EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000060138 (Gene tree)
Gene ID: 8531
Gene Symbol: YBX3
Alias: dbpA|ZONAB|CSDA1|CSDA
Full Name: Y-box binding protein 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 24,372 bases
Position: chr12:10,699,077-10,723,448
Accession: 2428
RBP type: canonical RBP
Summary: (Y-Box Binding Protein 3) is a Protein Coding gene. Diseases associated with YBX3 include Lyme Disease and Uterine Inflammatory Disease. Among its related pathways are Apoptosis-related network due to altered Notch3 in ovarian cancer and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is YBX1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000279550	CSD	PF00313.22	1.6e-25	1	1
ENSP00000228251	CSD	PF00313.22	1.9e-25	1	1
ENSP00000485718	CSD	PF00313.22	4.1e-14	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17562864	LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex.	Mol Cell Biol	2007 Sep	Goodier JL	-
31189097	The RNA-Binding Protein YBX3 Controls Amino Acid Levels by Regulating SLC mRNA Abundance.	Cell Rep	2019 Jun 11	Cooke A	doi: 10.1016/j.celrep.2019.05.039.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000366290	YBX3-204	512	-	-	- (aa)	-	-
ENST00000366286	YBX3-203	704	-	-	- (aa)	-	-
ENST00000540447	YBX3-208	6393	-	-	- (aa)	-	-
ENST00000544622	YBX3-216	685	XM_011520871	ENSP00000485718	92 (aa)	XP_011519173	A0A0D9SEI8
ENST00000228251	YBX3-201	1796	XM_017020122	ENSP00000228251	372 (aa)	XP_016875611	P16989
ENST00000542002	YBX3-212	952	-	-	- (aa)	-	-
ENST00000546164	YBX3-217	805	-	-	- (aa)	-	-
ENST00000536107	YBX3-205	438	-	-	- (aa)	-	-
ENST00000540975	YBX3-210	677	-	-	- (aa)	-	-
ENST00000541351	YBX3-211	717	-	-	- (aa)	-	-
ENST00000544501	YBX3-214	181	-	-	- (aa)	-	-
ENST00000536823	YBX3-206	840	-	-	- (aa)	-	-
ENST00000542641	YBX3-213	669	-	-	- (aa)	-	-
ENST00000539204	YBX3-207	649	-	-	- (aa)	-	-
ENST00000279550	YBX3-202	1708	XM_017020123	ENSP00000279550	303 (aa)	XP_016875612	P16989
ENST00000540747	YBX3-209	548	-	-	- (aa)	-	-
ENST00000544504	YBX3-215	583	-	-	- (aa)	-	-
ENST00000546298	YBX3-218	564	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000060138's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04530	Tight junction	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000060138	Cholesterol, LDL	6.30753578670415E-5	17903299
ENSG00000060138	Alanine Transaminase	3.82e-005	-
ENSG00000060138	Alanine Transaminase	7.249e-005	-
ENSG00000060138	Platelet Function Tests	6.4000000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000060138's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000060138	YBX3	70	95.312	ENSG00000065978	YBX1	85	55.034

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000060138	YBX3	91	96.429	ENSAMEG00000009393	YBX3	95	90.000	Ailuropoda_melanoleuca
ENSG00000060138	YBX3	91	95.238	ENSAPLG00000003147	YBX3	70	100.000	Anas_platyrhynchos
ENSG00000060138	YBX3	98	86.923	ENSANAG00000033366	-	93	86.923	Aotus_nancymaae
ENSG00000060138	YBX3	100	97.043	ENSANAG00000024492	-	100	98.418	Aotus_nancymaae
ENSG00000060138	YBX3	89	100.000	ENSBTAG00000009663	YBX3	100	77.003	Bos_taurus
ENSG00000060138	YBX3	82	90.667	ENSCJAG00000033824	-	98	91.892	Callithrix_jacchus
ENSG00000060138	YBX3	100	95.968	ENSCJAG00000021660	-	100	95.968	Callithrix_jacchus
ENSG00000060138	YBX3	91	97.619	ENSCAFG00000013401	YBX3	100	92.202	Canis_familiaris
ENSG00000060138	YBX3	100	87.467	ENSCAFG00020006412	YBX3	100	86.400	Canis_lupus_dingo
ENSG00000060138	YBX3	91	97.619	ENSCHIG00000010863	YBX3	100	81.183	Capra_hircus
ENSG00000060138	YBX3	91	97.619	ENSTSYG00000004204	-	88	94.774	Carlito_syrichta
ENSG00000060138	YBX3	100	75.248	ENSTSYG00000035821	-	97	80.357	Carlito_syrichta
ENSG00000060138	YBX3	91	97.619	ENSCAPG00000015039	YBX3	93	86.760	Cavia_aperea
ENSG00000060138	YBX3	91	97.619	ENSCPOG00000011329	YBX3	86	87.713	Cavia_porcellus
ENSG00000060138	YBX3	100	96.774	ENSCCAG00000016469	YBX3	100	96.774	Cebus_capucinus
ENSG00000060138	YBX3	100	98.660	ENSCATG00000034411	YBX3	100	98.660	Cercocebus_atys
ENSG00000060138	YBX3	91	96.429	ENSCLAG00000016030	YBX3	94	87.108	Chinchilla_lanigera
ENSG00000060138	YBX3	100	99.196	ENSCSAG00000008744	YBX3	100	99.196	Chlorocebus_sabaeus
ENSG00000060138	YBX3	89	100.000	ENSCHOG00000011988	YBX3	77	83.237	Choloepus_hoffmanni
ENSG00000060138	YBX3	92	97.647	ENSCPBG00000014147	YBX3	81	78.840	Chrysemys_picta_bellii
ENSG00000060138	YBX3	91	97.619	ENSCANG00000036801	YBX3	100	98.413	Colobus_angolensis_palliatus
ENSG00000060138	YBX3	91	97.619	ENSCGRG00001016148	Ybx3	100	84.409	Cricetulus_griseus_chok1gshd
ENSG00000060138	YBX3	91	97.619	ENSCGRG00000004563	Ybx3	98	89.384	Cricetulus_griseus_crigri
ENSG00000060138	YBX3	91	97.619	ENSDORG00000009103	Ybx3	81	90.592	Dipodomys_ordii
ENSG00000060138	YBX3	91	97.619	ENSETEG00000002557	YBX3	99	84.155	Echinops_telfairi
ENSG00000060138	YBX3	100	86.022	ENSEASG00005014726	YBX3	97	88.764	Equus_asinus_asinus
ENSG00000060138	YBX3	100	88.978	ENSECAG00000013777	YBX3	100	89.516	Equus_caballus
ENSG00000060138	YBX3	91	97.619	ENSEEUG00000010415	YBX3	100	92.254	Erinaceus_europaeus
ENSG00000060138	YBX3	100	92.246	ENSFCAG00000027748	YBX3	100	93.770	Felis_catus
ENSG00000060138	YBX3	97	89.888	ENSFALG00000003661	YBX3	71	98.837	Ficedula_albicollis
ENSG00000060138	YBX3	91	96.429	ENSFDAG00000021192	YBX3	92	84.321	Fukomys_damarensis
ENSG00000060138	YBX3	89	97.561	ENSGALG00000031890	YBX3	70	97.849	Gallus_gallus
ENSG00000060138	YBX3	92	97.647	ENSGAGG00000017780	YBX3	77	82.960	Gopherus_agassizii
ENSG00000060138	YBX3	100	99.732	ENSGGOG00000001352	YBX3	100	99.732	Gorilla_gorilla
ENSG00000060138	YBX3	91	94.048	ENSHGLG00000014798	-	86	76.431	Heterocephalus_glaber_female
ENSG00000060138	YBX3	88	100.000	ENSHGLG00000015495	-	80	76.364	Heterocephalus_glaber_female
ENSG00000060138	YBX3	82	100.000	ENSHGLG00100003589	YBX3	87	88.532	Heterocephalus_glaber_male
ENSG00000060138	YBX3	91	92.857	ENSSTOG00000032577	-	100	81.720	Ictidomys_tridecemlineatus
ENSG00000060138	YBX3	91	97.619	ENSSTOG00000002108	-	88	86.411	Ictidomys_tridecemlineatus
ENSG00000060138	YBX3	86	64.198	ENSJJAG00000014239	Ybx3	96	85.227	Jaculus_jaculus
ENSG00000060138	YBX3	100	91.398	ENSLAFG00000017247	YBX3	100	91.935	Loxodonta_africana
ENSG00000060138	YBX3	100	98.925	ENSMFAG00000039369	YBX3	100	98.925	Macaca_fascicularis
ENSG00000060138	YBX3	91	97.619	ENSMMUG00000022469	YBX3	100	98.769	Macaca_mulatta
ENSG00000060138	YBX3	100	98.656	ENSMNEG00000045109	YBX3	100	98.656	Macaca_nemestrina
ENSG00000060138	YBX3	91	97.619	ENSMLEG00000033618	YBX3	79	98.606	Mandrillus_leucophaeus
ENSG00000060138	YBX3	91	96.429	ENSMGAG00000014224	YBX3	93	100.000	Meleagris_gallopavo
ENSG00000060138	YBX3	91	97.619	ENSMAUG00000012185	Ybx3	98	86.293	Mesocricetus_auratus
ENSG00000060138	YBX3	89	97.561	ENSMICG00000031459	-	100	69.967	Microcebus_murinus
ENSG00000060138	YBX3	100	90.591	ENSMICG00000038002	-	100	92.204	Microcebus_murinus
ENSG00000060138	YBX3	91	97.619	ENSMOCG00000016291	Ybx3	96	91.186	Microtus_ochrogaster
ENSG00000060138	YBX3	89	97.561	ENSMODG00000018248	YBX3	91	84.028	Monodelphis_domestica
ENSG00000060138	YBX3	91	97.619	MGP_CAROLIEiJ_G0028947	Ybx3	100	83.871	Mus_caroli
ENSG00000060138	YBX3	91	97.619	ENSMUSG00000030189	Ybx3	100	83.871	Mus_musculus
ENSG00000060138	YBX3	91	97.619	MGP_PahariEiJ_G0022709	Ybx3	100	84.409	Mus_pahari
ENSG00000060138	YBX3	91	97.619	MGP_SPRETEiJ_G0029994	Ybx3	100	84.140	Mus_spretus
ENSG00000060138	YBX3	100	79.790	ENSMPUG00000011810	YBX3	100	79.265	Mustela_putorius_furo
ENSG00000060138	YBX3	91	97.619	ENSMLUG00000007476	YBX3	100	91.450	Myotis_lucifugus
ENSG00000060138	YBX3	91	96.429	ENSNGAG00000000710	Ybx3	91	83.333	Nannospalax_galili
ENSG00000060138	YBX3	95	94.085	ENSNLEG00000034844	YBX3	100	94.085	Nomascus_leucogenys
ENSG00000060138	YBX3	77	97.183	ENSMEUG00000002507	-	81	76.879	Notamacropus_eugenii
ENSG00000060138	YBX3	82	80.921	ENSODEG00000017957	YBX3	94	81.620	Octodon_degus
ENSG00000060138	YBX3	91	97.619	ENSOANG00000001663	-	79	97.170	Ornithorhynchus_anatinus
ENSG00000060138	YBX3	91	96.429	ENSOCUG00000001889	YBX3	85	87.119	Oryctolagus_cuniculus
ENSG00000060138	YBX3	100	89.974	ENSOGAG00000013245	YBX3	100	89.710	Otolemur_garnettii
ENSG00000060138	YBX3	89	100.000	ENSOARG00000020919	YBX3	99	82.492	Ovis_aries
ENSG00000060138	YBX3	100	92.742	ENSPPAG00000039068	YBX3	100	92.742	Pan_paniscus
ENSG00000060138	YBX3	100	91.979	ENSPPRG00000005859	YBX3	100	93.443	Panthera_pardus
ENSG00000060138	YBX3	91	97.619	ENSPTIG00000005322	YBX3	81	92.334	Panthera_tigris_altaica
ENSG00000060138	YBX3	100	99.465	ENSPTRG00000004681	YBX3	100	99.465	Pan_troglodytes
ENSG00000060138	YBX3	100	98.925	ENSPANG00000010280	YBX3	100	98.925	Papio_anubis
ENSG00000060138	YBX3	92	96.471	ENSPSIG00000009247	YBX3	95	100.000	Pelodiscus_sinensis
ENSG00000060138	YBX3	91	97.619	ENSPEMG00000012132	-	99	87.227	Peromyscus_maniculatus_bairdii
ENSG00000060138	YBX3	93	95.349	ENSPEMG00000010391	-	85	91.150	Peromyscus_maniculatus_bairdii
ENSG00000060138	YBX3	85	97.436	ENSPCIG00000029949	YBX3	100	79.615	Phascolarctos_cinereus
ENSG00000060138	YBX3	100	99.462	ENSPPYG00000004279	YBX3	100	99.462	Pongo_abelii
ENSG00000060138	YBX3	91	96.429	ENSPCAG00000001397	YBX3	95	100.000	Procavia_capensis
ENSG00000060138	YBX3	79	97.260	ENSPCOG00000011663	YBX3	100	85.769	Propithecus_coquereli
ENSG00000060138	YBX3	91	97.619	ENSPVAG00000006740	YBX3	77	91.724	Pteropus_vampyrus
ENSG00000060138	YBX3	91	97.619	ENSRNOG00000005480	Ybx3	100	84.677	Rattus_norvegicus
ENSG00000060138	YBX3	100	98.118	ENSRBIG00000039208	YBX3	100	98.118	Rhinopithecus_bieti
ENSG00000060138	YBX3	100	98.387	ENSRROG00000029638	YBX3	100	98.387	Rhinopithecus_roxellana
ENSG00000060138	YBX3	91	97.619	ENSSBOG00000030573	YBX3	87	95.593	Saimiri_boliviensis_boliviensis
ENSG00000060138	YBX3	89	97.561	ENSSHAG00000003262	YBX3	98	80.756	Sarcophilus_harrisii
ENSG00000060138	YBX3	89	97.590	ENSSPUG00000009911	-	66	87.857	Sphenodon_punctatus
ENSG00000060138	YBX3	91	97.619	ENSSSCG00000000633	YBX3	100	89.764	Sus_scrofa
ENSG00000060138	YBX3	98	90.000	ENSTGUG00000012047	YBX3	74	98.077	Taeniopygia_guttata
ENSG00000060138	YBX3	91	97.619	ENSTBEG00000012570	YBX3	81	94.539	Tupaia_belangeri
ENSG00000060138	YBX3	91	97.619	ENSTTRG00000008045	YBX3	100	84.586	Tursiops_truncatus
ENSG00000060138	YBX3	75	94.203	ENSUAMG00000016662	YBX3	100	88.489	Ursus_americanus
ENSG00000060138	YBX3	91	96.429	ENSUMAG00000016118	YBX3	94	91.638	Ursus_maritimus
ENSG00000060138	YBX3	57	100.000	ENSVPAG00000000876	YBX3	100	72.535	Vicugna_pacos
ENSG00000060138	YBX3	79	97.260	ENSVVUG00000004956	YBX3	100	89.209	Vulpes_vulpes
ENSG00000060138	YBX3	82	93.333	ENSXETG00000016239	ybx3	90	68.142	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IEA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	-	IEA	Function
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0003690	double-stranded DNA binding	2977358.	TAS	Function
GO:0003700	DNA-binding transcription factor activity	8710501.	NAS	Function
GO:0003714	transcription corepressor activity	8710501.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003730	mRNA 3'-UTR binding	22711822.	ISS	Function
GO:0005515	protein binding	25593058.	IPI	Function
GO:0005634	nucleus	22711822.	ISS	Component
GO:0005737	cytoplasm	7628487.	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005923	bicellular tight junction	22711822.	ISS	Component
GO:0007283	spermatogenesis	-	IEA	Process
GO:0008584	male gonad development	-	IEA	Process
GO:0009409	response to cold	8710501.	TAS	Process
GO:0009566	fertilization	-	IEA	Process
GO:0017048	Rho GTPase binding	-	ISS	Function
GO:0046622	positive regulation of organ growth	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	22711822.	ISS	Component
GO:0048642	negative regulation of skeletal muscle tissue development	-	IEA	Process
GO:0060546	negative regulation of necroptotic process	22711822.	IMP	Process
GO:0070935	3'-UTR-mediated mRNA stabilization	22711822.	IC	Process
GO:0071356	cellular response to tumor necrosis factor	22711822.	IMP	Process
GO:0071474	cellular hyperosmotic response	22711822.	IMP	Process
GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	22711822.	IMP	Process
GO:1905538	polysome binding	-	IEA	Function
GO:2000767	positive regulation of cytoplasmic translation	22711822.	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27569444	Gene expression profile analysis of dbpA knockdown in colorectal cancer cells.	Cell Biol Int	2016 Dec	Liu R	doi: 10.1002/cbin.10670
27430286	RNAi-mediated downregulation of DNA binding proteinA inhibits tumorigenesis in colorectal cancer.	Int J Mol Med	2016 Sep	Liu RT	doi: 10.3892/ijmm.2016.2662
19749785	Upregulation of human DNA binding protein A (dbpA) in gastric cancer cells.	Acta Pharmacol Sin	2009 Oct	Wang GR	doi: 10.1038/aps.2009.137

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	10704105	Missense_Mutation	NA	A275V	0.69
BLCA	chr12	10713267	Missense_Mutation	novel	D173Y	0.39
BLCA	chr12	10701986	Missense_Mutation	novel	N343D	0.3
BLCA	chr12	10701994	Missense_Mutation	rs184471157	R340H	0.37
BLCA	chr12	10701259	3'UTR	novel		0.12
BRCA	chr12	10702085	Missense_Mutation	novel	D310H	0.06
BRCA	chr12	10710024	Nonsense_Mutation	novel	Q222*	0.1
CESC	chr12	10699389	3'UTR	novel		0.32
CESC	chr12	10710002	Missense_Mutation	novel	R229H	0.25
CESC	chr12	10702033	Missense_Mutation	rs140201332	R327L	0.32
CESC	chr12	10699227	3'UTR	novel		0.05
COAD	chr12	10704066	Missense_Mutation	rs745797213	R288H	0.04
COAD	chr12	10710104	Missense_Mutation	rs749620675	E195G	0.52
ESCA	chr12	10699300	3'UTR	novel		0.26
GBM	chr12	10702114	Missense_Mutation	rs145744944	R300Q	0.45
GBM	chr12	10702022	Missense_Mutation	NA	R331C	0.5
KIRC	chr12	10713272	Missense_Mutation	rs371143914	A171V	0.39
KIRC	chr12	10701963	Missense_Mutation	NA	K350N	0.12
LIHC	chr12	10713273	Missense_Mutation	rs747930990	A171T	0.46
LUAD	chr12	10713308	Missense_Mutation	NA	G159D	0.4
LUAD	chr12	10704059	Silent	rs777444749	R290R	0.24
LUAD	chr12	10719119	Missense_Mutation	NA	K96R	0.25
LUAD	chr12	10718108	Missense_Mutation	NA	E114K	0.32
LUSC	chr12	10715738	Missense_Mutation	NA	G136R	0.56
LUSC	chr12	10722868	Missense_Mutation	NA	A82P	0.35
LUSC	chr12	10702009	Missense_Mutation	NA	Y335F	0.22
LUSC	chr12	10710003	Missense_Mutation	NA	R229C	0.38
LUSC	chr12	10715729	Missense_Mutation	novel	E139K	0.35
LUSC	chr12	10701960	Missense_Mutation	novel	E351D	0.31
OV	chr12	10713218	Missense_Mutation	NA	P189H	0.34
OV	chr12	10713288	Missense_Mutation	novel	E166K	0.09
OV	chr12	10702051	In_Frame_Del	novel	Q315_Q322del	0.07
READ	chr12	10709956	Silent	NA	Q244Q	0.25
READ	chr12	10702066	Missense_Mutation	novel	A316G	0.08
SKCM	chr12	10704115	Missense_Mutation	novel	P272S	0.56
SKCM	chr12	10709967	Missense_Mutation	novel	H241Y	0.32
SKCM	chr12	10704056	Silent	NA	Y291Y	0.13
SKCM	chr12	10704087	Missense_Mutation	NA	V281A	0.2
SKCM	chr12	10713279	Missense_Mutation	rs760752611	R169C	0.17
SKCM	chr12	10713264	Missense_Mutation	rs748937054	R174W	0.3
SKCM	chr12	10710028	Silent	NA	R220R	0.29
STAD	chr12	10715736	Silent	novel	G136G	0.29
STAD	chr12	10713279	Missense_Mutation	rs760752611	R169C	0.24
STAD	chr12	10704066	Missense_Mutation	rs745797213	R288H	0.33
STAD	chr12	10702024	Missense_Mutation	rs144824557	R330Q	0.08
STAD	chr12	10710085	Silent	rs750604266	S201S	0.42
STAD	chr12	10715710	Missense_Mutation	novel	V145A	0.37
STAD	chr12	10702120	Missense_Mutation	rs201062345	R298H	0.16
STAD	chr12	10701264	3'UTR	novel		0.43
STAD	chr12	10709991	Missense_Mutation	rs753555662	R233W	0.48
STAD	chr12	10702027	Missense_Mutation	NA	Y329C	0.22
STAD	chr12	10710014	Missense_Mutation	rs146058214	R225H	0.12
UCEC	chr12	10701984	Silent	rs749563516	N343N	0.24
UCEC	chr12	10719084	Missense_Mutation	NA	N108H	0.06
UCEC	chr12	10719094	Silent	novel	Y104Y	0.1
UCEC	chr12	10699383	3'UTR	novel		0.38
UCEC	chr12	10701963	Frame_Shift_Del	novel	*E351Rfs37**	0.52
UCEC	chr12	10710105	Frame_Shift_Del	novel	*E195Rfs73**	0.09
UCEC	chr12	10713264	Missense_Mutation	rs748937054	R174W	0.39
UCEC	chr12	10719089	Missense_Mutation	NA	F106C	0.3
UCEC	chr12	10704115	Missense_Mutation	novel	P272S	0.19
UCEC	chr12	10704148	Missense_Mutation	novel	A261T	0.06
UCEC	chr12	10699190	3'Flank	novel		0.29
UCEC	chr12	10702000	Missense_Mutation	novel	R338H	0.46
UCEC	chr12	10710029	Missense_Mutation	rs143435496	R220Q	0.4
UCEC	chr12	10699497	3'UTR	novel		0.12
UCEC	chr12	10710105	Missense_Mutation	novel	E195K	0.22
UCEC	chr12	10713273	Missense_Mutation	rs747930990	A171T	0.38
UCEC	chr12	10713304	Silent	rs201043365	P160P	0.33
UCEC	chr12	10715758	Missense_Mutation	rs769907120	R129Q	0.37
UCEC	chr12	10699279	3'UTR	novel		0.31
UCEC	chr12	10699434	3'UTR	novel		0.2
UCEC	chr12	10699389	3'UTR	novel		0.36
UCEC	chr12	10709983	Silent	NA	R235R	0.44
UCEC	chr12	10699212	3'Flank	rs565028231		0.38
UCEC	chr12	10701989	Missense_Mutation	novel	P342S	0.18
UCEC	chr12	10702120	Missense_Mutation	rs201062345	R298H	0.32
UCEC	chr12	10709973	Missense_Mutation	novel	P239S	0.59
UCEC	chr12	10713245	Missense_Mutation	novel	G180V	0.28
UCEC	chr12	10719081	Nonsense_Mutation	NA	R109*	0.39
UCEC	chr12	10699278	3'UTR	novel		0.47
UCEC	chr12	10704133	Missense_Mutation	novel	E266K	0.3
UCEC	chr12	10704056	Nonsense_Mutation	novel	Y291*	0.14
UCEC	chr12	10719141	Missense_Mutation	novel	T89A	0.28
UCEC	chr12	10710066	Missense_Mutation	novel	D208Y	0.4
UCEC	chr12	10719084	Missense_Mutation	NA	N108H	0.37
UCEC	chr12	10702120	Missense_Mutation	rs201062345	R298H	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.1152	0.05664
COAD	DEL	0.0931	0.087189
DLBC	DEL	0.0833	0.11856
GBM	DEL	0.104	0.0061973
LUAD	DEL	0.2074	1.5736e-06
MESO	DEL	0.0805	0.17495
PAAD	DEL	0.1359	0.0019175
READ	DEL	0.1273	0.064633
STAD	DEL	0.1519	0.00030002
TGCT	AMP	0.9467	3.5918e-21
THYM	AMP	0.0325	0.24554

Survival Analysis

Cancer	P-value	Q-value
THYM	0.015	Kaplan-Meier Survival Analysis
KIRC	0.00011	Kaplan-Meier Survival Analysis
ACC	0.0012	Kaplan-Meier Survival Analysis
SKCM	0.011	Kaplan-Meier Survival Analysis
ESCA	0.027	Kaplan-Meier Survival Analysis
KIRP	0.0043	Kaplan-Meier Survival Analysis
COAD	0.043	Kaplan-Meier Survival Analysis
PAAD	0.0026	Kaplan-Meier Survival Analysis
LAML	0.0027	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.023	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742