EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000064666 (Gene tree)
Gene ID: 1265
Gene Symbol: CNN2
Alias: N
Full Name: calponin 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 12,794 bases
Position: chr19:1,026,275-1,039,068
Accession: 2156
RBP type: non-canonical RBP
Summary: The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000565096	CNN2-207	2109	-	ENSP00000457968	298 (aa)	-	B4DDF4
ENST00000566695	CNN2-208	828	-	ENSP00000484533	191 (aa)	-	A0A087X1X5
ENST00000263097	CNN2-201	2179	-	ENSP00000263097	309 (aa)	-	Q99439
ENST00000562015	CNN2-203	563	-	ENSP00000479188	66 (aa)	-	A0A087WV51
ENST00000562075	CNN2-204	623	-	ENSP00000455777	154 (aa)	-	H3BQH0
ENST00000348419	CNN2-202	2033	-	ENSP00000340129	270 (aa)	-	Q99439
ENST00000607102	CNN2-212	307	-	ENSP00000475175	103 (aa)	-	U3KPS3
ENST00000568865	CNN2-209	1332	-	ENSP00000458137	218 (aa)	-	H3BVI6
ENST00000606983	CNN2-211	537	-	ENSP00000484749	179 (aa)	-	A0A087X271
ENST00000562958	CNN2-205	2194	-	ENSP00000456436	330 (aa)	-	B4DUT8
ENST00000564572	CNN2-206	2266	-	-	- (aa)	-	-
ENST00000569352	CNN2-210	731	-	ENSP00000468577	148 (aa)	-	K7ES69

Gene Model

Click here to download ENSG00000064666's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000064666	Macular Degeneration	3E-8	26691988
ENSG00000064666	Wet Macular Degeneration	3E-8	26691988

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000064666	rs4807455	19	1033560	A	Mean platelet volume	27863252	[0.02-0.037] unit decrease	0.02862183	EFO_0004584
ENSG00000064666	rs67538026	19	1031439	?	Advanced age-related macular degeneration	26691988		1.1111112	EFO_1001492\|EFO_0001365\|EFO_0004683
ENSG00000064666	rs930232	19	1036019	A	Granulocyte count	27863252	[0.016-0.03] unit increase	0.02305395	EFO_0007987

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000064666's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001725	stress fiber	16236705.	IDA	Component
GO:0003779	actin binding	-	IEA	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005856	cytoskeleton	8889829.	TAS	Component
GO:0005911	cell-cell junction	8889829.	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0007010	cytoskeleton organization	8889829.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0031032	actomyosin structure organization	-	IEA	Process
GO:0032970	regulation of actin filament-based process	16236705.	IDA	Process
GO:0035580	specific granule lumen	-	TAS	Component
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0071260	cellular response to mechanical stimulus	16236705.	IDA	Process
GO:1904724	tertiary granule lumen	-	TAS	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29333089	Lentivirus-mediated shRNA Targeting CNN2 Inhibits Hepatocarcinoma in Vitro and in Vivo.	Int J Med Sci	2018 Jan 1	Kang X	doi: 10.7150/ijms.21113
25099617	Calponin-h2: a potential serum marker for the early detection of human breast cancer?	Tumour Biol	2014 Nov	Debald M	doi: 10.1007/s13277-014-2419-6
28714360	Knockdown of calponin 2 suppressed cell growth in gastric cancer cells.	Tumour Biol	2017 Jul	Hu J	doi: 10.1177/1010428317706455.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr19	1036590	Intron	novel		0.13
BLCA	chr19	1036605	Intron	novel		0.35
BLCA	chr19	1032582	Missense_Mutation	NA	I92M	0.1
BLCA	chr19	1036478	Silent	novel	L190L	0.06
BLCA	chr19	1031130	Silent	novel	L41L	0.22
BLCA	chr19	1037966	3'UTR	novel		0.53
BLCA	chr19	1037664	Missense_Mutation	novel	D232N	0.28
BLCA	chr19	1037771	Missense_Mutation	NA	Q267H	0.36
BLCA	chr19	1036076	Intron	novel		0.41
BRCA	chr19	1032431	Missense_Mutation	rs568958979	I75M	0.32
CESC	chr19	1037783	Silent	NA	P271P	0.35
CESC	chr19	1038078	3'UTR	novel		0.31
CESC	chr19	1036643	Intron	novel		0.52
COAD	chr19	1037787	Missense_Mutation	novel	Y273D	0.74
COAD	chr19	1037658	Missense_Mutation	novel	I230V	0.44
COAD	chr19	1037662	Missense_Mutation	rs757933615	Y231C	0.41
COAD	chr19	1036170	Missense_Mutation	novel	V144A	0.23
COAD	chr19	1037864	Missense_Mutation	novel	E298D	0.39
COAD	chr19	1037679	Missense_Mutation	NA	T237A	0.44
COAD	chr19	1037815	Missense_Mutation	novel	G282V	0.15
COAD	chr19	1037849	Frame_Shift_Del	NA	*E295Rfs45**	0.46
COAD	chr19	1032390	Splice_Site	novel	X62_splice	0.13
DLBC	chr19	1037765	Silent	novel	G265G	0.25
GBM	chr19	1032681	Silent	rs775599276	L125L	0.35
GBM	chr19	1037690	Silent	novel	C240C	0.1
GBM	chr19	1036426	Missense_Mutation	novel	N173S	0.16
GBM	chr19	1032667	Frame_Shift_Del	novel	*Q121Rfs39**	0.59
HNSC	chr19	1032418	Missense_Mutation	novel	S71C	0.37
HNSC	chr19	1036566	Splice_Region	novel		0.38
KIRC	chr19	1037670	Missense_Mutation	NA	K234E	0.52
LGG	chr19	1037634	Missense_Mutation	novel	T222A	0.08
LIHC	chr19	1036447	Missense_Mutation	novel	G180D	0.32
LUAD	chr19	1037756	Silent	rs575306222	F262F	0.08
LUAD	chr19	1037794	Missense_Mutation	rs370941672	P275L	0.24
LUSC	chr19	1036165	Silent	novel	I142I	0.1
LUSC	chr19	1037868	Frame_Shift_Del	novel	*P301Lfs72**	0.22
LUSC	chr19	1036487	Silent	NA	P193P	0.12
OV	chr19	1036538	Missense_Mutation	NA	M210I	0.53
OV	chr19	1037671	Missense_Mutation	novel	K234M	0.28
PAAD	chr19	1032602	Missense_Mutation	novel	G99D	0.17
READ	chr19	1036490	Missense_Mutation	NA	K194N	0.13
SARC	chr19	1036081	Intron	novel		0.16
SARC	chr19	1032436	Missense_Mutation	novel	R77L	0.21
SKCM	chr19	1036120	Intron	NA		0.34
SKCM	chr19	1032431	Silent	NA	I75I	0.32
SKCM	chr19	1037847	Missense_Mutation	NA	P293S	0.24
SKCM	chr19	1037644	Missense_Mutation	NA	G225E	0.56
SKCM	chr19	1031118	Nonsense_Mutation	novel	W37*	0.39
SKCM	chr19	1036603	Intron	novel		0.06
SKCM	chr19	1036120	Intron	NA		0.15
SKCM	chr19	1031089	Missense_Mutation	novel	P28S	0.36
SKCM	chr19	1031122	Missense_Mutation	novel	E39K	0.25
STAD	chr19	1037929	3'UTR	rs528824723		0.4
STAD	chr19	1036232	Missense_Mutation	rs370563052	V165I	0.42
THCA	chr19	1037876	Nonsense_Mutation	NA	Y302*	0.3
THCA	chr19	1036607	Intron	novel		0.03
UCEC	chr19	1037745	Missense_Mutation	rs756697104	G259S	0.37
UCEC	chr19	1036558	Missense_Mutation	novel	S217N	0.23
UCEC	chr19	1036137	Missense_Mutation	rs780637979	T133N	0.33
UCEC	chr19	1032577	Missense_Mutation	NA	F91L	0.4
UCEC	chr19	1036138	Silent	novel	T133T	0.22
UCEC	chr19	1031121	Silent	rs771274718	I38I	0.53
UCEC	chr19	1036439	Silent	novel	S177S	0.35
UCEC	chr19	1036672	Intron	novel		0.63
UCEC	chr19	1036503	Frame_Shift_Del	novel	*M201Wfs21**	0.23
UCEC	chr19	1036503	Frame_Shift_Del	novel	*M201Wfs21**	0.48
UCEC	chr19	1032637	Missense_Mutation	novel	L111M	0.47
UCEC	chr19	1037763	Missense_Mutation	novel	G265C	0.34
UCEC	chr19	1037834	Silent	novel	G288G	0.42
UCEC	chr19	1037660	Silent	novel	I230I	0.34
UCEC	chr19	1038039	3'UTR	novel		0.62

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.2181	7.2756e-08
ESCA	DEL	0.3587	8.6035e-06
LIHC	DEL	0.1892	4.7028e-08
PAAD	DEL	0.1467	0.0060878
READ	DEL	0.1273	0.23023
SKCM	DEL	0.1771	0.0059983
THCA	DEL	0.012	0.10598
UCS	DEL	0.7857	8.0449e-14

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00041	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.0039	Kaplan-Meier Survival Analysis
BRCA	0.021	Kaplan-Meier Survival Analysis
ESCA	0.0059	Kaplan-Meier Survival Analysis
KIRP	0.0076	Kaplan-Meier Survival Analysis
CHOL	0.041	Kaplan-Meier Survival Analysis
UVM	0.0048	Kaplan-Meier Survival Analysis
OV	0.025	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742