EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000063244 (Gene tree)
Gene ID: 11338
Gene Symbol: U2AF2
Alias: U2AF65
Full Name: U2 small nuclear RNA auxiliary factor 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 20,667 bases
Position: chr19:55,654,050-55,674,716
Accession: 23156
RBP type: canonical RBP
Summary: U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000388475	RRM_1	PF00076.22	4.2e-34	1	3
ENSP00000388475	RRM_1	PF00076.22	4.2e-34	2	3
ENSP00000388475	RRM_1	PF00076.22	4.2e-34	3	3
ENSP00000307863	RRM_1	PF00076.22	4.4e-34	1	3
ENSP00000307863	RRM_1	PF00076.22	4.4e-34	2	3
ENSP00000307863	RRM_1	PF00076.22	4.4e-34	3	3
ENSP00000466935	RRM_1	PF00076.22	3.5e-31	1	2
ENSP00000466935	RRM_1	PF00076.22	3.5e-31	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16906767	The SF3b155 N-terminal domain is a scaffold important for splicing.	Biochemistry	2006 Aug 22	Cass DM	-
22792276	Binding of hnRNP H and U2AF65 to respective G-codes and a poly-uridine tract collaborate in the N50-5'ss selection of the REST N exon in H69 cells.	PLoS One	2012	Ortuno-Pineda C	doi: 10.1371/journal.pone.0040315
9512519	A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition.	Genes Dev	1998 Mar 15	Berglund JA	-
18842594	Solution conformation and thermodynamic characteristics of RNA binding by the splicing factor U2AF65.	J Biol Chem	2008 Nov 28	Jenkins JL	doi: 10.1074/jbc.M806297200
28977511	Towards enhanced and interpretable clustering/classification in integrative genomics.	Nucleic Acids Res	2017 Nov 16	Lu YY	doi: 10.1093/nar/gkx767.
16682775	Crystallization and preliminary X-ray analysis of a U2AF65 variant in complex with a polypyrimidine-tract analogue by use of protein engineering.	Acta Crystallogr Sect F Struct Biol Cryst Commun	2006 May 1	Sickmier EA	-
23175611	Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition.	Nucleic Acids Res	2013 Jan	Zhang Y	doi: 10.1093/nar/gks1097
29650551	HNRNPA1 promotes recognition of splice site decoys by U2AF2 in vivo.	Genome Res	2018 May	Howard JM	doi: 10.1101/gr.229062.117
27720643	Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.	Mol Cell	2016 Oct 20	Cretu C	doi: 10.1016/j.molcel.2016.08.036
9632785	RNA binding activity of heterodimeric splicing factor U2AF: at least one RS domain is required for high-affinity binding.	Mol Cell Biol	1998 Jul	Rudner DZ	-
9166400	Targeting of U2AF65 to sites of active splicing in the nucleus.	J Cell Biol	1997 Jun 2	Gama-Carvalho M	-
8781232	Interaction of U2AF65 RS region with pre-mRNA branch point and promotion of base pairing with U2 snRNA [corrected].	Science	1996 Sep 20	Valcarcel J	-
8713106	Biochemical properties of a novel U2AF65 protein isoform generated by alternative RNA splicing.	Biochem Biophys Res Commun	1996 Jul 25	Ding F	-
12083511	Identification of new poly(A) polymerase-inhibitory proteins capable of regulating pre-mRNA polyadenylation.	J Mol Biol	2002 May 17	Ko B	-
16420481	Major phosphorylation of SF1 on adjacent Ser-Pro motifs enhances interaction with U2AF65.	FEBS J	2006 Feb	Manceau V	-
10931847	An intronic downstream enhancer promotes 3' splice site usage of a neural cell-specific exon.	J Biol Chem	2000 Oct 27	Guo N	-
10864047	Differential recognition of the polypyrimidine-tract by the general splicing factor U2AF65 and the splicing repressor sex-lethal.	RNA	2000 Jun	Singh R	-
10606272	Splicing factor SF1 from Drosophila and Caenorhabditis: presence of an N-terminal RS domain and requirement for viability.	RNA	1999 Dec	Mazroui R	-
18067274	Alternative modes of binding by U2AF65 at the polypyrimidine tract.	Biochemistry	2008 Jan 8	Henscheid KL	-
17312947	Cloning and characterization of a novel splice variant of human U2AF1L3 gene.	DNA Seq	2006 Aug	Chen F	-
23374342	Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements.	Cell	2013 Jan 31	Zarnack K	doi: 10.1016/j.cell.2012.12.023.
27354116	Global regulation of alternative RNA splicing by the SR-rich protein RBM39.	Biochim Biophys Acta	2016 Aug	Mai S	doi: 10.1016/j.bbagrm.2016.06.007
29643205	In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors.	Genome Res	2018 May	Sutandy FXR	doi: 10.1101/gr.229757.117
15377657	Newly Initiated RNA encounters a factor involved in splicing immediately upon emerging from within RNA polymerase II.	J Biol Chem	2004 Nov 26	Ujvari A	-
16921380	Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells.	Nat Struct Mol Biol	2006 Sep	Listerman I	-
22570490	A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels.	J Biol Chem	2012 Jun 29	Liu G	doi: 10.1074/jbc.M112.357343
7535921	Multiple RNA binding domains (RBDs) just don't add up.	Nucleic Acids Res	1995 Mar 11	Shamoo Y	-
19470458	The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing.	Proc Natl Acad Sci U S A	2009 Jun 9	Warf MB	doi: 10.1073/pnas.0900342106
14506271	Structuring of the 3' splice site by U2AF65.	J Biol Chem	2003 Dec 12	Kent OA	-
21071404	An SF1 affinity model to identify branch point sequences in human introns.	Nucleic Acids Res	2011 Mar	Pastuszak AW	doi: 10.1093/nar/gkq1046
20606010	A flexible RNA backbone within the polypyrimidine tract is required for U2AF65 binding and pre-mRNA splicing in vivo.	Mol Cell Biol	2010 Sep	Chen C	doi: 10.1128/MCB.00531-10
23851510	Mechanisms of the androgen receptor splicing in prostate cancer cells.	Oncogene	2014 Jun 12	Liu LL	doi: 10.1038/onc.2013.284
27252533	Two Polypyrimidine Tracts in Intron 4 of the Major Immediate Early Gene Are Critical for Gene Expression Switching from IE1 to IE2 and for Replication of Human Cytomegalovirus.	J Virol	2016 Jul 27	Hou W	doi: 10.1128/JVI.00837-16

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000592874	U2AF2-208	849	-	ENSP00000466167	86 (aa)	-	K7ELP8
ENST00000308924	U2AF2-201	1698	-	ENSP00000307863	475 (aa)	-	P26368
ENST00000588850	U2AF2-205	637	-	-	- (aa)	-	-
ENST00000450554	U2AF2-202	3022	-	ENSP00000388475	471 (aa)	-	P26368
ENST00000592867	U2AF2-207	447	-	-	- (aa)	-	-
ENST00000590551	U2AF2-206	1104	XM_006722994	ENSP00000466935	307 (aa)	XP_006723057	K7ENG2
ENST00000587196	U2AF2-203	778	-	ENSP00000470020	51 (aa)	-	M0QYQ9
ENST00000587275	U2AF2-204	554	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000063244's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000063244	S-(3-hydroxypropyl)cysteine N-acetate	10E-7	26053186
ENSG00000063244	Smoking	10E-7	26053186

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000063244	rs79546472	19	55662011	?	3-hydroxypropylmercapturic acid levels in smokers	26053186	[NR] unit decrease	0.375	EFO_0004318\|EFO_0007014

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000063244's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000063244	U2AF2	83	37.255	ENSG00000179950	PUF60	54	36.000

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000063244	U2AF2	100	89.783	ENSAPOG00000023155	u2af2a	100	89.783	Acanthochromis_polyacanthus
ENSG00000063244	U2AF2	99	83.007	ENSAPOG00000002208	-	100	72.553	Acanthochromis_polyacanthus
ENSG00000063244	U2AF2	99	100.000	ENSAMEG00000003864	U2AF2	100	98.301	Ailuropoda_melanoleuca
ENSG00000063244	U2AF2	99	96.471	ENSACIG00000005749	u2af2a	94	93.548	Amphilophus_citrinellus
ENSG00000063244	U2AF2	99	80.952	ENSACIG00000014173	-	89	78.450	Amphilophus_citrinellus
ENSG00000063244	U2AF2	99	83.660	ENSAOCG00000003595	-	100	72.979	Amphiprion_ocellaris
ENSG00000063244	U2AF2	99	96.471	ENSAOCG00000015571	u2af2a	100	89.597	Amphiprion_ocellaris
ENSG00000063244	U2AF2	99	83.333	ENSAPEG00000020062	-	86	80.198	Amphiprion_percula
ENSG00000063244	U2AF2	99	96.471	ENSAPEG00000009376	u2af2a	95	93.300	Amphiprion_percula
ENSG00000063244	U2AF2	99	96.471	ENSATEG00000022332	u2af2a	100	89.407	Anabas_testudineus
ENSG00000063244	U2AF2	99	83.987	ENSATEG00000020577	-	88	80.693	Anabas_testudineus
ENSG00000063244	U2AF2	99	100.000	ENSACAG00000015489	U2AF2	100	96.421	Anolis_carolinensis
ENSG00000063244	U2AF2	99	100.000	ENSANAG00000028042	U2AF2	100	98.886	Aotus_nancymaae
ENSG00000063244	U2AF2	99	83.660	ENSACLG00000020793	-	100	72.979	Astatotilapia_calliptera
ENSG00000063244	U2AF2	99	96.471	ENSACLG00000022181	u2af2a	100	89.831	Astatotilapia_calliptera
ENSG00000063244	U2AF2	100	90.190	ENSAMXG00000033347	u2af2a	100	84.647	Astyanax_mexicanus
ENSG00000063244	U2AF2	99	92.941	ENSAMXG00000039454	u2af2b	99	85.138	Astyanax_mexicanus
ENSG00000063244	U2AF2	100	99.674	ENSBTAG00000002830	U2AF2	100	99.579	Bos_taurus
ENSG00000063244	U2AF2	99	62.745	WBGene00006697	uaf-1	100	56.081	Caenorhabditis_elegans
ENSG00000063244	U2AF2	100	100.000	ENSCJAG00000017128	U2AF2	100	100.000	Callithrix_jacchus
ENSG00000063244	U2AF2	100	100.000	ENSCAFG00000002551	U2AF2	100	100.000	Canis_familiaris
ENSG00000063244	U2AF2	99	100.000	ENSCAFG00020015445	U2AF2	97	95.896	Canis_lupus_dingo
ENSG00000063244	U2AF2	99	100.000	ENSCHIG00000023595	U2AF2	89	83.010	Capra_hircus
ENSG00000063244	U2AF2	100	100.000	ENSTSYG00000007432	U2AF2	100	100.000	Carlito_syrichta
ENSG00000063244	U2AF2	99	100.000	ENSCAPG00000008466	U2AF2	100	99.782	Cavia_aperea
ENSG00000063244	U2AF2	100	99.789	ENSCPOG00000001582	U2AF2	100	99.789	Cavia_porcellus
ENSG00000063244	U2AF2	100	100.000	ENSCCAG00000023336	U2AF2	100	100.000	Cebus_capucinus
ENSG00000063244	U2AF2	100	100.000	ENSCATG00000004637	U2AF2	100	100.000	Cercocebus_atys
ENSG00000063244	U2AF2	100	100.000	ENSCLAG00000000596	U2AF2	100	100.000	Chinchilla_lanigera
ENSG00000063244	U2AF2	100	100.000	ENSCSAG00000001722	U2AF2	100	100.000	Chlorocebus_sabaeus
ENSG00000063244	U2AF2	100	99.674	ENSCPBG00000004485	U2AF2	100	99.674	Chrysemys_picta_bellii
ENSG00000063244	U2AF2	99	71.336	ENSCING00000003455	-	80	70.918	Ciona_intestinalis
ENSG00000063244	U2AF2	99	71.010	ENSCSAVG00000006813	-	85	69.643	Ciona_savignyi
ENSG00000063244	U2AF2	99	100.000	ENSCANG00000031002	-	96	99.766	Colobus_angolensis_palliatus
ENSG00000063244	U2AF2	99	92.941	ENSCANG00000043845	-	100	92.194	Colobus_angolensis_palliatus
ENSG00000063244	U2AF2	99	93.137	ENSCGRG00001007486	-	99	88.085	Cricetulus_griseus_chok1gshd
ENSG00000063244	U2AF2	100	100.000	ENSCGRG00001003185	-	100	99.789	Cricetulus_griseus_chok1gshd
ENSG00000063244	U2AF2	99	93.137	ENSCGRG00000018587	-	99	88.085	Cricetulus_griseus_crigri
ENSG00000063244	U2AF2	75	99.130	ENSCGRG00000004524	-	79	94.672	Cricetulus_griseus_crigri
ENSG00000063244	U2AF2	99	81.046	ENSCSEG00000020504	-	88	78.894	Cynoglossus_semilaevis
ENSG00000063244	U2AF2	99	96.471	ENSCSEG00000018709	u2af2a	82	91.083	Cynoglossus_semilaevis
ENSG00000063244	U2AF2	99	83.333	ENSCVAG00000023307	-	100	73.191	Cyprinodon_variegatus
ENSG00000063244	U2AF2	99	96.471	ENSCVAG00000001259	u2af2a	100	89.407	Cyprinodon_variegatus
ENSG00000063244	U2AF2	99	95.294	ENSDARG00000011740	u2af2b	100	85.595	Danio_rerio
ENSG00000063244	U2AF2	100	93.506	ENSDARG00000012505	u2af2a	100	85.447	Danio_rerio
ENSG00000063244	U2AF2	99	100.000	ENSDNOG00000047039	U2AF2	96	99.766	Dasypus_novemcinctus
ENSG00000063244	U2AF2	100	100.000	ENSDORG00000003250	U2af2	100	100.000	Dipodomys_ordii
ENSG00000063244	U2AF2	98	54.321	FBgn0034834	LS2	85	53.904	Drosophila_melanogaster
ENSG00000063244	U2AF2	99	73.548	FBgn0005411	U2af50	100	72.776	Drosophila_melanogaster
ENSG00000063244	U2AF2	99	78.176	ENSEBUG00000010917	U2AF2	89	76.543	Eptatretus_burgeri
ENSG00000063244	U2AF2	99	62.866	ENSEBUG00000001732	U2AF2	90	62.562	Eptatretus_burgeri
ENSG00000063244	U2AF2	99	100.000	ENSEASG00005020708	U2AF2	90	97.168	Equus_asinus_asinus
ENSG00000063244	U2AF2	100	100.000	ENSECAG00000010110	U2AF2	100	96.815	Equus_caballus
ENSG00000063244	U2AF2	99	95.349	ENSELUG00000015850	u2af2a	100	87.917	Esox_lucius
ENSG00000063244	U2AF2	99	82.353	ENSELUG00000018459	-	100	71.489	Esox_lucius
ENSG00000063244	U2AF2	100	91.234	ENSELUG00000022291	u2af2b	100	83.298	Esox_lucius
ENSG00000063244	U2AF2	100	100.000	ENSFCAG00000011504	U2AF2	100	100.000	Felis_catus
ENSG00000063244	U2AF2	99	100.000	ENSFDAG00000011264	U2AF2	99	98.081	Fukomys_damarensis
ENSG00000063244	U2AF2	99	96.471	ENSFHEG00000016025	u2af2a	100	88.795	Fundulus_heteroclitus
ENSG00000063244	U2AF2	100	93.831	ENSGMOG00000004535	u2af2a	100	87.605	Gadus_morhua
ENSG00000063244	U2AF2	99	98.824	ENSGALG00000052748	U2AF2	65	95.887	Gallus_gallus
ENSG00000063244	U2AF2	99	83.007	ENSGAFG00000005628	-	100	72.766	Gambusia_affinis
ENSG00000063244	U2AF2	99	96.471	ENSGAFG00000013626	u2af2a	88	89.407	Gambusia_affinis
ENSG00000063244	U2AF2	100	94.463	ENSGACG00000010632	U2AF2	100	88.186	Gasterosteus_aculeatus
ENSG00000063244	U2AF2	99	81.877	ENSGACG00000014500	-	100	74.684	Gasterosteus_aculeatus
ENSG00000063244	U2AF2	100	99.674	ENSGAGG00000011849	U2AF2	100	99.674	Gopherus_agassizii
ENSG00000063244	U2AF2	84	89.494	ENSGGOG00000036399	-	96	89.494	Gorilla_gorilla
ENSG00000063244	U2AF2	99	96.471	ENSHBUG00000013935	u2af2a	100	89.831	Haplochromis_burtoni
ENSG00000063244	U2AF2	99	83.660	ENSHBUG00000017424	-	100	72.979	Haplochromis_burtoni
ENSG00000063244	U2AF2	100	100.000	ENSHGLG00000005889	U2AF2	100	100.000	Heterocephalus_glaber_female
ENSG00000063244	U2AF2	99	100.000	ENSHGLG00100004757	U2AF2	100	100.000	Heterocephalus_glaber_male
ENSG00000063244	U2AF2	100	91.693	ENSHCOG00000019367	u2af2a	100	87.265	Hippocampus_comes
ENSG00000063244	U2AF2	99	79.739	ENSIPUG00000009844	-	100	70.000	Ictalurus_punctatus
ENSG00000063244	U2AF2	100	92.532	ENSIPUG00000007717	u2af2a	100	83.368	Ictalurus_punctatus
ENSG00000063244	U2AF2	97	95.181	ENSIPUG00000009077	u2af2	99	84.519	Ictalurus_punctatus
ENSG00000063244	U2AF2	100	100.000	ENSSTOG00000019595	U2AF2	100	100.000	Ictidomys_tridecemlineatus
ENSG00000063244	U2AF2	100	99.789	ENSJJAG00000017705	U2af2	100	99.789	Jaculus_jaculus
ENSG00000063244	U2AF2	99	96.471	ENSKMAG00000005960	u2af2a	100	89.195	Kryptolebias_marmoratus
ENSG00000063244	U2AF2	99	96.471	ENSLBEG00000016162	u2af2a	100	89.407	Labrus_bergylta
ENSG00000063244	U2AF2	99	80.000	ENSLBEG00000005001	-	89	77.482	Labrus_bergylta
ENSG00000063244	U2AF2	100	98.371	ENSLACG00000001648	U2AF2	100	98.638	Latimeria_chalumnae
ENSG00000063244	U2AF2	99	97.647	ENSLOCG00000008050	u2af2b	80	96.043	Lepisosteus_oculatus
ENSG00000063244	U2AF2	99	83.987	ENSLOCG00000010843	-	100	73.191	Lepisosteus_oculatus
ENSG00000063244	U2AF2	100	100.000	ENSLAFG00000018056	-	100	99.368	Loxodonta_africana
ENSG00000063244	U2AF2	100	90.228	ENSLAFG00000028496	-	100	86.200	Loxodonta_africana
ENSG00000063244	U2AF2	100	100.000	ENSMFAG00000038383	U2AF2	100	100.000	Macaca_fascicularis
ENSG00000063244	U2AF2	100	99.789	ENSMMUG00000004810	U2AF2	100	99.789	Macaca_mulatta
ENSG00000063244	U2AF2	100	100.000	ENSMNEG00000042096	U2AF2	100	100.000	Macaca_nemestrina
ENSG00000063244	U2AF2	100	100.000	ENSMLEG00000032219	U2AF2	89	100.000	Mandrillus_leucophaeus
ENSG00000063244	U2AF2	99	95.294	ENSMAMG00000019817	u2af2a	100	88.075	Mastacembelus_armatus
ENSG00000063244	U2AF2	99	81.699	ENSMAMG00000020158	-	100	71.915	Mastacembelus_armatus
ENSG00000063244	U2AF2	99	96.471	ENSMZEG00005016563	u2af2a	100	89.831	Maylandia_zebra
ENSG00000063244	U2AF2	99	83.660	ENSMZEG00005023318	-	100	72.979	Maylandia_zebra
ENSG00000063244	U2AF2	99	100.000	ENSMAUG00000008180	U2af2	99	98.925	Mesocricetus_auratus
ENSG00000063244	U2AF2	100	100.000	ENSMICG00000027681	U2AF2	100	100.000	Microcebus_murinus
ENSG00000063244	U2AF2	98	96.429	ENSMOCG00000007227	-	100	87.261	Microtus_ochrogaster
ENSG00000063244	U2AF2	100	96.743	ENSMOCG00000001018	-	100	96.743	Microtus_ochrogaster
ENSG00000063244	U2AF2	100	99.789	ENSMOCG00000013214	-	100	99.789	Microtus_ochrogaster
ENSG00000063244	U2AF2	99	76.250	ENSMMOG00000000531	-	100	67.423	Mola_mola
ENSG00000063244	U2AF2	99	96.471	ENSMMOG00000016600	u2af2a	93	92.804	Mola_mola
ENSG00000063244	U2AF2	100	94.463	ENSMALG00000009985	u2af2a	100	88.795	Monopterus_albus
ENSG00000063244	U2AF2	100	100.000	MGP_CAROLIEiJ_G0029150	U2af2	100	100.000	Mus_caroli
ENSG00000063244	U2AF2	100	100.000	ENSMUSG00000030435	U2af2	100	100.000	Mus_musculus
ENSG00000063244	U2AF2	100	100.000	MGP_PahariEiJ_G0021017	U2af2	100	100.000	Mus_pahari
ENSG00000063244	U2AF2	100	100.000	MGP_SPRETEiJ_G0030203	U2af2	100	100.000	Mus_spretus
ENSG00000063244	U2AF2	100	100.000	ENSMPUG00000007135	U2AF2	100	100.000	Mustela_putorius_furo
ENSG00000063244	U2AF2	77	94.606	ENSMLUG00000011051	-	100	95.851	Myotis_lucifugus
ENSG00000063244	U2AF2	100	99.579	ENSNGAG00000020369	U2af2	100	99.579	Nannospalax_galili
ENSG00000063244	U2AF2	99	96.471	ENSNBRG00000002568	u2af2a	100	89.831	Neolamprologus_brichardi
ENSG00000063244	U2AF2	99	81.270	ENSNBRG00000011100	-	89	78.692	Neolamprologus_brichardi
ENSG00000063244	U2AF2	100	100.000	ENSNLEG00000010562	U2AF2	100	100.000	Nomascus_leucogenys
ENSG00000063244	U2AF2	97	89.157	ENSMEUG00000002346	U2AF2	90	83.619	Notamacropus_eugenii
ENSG00000063244	U2AF2	96	82.712	ENSODEG00000009254	-	100	70.085	Octodon_degus
ENSG00000063244	U2AF2	99	100.000	ENSODEG00000012729	-	100	94.737	Octodon_degus
ENSG00000063244	U2AF2	99	96.471	ENSONIG00000012793	u2af2a	100	89.641	Oreochromis_niloticus
ENSG00000063244	U2AF2	99	83.660	ENSONIG00000009682	-	100	72.979	Oreochromis_niloticus
ENSG00000063244	U2AF2	99	95.294	ENSORLG00000011545	u2af2a	100	87.261	Oryzias_latipes
ENSG00000063244	U2AF2	99	95.294	ENSORLG00020006941	u2af2a	100	87.261	Oryzias_latipes_hni
ENSG00000063244	U2AF2	99	95.294	ENSORLG00015012843	u2af2a	100	87.261	Oryzias_latipes_hsok
ENSG00000063244	U2AF2	99	95.294	ENSOMEG00000011386	u2af2a	100	88.960	Oryzias_melastigma
ENSG00000063244	U2AF2	94	73.540	ENSOGAG00000034729	-	80	63.978	Otolemur_garnettii
ENSG00000063244	U2AF2	100	100.000	ENSOGAG00000007206	-	100	100.000	Otolemur_garnettii
ENSG00000063244	U2AF2	99	100.000	ENSOARG00000001091	U2AF2	100	88.470	Ovis_aries
ENSG00000063244	U2AF2	100	100.000	ENSPPAG00000039782	U2AF2	100	100.000	Pan_paniscus
ENSG00000063244	U2AF2	100	100.000	ENSPPRG00000013843	U2AF2	100	100.000	Panthera_pardus
ENSG00000063244	U2AF2	99	100.000	ENSPTIG00000005489	U2AF2	90	93.720	Panthera_tigris_altaica
ENSG00000063244	U2AF2	100	100.000	ENSPTRG00000011523	U2AF2	100	100.000	Pan_troglodytes
ENSG00000063244	U2AF2	100	100.000	ENSPANG00000008459	U2AF2	100	100.000	Papio_anubis
ENSG00000063244	U2AF2	99	82.353	ENSPKIG00000014878	-	100	73.830	Paramormyrops_kingsleyae
ENSG00000063244	U2AF2	99	97.647	ENSPKIG00000024346	u2af2b	91	95.190	Paramormyrops_kingsleyae
ENSG00000063244	U2AF2	99	98.824	ENSPSIG00000008014	U2AF2	100	75.745	Pelodiscus_sinensis
ENSG00000063244	U2AF2	100	84.858	ENSPMGG00000022980	u2af2a	92	84.988	Periophthalmus_magnuspinnatus
ENSG00000063244	U2AF2	100	100.000	ENSPEMG00000007378	U2af2	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000063244	U2AF2	99	78.502	ENSPMAG00000004097	u2af2a	87	78.894	Petromyzon_marinus
ENSG00000063244	U2AF2	100	98.947	ENSPCIG00000018013	U2AF2	100	98.947	Phascolarctos_cinereus
ENSG00000063244	U2AF2	99	83.333	ENSPFOG00000006433	-	100	73.191	Poecilia_formosa
ENSG00000063244	U2AF2	99	96.471	ENSPFOG00000010799	u2af2a	100	89.384	Poecilia_formosa
ENSG00000063244	U2AF2	99	96.471	ENSPLAG00000014365	u2af2a	100	89.407	Poecilia_latipinna
ENSG00000063244	U2AF2	99	83.333	ENSPLAG00000003275	-	89	80.446	Poecilia_latipinna
ENSG00000063244	U2AF2	99	96.471	ENSPMEG00000002969	u2af2a	100	89.407	Poecilia_mexicana
ENSG00000063244	U2AF2	99	83.333	ENSPMEG00000003734	-	89	80.198	Poecilia_mexicana
ENSG00000063244	U2AF2	99	83.007	ENSPREG00000013036	-	100	75.676	Poecilia_reticulata
ENSG00000063244	U2AF2	99	96.471	ENSPREG00000008739	u2af2a	100	89.407	Poecilia_reticulata
ENSG00000063244	U2AF2	92	98.195	ENSPPYG00000010429	-	78	98.195	Pongo_abelii
ENSG00000063244	U2AF2	100	83.654	ENSPCAG00000014399	-	100	83.193	Procavia_capensis
ENSG00000063244	U2AF2	99	84.314	ENSPCAG00000003709	-	99	82.266	Procavia_capensis
ENSG00000063244	U2AF2	100	100.000	ENSPCOG00000025870	U2AF2	100	100.000	Propithecus_coquereli
ENSG00000063244	U2AF2	100	99.579	ENSPVAG00000004540	U2AF2	100	99.579	Pteropus_vampyrus
ENSG00000063244	U2AF2	99	83.660	ENSPNYG00000011605	-	100	72.979	Pundamilia_nyererei
ENSG00000063244	U2AF2	99	96.471	ENSPNYG00000001438	u2af2a	100	89.831	Pundamilia_nyererei
ENSG00000063244	U2AF2	99	83.333	ENSPNAG00000007182	-	100	72.979	Pygocentrus_nattereri
ENSG00000063244	U2AF2	99	93.160	ENSPNAG00000027289	u2af2b	99	86.412	Pygocentrus_nattereri
ENSG00000063244	U2AF2	100	93.831	ENSPNAG00000017620	u2af2a	100	85.447	Pygocentrus_nattereri
ENSG00000063244	U2AF2	100	100.000	ENSRNOG00000015914	U2af2	100	100.000	Rattus_norvegicus
ENSG00000063244	U2AF2	100	99.789	ENSRBIG00000041018	U2AF2	100	99.789	Rhinopithecus_bieti
ENSG00000063244	U2AF2	100	94.480	ENSRROG00000031238	-	100	94.480	Rhinopithecus_roxellana
ENSG00000063244	U2AF2	99	100.000	ENSRROG00000031103	-	100	99.758	Rhinopithecus_roxellana
ENSG00000063244	U2AF2	100	100.000	ENSSBOG00000023891	U2AF2	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000063244	U2AF2	99	68.033	ENSSHAG00000001167	U2AF2	85	77.898	Sarcophilus_harrisii
ENSG00000063244	U2AF2	100	94.481	ENSSFOG00015019182	u2af2b	89	94.430	Scleropages_formosus
ENSG00000063244	U2AF2	99	82.026	ENSSFOG00015003884	-	94	81.888	Scleropages_formosus
ENSG00000063244	U2AF2	99	96.471	ENSSMAG00000012582	u2af2a	100	88.347	Scophthalmus_maximus
ENSG00000063244	U2AF2	99	83.987	ENSSMAG00000013779	-	100	72.766	Scophthalmus_maximus
ENSG00000063244	U2AF2	99	80.757	ENSSDUG00000021434	-	84	78.313	Seriola_dumerili
ENSG00000063244	U2AF2	99	96.471	ENSSDUG00000009457	u2af2a	100	89.384	Seriola_dumerili
ENSG00000063244	U2AF2	99	80.757	ENSSLDG00000016151	-	89	78.313	Seriola_lalandi_dorsalis
ENSG00000063244	U2AF2	99	96.471	ENSSLDG00000022742	u2af2a	100	89.407	Seriola_lalandi_dorsalis
ENSG00000063244	U2AF2	99	100.000	ENSSPUG00000010229	U2AF2	100	94.990	Sphenodon_punctatus
ENSG00000063244	U2AF2	99	83.333	ENSSPAG00000005241	-	100	72.766	Stegastes_partitus
ENSG00000063244	U2AF2	99	96.471	ENSSPAG00000022519	u2af2a	100	89.619	Stegastes_partitus
ENSG00000063244	U2AF2	100	100.000	ENSSSCG00000034815	U2AF2	100	100.000	Sus_scrofa
ENSG00000063244	U2AF2	99	96.471	ENSTRUG00000005514	u2af2a	90	90.819	Takifugu_rubripes
ENSG00000063244	U2AF2	99	82.085	ENSTNIG00000011257	-	100	73.248	Tetraodon_nigroviridis
ENSG00000063244	U2AF2	99	96.471	ENSTNIG00000008106	U2AF2	100	88.983	Tetraodon_nigroviridis
ENSG00000063244	U2AF2	99	91.765	ENSTBEG00000009104	U2AF2	100	95.135	Tupaia_belangeri
ENSG00000063244	U2AF2	100	100.000	ENSTTRG00000000987	U2AF2	100	100.000	Tursiops_truncatus
ENSG00000063244	U2AF2	99	100.000	ENSUAMG00000019883	U2AF2	100	96.937	Ursus_americanus
ENSG00000063244	U2AF2	100	100.000	ENSUMAG00000024586	U2AF2	100	100.000	Ursus_maritimus
ENSG00000063244	U2AF2	100	100.000	ENSVVUG00000006956	U2AF2	67	100.000	Vulpes_vulpes
ENSG00000063244	U2AF2	99	98.824	ENSXETG00000019128	u2af2	100	93.333	Xenopus_tropicalis
ENSG00000063244	U2AF2	99	96.471	ENSXCOG00000019406	u2af2a	92	93.300	Xiphophorus_couchianus
ENSG00000063244	U2AF2	99	82.680	ENSXMAG00000000768	-	96	72.553	Xiphophorus_maculatus
ENSG00000063244	U2AF2	99	96.471	ENSXMAG00000011979	u2af2a	100	89.407	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000243	commitment complex	21873635.	IBA	Component
GO:0000398	mRNA splicing, via spliceosome	9731529.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	1824937.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000974	Prp19 complex	21536736.	IDA	Component
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	9237760.9447963.10449420.11551507.12718882.16189514.16713569.17024186.17589525.18559666.18951082.20467437.20696395.21460037.21516116.21536736.21988832.22365833.22569250.22905162.23273425.23602568.24389012.25416956.26420826.	IPI	Function
GO:0005634	nucleus	1824937.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	9731529.	IDA	Component
GO:0006397	mRNA processing	1538748.	TAS	Process
GO:0006405	RNA export from nucleus	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0008187	poly-pyrimidine tract binding	21873635.	IBA	Function
GO:0016607	nuclear speck	21873635.	IBA	Component
GO:0016607	nuclear speck	1824937.21984414.	IDA	Component
GO:0019899	enzyme binding	19574390.	IPI	Function
GO:0030628	pre-mRNA 3'-splice site binding	21873635.	IBA	Function
GO:0030628	pre-mRNA 3'-splice site binding	2531895.	IDA	Function
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0031397	negative regulation of protein ubiquitination	24389012.	IDA	Process
GO:0031397	negative regulation of protein ubiquitination	24389012.	IMP	Process
GO:0033120	positive regulation of RNA splicing	21536736.	IDA	Process
GO:0048025	negative regulation of mRNA splicing, via spliceosome	15009664.	IDA	Process
GO:0070742	C2H2 zinc finger domain binding	-	IEA	Function
GO:0071004	U2-type prespliceosome	21873635.	IBA	Component
GO:0071004	U2-type prespliceosome	2531895.	IDA	Component
GO:0089701	U2AF	21873635.	IBA	Component
GO:0089701	U2AF	1824937.2531895.	IDA	Component