EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000064607 (Gene tree)
Gene ID: 10147
Gene Symbol: SUGP2
Alias: KIAA0365|SFRS14
Full Name: SURP and G-patch domain containing 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 43,136 bases
Position: chr19:18,990,888-19,034,023
Accession: 18641
RBP type: canonical RBP
Summary: This gene encodes a member of the arginine/serine-rich family of splicing factors. The encoded protein functions in mRNA processing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000337926	Surp	PF01805.20	2.6e-15	1	1
ENSP00000389380	Surp	PF01805.20	2.6e-15	1	1
ENSP00000472286	Surp	PF01805.20	2.6e-15	1	1
ENSP00000472914	Surp	PF01805.20	2.7e-15	1	1
ENSP00000337926	G-patch	PF01585.23	4.9e-14	1	1
ENSP00000389380	G-patch	PF01585.23	4.9e-14	1	1
ENSP00000472286	G-patch	PF01585.23	4.9e-14	1	1
ENSP00000472914	G-patch	PF01585.23	5e-14	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12594045	SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11.	Gene	2003 Feb 13	Sampson ND	-
22125086	The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1.	Hum Mutat	2012 Mar	Nordin A	doi: 10.1002/humu.22002

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000597095	SUGP2-207	536	-	-	- (aa)	-	-
ENST00000452918	SUGP2-203	6176	-	ENSP00000389380	1082 (aa)	-	Q8IX01
ENST00000597280	SUGP2-209	814	-	ENSP00000472878	65 (aa)	-	M0R2Y3
ENST00000594773	SUGP2-206	4169	-	ENSP00000470915	1040 (aa)	-	Q8IX01
ENST00000601879	SUGP2-215	5546	-	ENSP00000472286	1082 (aa)	-	Q8IX01
ENST00000600239	SUGP2-213	5565	-	ENSP00000473187	841 (aa)	-	M0R3F6
ENST00000594445	SUGP2-205	732	-	ENSP00000471042	111 (aa)	-	M0R065
ENST00000600377	SUGP2-214	4752	XM_024451307	ENSP00000472914	1096 (aa)	XP_024307075	M0R2Z9
ENST00000593795	SUGP2-204	747	-	ENSP00000472183	53 (aa)	-	M0R1Y3
ENST00000337018	SUGP2-202	3640	-	ENSP00000337926	1082 (aa)	-	Q8IX01
ENST00000597163	SUGP2-208	423	-	-	- (aa)	-	-
ENST00000330854	SUGP2-201	3629	-	ENSP00000332373	1030 (aa)	-	Q8IX01
ENST00000598240	SUGP2-211	3235	-	ENSP00000472244	170 (aa)	-	M0R216
ENST00000598863	SUGP2-212	551	-	-	- (aa)	-	-
ENST00000598202	SUGP2-210	764	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000064607's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000064607	rs141292672	19	19020204	?	DNA methylation variation (age effect)	30348214			GO_0006306

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000064607's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000064607	SUGP2	100	86.941	ENSAMEG00000011613	SUGP2	100	86.575	Ailuropoda_melanoleuca
ENSG00000064607	SUGP2	98	76.978	ENSAPLG00000006469	SUGP2	100	52.551	Anas_platyrhynchos
ENSG00000064607	SUGP2	100	96.396	ENSANAG00000027159	SUGP2	100	95.199	Aotus_nancymaae
ENSG00000064607	SUGP2	100	92.958	ENSBTAG00000013288	SUGP2	94	92.958	Bos_taurus
ENSG00000064607	SUGP2	100	97.297	ENSCJAG00000019714	SUGP2	100	95.568	Callithrix_jacchus
ENSG00000064607	SUGP2	100	87.281	ENSCAFG00000014431	SUGP2	100	87.281	Canis_familiaris
ENSG00000064607	SUGP2	100	87.061	ENSCAFG00020012392	SUGP2	100	87.056	Canis_lupus_dingo
ENSG00000064607	SUGP2	100	92.254	ENSCHIG00000000571	SUGP2	100	85.305	Capra_hircus
ENSG00000064607	SUGP2	100	89.246	ENSTSYG00000027045	SUGP2	100	89.020	Carlito_syrichta
ENSG00000064607	SUGP2	100	75.556	ENSCAPG00000017450	SUGP2	100	72.313	Cavia_aperea
ENSG00000064607	SUGP2	100	75.556	ENSCPOG00000006372	SUGP2	100	73.455	Cavia_porcellus
ENSG00000064607	SUGP2	100	96.396	ENSCCAG00000023178	SUGP2	100	96.214	Cebus_capucinus
ENSG00000064607	SUGP2	100	99.099	ENSCATG00000029755	SUGP2	100	97.786	Cercocebus_atys
ENSG00000064607	SUGP2	100	80.240	ENSCLAG00000011375	SUGP2	100	76.658	Chinchilla_lanigera
ENSG00000064607	SUGP2	100	99.099	ENSCSAG00000005226	SUGP2	100	97.970	Chlorocebus_sabaeus
ENSG00000064607	SUGP2	96	79.167	ENSCPBG00000012487	SUGP2	92	80.952	Chrysemys_picta_bellii
ENSG00000064607	SUGP2	100	97.297	ENSCANG00000040758	SUGP2	100	97.240	Colobus_angolensis_palliatus
ENSG00000064607	SUGP2	100	77.901	ENSCGRG00001018264	Sugp2	98	77.901	Cricetulus_griseus_chok1gshd
ENSG00000064607	SUGP2	100	77.901	ENSCGRG00000009524	Sugp2	98	77.901	Cricetulus_griseus_crigri
ENSG00000064607	SUGP2	75	77.165	ENSDNOG00000037751	-	99	71.292	Dasypus_novemcinctus
ENSG00000064607	SUGP2	96	68.750	ENSDORG00000011519	Sugp2	100	69.164	Dipodomys_ordii
ENSG00000064607	SUGP2	99	70.065	ENSETEG00000010805	SUGP2	99	70.343	Echinops_telfairi
ENSG00000064607	SUGP2	100	86.517	ENSEASG00005006565	SUGP2	100	85.441	Equus_asinus_asinus
ENSG00000064607	SUGP2	100	86.839	ENSECAG00000000129	SUGP2	94	94.366	Equus_caballus
ENSG00000064607	SUGP2	100	87.158	ENSFCAG00000009765	SUGP2	100	87.432	Felis_catus
ENSG00000064607	SUGP2	99	77.273	ENSFDAG00000021304	SUGP2	99	75.386	Fukomys_damarensis
ENSG00000064607	SUGP2	92	81.000	ENSGALG00000003047	SUGP2	87	81.000	Gallus_gallus
ENSG00000064607	SUGP2	96	79.167	ENSGAGG00000006784	SUGP2	94	80.556	Gopherus_agassizii
ENSG00000064607	SUGP2	100	100.000	ENSGGOG00000013540	SUGP2	100	99.538	Gorilla_gorilla
ENSG00000064607	SUGP2	100	75.568	ENSHGLG00000007497	SUGP2	99	75.477	Heterocephalus_glaber_female
ENSG00000064607	SUGP2	97	75.908	ENSHGLG00100006566	SUGP2	99	74.672	Heterocephalus_glaber_male
ENSG00000064607	SUGP2	100	88.288	ENSSTOG00000026887	SUGP2	100	85.909	Ictidomys_tridecemlineatus
ENSG00000064607	SUGP2	100	75.676	ENSJJAG00000005264	Sugp2	100	74.497	Jaculus_jaculus
ENSG00000064607	SUGP2	85	63.235	ENSLACG00000010085	SUGP2	78	63.235	Latimeria_chalumnae
ENSG00000064607	SUGP2	100	78.105	ENSLAFG00000018646	SUGP2	100	78.473	Loxodonta_africana
ENSG00000064607	SUGP2	100	98.198	ENSMFAG00000040352	SUGP2	100	97.450	Macaca_fascicularis
ENSG00000064607	SUGP2	100	99.099	ENSMMUG00000019665	SUGP2	99	97.325	Macaca_mulatta
ENSG00000064607	SUGP2	100	99.099	ENSMNEG00000043062	SUGP2	100	97.632	Macaca_nemestrina
ENSG00000064607	SUGP2	96	97.603	ENSMLEG00000036719	SUGP2	100	97.603	Mandrillus_leucophaeus
ENSG00000064607	SUGP2	91	75.887	ENSMGAG00000004496	SUGP2	99	54.377	Meleagris_gallopavo
ENSG00000064607	SUGP2	100	77.348	ENSMAUG00000011371	Sugp2	100	73.035	Mesocricetus_auratus
ENSG00000064607	SUGP2	100	80.702	ENSMOCG00000009704	Sugp2	100	73.564	Microtus_ochrogaster
ENSG00000064607	SUGP2	100	60.374	ENSMODG00000003992	SUGP2	100	60.765	Monodelphis_domestica
ENSG00000064607	SUGP2	100	80.702	MGP_CAROLIEiJ_G0031137	Sugp2	100	72.678	Mus_caroli
ENSG00000064607	SUGP2	100	75.543	ENSMUSG00000036054	Sugp2	100	73.535	Mus_musculus
ENSG00000064607	SUGP2	100	79.532	MGP_PahariEiJ_G0021602	Sugp2	100	72.628	Mus_pahari
ENSG00000064607	SUGP2	100	76.087	MGP_SPRETEiJ_G0032255	Sugp2	100	73.718	Mus_spretus
ENSG00000064607	SUGP2	100	87.250	ENSMPUG00000015478	SUGP2	100	87.250	Mustela_putorius_furo
ENSG00000064607	SUGP2	100	84.147	ENSMLUG00000012189	SUGP2	100	84.147	Myotis_lucifugus
ENSG00000064607	SUGP2	100	79.444	ENSNGAG00000005936	Sugp2	100	74.702	Nannospalax_galili
ENSG00000064607	SUGP2	100	100.000	ENSNLEG00000006162	SUGP2	100	96.185	Nomascus_leucogenys
ENSG00000064607	SUGP2	86	83.688	ENSMEUG00000011307	SUGP2	96	63.774	Notamacropus_eugenii
ENSG00000064607	SUGP2	78	89.189	ENSOPRG00000015993	-	84	69.156	Ochotona_princeps
ENSG00000064607	SUGP2	100	78.212	ENSODEG00000012058	SUGP2	100	75.708	Octodon_degus
ENSG00000064607	SUGP2	98	56.757	ENSOANG00000004574	SUGP2	99	56.645	Ornithorhynchus_anatinus
ENSG00000064607	SUGP2	100	90.991	ENSOGAG00000024068	SUGP2	100	89.770	Otolemur_garnettii
ENSG00000064607	SUGP2	100	92.958	ENSOARG00000009811	SUGP2	100	82.550	Ovis_aries
ENSG00000064607	SUGP2	96	99.424	ENSPPAG00000043787	SUGP2	98	99.424	Pan_paniscus
ENSG00000064607	SUGP2	100	87.511	ENSPPRG00000010924	SUGP2	100	87.603	Panthera_pardus
ENSG00000064607	SUGP2	100	86.888	ENSPTIG00000012003	SUGP2	100	86.981	Panthera_tigris_altaica
ENSG00000064607	SUGP2	100	100.000	ENSPTRG00000010727	SUGP2	100	99.361	Pan_troglodytes
ENSG00000064607	SUGP2	100	99.099	ENSPANG00000004442	SUGP2	100	97.632	Papio_anubis
ENSG00000064607	SUGP2	69	79.167	ENSPSIG00000008256	SUGP2	92	80.556	Pelodiscus_sinensis
ENSG00000064607	SUGP2	100	77.901	ENSPEMG00000009700	Sugp2	98	77.901	Peromyscus_maniculatus_bairdii
ENSG00000064607	SUGP2	100	59.946	ENSPCIG00000000974	SUGP2	99	60.978	Phascolarctos_cinereus
ENSG00000064607	SUGP2	100	100.000	ENSPPYG00000009756	SUGP2	100	98.244	Pongo_abelii
ENSG00000064607	SUGP2	100	89.935	ENSPCOG00000016042	SUGP2	100	89.718	Propithecus_coquereli
ENSG00000064607	SUGP2	74	84.921	ENSPVAG00000005047	SUGP2	74	87.739	Pteropus_vampyrus
ENSG00000064607	SUGP2	100	77.348	ENSRNOG00000020269	Sugp2	100	73.010	Rattus_norvegicus
ENSG00000064607	SUGP2	100	98.198	ENSRBIG00000020354	SUGP2	100	97.905	Rhinopithecus_bieti
ENSG00000064607	SUGP2	100	98.198	ENSRROG00000029264	SUGP2	100	97.970	Rhinopithecus_roxellana
ENSG00000064607	SUGP2	100	97.297	ENSSBOG00000020629	SUGP2	100	92.160	Saimiri_boliviensis_boliviensis
ENSG00000064607	SUGP2	100	60.536	ENSSHAG00000011705	SUGP2	100	61.552	Sarcophilus_harrisii
ENSG00000064607	SUGP2	100	74.354	ENSSARG00000007461	SUGP2	100	74.354	Sorex_araneus
ENSG00000064607	SUGP2	100	48.551	ENSSPUG00000010736	-	100	49.139	Sphenodon_punctatus
ENSG00000064607	SUGP2	100	45.946	ENSSPUG00000010778	-	100	46.335	Sphenodon_punctatus
ENSG00000064607	SUGP2	100	86.873	ENSSSCG00000025839	SUGP2	100	86.782	Sus_scrofa
ENSG00000064607	SUGP2	69	65.957	ENSTGUG00000001088	SUGP2	100	54.648	Taeniopygia_guttata
ENSG00000064607	SUGP2	100	92.254	ENSTTRG00000006138	SUGP2	100	86.606	Tursiops_truncatus
ENSG00000064607	SUGP2	100	87.158	ENSUAMG00000007085	SUGP2	100	86.794	Ursus_americanus
ENSG00000064607	SUGP2	100	83.698	ENSUMAG00000006467	SUGP2	100	83.424	Ursus_maritimus
ENSG00000064607	SUGP2	89	88.923	ENSVPAG00000006943	SUGP2	92	88.923	Vicugna_pacos
ENSG00000064607	SUGP2	100	87.079	ENSVVUG00000007744	SUGP2	100	85.755	Vulpes_vulpes
ENSG00000064607	SUGP2	65	37.573	ENSXETG00000030450	-	98	38.305	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0016604	nuclear body	-	IDA	Component