EuRBPDB

Description

Ensembl ID: ENSG00000065268 (Gene tree)
Gene ID: 57418
Gene Symbol: WDR18
Alias: Ipi3
Full Name: WD repeat domain 18
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 14,168 bases
Position: chr19:984,271-998,438
Accession: 17956
RBP type: non-canonical RBP
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000607440	WDR18-211	1397	-	ENSP00000475744	394 (aa)	-	U3KQC1
ENST00000591985	WDR18-209	1498	-	ENSP00000466551	268 (aa)	-	K7EML4
ENST00000591997	WDR18-210	577	-	ENSP00000484670	144 (aa)	-	A0A087X237
ENST00000590354	WDR18-205	678	-	ENSP00000475953	48 (aa)	-	U3KQK3
ENST00000591155	WDR18-207	417	-	-	- (aa)	-	-
ENST00000251289	WDR18-201	1501	-	ENSP00000251289	429 (aa)	-	A0A0A0MQU0
ENST00000586317	WDR18-203	831	-	-	- (aa)	-	-
ENST00000585809	WDR18-202	1608	-	ENSP00000476117	432 (aa)	-	Q9BV38
ENST00000591276	WDR18-208	607	-	-	- (aa)	-	-
ENST00000587001	WDR18-204	1465	-	ENSP00000464855	409 (aa)	-	K7EIR0
ENST00000590397	WDR18-206	1083	-	ENSP00000465826	152 (aa)	-	K7EKX5

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000065268	rs118012496	19	994532	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000065268	rs2240147	19	989730	?	Lung function (FVC)	30595370			EFO_0004312

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000027	ribosomal large subunit assembly	21873635.	IBA	Process
GO:0005515	protein binding	21326211.30021884.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005656	nuclear pre-replicative complex	21873635.	IBA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006267	pre-replicative complex assembly involved in nuclear cell cycle DNA replication	21873635.	IBA	Process
GO:0006364	rRNA processing	21873635.	IBA	Process
GO:0006364	rRNA processing	-	TAS	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0030174	regulation of DNA-dependent DNA replication initiation	21873635.	IBA	Process
GO:0097344	Rix1 complex	21873635.	IBA	Component