EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000062485 (Gene tree)
Gene ID: 1431
Gene Symbol: CS
Alias: N
Full Name: citrate synthase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 28,694 bases
Position: chr12:56,271,699-56,300,392
Accession: 2422
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000551936	CS-229	744	-	ENSP00000450312	144 (aa)	-	F8VPA1
ENST00000351328	CS-201	2975	-	ENSP00000342056	466 (aa)	-	O75390
ENST00000550700	CS-220	559	-	-	- (aa)	-	-
ENST00000552222	CS-231	555	-	ENSP00000447582	75 (aa)	-	F8W0J2
ENST00000547298	CS-208	656	-	ENSP00000448409	117 (aa)	-	F8VRP1
ENST00000549143	CS-215	2811	-	ENSP00000449571	49 (aa)	-	F8VVY4
ENST00000551137	CS-223	903	-	ENSP00000449753	114 (aa)	-	F8VX07
ENST00000548041	CS-211	561	-	ENSP00000447986	149 (aa)	-	F8VTT8
ENST00000547283	CS-207	555	-	-	- (aa)	-	-
ENST00000546891	CS-205	911	-	ENSP00000446492	190 (aa)	-	H0YH82
ENST00000550996	CS-222	718	-	-	- (aa)	-	-
ENST00000551441	CS-227	636	-	-	- (aa)	-	-
ENST00000552688	CS-233	580	-	ENSP00000447442	157 (aa)	-	F8W1S4
ENST00000542324	CS-202	1893	-	ENSP00000440543	453 (aa)	-	B4DJV2
ENST00000551155	CS-224	558	-	-	- (aa)	-	-
ENST00000552331	CS-232	526	-	-	- (aa)	-	-
ENST00000551968	CS-230	542	-	ENSP00000447948	142 (aa)	-	F8VU34
ENST00000548849	CS-214	1028	-	ENSP00000449491	132 (aa)	-	F8VWQ5
ENST00000547449	CS-209	434	-	-	- (aa)	-	-
ENST00000546621	CS-204	1513	-	-	- (aa)	-	-
ENST00000550655	CS-219	589	-	ENSP00000448172	178 (aa)	-	F8W4S1
ENST00000546930	CS-206	568	-	ENSP00000450403	146 (aa)	-	F8VR34
ENST00000547912	CS-210	674	-	-	- (aa)	-	-
ENST00000550734	CS-221	747	-	ENSP00000449025	144 (aa)	-	F8VPA1
ENST00000546585	CS-203	1803	-	-	- (aa)	-	-
ENST00000549221	CS-216	553	-	ENSP00000448667	140 (aa)	-	F8VRI6
ENST00000551253	CS-225	676	-	ENSP00000450101	140 (aa)	-	F8VPF9
ENST00000551430	CS-226	751	-	ENSP00000448166	66 (aa)	-	F8W642
ENST00000548746	CS-213	551	-	ENSP00000449080	123 (aa)	-	H0YIC4
ENST00000548567	CS-212	3057	-	ENSP00000446779	400 (aa)	-	A0A0C4DGI3
ENST00000551473	CS-228	797	-	ENSP00000449427	120 (aa)	-	F8VX68
ENST00000550159	CS-218	646	-	ENSP00000447346	80 (aa)	-	F8VZK9
ENST00000550044	CS-217	546	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000062485's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00020	Citrate cycle (TCA cycle)	KEGG
hsa00630	Glyoxylate and dicarboxylate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01210	2-Oxocarboxylic acid metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000062485	Body Height	1.23527302841217E-7	17903300
ENSG00000062485	Body Height	1.73824348873374E-7	17903300
ENSG00000062485	Body Height	7.18500823359926E-7	17903300
ENSG00000062485	Platelet Function Tests	1.4581400E-005	-
ENSG00000062485	Platelet Function Tests	1.3415600E-005	-
ENSG00000062485	Child Development Disorders, Pervasive	3.9140000E-005	-
ENSG00000062485	Autistic Disorder	2.4355000E-005	-
ENSG00000062485	Autistic Disorder	1.7847000E-005	-
ENSG00000062485	Thyroxine	3.3520000E-005	-
ENSG00000062485	Thyroxine	4.7300000E-005	-
ENSG00000062485	Psoriasis	3E-12	25574825
ENSG00000062485	Body Height	3E-9	23456168

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000062485	rs369160772	12	56279779	CA	Blood protein levels	29875488	[0.28-0.48] unit decrease	0.38	EFO_0007937
ENSG00000062485	rs3816804	12	56286961	C	Height	23456168	[0.082-0.164] unit increase	0.123	EFO_0004339

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000062485's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000062485	CS	98	80.000	WBGene00000833	cts-1	95	69.526	Caenorhabditis_elegans
ENSG00000062485	CS	98	80.165	FBgn0261955	kdn	94	73.288	Drosophila_melanogaster
ENSG00000062485	CS	98	97.521	ENSMUSG00000005683	Cs	98	94.481	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004108	citrate (Si)-synthase activity	21873635.	IBA	Function
GO:0004108	citrate (Si)-synthase activity	9543345.	IDA	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	9543345.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005975	carbohydrate metabolic process	21873635.	IBA	Process
GO:0005975	carbohydrate metabolic process	9543345.	IDA	Process
GO:0006099	tricarboxylic acid cycle	21873635.	IBA	Process
GO:0006099	tricarboxylic acid cycle	-	IEA	Process
GO:0006099	tricarboxylic acid cycle	-	TAS	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component