYF8
ENST00000479928	GDI2-207	2499	-	-	- (aa)	-	-
ENST00000380127	GDI2-201	584	-	ENSP00000369470	148 (aa)	-	Q5SX90
ENST00000380191	GDI2-203	2412	XM_017016071	ENSP00000369538	445 (aa)	XP_016871560	P50395
ENST00000380181	GDI2-202	1408	-	ENSP00000369528	400 (aa)	-	P50395
ENST00000609712	GDI2-209	622	-	ENSP00000476832	125 (aa)	-	V9GYJ7
ENST00000447751	GDI2-205	834	-	ENSP00000387565	203 (aa)	-	Q5SX91

Gene Model

Click here to download ENSG00000057608's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000057608	rs151282944	10	5765580	G	Interleukin-2 receptor antagonist levels	27989323	[0.32-0.82] SD units increase	0.5731	EFO_0008332
ENSG00000057608	rs2890364	10	5791785	G	Blood protein levels	30072576	[0.16-0.28] unit increase	0.219	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000057608's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000057608	GDI2	100	96.404	ENSMUSG00000021218	Gdi2	100	96.404	Mus_musculus
ENSG00000057608	GDI2	100	58.209	YER136W	GDI1	96	56.351	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005093	Rab GDP-dissociation inhibitor activity	-	IEA	Function
GO:0005096	GTPase activator activity	-	IEA	Function
GO:0005515	protein binding	11809807.19570034.20176951.25860027.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005794	Golgi apparatus	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0007165	signal transduction	16130169.	TAS	Process
GO:0007264	small GTPase mediated signal transduction	-	IEA	Process
GO:0015031	protein transport	-	IEA	Process
GO:0016020	membrane	-	IEA	Component
GO:0031267	small GTPase binding	-	IEA	Function
GO:0031982	vesicle	19190083.	HDA	Component
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0045202	synapse	-	IEA	Component
GO:0051056	regulation of small GTPase mediated signal transduction	-	TAS	Process
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component