EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000065243 (Gene tree)
Gene ID: 5586
Gene Symbol: PKN2
Alias: PRK2|Pak-2|STK7|PRKCL2
Full Name: protein kinase N2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 152,063 bases
Position: chr1:88,684,193-88,836,255
Accession: 9406
RBP type: non-canonical RBP
Summary: (Protein Kinase N2) is a Protein Coding gene. Among its related pathways are Salmonella infection (KEGG) and RhoA signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is PKN1.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000370513	PKN2-202	2890	XM_017001783	ENSP00000359544	936 (aa)	XP_016857272	Q16513
ENST00000316005	PKN2-201	2632	-	ENSP00000317851	604 (aa)	-	B1AL79
ENST00000495119	PKN2-206	416	-	-	- (aa)	-	-
ENST00000449189	PKN2-205	342	-	ENSP00000389076	65 (aa)	-	H0Y429
ENST00000436111	PKN2-204	632	-	ENSP00000401125	211 (aa)	-	H0Y5V5
ENST00000370521	PKN2-203	6121	XM_011541772	ENSP00000359552	984 (aa)	XP_011540074	Q16513

Gene Model

Click here to download ENSG00000065243's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa05132	Salmonella infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000065243	Respiratory Function Tests	5.43702158193182E-5	17903307
ENSG00000065243	Respiratory Function Tests	6.20174811485997E-5	17903307
ENSG00000065243	Glomerular Filtration Rate	1.40184250810584E-6	17903292
ENSG00000065243	Glomerular Filtration Rate	6.77424971315943E-6	17903292
ENSG00000065243	Glomerular Filtration Rate	3.34721683883883E-6	17903292
ENSG00000065243	Echocardiography	9.6590774676164E-5	17903301
ENSG00000065243	Hip	3.74685255660146E-6	17903296
ENSG00000065243	Monocytes	7.5310000E-005	-
ENSG00000065243	Monocytes	5.6250000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000065243	rs786906	1	88805891	T	Intraocular pressure	29617998	[0.052-0.106] unit increase	0.079	EFO_0004695
ENSG00000065243	rs56969212	1	88705538	CA	Heel bone mineral density	28869591	[0.016-0.029] unit increase	0.0224347	EFO_0009270
ENSG00000065243	rs56969212	1	88705538	CA	Heel bone mineral density	28869591	[0.013-0.032] unit increase	0.0224727	EFO_0009270
ENSG00000065243	rs950037	1	88685915	T	Coronary artery disease	29212778	[0.016-0.039] unit decrease	0.0274	EFO_0000378
ENSG00000065243	rs786906	1	88805891	T	Systolic blood pressure	27618447	mmHg increase	0.213	EFO_0006335
ENSG00000065243	rs56969212	1	88705538	?	Heel bone mineral density	30048462	[0.011-0.02] unit increase	0.0155128	EFO_0009270
ENSG00000065243	rs167365	1	88715162	?	Heel bone mineral density	30048462	[0.014-0.022] unit increase	0.0177402	EFO_0009270
ENSG00000065243	rs167365	1	88715162	C	Heel bone mineral density	30598549	[0.015-0.023] unit increase	0.0188777	EFO_0009270
ENSG00000065243	rs786914	1	88830082	?	Red blood cell count	30595370			EFO_0004305
ENSG00000065243	rs786919	1	88815846	A	Diastolic blood pressure	27841878	unit increase	0.109	EFO_0006336
ENSG00000065243	rs786919	1	88815846	A	Systolic blood pressure	27841878	unit increase	0.262	EFO_0006335
ENSG00000065243	rs786919	1	88815846	A	Pulse pressure	27841878	unit increase	0.156	EFO_0005763
ENSG00000065243	rs10801682	1	88708570	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000065243	rs6671230	1	88789356	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000065243	rs305221	1	88733302	?	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy)	30940143			EFO_0004325\|EFO_0000341

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000065243's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004672	protein kinase activity	7851406.	TAS	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	20188095.	IDA	Function
GO:0004697	protein kinase C activity	-	IEA	Function
GO:0005515	protein binding	10026169.11356191.15364941.17110931.20974804.27104747.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	11356191.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	17332740.	IDA	Component
GO:0005813	centrosome	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006468	protein phosphorylation	17332740.	IDA	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007155	cell adhesion	-	IEA	Process
GO:0007165	signal transduction	7851406.	TAS	Process
GO:0010631	epithelial cell migration	21754995.	IDA	Process
GO:0016301	kinase activity	15364941.	IDA	Function
GO:0016604	nuclear body	-	IDA	Component
GO:0017049	GTP-Rho binding	-	IEA	Function
GO:0018105	peptidyl-serine phosphorylation	21873635.	IBA	Process
GO:0030027	lamellipodium	11356191.	IDA	Component
GO:0030030	cell projection organization	-	IEA	Process
GO:0030496	midbody	17332740.	IDA	Component
GO:0032154	cleavage furrow	17332740.	IDA	Component
GO:0032467	positive regulation of cytokinesis	17332740.	IMP	Process
GO:0032991	protein-containing complex	-	IEA	Component
GO:0035556	intracellular signal transduction	21873635.	IBA	Process
GO:0042826	histone deacetylase binding	20188095.	IDA	Function
GO:0043296	apical junction complex	20974804.	IDA	Component
GO:0043297	apical junction assembly	20974804.	IMP	Process
GO:0045070	positive regulation of viral genome replication	15364941.	IMP	Process
GO:0045111	intermediate filament cytoskeleton	-	IDA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045931	positive regulation of mitotic cell cycle	17332740.	IMP	Process
GO:0048471	perinuclear region of cytoplasm	15364941.	IDA	Component
GO:0051301	cell division	-	IEA	Process
GO:0070063	RNA polymerase binding	15364941.	IPI	Function
GO:2000145	regulation of cell motility	21754995.	IMP	Process