EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000060491 (Gene tree)
Gene ID: 11054
Gene Symbol: OGFR
Alias: 7-60
Full Name: opioid growth factor receptor
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 9,176 bases
Position: chr20:62,804,825-62,814,000
Accession: 15768
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000290291	OGFR-201	2410	-	ENSP00000290291	677 (aa)	-	Q9NZT2
ENST00000370461	OGFR-202	4506	-	ENSP00000359491	625 (aa)	-	A0A0A0MRN5
ENST00000621591	OGFR-204	1194	-	ENSP00000483055	390 (aa)	-	A0A087X028
ENST00000450048	OGFR-203	553	-	ENSP00000395168	94 (aa)	-	Q4VXW3

Gene Model

Click here to download ENSG00000060491's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000060491's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001558	regulation of cell growth	10677613.	NAS	Process
GO:0004985	opioid receptor activity	10677613.	NAS	Function
GO:0005515	protein binding	21044950.	IPI	Function
GO:0005575	cellular_component	-	ND	Component
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0016020	membrane	-	IEA	Component
GO:0038003	opioid receptor signaling pathway	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
16685459	Progression of squamous cell carcinoma of the head and neck is associated with down-regulation of the opioid growth factor receptor.	Int J Oncol	2006 Jun	McLaughlin PJ	-
19297547	Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis.	Am J Physiol Regul Integr Comp Physiol	2009 Jun	Donahue RN	doi: 10.1152/ajpregu.00075.2009
23856908	Targeting the opioid growth factor: opioid growth factor receptor axis for treatment of human ovarian cancer.	Exp Biol Med (Maywood)	2013 May	Zagon IS	doi: 10.1177/1535370213488483.
18636152	Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor.	Int J Oncol	2008 Aug	Zagon IS	-
22328595	Under-expression of the opioid growth factor receptor promotes progression of human ovarian cancer.	Exp Biol Med (Maywood)	2012 Feb	Donahue RN	doi: 10.1258/ebm.2011.011321
27167686	Morphine Suppresses Lung Cancer Cell Proliferation Through the Interaction with Opioid Growth Factor Receptor: An In Vitro and Human Lung Tissue Study.	Anesth Analg	2016 Dec	Kim JY	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr20	62812987	Missense_Mutation	novel	R458W	0.37
ACC	chr20	62812461	Silent	novel	C282C	0.13
ACC	chr20	62812909	Missense_Mutation	novel	G432C	0.26
BLCA	chr20	62807662	Intron	novel		0.31
BLCA	chr20	62810541	Silent	novel	K147K	0.25
BRCA	chr20	62809649	Silent	NA	H128H	0.8
CESC	chr20	62813163	Silent	NA	G516G	0.36
CESC	chr20	62812492	Missense_Mutation	rs774947493	R293W	0.39
CESC	chr20	62813024	Missense_Mutation	rs749941602	A470V	0.39
CHOL	chr20	62811571	Missense_Mutation	novel	R192Q	0.24
COAD	chr20	62812846	Missense_Mutation	rs564432812	A411T	0.4
COAD	chr20	62813049	Silent	novel	T478T	0.31
COAD	chr20	62807669	Intron	novel		0.33
COAD	chr20	62813586	Frame_Shift_Del	novel	*E659Rfs55**	0.11
COAD	chr20	62813553	Silent	rs772919866	P646P	0.28
COAD	chr20	62813669	3'UTR	rs183567702		0.18
COAD	chr20	62812346	Missense_Mutation	rs777605843	R244Q	0.61
COAD	chr20	62807645	Intron	rs758772695		0.34
COAD	chr20	62812595	Missense_Mutation	NA	G327D	0.26
COAD	chr20	62812414	Missense_Mutation	novel	R267C	0.39
DLBC	chr20	62812312	Missense_Mutation	novel	V233I	0.31
ESCA	chr20	62813532	Silent	novel	S639S	0.19
ESCA	chr20	62808143	Intron	novel		0.42
ESCA	chr20	62813811	3'UTR	novel		0.3
ESCA	chr20	62813790	3'UTR	rs750029594		0.3
GBM	chr20	62809594	Frame_Shift_Del	novel	*I110Mfs33**	0.18
HNSC	chr20	62812454	Missense_Mutation	novel	P280L	0.2
KIRC	chr20	62812748	Missense_Mutation	rs6122312	S378I	0.28
KIRP	chr20	62805007	Missense_Mutation	novel	A50P	0.24
KIRP	chr20	62808192	Intron	novel		0.37
KIRP	chr20	62812584	Silent	novel	A323A	0.21
LGG	chr20	62811492	Missense_Mutation	novel	R166W	0.58
LIHC	chr20	62812629	Silent	novel	G338G	0.38
LIHC	chr20	62812612	Missense_Mutation	NA	E333Q	0.4
LUAD	chr20	62812842	Silent	NA	K409K	0.21
LUAD	chr20	62813697	3'UTR	novel		0.08
LUAD	chr20	62808274	Missense_Mutation	novel	D90Y	0.4
LUAD	chr20	62813029	Missense_Mutation	novel	A472S	0.31
LUSC	chr20	62813153	Missense_Mutation	NA	G513D	0.17
LUSC	chr20	62807725	Intron	novel		0.4
LUSC	chr20	62813798	3'UTR	novel		0.39
OV	chr20	62813095	Missense_Mutation	NA	G494R	0.17
PAAD	chr20	62812865	Missense_Mutation	novel	C417Y	0.05
PAAD	chr20	62812523	Missense_Mutation	rs750321486	P303L	0.22
READ	chr20	62812579	Missense_Mutation	rs373078338	E322K	0.3
READ	chr20	62813813	3'UTR	novel		0.08
SKCM	chr20	62807500	Intron	novel		0.4
SKCM	chr20	62813723	3'UTR	novel		0.5
SKCM	chr20	62812791	Silent	novel	R392R	0.2
SKCM	chr20	62812449	Silent	NA	F278F	0.5
SKCM	chr20	62807517	Intron	NA		0.18
SKCM	chr20	62809651	Missense_Mutation	NA	S129F	0.17
SKCM	chr20	62813750	3'UTR	novel		0.42
SKCM	chr20	62813751	3'UTR	rs775701526		0.42
SKCM	chr20	62812801	Missense_Mutation	NA	P396S	0.34
SKCM	chr20	62813062	Missense_Mutation	rs375174582	G483R	0.4
SKCM	chr20	62813662	3'UTR	novel		0.31
STAD	chr20	62809647	Missense_Mutation	NA	H128Y	0.08
STAD	chr20	62809614	Missense_Mutation	novel	W117R	0.37
STAD	chr20	62807644	Intron	rs531087727		0.36
STAD	chr20	62812884	Silent	rs775575581	S423S	0.26
STAD	chr20	62810562	Silent	rs768880230	V154V	0.13
STAD	chr20	62812509	Silent	NA	S298S	0.15
STAD	chr20	62812561	Missense_Mutation	NA	P316T	0.57
UCEC	chr20	62809592	Missense_Mutation	NA	F109L	0.44
UCEC	chr20	62811524	Silent	novel	G176G	0.17
UCEC	chr20	62812960	Missense_Mutation	novel	A449T	0.4
UCEC	chr20	62811522	Missense_Mutation	NA	G176S	0.31
UCEC	chr20	62812291	Missense_Mutation	rs772103301	E226K	0.25
UCEC	chr20	62813109	Missense_Mutation	NA	N498K	0.31
UCEC	chr20	62813025	Silent	rs372059243	A470A	0.11
UCEC	chr20	62812348	Missense_Mutation	novel	E245K	0.52
UCEC	chr20	62812235	Missense_Mutation	novel	S207N	0.46
UCEC	chr20	62813418	Silent	novel	T601T	0.42
UCEC	chr20	62808195	Intron	NA		0.2
UCEC	chr20	62813134	Nonsense_Mutation	NA	R507*	0.29
UCEC	chr20	62810562	Silent	rs768880230	V154V	0.44
UCEC	chr20	62808260	Missense_Mutation	rs375190272	R85Q	0.1
UCEC	chr20	62809618	Missense_Mutation	rs373508388	T118M	0.07
UCEC	chr20	62809625	Missense_Mutation	novel	N120K	0.36
UCEC	chr20	62807529	Splice_Region	novel		0.56
UCEC	chr20	62808167	Intron	rs776869612		0.28
UCEC	chr20	62807578	Silent	novel	D71D	0.3
UCEC	chr20	62807952	Intron	rs184856480		0.31
UCEC	chr20	62811530	Silent	rs775204348	Y178Y	0.54
UCEC	chr20	62812449	Missense_Mutation	novel	F278L	0.48
UCEC	chr20	62808322	Missense_Mutation	NA	N106D	0.37
UCEC	chr20	62807604	Missense_Mutation	rs757955533	P80L	0.37
UCEC	chr20	62808221	Intron	novel		0.34
UCEC	chr20	62807610	Splice_Region	novel		0.13
UCEC	chr20	62808142	Intron	novel		0.09
UCEC	chr20	62812606	Missense_Mutation	novel	G331W	0.54
UCEC	chr20	62812456	Missense_Mutation	novel	R281C	0.8
UCEC	chr20	62813497	Nonsense_Mutation	novel	G628*	0.29
UCEC	chr20	62808174	Intron	rs533514486		0.36
UCEC	chr20	62808239	Splice_Region	novel		0.36
UCEC	chr20	62813536	Missense_Mutation	novel	T641A	0.28
UCEC	chr20	62808239	Splice_Region	novel		0.47
UCEC	chr20	62808222	Intron	rs761867674		0.1
UCEC	chr20	62812787	Missense_Mutation	NA	R391L	0.36
UCEC	chr20	62813147	Missense_Mutation	novel	K511R	0.25
UCEC	chr20	62812231	Missense_Mutation	NA	R206C	0.17
UCEC	chr20	62808189	Intron	novel		0.27
UCEC	chr20	62812494	Silent	novel	R293R	0.44
UCEC	chr20	62807709	Intron	novel		0.41
UCEC	chr20	62813585	Frame_Shift_Ins	novel	*E659Gfs58**	0.53
UCS	chr20	62808124	Intron	novel		0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LIHC	AMP	0.2892	0.013414
PRAD	AMP	0.0569	0.07085
READ	AMP	0.8606	0.033971
SARC	AMP	0.3113	0.033553
SKCM	AMP	0.4496	0.058021

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
STAD	0.033	Kaplan-Meier Survival Analysis
MESO	0.0063	Kaplan-Meier Survival Analysis
SKCM	0.0012	Kaplan-Meier Survival Analysis
PRAD	0.042	Kaplan-Meier Survival Analysis
LUSC	0.0075	Kaplan-Meier Survival Analysis
BLCA	0.00065	Kaplan-Meier Survival Analysis
CESC	0.045	Kaplan-Meier Survival Analysis
LAML	0.0052	Kaplan-Meier Survival Analysis
GBM	0.05	Kaplan-Meier Survival Analysis
LIHC	0.0075	Kaplan-Meier Survival Analysis
LGG	0.0033	Kaplan-Meier Survival Analysis
UVM	0.013	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Select Dataset :

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742