EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000058729 (Gene tree)
Gene ID: 55781
Gene Symbol: RIOK2
Alias: FLJ11159
Full Name: RIO kinase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 22,435 bases
Position: chr5:97,160,867-97,183,301
Accession: 18999
RBP type: canonical RBP
Summary: (RIO Kinase 2) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing in the nucleus and cytosol. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is RIOK1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000420932	RIO1	PF01163.22	8.5e-55	1	1
ENSP00000283109	RIO1	PF01163.22	9.8e-55	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21283762	Protein-protein interactions within late pre-40S ribosomes.	PLoS One	2011 Jan 20	Campbell MG	doi: 10.1371/journal.pone.0016194.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000283109	RIOK2-201	3922	XM_017009628	ENSP00000283109	552 (aa)	XP_016865117	Q9BVS4
ENST00000511012	RIOK2-205	442	-	ENSP00000422772	140 (aa)	-	H0Y919
ENST00000510384	RIOK2-204	493	-	ENSP00000424325	37 (aa)	-	D6RB96
ENST00000508447	RIOK2-202	2149	-	ENSP00000420932	474 (aa)	-	Q9BVS4
ENST00000511293	RIOK2-206	603	-	ENSP00000421830	159 (aa)	-	H0Y8R4
ENST00000508991	RIOK2-203	589	-	-	- (aa)	-	-
ENST00000511920	RIOK2-207	399	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000058729's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000058729	Cholesterol, LDL	1.21419778381046E-5	17903299
ENSG00000058729	Cholesterol	1.31666244032281E-6	17903299
ENSG00000058729	Cholesterol	3.79023941851598E-6	17903299
ENSG00000058729	Deafness, Aminoglycoside-Induced	5E-6	28039263
ENSG00000058729	Cisplatin	5E-6	28039263

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000058729's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000058729	RIOK2	68	82.555	ENSAPOG00000011797	riok2	100	64.107	Acanthochromis_polyacanthus
ENSG00000058729	RIOK2	100	86.232	ENSAMEG00000014615	RIOK2	100	86.232	Ailuropoda_melanoleuca
ENSG00000058729	RIOK2	80	57.237	ENSACIG00000020646	riok2	89	58.333	Amphilophus_citrinellus
ENSG00000058729	RIOK2	68	83.178	ENSAOCG00000021840	riok2	100	63.458	Amphiprion_ocellaris
ENSG00000058729	RIOK2	68	82.555	ENSAPEG00000020853	riok2	100	63.102	Amphiprion_percula
ENSG00000058729	RIOK2	99	63.587	ENSATEG00000005671	riok2	100	64.014	Anabas_testudineus
ENSG00000058729	RIOK2	99	69.027	ENSACAG00000011858	RIOK2	100	69.027	Anolis_carolinensis
ENSG00000058729	RIOK2	100	92.935	ENSANAG00000015977	RIOK2	100	92.935	Aotus_nancymaae
ENSG00000058729	RIOK2	99	61.812	ENSACLG00000002755	riok2	100	62.345	Astatotilapia_calliptera
ENSG00000058729	RIOK2	99	66.062	ENSAMXG00000002368	riok2	100	66.062	Astyanax_mexicanus
ENSG00000058729	RIOK2	100	86.957	ENSBTAG00000011763	RIOK2	100	86.957	Bos_taurus
ENSG00000058729	RIOK2	66	59.615	WBGene00013688	riok-2	59	59.615	Caenorhabditis_elegans
ENSG00000058729	RIOK2	100	91.486	ENSCJAG00000040045	RIOK2	100	91.486	Callithrix_jacchus
ENSG00000058729	RIOK2	100	84.783	ENSCAFG00000007745	RIOK2	100	84.783	Canis_familiaris
ENSG00000058729	RIOK2	71	81.871	ENSCAFG00020015532	-	94	81.871	Canis_lupus_dingo
ENSG00000058729	RIOK2	100	83.696	ENSCAFG00020011453	-	100	83.696	Canis_lupus_dingo
ENSG00000058729	RIOK2	100	86.232	ENSCHIG00000016709	RIOK2	100	86.232	Capra_hircus
ENSG00000058729	RIOK2	100	88.587	ENSTSYG00000001916	RIOK2	100	88.587	Carlito_syrichta
ENSG00000058729	RIOK2	96	77.127	ENSCAPG00000006762	RIOK2	100	77.127	Cavia_aperea
ENSG00000058729	RIOK2	99	84.392	ENSCPOG00000010551	RIOK2	100	84.392	Cavia_porcellus
ENSG00000058729	RIOK2	100	91.667	ENSCCAG00000025712	RIOK2	100	91.667	Cebus_capucinus
ENSG00000058729	RIOK2	100	96.377	ENSCATG00000035047	RIOK2	100	96.377	Cercocebus_atys
ENSG00000058729	RIOK2	100	85.326	ENSCLAG00000006790	RIOK2	100	85.326	Chinchilla_lanigera
ENSG00000058729	RIOK2	77	95.355	ENSCSAG00000014233	RIOK2	100	95.213	Chlorocebus_sabaeus
ENSG00000058729	RIOK2	82	86.154	ENSCHOG00000003803	RIOK2	82	86.154	Choloepus_hoffmanni
ENSG00000058729	RIOK2	99	71.327	ENSCPBG00000015732	RIOK2	100	71.327	Chrysemys_picta_bellii
ENSG00000058729	RIOK2	81	70.874	ENSCING00000002364	-	99	50.725	Ciona_intestinalis
ENSG00000058729	RIOK2	98	52.034	ENSCSAVG00000006970	-	99	50.092	Ciona_savignyi
ENSG00000058729	RIOK2	100	85.379	ENSCANG00000042169	RIOK2	100	85.379	Colobus_angolensis_palliatus
ENSG00000058729	RIOK2	100	84.601	ENSCGRG00001000871	Riok2	100	84.601	Cricetulus_griseus_chok1gshd
ENSG00000058729	RIOK2	100	84.601	ENSCGRG00000008541	Riok2	100	84.601	Cricetulus_griseus_crigri
ENSG00000058729	RIOK2	98	65.096	ENSCSEG00000014204	riok2	100	64.376	Cynoglossus_semilaevis
ENSG00000058729	RIOK2	99	64.865	ENSCVAG00000012034	riok2	100	64.695	Cyprinodon_variegatus
ENSG00000058729	RIOK2	99	65.371	ENSDARG00000035264	riok2	100	65.371	Danio_rerio
ENSG00000058729	RIOK2	100	86.257	ENSDNOG00000037305	RIOK2	100	86.257	Dasypus_novemcinctus
ENSG00000058729	RIOK2	100	84.783	ENSDORG00000016345	Riok2	100	84.783	Dipodomys_ordii
ENSG00000058729	RIOK2	98	45.617	FBgn0039306	RIOK2	99	45.438	Drosophila_melanogaster
ENSG00000058729	RIOK2	66	99.048	ENSETEG00000013220	-	80	99.048	Echinops_telfairi
ENSG00000058729	RIOK2	78	59.946	ENSEBUG00000006099	riok2	82	52.066	Eptatretus_burgeri
ENSG00000058729	RIOK2	100	88.587	ENSEASG00005018799	RIOK2	100	88.587	Equus_asinus_asinus
ENSG00000058729	RIOK2	100	87.500	ENSECAG00000018441	RIOK2	100	87.500	Equus_caballus
ENSG00000058729	RIOK2	62	100.000	ENSEEUG00000013535	RIOK2	88	69.521	Erinaceus_europaeus
ENSG00000058729	RIOK2	71	81.100	ENSELUG00000011239	riok2	96	81.100	Esox_lucius
ENSG00000058729	RIOK2	100	84.239	ENSFCAG00000024077	RIOK2	100	84.239	Felis_catus
ENSG00000058729	RIOK2	95	66.239	ENSFALG00000010277	RIOK2	100	66.976	Ficedula_albicollis
ENSG00000058729	RIOK2	100	85.326	ENSFDAG00000015288	RIOK2	100	85.326	Fukomys_damarensis
ENSG00000058729	RIOK2	77	81.308	ENSFHEG00000010950	riok2	100	64.621	Fundulus_heteroclitus
ENSG00000058729	RIOK2	68	79.751	ENSGMOG00000011354	riok2	100	62.319	Gadus_morhua
ENSG00000058729	RIOK2	99	66.963	ENSGALG00000015288	RIOK2	100	66.963	Gallus_gallus
ENSG00000058729	RIOK2	82	71.392	ENSGAFG00000012056	riok2	100	64.855	Gambusia_affinis
ENSG00000058729	RIOK2	77	79.751	ENSGACG00000009754	riok2	100	61.649	Gasterosteus_aculeatus
ENSG00000058729	RIOK2	99	71.250	ENSGAGG00000013791	RIOK2	100	71.250	Gopherus_agassizii
ENSG00000058729	RIOK2	100	99.094	ENSGGOG00000022136	RIOK2	100	99.094	Gorilla_gorilla
ENSG00000058729	RIOK2	99	61.279	ENSHBUG00000010705	riok2	100	62.301	Haplochromis_burtoni
ENSG00000058729	RIOK2	100	86.232	ENSHGLG00000009139	-	100	86.232	Heterocephalus_glaber_female
ENSG00000058729	RIOK2	100	85.870	ENSHGLG00100014700	RIOK2	100	85.870	Heterocephalus_glaber_male
ENSG00000058729	RIOK2	78	83.489	ENSHCOG00000015555	riok2	100	63.879	Hippocampus_comes
ENSG00000058729	RIOK2	99	62.172	ENSIPUG00000007450	riok2	100	63.540	Ictalurus_punctatus
ENSG00000058729	RIOK2	100	87.681	ENSSTOG00000006659	RIOK2	100	87.681	Ictidomys_tridecemlineatus
ENSG00000058729	RIOK2	100	84.783	ENSJJAG00000016582	Riok2	100	84.783	Jaculus_jaculus
ENSG00000058729	RIOK2	77	81.931	ENSKMAG00000013229	riok2	100	63.884	Kryptolebias_marmoratus
ENSG00000058729	RIOK2	99	63.768	ENSLBEG00000015421	riok2	100	63.768	Labrus_bergylta
ENSG00000058729	RIOK2	99	62.544	ENSLACG00000000274	RIOK2	100	63.864	Latimeria_chalumnae
ENSG00000058729	RIOK2	99	66.489	ENSLOCG00000006432	riok2	100	67.145	Lepisosteus_oculatus
ENSG00000058729	RIOK2	100	86.957	ENSLAFG00000000919	RIOK2	100	86.957	Loxodonta_africana
ENSG00000058729	RIOK2	100	96.196	ENSMFAG00000033056	RIOK2	100	96.196	Macaca_fascicularis
ENSG00000058729	RIOK2	100	96.558	ENSMMUG00000000307	RIOK2	100	96.558	Macaca_mulatta
ENSG00000058729	RIOK2	100	96.377	ENSMNEG00000029708	RIOK2	100	96.377	Macaca_nemestrina
ENSG00000058729	RIOK2	89	95.706	ENSMLEG00000040038	RIOK2	100	95.706	Mandrillus_leucophaeus
ENSG00000058729	RIOK2	99	61.348	ENSMAMG00000013310	riok2	100	63.298	Mastacembelus_armatus
ENSG00000058729	RIOK2	99	61.279	ENSMZEG00005017067	riok2	100	62.478	Maylandia_zebra
ENSG00000058729	RIOK2	97	66.000	ENSMGAG00000006986	RIOK2	99	66.364	Meleagris_gallopavo
ENSG00000058729	RIOK2	77	95.556	ENSMAUG00000019527	Riok2	100	95.556	Mesocricetus_auratus
ENSG00000058729	RIOK2	100	89.693	ENSMICG00000037437	RIOK2	100	89.693	Microcebus_murinus
ENSG00000058729	RIOK2	100	83.877	ENSMOCG00000004230	Riok2	100	83.877	Microtus_ochrogaster
ENSG00000058729	RIOK2	68	81.620	ENSMMOG00000018155	riok2	100	62.478	Mola_mola
ENSG00000058729	RIOK2	99	75.536	ENSMODG00000015548	RIOK2	100	75.536	Monodelphis_domestica
ENSG00000058729	RIOK2	99	62.014	ENSMALG00000011266	riok2	100	62.014	Monopterus_albus
ENSG00000058729	RIOK2	100	82.971	ENSMUSG00000116564	Riok2	100	93.798	Mus_musculus
ENSG00000058729	RIOK2	100	86.594	ENSMPUG00000004450	RIOK2	100	86.594	Mustela_putorius_furo
ENSG00000058729	RIOK2	100	90.217	ENSMLUG00000016113	RIOK2	100	90.217	Myotis_lucifugus
ENSG00000058729	RIOK2	100	85.870	ENSNGAG00000017971	Riok2	100	85.870	Nannospalax_galili
ENSG00000058729	RIOK2	100	98.011	ENSNLEG00000014474	RIOK2	100	98.011	Nomascus_leucogenys
ENSG00000058729	RIOK2	96	55.871	ENSMEUG00000010529	RIOK2	100	55.871	Notamacropus_eugenii
ENSG00000058729	RIOK2	99	61.101	ENSONIG00000013689	riok2	100	63.604	Oreochromis_niloticus
ENSG00000058729	RIOK2	96	71.429	ENSOANG00000001225	RIOK2	99	71.321	Ornithorhynchus_anatinus
ENSG00000058729	RIOK2	100	85.145	ENSOCUG00000001656	RIOK2	100	85.145	Oryctolagus_cuniculus
ENSG00000058729	RIOK2	78	81.620	ENSORLG00020011553	riok2	100	64.247	Oryzias_latipes_hni
ENSG00000058729	RIOK2	68	81.308	ENSORLG00015001085	riok2	100	63.750	Oryzias_latipes_hsok
ENSG00000058729	RIOK2	68	82.555	ENSOMEG00000004617	riok2	100	63.186	Oryzias_melastigma
ENSG00000058729	RIOK2	100	82.640	ENSOGAG00000008467	RIOK2	100	82.640	Otolemur_garnettii
ENSG00000058729	RIOK2	100	86.594	ENSOARG00000018138	RIOK2	100	86.594	Ovis_aries
ENSG00000058729	RIOK2	100	98.312	ENSPPAG00000027414	RIOK2	100	98.312	Pan_paniscus
ENSG00000058729	RIOK2	100	84.058	ENSPPRG00000000169	RIOK2	100	84.058	Panthera_pardus
ENSG00000058729	RIOK2	100	84.601	ENSPTIG00000008344	RIOK2	100	84.601	Panthera_tigris_altaica
ENSG00000058729	RIOK2	100	98.913	ENSPTRG00000017100	RIOK2	100	98.913	Pan_troglodytes
ENSG00000058729	RIOK2	100	96.014	ENSPANG00000011977	RIOK2	100	96.014	Papio_anubis
ENSG00000058729	RIOK2	99	65.586	ENSPKIG00000016220	riok2	100	65.946	Paramormyrops_kingsleyae
ENSG00000058729	RIOK2	99	68.861	ENSPSIG00000013238	RIOK2	100	68.861	Pelodiscus_sinensis
ENSG00000058729	RIOK2	99	63.225	ENSPMGG00000021822	riok2	100	62.883	Periophthalmus_magnuspinnatus
ENSG00000058729	RIOK2	100	84.239	ENSPEMG00000018872	Riok2	100	84.239	Peromyscus_maniculatus_bairdii
ENSG00000058729	RIOK2	99	63.291	ENSPFOG00000017064	riok2	100	63.036	Poecilia_formosa
ENSG00000058729	RIOK2	99	63.177	ENSPLAG00000003043	riok2	100	62.857	Poecilia_latipinna
ENSG00000058729	RIOK2	99	63.406	ENSPMEG00000007622	riok2	100	63.685	Poecilia_mexicana
ENSG00000058729	RIOK2	68	82.243	ENSPREG00000002255	riok2	100	63.036	Poecilia_reticulata
ENSG00000058729	RIOK2	100	98.370	ENSPPYG00000015654	RIOK2	100	98.370	Pongo_abelii
ENSG00000058729	RIOK2	98	82.581	ENSPCAG00000006508	RIOK2	99	80.944	Procavia_capensis
ENSG00000058729	RIOK2	100	90.761	ENSPCOG00000024315	RIOK2	100	90.761	Propithecus_coquereli
ENSG00000058729	RIOK2	100	80.072	ENSPVAG00000016658	RIOK2	100	80.072	Pteropus_vampyrus
ENSG00000058729	RIOK2	99	61.279	ENSPNYG00000018868	riok2	100	62.345	Pundamilia_nyererei
ENSG00000058729	RIOK2	99	65.364	ENSPNAG00000010841	riok2	100	65.364	Pygocentrus_nattereri
ENSG00000058729	RIOK2	100	81.703	ENSRNOG00000012692	Riok2	100	81.703	Rattus_norvegicus
ENSG00000058729	RIOK2	100	96.739	ENSRBIG00000030658	RIOK2	100	96.739	Rhinopithecus_bieti
ENSG00000058729	RIOK2	100	96.558	ENSRROG00000039203	RIOK2	100	96.558	Rhinopithecus_roxellana
ENSG00000058729	RIOK2	76	41.667	YNL207W	-	93	41.667	Saccharomyces_cerevisiae
ENSG00000058729	RIOK2	100	91.667	ENSSBOG00000032152	RIOK2	100	91.667	Saimiri_boliviensis_boliviensis
ENSG00000058729	RIOK2	99	74.419	ENSSHAG00000006935	-	100	75.134	Sarcophilus_harrisii
ENSG00000058729	RIOK2	99	65.591	ENSSFOG00015005966	riok2	100	66.129	Scleropages_formosus
ENSG00000058729	RIOK2	68	83.178	ENSSMAG00000010529	riok2	100	63.949	Scophthalmus_maximus
ENSG00000058729	RIOK2	68	82.555	ENSSDUG00000014891	riok2	100	63.830	Seriola_dumerili
ENSG00000058729	RIOK2	68	82.555	ENSSLDG00000001926	riok2	100	63.652	Seriola_lalandi_dorsalis
ENSG00000058729	RIOK2	100	67.986	ENSSARG00000001798	RIOK2	100	67.986	Sorex_araneus
ENSG00000058729	RIOK2	91	67.963	ENSSPUG00000003509	RIOK2	99	67.963	Sphenodon_punctatus
ENSG00000058729	RIOK2	73	82.828	ENSSPAG00000016554	riok2	100	61.967	Stegastes_partitus
ENSG00000058729	RIOK2	62	100.000	ENSSSCG00000036529	-	96	98.352	Sus_scrofa
ENSG00000058729	RIOK2	99	67.196	ENSTGUG00000001223	RIOK2	100	67.806	Taeniopygia_guttata
ENSG00000058729	RIOK2	68	81.931	ENSTRUG00000011455	riok2	100	62.411	Takifugu_rubripes
ENSG00000058729	RIOK2	91	44.828	ENSTNIG00000015401	riok2	100	58.537	Tetraodon_nigroviridis
ENSG00000058729	RIOK2	100	86.232	ENSTTRG00000010640	RIOK2	100	86.232	Tursiops_truncatus
ENSG00000058729	RIOK2	96	86.364	ENSUAMG00000008585	RIOK2	100	86.364	Ursus_americanus
ENSG00000058729	RIOK2	100	87.138	ENSUMAG00000006726	RIOK2	100	87.138	Ursus_maritimus
ENSG00000058729	RIOK2	88	96.939	ENSVPAG00000001542	RIOK2	88	96.939	Vicugna_pacos
ENSG00000058729	RIOK2	100	85.145	ENSVVUG00000020170	RIOK2	100	85.145	Vulpes_vulpes
ENSG00000058729	RIOK2	99	66.845	ENSXETG00000013194	riok2	100	67.201	Xenopus_tropicalis
ENSG00000058729	RIOK2	68	81.931	ENSXCOG00000016879	riok2	100	63.750	Xiphophorus_couchianus
ENSG00000058729	RIOK2	99	62.319	ENSXMAG00000007425	riok2	100	64.855	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004672	protein kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	-	IEA	Function
GO:0005515	protein binding	21880710.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	19564402.	IMP	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007049	cell cycle	-	IEA	Process
GO:0030071	regulation of mitotic metaphase/anaphase transition	21880710.	IMP	Process
GO:0030490	maturation of SSU-rRNA	21873635.	IBA	Process
GO:0030490	maturation of SSU-rRNA	19564402.	IMP	Process
GO:0030688	preribosome, small subunit precursor	21873635.	IBA	Component
GO:0030688	preribosome, small subunit precursor	19564402.	IDA	Component
GO:0042274	ribosomal small subunit biogenesis	19564402.	IMP	Process
GO:0046777	protein autophosphorylation	21880710.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:2000208	positive regulation of ribosomal small subunit export from nucleus	19564402.	IMP	Process
GO:2000234	positive regulation of rRNA processing	19564402.	IDA	Process