EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000065135 (Gene tree)
Gene ID: 2773
Gene Symbol: GNAI3
Alias: 87U6
Full Name: G protein subunit alpha i3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 69,758 bases
Position: chr1:109,548,564-109,618,321
Accession: 4387
RBP type: non-canonical RBP
Summary: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000369851	GNAI3-201	27174	-	ENSP00000358867	354 (aa)	-	P08754

Gene Model

Click here to download ENSG00000065135's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04015	Rap1 signaling pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04062	Chemokine signaling pathway	KEGG
hsa04071	Sphingolipid signaling pathway	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04360	Axon guidance	KEGG
hsa04371	Apelin signaling pathway	KEGG
hsa04540	Gap junction	KEGG
hsa04611	Platelet activation	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa04713	Circadian entrainment	KEGG
hsa04723	Retrograde endocannabinoid signaling	KEGG
hsa04724	Glutamatergic synapse	KEGG
hsa04725	Cholinergic synapse	KEGG
hsa04726	Serotonergic synapse	KEGG
hsa04727	GABAergic synapse	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa04730	Long-term depression	KEGG
hsa04914	Progesterone-mediated oocyte maturation	KEGG
hsa04915	Estrogen signaling pathway	KEGG
hsa04916	Melanogenesis	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa04923	Regulation of lipolysis in adipocytes	KEGG
hsa04924	Renin secretion	KEGG
hsa04926	Relaxin signaling pathway	KEGG
hsa04928	Parathyroid hormone synthesis, secretion and action	KEGG
hsa04934	Cushing syndrome	KEGG
hsa04971	Gastric acid secretion	KEGG
hsa05012	Parkinson disease	KEGG
hsa05030	Cocaine addiction	KEGG
hsa05032	Morphine addiction	KEGG
hsa05034	Alcoholism	KEGG
hsa05133	Pertussis	KEGG
hsa05142	Chagas disease (American trypanosomiasis)	KEGG
hsa05145	Toxoplasmosis	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG
hsa05200	Pathways in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000065135	Platelet Function Tests	2.2204460E-016	-
ENSG00000065135	Depressive Disorder	1E-6	20125088

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000065135	rs17024393	1	109612066	T	Hip circumference	25673412	[0.044-0.083] unit decrease	0.0632	EFO_0005093
ENSG00000065135	rs17024393	1	109612066	T	Hip circumference	25673412	[0.058-0.11] unit decrease	0.0842	EFO_0005093
ENSG00000065135	rs17024393	1	109612066	C	Childhood body mass index	26604143			EFO_0004340
ENSG00000065135	rs17024258	1	109604699	T	Obesity	23563607	[NR]	1.25	EFO_0001073
ENSG00000065135	rs6537837	1	109577110	T	Major depressive disorder	20125088		1.43	EFO_0003761
ENSG00000065135	rs17024393	1	109612066	C	Body mass index in physically active individuals	28448500	[0.056-0.099] kg/m2 increase	0.0775	EFO_0008002\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	T	BMI (adjusted for smoking behaviour)	28443625	[0.044-0.089] kg/m2 decrease	0.0661	EFO_0004318\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	T	BMI (adjusted for smoking behaviour)	28443625	[0.048-0.083] kg/m2 decrease	0.0656	EFO_0004318\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	T	BMI (adjusted for smoking behaviour)	28443625	[0.037-0.091] kg/m2 decrease	0.0641	EFO_0004318\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	T	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	T	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	T	BMI in non-smokers	28443625	[0.043-0.084] kg/m2 decrease	0.0632	EFO_0004340
ENSG00000065135	rs17024393	1	109612066	T	BMI in non-smokers	28443625	[0.035-0.085] kg/m2 decrease	0.06	EFO_0004340
ENSG00000065135	rs17024393	1	109612066	C	Body mass index	28448500	[0.058-0.096] kg/m2 increase	0.0771	EFO_0008002\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	C	Body mass index	28448500	[0.041-0.101] kg/m2 increase	0.0709	EFO_0008002\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	C	Body mass index	28448500	[0.063-0.104] kg/m2 increase	0.0835	EFO_0008002\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	C	Body mass index	28448500	[0.061-0.115] kg/m2 increase	0.0881	EFO_0008002\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	C	Body mass index	28448500	[0.044-0.101] kg/m2 increase	0.0723	EFO_0008002\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	C	Body mass index in physically active individuals	28448500	[0.061-0.12] kg/m2 increase	0.0906	EFO_0008002\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	C	Body mass index in physically active individuals	28448500	[0.06-0.106] kg/m2 increase	0.0831	EFO_0008002\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000065135	rs17024393	1	109612066	T	Hand grip strength	29691431	[0.0032-0.0068] unit increase	0.005	EFO_0006941
ENSG00000065135	rs17024393	1	109612066	T	Body mass index	30108127	[NR] unit decrease	0.053	EFO_0004340
ENSG00000065135	rs17024393	1	109612066	C	Body mass index	26961502	[0.045-0.095] unit increase	0.07	EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000065135's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	12642577.	IDA	Component
GO:0001664	G protein-coupled receptor binding	21873635.	IBA	Function
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	19478087.	IDA	Function
GO:0005515	protein binding	18434541.21988832.25416956.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	17635935.	IDA	Component
GO:0005765	lysosomal membrane	17897319.	HDA	Component
GO:0005789	endoplasmic reticulum membrane	12642577.	IDA	Component
GO:0005813	centrosome	17635935.	IDA	Component
GO:0005834	heterotrimeric G-protein complex	21873635.	IBA	Component
GO:0005886	plasma membrane	17635935.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006457	protein folding	-	TAS	Process
GO:0006906	vesicle fusion	-	IEA	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007186	G protein-coupled receptor signaling pathway	-	TAS	Process
GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	21873635.	IBA	Process
GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	19478087.	IDA	Process
GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	-	TAS	Process
GO:0007194	negative regulation of adenylate cyclase activity	7608168.	TAS	Process
GO:0007212	dopamine receptor signaling pathway	19478087.	IDA	Process
GO:0007420	brain development	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016239	positive regulation of macroautophagy	12642577.	IMP	Process
GO:0019003	GDP binding	19478087.	IDA	Function
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0030496	midbody	17635935.	IDA	Component
GO:0031683	G-protein beta/gamma-subunit complex binding	21873635.	IBA	Function
GO:0031821	G protein-coupled serotonin receptor binding	-	IEA	Function
GO:0032794	GTPase activating protein binding	-	IEA	Function
GO:0032930	positive regulation of superoxide anion generation	-	IEA	Process
GO:0033864	positive regulation of NAD(P)H oxidase activity	-	IEA	Process
GO:0042588	zymogen granule	-	IEA	Component
GO:0045121	membrane raft	-	IEA	Component
GO:0046039	GTP metabolic process	19478087.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051301	cell division	17635935.	IDA	Process
GO:0070062	extracellular exosome	19056867.20458337.	HDA	Component
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	-	IEA	Process
GO:2001234	negative regulation of apoptotic signaling pathway	-	IEA	Process