EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000058262 (Gene tree)
Gene ID: 29927
Gene Symbol: SEC61A1
Alias: N
Full Name: Sec61 translocon alpha 1 subunit
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 20,043 bases
Position: chr3:128,051,641-128,071,683
Accession: 18276
RBP type: non-canonical RBP
Summary: The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25063809	Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum.	J Biol Chem	2014 Sep 12	Jagannathan S	doi: 10.1074/jbc.M114.580688

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000498837	SEC61A1-207	555	-	-	- (aa)	-	-
ENST00000491668	SEC61A1-206	558	-	-	- (aa)	-	-
ENST00000243253	SEC61A1-201	3635	-	ENSP00000243253	476 (aa)	-	P61619
ENST00000481210	SEC61A1-204	521	-	ENSP00000419172	101 (aa)	-	C9JXC6
ENST00000424880	SEC61A1-202	3238	-	ENSP00000411445	356 (aa)	-	P61619
ENST00000464451	SEC61A1-203	1871	-	ENSP00000418493	482 (aa)	-	B4DR61
ENST00000483956	SEC61A1-205	3046	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000058262's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03060	Protein export	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa04145	Phagosome	KEGG
hsa05110	Vibrio cholerae infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000058262's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000058262	SEC61A1	100	94.059	FBgn0086357	Sec61alpha	100	89.286	Drosophila_melanogaster
ENSG00000058262	SEC61A1	100	100.000	ENSMUSG00000030082	Sec61a1	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005048	signal sequence binding	21873635.	IBA	Function
GO:0005262	calcium channel activity	28782633.	IMP	Function
GO:0005515	protein binding	22314232.22796945.29568061.	IPI	Function
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005784	Sec61 translocon complex	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	27392076.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006613	cotranslational protein targeting to membrane	28782633.	IMP	Process
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	22375059.	IMP	Process
GO:0006616	SRP-dependent cotranslational protein targeting to membrane, translocation	21873635.	IBA	Process
GO:0006620	posttranslational protein targeting to endoplasmic reticulum membrane	21873635.	IBA	Process
GO:0006620	posttranslational protein targeting to endoplasmic reticulum membrane	22375059.	IMP	Process
GO:0007029	endoplasmic reticulum organization	22375059.	IMP	Process
GO:0008320	protein transmembrane transporter activity	21873635.	IBA	Function
GO:0016020	membrane	22375059.	IDA	Component
GO:0030176	integral component of endoplasmic reticulum membrane	-	ISS	Component
GO:0031204	posttranslational protein targeting to membrane, translocation	29719251.	IMP	Process
GO:0034341	response to interferon-gamma	-	IEA	Process
GO:0039019	pronephric nephron development	-	ISS	Process
GO:0043022	ribosome binding	-	ISS	Function
GO:0045047	protein targeting to ER	-	ISS	Process
GO:0070588	calcium ion transmembrane transport	-	IEA	Process