EuRBPDB

Description

Ensembl ID: ENSG00000062650 (Gene tree)
Gene ID: 23063
Gene Symbol: WAPL
Alias: FOE|KIAA0261|WAPAL
Full Name: WAPL cohesin release factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 86,561 bases
Position: chr10:86,435,256-86,521,816
Accession: 23293
RBP type: non-canonical RBP
Summary: (WAPL Cohesin Release Factor) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and DNA Damage.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000372075	WAPL-203	1799	-	ENSP00000361145	421 (aa)	-	F6QZY1
ENST00000618527	WAPL-206	6152	-	ENSP00000481451	1190 (aa)	-	Q7Z5K2
ENST00000489996	WAPL-205	646	-	-	- (aa)	-	-
ENST00000484070	WAPL-204	3207	-	-	- (aa)	-	-
ENST00000263070	WAPL-201	5987	-	ENSP00000263070	402 (aa)	-	Q8WVX6
ENST00000298767	WAPL-202	6333	XM_011539548	ENSP00000298767	1190 (aa)	XP_011537850	Q7Z5K2

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000062650	Bronchodilator Agents	5E-7	26634245
ENSG00000062650	Forced Expiratory Volume	5E-7	26634245
ENSG00000062650	Bronchodilator Agents	8E-7	26634245
ENSG00000062650	Lung Volume Measurements	8E-7	26634245
ENSG00000062650	Migraine Disorders	6E-7	23793025

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000062650	rs7075426	10	86456645	A	Migraine without aura	23793025	[1.06-1.15]	1.11	EFO_0003821
ENSG00000062650	rs3858281	10	86504258	G	Self-reported math ability	30038396	[0.0078-0.0164] unit decrease	0.0121	EFO_0004875
ENSG00000062650	rs3858281	10	86504258	A	Self-reported math ability (MTAG)	30038396	[0.0079-0.0157] unit increase	0.0118	EFO_0004875

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000062650	WAPL	100	98.052	ENSMUSG00000041408	Wapl	99	98.052	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000278	mitotic cell cycle	-	IEA	Process
GO:0000775	chromosome, centromeric region	-	TAS	Component
GO:0000785	chromatin	17113138.19696148.	IDA	Component
GO:0000795	synaptonemal complex	-	IEA	Component
GO:0005515	protein binding	17112726.17113138.19696148.19907496.20360068.21111234.25173175.26496610.	IPI	Function
GO:0005634	nucleus	17113138.19696148.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	TAS	Component
GO:0005737	cytoplasm	17113138.19696148.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0008156	negative regulation of DNA replication	19907496.	IMP	Process
GO:0008278	cohesin complex	17113138.19696148.	IDA	Component
GO:0009636	response to toxic substance	-	IEA	Process
GO:0016032	viral process	-	IEA	Process
GO:0035562	negative regulation of chromatin binding	17113138.19696148.	IMP	Process
GO:0045132	meiotic chromosome segregation	21873635.	IBA	Process
GO:0045875	negative regulation of sister chromatid cohesion	17113138.19696148.21111234.	IMP	Process
GO:0048146	positive regulation of fibroblast proliferation	-	IEA	Process
GO:0051301	cell division	-	IEA	Process
GO:0060623	regulation of chromosome condensation	21873635.	IBA	Process
GO:0071168	protein localization to chromatin	21111234.	IMP	Process
GO:0071922	regulation of cohesin loading	21873635.	IBA	Process
GO:0071922	regulation of cohesin loading	17113138.	IMP	Process