EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000065150 (Gene tree)
Gene ID: 3843
Gene Symbol: IPO5
Alias: IMB3|MGC2068|Pse1|KPNB3|RANBP5
Full Name: importin 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 70,660 bases
Position: chr13:97,953,638-98,024,297
Accession: 6402
RBP type: canonical RBP
Summary: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000419860	IBN_N	PF03810.19	1.5e-05	1	1
ENSP00000419766	IBN_N	PF03810.19	1.6e-05	1	1
ENSP00000385938	IBN_N	PF03810.19	2.2e-05	1	1
ENSP00000420284	IBN_N	PF03810.19	2.4e-05	1	1
ENSP00000420079	IBN_N	PF03810.19	2.8e-05	1	1
ENSP00000420491	IBN_N	PF03810.19	3.3e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17548253	Identification of genes upregulated by recombinant interferon-alpha in HepG2 cells by suppressive subtractive hybridization analysis.	Hepatobiliary Pancreat Dis Int	2007 Jun	Qu JH	-
25782991	RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus.	FASEB J	2015 Jul	Sutherland JM	doi: 10.1096/fj.14-265868
8702520	Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element.	J Biol Chem	1996 Aug 2	Warriar N	-
12634303	Expression of testicular germ cell genes identified by differential display analysis.	J Androl	2003 Mar-Apr	Anway MD	-
17005651	Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex.	J Virol	2006 Dec	Deng T	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000481455	IPO5-216	555	-	ENSP00000419766	119 (aa)	-	E7EX05
ENST00000493122	IPO5-224	651	-	-	- (aa)	-	-
ENST00000631030	IPO5-229	192	-	ENSP00000487097	63 (aa)	-	F8WF30
ENST00000473582	IPO5-211	536	-	ENSP00000420491	165 (aa)	-	C9JMV5
ENST00000485433	IPO5-219	524	-	ENSP00000417721	75 (aa)	-	C9J875
ENST00000491555	IPO5-223	3688	-	-	- (aa)	-	-
ENST00000479736	IPO5-213	668	-	-	- (aa)	-	-
ENST00000496368	IPO5-227	542	-	ENSP00000417162	98 (aa)	-	E7ESA1
ENST00000493281	IPO5-225	544	-	ENSP00000419166	64 (aa)	-	C9JXE0
ENST00000489058	IPO5-220	522	-	ENSP00000417993	50 (aa)	-	C9J583
ENST00000490369	IPO5-221	542	-	ENSP00000419398	63 (aa)	-	F8WF30
ENST00000421861	IPO5-204	564	-	ENSP00000408885	106 (aa)	-	E7ESZ1
ENST00000460070	IPO5-205	544	-	ENSP00000420284	142 (aa)	-	E7EV12
ENST00000490680	IPO5-222	3419	-	ENSP00000418393	1097 (aa)	-	O00410
ENST00000481689	IPO5-217	568	-	ENSP00000420043	128 (aa)	-	E7ETV8
ENST00000480611	IPO5-214	591	-	ENSP00000419860	117 (aa)	-	E7EWK4
ENST00000463157	IPO5-206	493	-	ENSP00000420149	88 (aa)	-	C9JQT6
ENST00000471898	IPO5-210	556	-	ENSP00000419797	74 (aa)	-	C9JZD8
ENST00000482642	IPO5-218	724	-	-	- (aa)	-	-
ENST00000497270	IPO5-228	536	-	ENSP00000417647	126 (aa)	-	E7EQT5
ENST00000468620	IPO5-207	480	-	-	- (aa)	-	-
ENST00000470493	IPO5-209	548	-	-	- (aa)	-	-
ENST00000403772	IPO5-203	547	-	ENSP00000385938	182 (aa)	-	H0Y3V4
ENST00000475420	IPO5-212	883	-	ENSP00000420079	170 (aa)	-	E7ETV3
ENST00000357602	IPO5-202	4335	-	ENSP00000350219	1097 (aa)	-	O00410
ENST00000261574	IPO5-201	6003	XM_005254052	ENSP00000261574	1115 (aa)	XP_005254109	O00410
ENST00000469360	IPO5-208	3505	-	ENSP00000419764	1099 (aa)	-	H0Y8C6
ENST00000480641	IPO5-215	543	-	ENSP00000419003	77 (aa)	-	C9JZ53
ENST00000493492	IPO5-226	474	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000065150's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000065150	Bone Density	5E-6	28181694

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000065150	rs117023938	13	97989604	T	Pediatric bone mineral density (hip)	28181694	[0.28-0.69] unit increase	0.482788	EFO_0007702

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000065150's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000065150	IPO5	99	93.613	ENSACAG00000016245	-	99	93.613	Anolis_carolinensis
ENSG00000065150	IPO5	100	100.000	ENSANAG00000028954	IPO5	97	99.458	Aotus_nancymaae
ENSG00000065150	IPO5	100	100.000	ENSCJAG00000004323	IPO5	100	99.544	Callithrix_jacchus
ENSG00000065150	IPO5	99	96.007	ENSTSYG00000005940	IPO5	99	96.961	Carlito_syrichta
ENSG00000065150	IPO5	100	100.000	ENSCATG00000038175	IPO5	100	98.394	Cercocebus_atys
ENSG00000065150	IPO5	87	88.073	ENSCGRG00001014189	-	100	88.073	Cricetulus_griseus_chok1gshd
ENSG00000065150	IPO5	100	86.486	ENSCGRG00001002524	-	89	87.037	Cricetulus_griseus_chok1gshd
ENSG00000065150	IPO5	100	93.506	ENSETEG00000000152	IPO5	93	92.715	Echinops_telfairi
ENSG00000065150	IPO5	99	89.570	ENSLACG00000015338	IPO5	99	89.551	Latimeria_chalumnae
ENSG00000065150	IPO5	100	100.000	ENSMFAG00000002597	IPO5	100	99.821	Macaca_fascicularis
ENSG00000065150	IPO5	100	100.000	ENSMMUG00000013531	IPO5	100	100.000	Macaca_mulatta
ENSG00000065150	IPO5	100	100.000	ENSMNEG00000034763	IPO5	100	98.394	Macaca_nemestrina
ENSG00000065150	IPO5	100	98.701	ENSMLEG00000028889	IPO5	99	98.389	Mandrillus_leucophaeus
ENSG00000065150	IPO5	100	98.701	ENSMAUG00000016575	-	100	98.969	Mesocricetus_auratus
ENSG00000065150	IPO5	100	100.000	ENSMICG00000012711	IPO5	100	96.825	Microcebus_murinus
ENSG00000065150	IPO5	98	96.465	ENSMODG00000008520	IPO5	97	94.555	Monodelphis_domestica
ENSG00000065150	IPO5	100	100.000	ENSNGAG00000014885	Ipo5	100	96.727	Nannospalax_galili
ENSG00000065150	IPO5	99	100.000	ENSMEUG00000002867	IPO5	91	97.441	Notamacropus_eugenii
ENSG00000065150	IPO5	100	93.506	ENSOPRG00000015494	-	100	87.295	Ochotona_princeps
ENSG00000065150	IPO5	100	96.354	ENSODEG00000019128	-	100	96.354	Octodon_degus
ENSG00000065150	IPO5	100	94.805	ENSODEG00000016371	-	100	92.069	Octodon_degus
ENSG00000065150	IPO5	100	97.403	ENSODEG00000010941	-	100	91.682	Octodon_degus
ENSG00000065150	IPO5	91	80.000	ENSOANG00000014256	-	83	75.610	Ornithorhynchus_anatinus
ENSG00000065150	IPO5	97	95.429	ENSOANG00000005460	-	100	95.429	Ornithorhynchus_anatinus
ENSG00000065150	IPO5	100	97.403	ENSOCUG00000003898	IPO5	100	98.876	Oryctolagus_cuniculus
ENSG00000065150	IPO5	100	100.000	ENSPTRG00000005984	IPO5	100	97.651	Pan_troglodytes
ENSG00000065150	IPO5	100	100.000	ENSPANG00000009971	IPO5	100	98.394	Papio_anubis
ENSG00000065150	IPO5	99	100.000	ENSPCIG00000027635	IPO5	100	97.091	Phascolarctos_cinereus
ENSG00000065150	IPO5	100	98.649	ENSPCOG00000016473	IPO5	100	96.997	Propithecus_coquereli
ENSG00000065150	IPO5	100	98.649	ENSRNOG00000010989	Ipo5	100	98.947	Rattus_norvegicus
ENSG00000065150	IPO5	100	98.701	ENSRBIG00000036317	IPO5	100	96.047	Rhinopithecus_bieti
ENSG00000065150	IPO5	100	97.403	ENSSBOG00000028024	IPO5	100	95.442	Saimiri_boliviensis_boliviensis
ENSG00000065150	IPO5	100	93.506	ENSSHAG00000001752	IPO5	99	93.601	Sarcophilus_harrisii
ENSG00000065150	IPO5	100	88.312	ENSSPUG00000003786	IPO5	100	93.413	Sphenodon_punctatus
ENSG00000065150	IPO5	99	90.876	ENSTGUG00000011084	IPO5	99	91.017	Taeniopygia_guttata
ENSG00000065150	IPO5	95	97.260	ENSUAMG00000028286	IPO5	99	98.171	Ursus_americanus
ENSG00000065150	IPO5	99	90.340	ENSXETG00000023496	ipo5	99	90.009	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005095	GTPase inhibitor activity	9271386.	TAS	Function
GO:0005515	protein binding	10799599.15282309.20562859.20828572.21044950.22730302.	IPI	Function
GO:0005634	nucleus	-	ISS	Component
GO:0005643	nuclear pore	9271386.	TAS	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0006607	NLS-bearing protein import into nucleus	21873635.	IBA	Process
GO:0006607	NLS-bearing protein import into nucleus	-	ISS	Process
GO:0006610	ribosomal protein import into nucleus	21873635.	IBA	Process
GO:0006610	ribosomal protein import into nucleus	9687515.	IDA	Process
GO:0008139	nuclear localization sequence binding	21873635.	IBA	Function
GO:0008536	Ran GTPase binding	-	IEA	Function
GO:0008565	protein transporter activity	21873635.	IBA	Function
GO:0008565	protein transporter activity	-	ISS	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0031965	nuclear membrane	21873635.	IBA	Component
GO:0034260	negative regulation of GTPase activity	-	IEA	Process
GO:0034399	nuclear periphery	21873635.	IBA	Component
GO:0042307	positive regulation of protein import into nucleus	-	ISS	Process
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	17491008.	TAS	Process
GO:0071230	cellular response to amino acid stimulus	-	ISS	Process