EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000063177 (Gene tree)
Gene ID: 6141
Gene Symbol: RPL18
Alias: L18
Full Name: ribosomal protein L18
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 4,210 bases
Position: chr19:48,615,327-48,619,536
Accession: 10310
RBP type: non-canonical RBP
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11964156	The solution structure of ribosomal protein L18 from Thermus thermophilus reveals a conserved RNA-binding fold.	Biochem J	2002 May 1	Woestenenk EA	-
2429677	Construction and functional analysis of ribosomal 5S RNA from Escherichia coli with single base changes in the ribosomal protein binding sites.	Biol Chem Hoppe Seyler	1986 Aug	Goringer HU	-
7038676	double helix in a RNA-protein contact site.	Proc Natl Acad Sci U S A	1981 Dec	Peattie DA	-
2990903	Does unpaired adenosine-66 from helix II of Escherichia coli 5S RNA bind to protein L18?	EMBO J	1985 Apr	Christiansen J	-
2472486	Protein L18 binds primarily at the junctions of helix II and internal loops A and B in Escherichia coli 5 S RNA. Implications for 5 S RNA structure.	J Mol Biol	1989 Apr 20	Egebjerg J	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000549920	RPL18-208	1004	-	ENSP00000447001	188 (aa)	-	Q07020
ENST00000547897	RPL18-204	440	-	ENSP00000470988	138 (aa)	-	A0A075B7A0
ENST00000547892	RPL18-203	3844	-	-	- (aa)	-	-
ENST00000084795	RPL18-201	612	-	ENSP00000084795	190 (aa)	-	J3QQ67
ENST00000550645	RPL18-209	463	-	ENSP00000448899	133 (aa)	-	F8VYV2
ENST00000546623	RPL18-202	541	-	ENSP00000446634	167 (aa)	-	H0YHA7
ENST00000551749	RPL18-212	2091	-	-	- (aa)	-	-
ENST00000549533	RPL18-207	666	-	-	- (aa)	-	-
ENST00000550973	RPL18-211	1111	-	ENSP00000447894	130 (aa)	-	F8VUA6
ENST00000552347	RPL18-213	1645	-	-	- (aa)	-	-
ENST00000552588	RPL18-214	559	-	ENSP00000449204	159 (aa)	-	Q07020
ENST00000549273	RPL18-205	1036	-	ENSP00000449610	164 (aa)	-	G3V203
ENST00000552705	RPL18-215	1081	-	-	- (aa)	-	-
ENST00000552851	RPL18-216	691	-	-	- (aa)	-	-
ENST00000549370	RPL18-206	628	-	ENSP00000449067	84 (aa)	-	F8VXR6
ENST00000550671	RPL18-210	764	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000063177's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000063177	Carcinoembryonic Antigen	7E-12	24941225

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000063177's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000063177	RPL18	99	67.089	WBGene00004430	rpl-18	100	65.957	Caenorhabditis_elegans
ENSG00000063177	RPL18	99	87.597	ENSDARG00000029533	rpl18	100	84.756	Danio_rerio
ENSG00000063177	RPL18	99	69.519	FBgn0035753	RpL18	99	69.355	Drosophila_melanogaster
ENSG00000063177	RPL18	100	96.277	ENSMUSG00000059070	Rpl18	100	96.277	Mus_musculus
ENSG00000063177	RPL18	99	57.325	YOL120C	RPL18A	93	53.977	Saccharomyces_cerevisiae
ENSG00000063177	RPL18	99	57.325	YNL301C	RPL18B	93	53.977	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	Process
GO:0002181	cytoplasmic translation	25957688.	IDA	Process
GO:0003723	RNA binding	8218404.	TAS	Function
GO:0003735	structural constituent of ribosome	12962325.	NAS	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005791	rough endoplasmic reticulum	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006412	translation	12962325.	NAS	Process
GO:0006413	translational initiation	-	TAS	Process
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019083	viral transcription	-	TAS	Process
GO:0022625	cytosolic large ribosomal subunit	12962325.	HDA	Component
GO:0022625	cytosolic large ribosomal subunit	21873635.	IBA	Component
GO:0022625	cytosolic large ribosomal subunit	25957688.	IDA	Component
GO:0042788	polysomal ribosome	25957688.	IDA	Component