EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000061936 (Gene tree)
Gene ID: 6433
Gene Symbol: SFSWAP
Alias: SWAP|SFRS8
Full Name: splicing factor SWAP
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 88,658 bases
Position: chr12:131,711,081-131,799,738
Accession: 10790
RBP type: canonical RBP
Summary: This gene encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000261674	DRY_EERY	PF09750.9	2.8e-32	1	1
ENSP00000437738	DRY_EERY	PF09750.9	3e-32	1	1
ENSP00000261674	Surp	PF01805.20	4.5e-27	1	2
ENSP00000261674	Surp	PF01805.20	4.5e-27	2	2
ENSP00000437738	Surp	PF01805.20	5.1e-27	1	2
ENSP00000437738	Surp	PF01805.20	5.1e-27	2	2
ENSP00000439957	Surp	PF01805.20	4.4e-13	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000261674	SFSWAP-201	3246	XM_011538655	ENSP00000261674	951 (aa)	XP_011536957	Q12872
ENST00000535202	SFSWAP-202	567	-	-	- (aa)	-	-
ENST00000538548	SFSWAP-207	2636	-	ENSP00000445832	121 (aa)	-	F5H1A5
ENST00000541286	SFSWAP-210	3219	XM_011538653	ENSP00000437738	1003 (aa)	XP_011536955	Q12872
ENST00000535399	SFSWAP-204	778	-	-	- (aa)	-	-
ENST00000540469	SFSWAP-209	3536	-	-	- (aa)	-	-
ENST00000535236	SFSWAP-203	5593	-	-	- (aa)	-	-
ENST00000537582	SFSWAP-206	1576	-	-	- (aa)	-	-
ENST00000539506	SFSWAP-208	3149	-	-	- (aa)	-	-
ENST00000542813	SFSWAP-211	373	-	-	- (aa)	-	-
ENST00000537164	SFSWAP-205	961	-	ENSP00000439957	320 (aa)	-	H0YFR9

Gene Model

Click here to download ENSG00000061936's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000061936	Heart Failure	3.3876308E-005	-
ENSG00000061936	Heart Failure	6.1412555E-004	-
ENSG00000061936	Heart Failure	1.1038073E-004	-
ENSG00000061936	Eosinophils	9.038e-005	-
ENSG00000061936	Eosinophils	6.766e-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000061936	rs11246807	12	131791220	?	Psychosis proneness (perceptual aberration scale)	28525603			EFO_0008337
ENSG00000061936	rs1107871	12	131756114	A	Educational attainment (MTAG)	30038396	[0.0059-0.0109] unit decrease	0.0084	EFO_0004784
ENSG00000061936	rs1107871	12	131756114	A	Highest math class taken (MTAG)	30038396	[0.0074-0.014] unit decrease	0.0107	EFO_0004875
ENSG00000061936	rs1107871	12	131756114	A	Educational attainment (years of education)	30038396	[0.0056-0.011] unit decrease	0.0083	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000061936's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000061936	SFSWAP	68	37.805	ENSG00000104859	CLASRP	53	47.826

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000061936	SFSWAP	84	66.346	ENSAPOG00000005784	sfswap	87	78.571	Acanthochromis_polyacanthus
ENSG00000061936	SFSWAP	94	97.368	ENSAMEG00000013818	SFSWAP	100	85.068	Ailuropoda_melanoleuca
ENSG00000061936	SFSWAP	84	66.346	ENSACIG00000009240	-	68	82.222	Amphilophus_citrinellus
ENSG00000061936	SFSWAP	68	79.268	ENSAOCG00000016469	sfswap	66	60.526	Amphiprion_ocellaris
ENSG00000061936	SFSWAP	68	79.268	ENSAPEG00000004965	sfswap	97	52.505	Amphiprion_percula
ENSG00000061936	SFSWAP	67	80.247	ENSATEG00000021053	sfswap	88	65.344	Anabas_testudineus
ENSG00000061936	SFSWAP	100	79.084	ENSAPLG00000013808	SFSWAP	97	80.624	Anas_platyrhynchos
ENSG00000061936	SFSWAP	97	71.000	ENSACAG00000007220	SFSWAP	100	72.303	Anolis_carolinensis
ENSG00000061936	SFSWAP	100	97.482	ENSANAG00000001518	SFSWAP	100	97.482	Aotus_nancymaae
ENSG00000061936	SFSWAP	84	66.346	ENSACLG00000020159	sfswap	85	68.097	Astatotilapia_calliptera
ENSG00000061936	SFSWAP	100	90.852	ENSBTAG00000000439	SFSWAP	100	91.905	Bos_taurus
ENSG00000061936	SFSWAP	100	97.059	ENSCJAG00000003613	SFSWAP	100	97.059	Callithrix_jacchus
ENSG00000061936	SFSWAP	94	96.491	ENSCAFG00000006625	SFSWAP	100	88.013	Canis_familiaris
ENSG00000061936	SFSWAP	87	80.825	ENSCAFG00020011254	SFSWAP	99	80.586	Canis_lupus_dingo
ENSG00000061936	SFSWAP	100	90.852	ENSCHIG00000008838	SFSWAP	100	90.747	Capra_hircus
ENSG00000061936	SFSWAP	100	93.270	ENSTSYG00000010303	SFSWAP	100	93.060	Carlito_syrichta
ENSG00000061936	SFSWAP	98	88.350	ENSCAPG00000004394	SFSWAP	96	88.523	Cavia_aperea
ENSG00000061936	SFSWAP	100	89.542	ENSCPOG00000005280	SFSWAP	100	89.076	Cavia_porcellus
ENSG00000061936	SFSWAP	100	97.164	ENSCCAG00000037255	SFSWAP	100	97.164	Cebus_capucinus
ENSG00000061936	SFSWAP	100	98.738	ENSCATG00000031094	SFSWAP	100	98.738	Cercocebus_atys
ENSG00000061936	SFSWAP	100	91.693	ENSCLAG00000008380	SFSWAP	100	91.272	Chinchilla_lanigera
ENSG00000061936	SFSWAP	100	98.528	ENSCSAG00000001884	SFSWAP	100	98.528	Chlorocebus_sabaeus
ENSG00000061936	SFSWAP	92	75.740	ENSCHOG00000003578	SFSWAP	99	77.397	Choloepus_hoffmanni
ENSG00000061936	SFSWAP	98	79.412	ENSCPBG00000024757	SFSWAP	96	78.535	Chrysemys_picta_bellii
ENSG00000061936	SFSWAP	100	98.423	ENSCANG00000036501	SFSWAP	100	98.423	Colobus_angolensis_palliatus
ENSG00000061936	SFSWAP	100	88.749	ENSCGRG00001011284	Sfswap	100	88.328	Cricetulus_griseus_chok1gshd
ENSG00000061936	SFSWAP	100	88.749	ENSCGRG00000017417	Sfswap	100	88.328	Cricetulus_griseus_crigri
ENSG00000061936	SFSWAP	67	81.481	ENSCSEG00000003773	sfswap	68	60.375	Cynoglossus_semilaevis
ENSG00000061936	SFSWAP	100	59.504	ENSCVAG00000001208	-	77	75.281	Cyprinodon_variegatus
ENSG00000061936	SFSWAP	87	46.000	ENSCVAG00000001205	-	92	78.000	Cyprinodon_variegatus
ENSG00000061936	SFSWAP	89	67.593	ENSDARG00000005980	sfswap	99	54.073	Danio_rerio
ENSG00000061936	SFSWAP	94	94.737	ENSDNOG00000018742	SFSWAP	100	87.903	Dasypus_novemcinctus
ENSG00000061936	SFSWAP	97	85.514	ENSDORG00000010352	Sfswap	99	81.868	Dipodomys_ordii
ENSG00000061936	SFSWAP	68	56.627	FBgn0003638	su(w[a])	56	55.556	Drosophila_melanogaster
ENSG00000061936	SFSWAP	97	82.547	ENSETEG00000016657	-	86	85.849	Echinops_telfairi
ENSG00000061936	SFSWAP	69	60.465	ENSEBUG00000016748	SFSWAP	99	37.143	Eptatretus_burgeri
ENSG00000061936	SFSWAP	94	97.368	ENSEASG00005016502	SFSWAP	100	91.167	Equus_asinus_asinus
ENSG00000061936	SFSWAP	94	97.368	ENSECAG00000007657	SFSWAP	100	90.229	Equus_caballus
ENSG00000061936	SFSWAP	98	83.495	ENSEEUG00000001713	SFSWAP	99	72.039	Erinaceus_europaeus
ENSG00000061936	SFSWAP	94	67.544	ENSELUG00000010942	sfswap	90	64.819	Esox_lucius
ENSG00000061936	SFSWAP	94	96.491	ENSFCAG00000010778	SFSWAP	100	89.695	Felis_catus
ENSG00000061936	SFSWAP	100	77.812	ENSFALG00000009577	SFSWAP	96	79.849	Ficedula_albicollis
ENSG00000061936	SFSWAP	100	88.901	ENSFDAG00000017235	SFSWAP	100	88.901	Fukomys_damarensis
ENSG00000061936	SFSWAP	94	61.404	ENSFHEG00000011149	-	90	59.451	Fundulus_heteroclitus
ENSG00000061936	SFSWAP	67	80.247	ENSGMOG00000009205	sfswap	76	70.432	Gadus_morhua
ENSG00000061936	SFSWAP	98	75.238	ENSGALG00000002487	SFSWAP	98	79.188	Gallus_gallus
ENSG00000061936	SFSWAP	67	79.012	ENSGAFG00000006272	sfswap	89	67.751	Gambusia_affinis
ENSG00000061936	SFSWAP	90	66.667	ENSGACG00000017647	sfswap	99	55.834	Gasterosteus_aculeatus
ENSG00000061936	SFSWAP	98	79.412	ENSGAGG00000002611	SFSWAP	96	79.103	Gopherus_agassizii
ENSG00000061936	SFSWAP	100	99.302	ENSGGOG00000014877	SFSWAP	100	99.302	Gorilla_gorilla
ENSG00000061936	SFSWAP	84	66.346	ENSHBUG00000005629	sfswap	56	68.464	Haplochromis_burtoni
ENSG00000061936	SFSWAP	100	91.483	ENSHGLG00000019216	SFSWAP	100	91.062	Heterocephalus_glaber_female
ENSG00000061936	SFSWAP	100	91.062	ENSHGLG00100019350	SFSWAP	100	90.641	Heterocephalus_glaber_male
ENSG00000061936	SFSWAP	72	75.000	ENSHCOG00000009475	sfswap	97	52.108	Hippocampus_comes
ENSG00000061936	SFSWAP	84	69.608	ENSIPUG00000010598	sfswap	98	57.625	Ictalurus_punctatus
ENSG00000061936	SFSWAP	100	90.021	ENSSTOG00000000773	SFSWAP	100	89.706	Ictidomys_tridecemlineatus
ENSG00000061936	SFSWAP	100	88.118	ENSJJAG00000006609	Sfswap	100	88.118	Jaculus_jaculus
ENSG00000061936	SFSWAP	67	80.247	ENSKMAG00000013168	sfswap	69	58.414	Kryptolebias_marmoratus
ENSG00000061936	SFSWAP	67	79.012	ENSLBEG00000010239	sfswap	72	60.058	Labrus_bergylta
ENSG00000061936	SFSWAP	96	70.103	ENSLACG00000018678	SFSWAP	96	65.702	Latimeria_chalumnae
ENSG00000061936	SFSWAP	98	85.294	ENSLAFG00000014462	SFSWAP	100	89.444	Loxodonta_africana
ENSG00000061936	SFSWAP	100	97.607	ENSMFAG00000037352	SFSWAP	100	97.607	Macaca_fascicularis
ENSG00000061936	SFSWAP	100	98.423	ENSMMUG00000020343	SFSWAP	100	98.423	Macaca_mulatta
ENSG00000061936	SFSWAP	100	98.423	ENSMNEG00000041002	SFSWAP	100	98.423	Macaca_nemestrina
ENSG00000061936	SFSWAP	100	96.320	ENSMLEG00000035728	SFSWAP	100	96.320	Mandrillus_leucophaeus
ENSG00000061936	SFSWAP	84	67.308	ENSMAMG00000006631	sfswap	97	53.815	Mastacembelus_armatus
ENSG00000061936	SFSWAP	88	64.602	ENSMZEG00005009699	-	88	67.925	Maylandia_zebra
ENSG00000061936	SFSWAP	97	78.362	ENSMGAG00000002191	SFSWAP	97	78.499	Meleagris_gallopavo
ENSG00000061936	SFSWAP	100	93.592	ENSMICG00000004465	SFSWAP	100	93.487	Microcebus_murinus
ENSG00000061936	SFSWAP	100	88.854	ENSMOCG00000014390	Sfswap	100	88.433	Microtus_ochrogaster
ENSG00000061936	SFSWAP	67	61.728	ENSMMOG00000021053	-	76	65.035	Mola_mola
ENSG00000061936	SFSWAP	99	75.340	ENSMODG00000015581	SFSWAP	99	73.733	Monodelphis_domestica
ENSG00000061936	SFSWAP	67	80.247	ENSMALG00000012603	sfswap	97	51.446	Monopterus_albus
ENSG00000061936	SFSWAP	100	90.909	MGP_CAROLIEiJ_G0027780	Sfswap	100	90.909	Mus_caroli
ENSG00000061936	SFSWAP	100	90.909	ENSMUSG00000029439	Sfswap	100	90.909	Mus_musculus
ENSG00000061936	SFSWAP	100	91.736	MGP_PahariEiJ_G0024360	Sfswap	100	91.736	Mus_pahari
ENSG00000061936	SFSWAP	100	90.909	MGP_SPRETEiJ_G0028779	Sfswap	100	90.909	Mus_spretus
ENSG00000061936	SFSWAP	94	97.368	ENSMPUG00000002218	SFSWAP	100	88.644	Mustela_putorius_furo
ENSG00000061936	SFSWAP	94	97.368	ENSMLUG00000011296	SFSWAP	100	83.630	Myotis_lucifugus
ENSG00000061936	SFSWAP	100	89.380	ENSNGAG00000018167	Sfswap	100	88.959	Nannospalax_galili
ENSG00000061936	SFSWAP	98	97.653	ENSNLEG00000008386	SFSWAP	100	95.593	Nomascus_leucogenys
ENSG00000061936	SFSWAP	71	88.530	ENSMEUG00000009556	-	80	88.172	Notamacropus_eugenii
ENSG00000061936	SFSWAP	100	74.027	ENSOPRG00000006983	-	100	73.502	Ochotona_princeps
ENSG00000061936	SFSWAP	100	90.852	ENSODEG00000008020	SFSWAP	100	90.431	Octodon_degus
ENSG00000061936	SFSWAP	97	59.406	ENSONIG00000003757	sfswap	99	56.677	Oreochromis_niloticus
ENSG00000061936	SFSWAP	98	86.139	ENSOANG00000013861	SFSWAP	100	83.995	Ornithorhynchus_anatinus
ENSG00000061936	SFSWAP	94	94.737	ENSOCUG00000002165	SFSWAP	100	85.227	Oryctolagus_cuniculus
ENSG00000061936	SFSWAP	67	80.247	ENSORLG00000010983	sfswap	57	67.302	Oryzias_latipes
ENSG00000061936	SFSWAP	67	80.247	ENSORLG00020010779	sfswap	54	67.302	Oryzias_latipes_hni
ENSG00000061936	SFSWAP	67	80.247	ENSORLG00015023093	sfswap	89	67.302	Oryzias_latipes_hsok
ENSG00000061936	SFSWAP	68	79.268	ENSOMEG00000022065	sfswap	97	53.189	Oryzias_melastigma
ENSG00000061936	SFSWAP	94	97.368	ENSOGAG00000016724	SFSWAP	99	93.743	Otolemur_garnettii
ENSG00000061936	SFSWAP	94	96.491	ENSOARG00000014314	SFSWAP	100	90.346	Ovis_aries
ENSG00000061936	SFSWAP	100	99.501	ENSPPAG00000036706	SFSWAP	100	99.501	Pan_paniscus
ENSG00000061936	SFSWAP	94	96.491	ENSPPRG00000017318	SFSWAP	100	83.566	Panthera_pardus
ENSG00000061936	SFSWAP	94	95.614	ENSPTIG00000004304	SFSWAP	99	75.667	Panthera_tigris_altaica
ENSG00000061936	SFSWAP	100	99.159	ENSPTRG00000005640	SFSWAP	100	99.159	Pan_troglodytes
ENSG00000061936	SFSWAP	100	98.738	ENSPANG00000019737	SFSWAP	100	98.738	Papio_anubis
ENSG00000061936	SFSWAP	82	72.277	ENSPKIG00000008327	sfswap	97	55.867	Paramormyrops_kingsleyae
ENSG00000061936	SFSWAP	95	79.412	ENSPSIG00000017807	SFSWAP	100	76.489	Pelodiscus_sinensis
ENSG00000061936	SFSWAP	90	63.636	ENSPMGG00000008093	-	90	64.151	Periophthalmus_magnuspinnatus
ENSG00000061936	SFSWAP	100	88.025	ENSPEMG00000001237	Sfswap	100	87.605	Peromyscus_maniculatus_bairdii
ENSG00000061936	SFSWAP	71	77.907	ENSPMAG00000008279	sfswap	77	62.535	Petromyzon_marinus
ENSG00000061936	SFSWAP	99	79.562	ENSPCIG00000006062	SFSWAP	99	78.741	Phascolarctos_cinereus
ENSG00000061936	SFSWAP	96	52.038	ENSPFOG00000019657	sfswap	89	68.022	Poecilia_formosa
ENSG00000061936	SFSWAP	67	80.247	ENSPLAG00000008513	sfswap	89	68.022	Poecilia_latipinna
ENSG00000061936	SFSWAP	67	80.247	ENSPMEG00000008716	sfswap	89	68.022	Poecilia_mexicana
ENSG00000061936	SFSWAP	67	80.247	ENSPREG00000006692	sfswap	51	67.480	Poecilia_reticulata
ENSG00000061936	SFSWAP	98	98.607	ENSPPYG00000005129	SFSWAP	100	98.607	Pongo_abelii
ENSG00000061936	SFSWAP	94	93.860	ENSPCAG00000004977	-	65	87.500	Procavia_capensis
ENSG00000061936	SFSWAP	100	94.006	ENSPCOG00000023786	SFSWAP	100	93.796	Propithecus_coquereli
ENSG00000061936	SFSWAP	94	95.614	ENSPVAG00000014918	SFSWAP	92	87.456	Pteropus_vampyrus
ENSG00000061936	SFSWAP	97	56.604	ENSPNAG00000007073	sfswap	98	49.718	Pygocentrus_nattereri
ENSG00000061936	SFSWAP	100	87.438	ENSRNOG00000000931	Sfswap	100	87.039	Rattus_norvegicus
ENSG00000061936	SFSWAP	98	97.030	ENSRBIG00000036330	SFSWAP	100	91.798	Rhinopithecus_bieti
ENSG00000061936	SFSWAP	100	98.212	ENSRROG00000032001	SFSWAP	100	98.212	Rhinopithecus_roxellana
ENSG00000061936	SFSWAP	100	96.639	ENSSBOG00000026217	SFSWAP	100	96.639	Saimiri_boliviensis_boliviensis
ENSG00000061936	SFSWAP	98	81.905	ENSSHAG00000014232	SFSWAP	100	83.446	Sarcophilus_harrisii
ENSG00000061936	SFSWAP	96	56.567	ENSSFOG00015000766	sfswap	97	58.577	Scleropages_formosus
ENSG00000061936	SFSWAP	94	59.649	ENSSMAG00000018718	sfswap	97	51.796	Scophthalmus_maximus
ENSG00000061936	SFSWAP	67	81.481	ENSSDUG00000021680	sfswap	56	67.196	Seriola_dumerili
ENSG00000061936	SFSWAP	67	81.481	ENSSLDG00000010835	sfswap	78	66.489	Seriola_lalandi_dorsalis
ENSG00000061936	SFSWAP	86	89.231	ENSSARG00000000424	SFSWAP	85	87.363	Sorex_araneus
ENSG00000061936	SFSWAP	98	75.248	ENSSPUG00000010272	SFSWAP	99	75.725	Sphenodon_punctatus
ENSG00000061936	SFSWAP	94	97.368	ENSSSCG00000009744	SFSWAP	100	90.136	Sus_scrofa
ENSG00000061936	SFSWAP	97	79.396	ENSTGUG00000004623	SFSWAP	99	79.676	Taeniopygia_guttata
ENSG00000061936	SFSWAP	89	65.741	ENSTNIG00000006156	-	92	64.310	Tetraodon_nigroviridis
ENSG00000061936	SFSWAP	54	90.625	ENSTBEG00000004983	-	67	90.625	Tupaia_belangeri
ENSG00000061936	SFSWAP	94	96.491	ENSTTRG00000013478	SFSWAP	92	93.627	Tursiops_truncatus
ENSG00000061936	SFSWAP	94	97.368	ENSUAMG00000016807	SFSWAP	100	87.382	Ursus_americanus
ENSG00000061936	SFSWAP	94	97.368	ENSUMAG00000002957	SFSWAP	91	83.293	Ursus_maritimus
ENSG00000061936	SFSWAP	94	94.737	ENSVPAG00000010479	-	74	95.122	Vicugna_pacos
ENSG00000061936	SFSWAP	94	95.614	ENSVVUG00000010753	SFSWAP	100	87.802	Vulpes_vulpes
ENSG00000061936	SFSWAP	93	76.471	ENSXETG00000009350	sfswap	98	61.648	Xenopus_tropicalis
ENSG00000061936	SFSWAP	94	60.526	ENSXCOG00000005131	sfswap	77	71.479	Xiphophorus_couchianus
ENSG00000061936	SFSWAP	67	80.247	ENSXMAG00000009020	sfswap	89	67.751	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000380	alternative mRNA splicing, via spliceosome	-	IEA	Process
GO:0000395	mRNA 5'-splice site recognition	21873635.	IBA	Process
GO:0003723	RNA binding	-	IEA	Function
GO:0005515	protein binding	26420826.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0048025	negative regulation of mRNA splicing, via spliceosome	-	ISS	Process