EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000065427 (Gene tree)
Gene ID: 3735
Gene Symbol: KARS
Alias: KARS2|KARS1|DFNB89
Full Name: lysyl-tRNA synthetase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 21,170 bases
Position: chr16:75,627,474-75,648,643
Accession: 6215
RBP type: canonical RBP
Summary: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000458028	tRNA_anti-codon	PF01336.25	2.5e-14	1	1
ENSP00000303043	tRNA_anti-codon	PF01336.25	9e-14	1	1
ENSP00000325448	tRNA_anti-codon	PF01336.25	9.8e-14	1	1
ENSP00000303043	tRNA-synt_2	PF00152.20	7.5e-81	1	1
ENSP00000325448	tRNA-synt_2	PF00152.20	8.2e-81	1	1
ENSP00000455488	tRNA-synt_2	PF00152.20	9.9e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12417586	Functional dissection of the eukaryotic-specific tRNA-interacting factor of lysyl-tRNA synthetase.	J Biol Chem	2003 Jan 17	Francin M	-
11706011	The N-terminal domain of mammalian Lysyl-tRNA synthetase is a functional tRNA-binding domain.	J Biol Chem	2002 Jan 18	Francin M	-
23264568	Molecular mimicry of human tRNALys anti-codon domain by HIV-1 RNA genome facilitates tRNA primer annealing.	RNA	2013 Feb	Jones CP	doi: 10.1261/rna.036681.112

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000570215	KARS-212	994	-	ENSP00000458028	256 (aa)	-	H3BVA8
ENST00000562875	KARS-203	801	-	ENSP00000456185	76 (aa)	-	H3BRC9
ENST00000566560	KARS-207	1231	-	-	- (aa)	-	-
ENST00000302445	KARS-201	2005	XM_017023217	ENSP00000303043	597 (aa)	XP_016878706	Q15046
ENST00000568682	KARS-210	870	-	ENSP00000462057	102 (aa)	-	J3KRL2
ENST00000319410	KARS-202	2421	-	ENSP00000325448	625 (aa)	-	Q15046
ENST00000565738	KARS-205	607	-	-	- (aa)	-	-
ENST00000564578	KARS-204	1942	-	ENSP00000455818	124 (aa)	-	H3BQK5
ENST00000568378	KARS-209	459	-	ENSP00000454512	67 (aa)	-	H3BMR9
ENST00000566772	KARS-208	644	-	ENSP00000455488	104 (aa)	-	H3BPV7
ENST00000566249	KARS-206	649	-	ENSP00000456786	86 (aa)	-	H3BSN6
ENST00000569298	KARS-211	589	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000065427's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000065427's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000065427	KARS	100	85.294	ENSAPOG00000010997	kars	98	79.685	Acanthochromis_polyacanthus
ENSG00000065427	KARS	100	99.020	ENSAMEG00000005347	KARS	100	92.800	Ailuropoda_melanoleuca
ENSG00000065427	KARS	100	90.196	ENSACIG00000000304	kars	99	74.660	Amphilophus_citrinellus
ENSG00000065427	KARS	100	88.235	ENSAOCG00000012971	kars	97	80.142	Amphiprion_ocellaris
ENSG00000065427	KARS	100	88.235	ENSAPEG00000011144	kars	99	79.422	Amphiprion_percula
ENSG00000065427	KARS	100	88.235	ENSATEG00000004954	kars	99	78.571	Anabas_testudineus
ENSG00000065427	KARS	100	91.176	ENSAPLG00000012705	KARS	97	85.316	Anas_platyrhynchos
ENSG00000065427	KARS	100	90.196	ENSACAG00000007577	KARS	96	77.236	Anolis_carolinensis
ENSG00000065427	KARS	100	98.039	ENSANAG00000030403	-	100	97.120	Aotus_nancymaae
ENSG00000065427	KARS	99	81.987	ENSANAG00000031739	-	97	81.897	Aotus_nancymaae
ENSG00000065427	KARS	100	89.216	ENSACLG00000001613	kars	97	79.281	Astatotilapia_calliptera
ENSG00000065427	KARS	100	90.196	ENSAMXG00000030719	kars	98	80.279	Astyanax_mexicanus
ENSG00000065427	KARS	100	99.020	ENSBTAG00000015677	KARS	77	93.467	Bos_taurus
ENSG00000065427	KARS	100	56.863	WBGene00002238	kars-1	98	64.016	Caenorhabditis_elegans
ENSG00000065427	KARS	100	98.039	ENSCJAG00000014213	KARS	100	96.960	Callithrix_jacchus
ENSG00000065427	KARS	100	99.020	ENSCAFG00000020069	KARS	100	93.600	Canis_familiaris
ENSG00000065427	KARS	100	99.020	ENSCAFG00020001721	KARS	100	94.305	Canis_lupus_dingo
ENSG00000065427	KARS	100	98.039	ENSCHIG00000016073	-	95	92.348	Capra_hircus
ENSG00000065427	KARS	100	99.020	ENSCHIG00000014108	-	100	93.635	Capra_hircus
ENSG00000065427	KARS	100	99.020	ENSTSYG00000001643	KARS	99	96.007	Carlito_syrichta
ENSG00000065427	KARS	100	97.059	ENSCAPG00000016234	KARS	100	86.880	Cavia_aperea
ENSG00000065427	KARS	100	97.059	ENSCPOG00000012036	KARS	100	94.305	Cavia_porcellus
ENSG00000065427	KARS	100	98.039	ENSCCAG00000034307	-	100	97.440	Cebus_capucinus
ENSG00000065427	KARS	99	84.000	ENSCCAG00000030337	-	100	78.899	Cebus_capucinus
ENSG00000065427	KARS	100	99.020	ENSCATG00000038129	KARS	99	96.940	Cercocebus_atys
ENSG00000065427	KARS	100	99.020	ENSCLAG00000007905	KARS	100	94.807	Chinchilla_lanigera
ENSG00000065427	KARS	100	98.039	ENSCSAG00000003664	KARS	100	96.800	Chlorocebus_sabaeus
ENSG00000065427	KARS	100	96.078	ENSCHOG00000013447	KARS	82	97.216	Choloepus_hoffmanni
ENSG00000065427	KARS	100	92.157	ENSCPBG00000026969	KARS	99	83.953	Chrysemys_picta_bellii
ENSG00000065427	KARS	100	73.529	ENSCPBG00000002553	-	94	73.218	Chrysemys_picta_bellii
ENSG00000065427	KARS	100	75.490	ENSCING00000009513	-	97	68.772	Ciona_intestinalis
ENSG00000065427	KARS	100	72.549	ENSCSAVG00000007684	-	98	68.924	Ciona_savignyi
ENSG00000065427	KARS	53	70.846	ENSCSAVG00000001136	-	98	74.609	Ciona_savignyi
ENSG00000065427	KARS	100	99.020	ENSCANG00000032813	KARS	100	93.760	Colobus_angolensis_palliatus
ENSG00000065427	KARS	100	96.078	ENSCGRG00001004055	KARS	100	93.144	Cricetulus_griseus_chok1gshd
ENSG00000065427	KARS	100	96.078	ENSCGRG00000014242	KARS	100	93.144	Cricetulus_griseus_crigri
ENSG00000065427	KARS	100	88.235	ENSCSEG00000008324	kars	99	79.452	Cynoglossus_semilaevis
ENSG00000065427	KARS	100	87.255	ENSCVAG00000019686	kars	98	79.617	Cyprinodon_variegatus
ENSG00000065427	KARS	100	90.196	ENSDARG00000103799	kars	98	86.139	Danio_rerio
ENSG00000065427	KARS	100	97.059	ENSDNOG00000002241	KARS	100	94.880	Dasypus_novemcinctus
ENSG00000065427	KARS	100	72.362	ENSDORG00000024214	-	100	72.362	Dipodomys_ordii
ENSG00000065427	KARS	100	100.000	ENSDORG00000004780	-	100	94.975	Dipodomys_ordii
ENSG00000065427	KARS	100	75.490	FBgn0027084	LysRS	98	69.352	Drosophila_melanogaster
ENSG00000065427	KARS	100	97.059	ENSETEG00000008353	KARS	100	90.575	Echinops_telfairi
ENSG00000065427	KARS	100	72.549	ENSEBUG00000001284	-	97	70.906	Eptatretus_burgeri
ENSG00000065427	KARS	100	99.020	ENSEASG00005013497	KARS	100	96.327	Equus_asinus_asinus
ENSG00000065427	KARS	100	99.020	ENSECAG00000013424	KARS	100	96.327	Equus_caballus
ENSG00000065427	KARS	100	96.078	ENSEEUG00000007042	KARS	100	84.480	Erinaceus_europaeus
ENSG00000065427	KARS	100	88.235	ENSELUG00000014575	kars	98	71.039	Esox_lucius
ENSG00000065427	KARS	100	100.000	ENSFCAG00000008573	KARS	100	95.310	Felis_catus
ENSG00000065427	KARS	100	87.255	ENSFALG00000002543	KARS	100	80.865	Ficedula_albicollis
ENSG00000065427	KARS	100	98.039	ENSFDAG00000007155	KARS	100	95.477	Fukomys_damarensis
ENSG00000065427	KARS	100	85.294	ENSFHEG00000006172	kars	99	78.194	Fundulus_heteroclitus
ENSG00000065427	KARS	100	83.810	ENSGMOG00000002633	kars	92	77.758	Gadus_morhua
ENSG00000065427	KARS	100	91.176	ENSGALG00000000907	KARS	99	83.882	Gallus_gallus
ENSG00000065427	KARS	100	88.235	ENSGAFG00000017252	kars	99	79.690	Gambusia_affinis
ENSG00000065427	KARS	100	86.667	ENSGACG00000015749	kars	98	76.795	Gasterosteus_aculeatus
ENSG00000065427	KARS	100	92.157	ENSGAGG00000023836	KARS	99	83.531	Gopherus_agassizii
ENSG00000065427	KARS	100	73.529	ENSGAGG00000011960	-	95	74.257	Gopherus_agassizii
ENSG00000065427	KARS	100	99.840	ENSGGOG00000005515	KARS	100	99.840	Gorilla_gorilla
ENSG00000065427	KARS	100	89.216	ENSHBUG00000013619	kars	97	79.281	Haplochromis_burtoni
ENSG00000065427	KARS	100	88.235	ENSHGLG00000015235	-	100	84.757	Heterocephalus_glaber_female
ENSG00000065427	KARS	100	98.039	ENSHGLG00000011898	KARS	100	95.321	Heterocephalus_glaber_female
ENSG00000065427	KARS	99	77.741	ENSHGLG00000001298	-	99	77.741	Heterocephalus_glaber_female
ENSG00000065427	KARS	100	88.235	ENSHGLG00100012523	-	100	84.590	Heterocephalus_glaber_male
ENSG00000065427	KARS	99	77.575	ENSHGLG00100006466	-	99	77.575	Heterocephalus_glaber_male
ENSG00000065427	KARS	100	98.039	ENSHGLG00100012264	KARS	100	94.975	Heterocephalus_glaber_male
ENSG00000065427	KARS	100	87.255	ENSHCOG00000002900	kars	96	78.209	Hippocampus_comes
ENSG00000065427	KARS	100	88.235	ENSIPUG00000009862	kars	98	79.756	Ictalurus_punctatus
ENSG00000065427	KARS	100	100.000	ENSSTOG00000004205	KARS	100	95.645	Ictidomys_tridecemlineatus
ENSG00000065427	KARS	100	97.059	ENSJJAG00000020406	Kars	100	93.300	Jaculus_jaculus
ENSG00000065427	KARS	100	88.235	ENSKMAG00000006434	kars	99	80.416	Kryptolebias_marmoratus
ENSG00000065427	KARS	100	87.255	ENSLBEG00000026537	kars	99	75.286	Labrus_bergylta
ENSG00000065427	KARS	100	73.529	ENSLACG00000016399	-	99	74.308	Latimeria_chalumnae
ENSG00000065427	KARS	100	88.235	ENSLACG00000006667	KARS	100	79.712	Latimeria_chalumnae
ENSG00000065427	KARS	100	71.569	ENSLOCG00000013608	-	93	71.595	Lepisosteus_oculatus
ENSG00000065427	KARS	100	92.157	ENSLOCG00000004002	kars	98	81.217	Lepisosteus_oculatus
ENSG00000065427	KARS	100	100.000	ENSLAFG00000015340	KARS	100	93.760	Loxodonta_africana
ENSG00000065427	KARS	100	98.039	ENSMFAG00000040024	KARS	100	96.985	Macaca_fascicularis
ENSG00000065427	KARS	100	98.039	ENSMMUG00000005754	-	94	97.273	Macaca_mulatta
ENSG00000065427	KARS	100	98.039	ENSMNEG00000035832	-	99	94.951	Macaca_nemestrina
ENSG00000065427	KARS	100	98.039	ENSMNEG00000042879	-	100	96.985	Macaca_nemestrina
ENSG00000065427	KARS	100	99.020	ENSMLEG00000034947	KARS	100	97.152	Mandrillus_leucophaeus
ENSG00000065427	KARS	100	90.196	ENSMAMG00000021559	kars	95	78.179	Mastacembelus_armatus
ENSG00000065427	KARS	100	89.216	ENSMZEG00005014382	kars	97	79.281	Maylandia_zebra
ENSG00000065427	KARS	100	90.196	ENSMGAG00000009000	KARS	100	83.894	Meleagris_gallopavo
ENSG00000065427	KARS	100	99.020	ENSMICG00000011997	KARS	100	95.142	Microcebus_murinus
ENSG00000065427	KARS	100	96.078	ENSMOCG00000011829	Kars	99	92.736	Microtus_ochrogaster
ENSG00000065427	KARS	100	95.098	ENSMOCG00000019029	-	100	89.280	Microtus_ochrogaster
ENSG00000065427	KARS	100	89.216	ENSMMOG00000016934	kars	99	80.212	Mola_mola
ENSG00000065427	KARS	100	85.294	ENSMODG00000002215	-	99	87.326	Monodelphis_domestica
ENSG00000065427	KARS	99	93.069	ENSMODG00000002238	-	99	80.096	Monodelphis_domestica
ENSG00000065427	KARS	100	87.255	ENSMALG00000020858	kars	99	78.535	Monopterus_albus
ENSG00000065427	KARS	99	77.333	MGP_CAROLIEiJ_G0031588	Kars	100	90.451	Mus_caroli
ENSG00000065427	KARS	100	96.078	ENSMUSG00000031948	Kars	100	91.792	Mus_musculus
ENSG00000065427	KARS	100	95.098	MGP_PahariEiJ_G0023186	Kars	100	91.122	Mus_pahari
ENSG00000065427	KARS	100	96.078	MGP_SPRETEiJ_G0032706	Kars	100	91.792	Mus_spretus
ENSG00000065427	KARS	100	100.000	ENSMPUG00000009871	KARS	100	93.760	Mustela_putorius_furo
ENSG00000065427	KARS	89	72.059	ENSMLUG00000026871	-	98	58.779	Myotis_lucifugus
ENSG00000065427	KARS	100	98.039	ENSMLUG00000015119	-	100	94.137	Myotis_lucifugus
ENSG00000065427	KARS	100	94.118	ENSNGAG00000022944	-	96	92.920	Nannospalax_galili
ENSG00000065427	KARS	100	96.078	ENSNGAG00000018820	-	100	93.635	Nannospalax_galili
ENSG00000065427	KARS	100	89.216	ENSNBRG00000011098	kars	97	79.381	Neolamprologus_brichardi
ENSG00000065427	KARS	100	100.000	ENSNLEG00000013072	KARS	100	99.330	Nomascus_leucogenys
ENSG00000065427	KARS	99	95.050	ENSMEUG00000008684	KARS	98	82.867	Notamacropus_eugenii
ENSG00000065427	KARS	100	100.000	ENSOPRG00000012544	KARS	100	93.301	Ochotona_princeps
ENSG00000065427	KARS	100	97.059	ENSODEG00000013099	-	100	93.132	Octodon_degus
ENSG00000065427	KARS	97	71.717	ENSODEG00000009464	-	100	67.414	Octodon_degus
ENSG00000065427	KARS	100	89.216	ENSONIG00000005937	kars	99	79.452	Oreochromis_niloticus
ENSG00000065427	KARS	100	93.137	ENSOANG00000008179	KARS	97	88.194	Ornithorhynchus_anatinus
ENSG00000065427	KARS	100	97.059	ENSOCUG00000015553	KARS	100	87.772	Oryctolagus_cuniculus
ENSG00000065427	KARS	100	90.196	ENSORLG00000007627	kars	98	77.355	Oryzias_latipes
ENSG00000065427	KARS	100	90.196	ENSORLG00020010056	kars	98	77.190	Oryzias_latipes_hni
ENSG00000065427	KARS	100	90.196	ENSORLG00015008179	kars	98	77.190	Oryzias_latipes_hsok
ENSG00000065427	KARS	100	89.216	ENSOMEG00000001710	kars	98	80.138	Oryzias_melastigma
ENSG00000065427	KARS	100	99.020	ENSOGAG00000005903	KARS	100	88.000	Otolemur_garnettii
ENSG00000065427	KARS	100	99.020	ENSOARG00000006928	KARS	96	93.455	Ovis_aries
ENSG00000065427	KARS	100	100.000	ENSPPAG00000036192	KARS	100	99.665	Pan_paniscus
ENSG00000065427	KARS	100	100.000	ENSPPRG00000003027	KARS	100	95.310	Panthera_pardus
ENSG00000065427	KARS	100	100.000	ENSPTIG00000008011	KARS	100	95.477	Panthera_tigris_altaica
ENSG00000065427	KARS	100	100.000	ENSPTRG00000008364	KARS	100	99.840	Pan_troglodytes
ENSG00000065427	KARS	100	99.020	ENSPANG00000024106	KARS	100	97.120	Papio_anubis
ENSG00000065427	KARS	100	85.294	ENSPKIG00000009896	kars	99	78.194	Paramormyrops_kingsleyae
ENSG00000065427	KARS	100	91.176	ENSPSIG00000009294	KARS	96	86.404	Pelodiscus_sinensis
ENSG00000065427	KARS	100	75.490	ENSPSIG00000003041	-	95	74.423	Pelodiscus_sinensis
ENSG00000065427	KARS	100	87.255	ENSPMGG00000006117	kars	99	79.646	Periophthalmus_magnuspinnatus
ENSG00000065427	KARS	100	96.078	ENSPEMG00000012277	Kars	100	92.965	Peromyscus_maniculatus_bairdii
ENSG00000065427	KARS	100	78.431	ENSPMAG00000008360	-	99	70.853	Petromyzon_marinus
ENSG00000065427	KARS	99	93.069	ENSPCIG00000025469	-	99	82.504	Phascolarctos_cinereus
ENSG00000065427	KARS	100	98.039	ENSPCIG00000010761	-	97	90.878	Phascolarctos_cinereus
ENSG00000065427	KARS	100	88.235	ENSPFOG00000013253	kars	94	78.411	Poecilia_formosa
ENSG00000065427	KARS	100	89.216	ENSPLAG00000004189	kars	99	79.412	Poecilia_latipinna
ENSG00000065427	KARS	100	88.235	ENSPMEG00000015698	kars	99	79.585	Poecilia_mexicana
ENSG00000065427	KARS	100	88.235	ENSPREG00000023179	kars	99	79.002	Poecilia_reticulata
ENSG00000065427	KARS	100	100.000	ENSPPYG00000007567	KARS	100	99.360	Pongo_abelii
ENSG00000065427	KARS	100	98.039	ENSPCAG00000010790	KARS	100	86.807	Procavia_capensis
ENSG00000065427	KARS	100	99.020	ENSPCOG00000003166	KARS	100	85.440	Propithecus_coquereli
ENSG00000065427	KARS	100	98.039	ENSPVAG00000006746	KARS	100	93.440	Pteropus_vampyrus
ENSG00000065427	KARS	100	89.216	ENSPNYG00000013095	kars	97	79.281	Pundamilia_nyererei
ENSG00000065427	KARS	100	92.157	ENSPNAG00000013828	kars	98	81.326	Pygocentrus_nattereri
ENSG00000065427	KARS	100	95.098	ENSRNOG00000019456	Kars	100	91.214	Rattus_norvegicus
ENSG00000065427	KARS	100	99.020	ENSRBIG00000030118	KARS	99	97.585	Rhinopithecus_bieti
ENSG00000065427	KARS	100	99.020	ENSRROG00000041418	KARS	100	97.600	Rhinopithecus_roxellana
ENSG00000065427	KARS	100	49.533	YDR037W	KRS1	95	57.168	Saccharomyces_cerevisiae
ENSG00000065427	KARS	79	32.866	YNL073W	-	86	32.866	Saccharomyces_cerevisiae
ENSG00000065427	KARS	100	98.039	ENSSBOG00000019255	KARS	100	96.960	Saimiri_boliviensis_boliviensis
ENSG00000065427	KARS	99	72.552	ENSSHAG00000002050	-	99	72.231	Sarcophilus_harrisii
ENSG00000065427	KARS	91	95.789	ENSSHAG00000001359	-	99	82.100	Sarcophilus_harrisii
ENSG00000065427	KARS	99	83.168	ENSSHAG00000009005	-	98	77.289	Sarcophilus_harrisii
ENSG00000065427	KARS	100	86.275	ENSSFOG00015014837	kars	99	79.323	Scleropages_formosus
ENSG00000065427	KARS	100	88.235	ENSSMAG00000021441	kars	99	79.387	Scophthalmus_maximus
ENSG00000065427	KARS	100	88.235	ENSSDUG00000001202	kars	99	79.387	Seriola_dumerili
ENSG00000065427	KARS	100	88.235	ENSSLDG00000021220	kars	97	80.247	Seriola_lalandi_dorsalis
ENSG00000065427	KARS	100	98.039	ENSSARG00000011493	KARS	79	96.396	Sorex_araneus
ENSG00000065427	KARS	100	72.549	ENSSPUG00000000449	-	82	68.286	Sphenodon_punctatus
ENSG00000065427	KARS	100	93.137	ENSSPUG00000004974	KARS	100	82.609	Sphenodon_punctatus
ENSG00000065427	KARS	100	87.255	ENSSPAG00000020365	kars	97	79.329	Stegastes_partitus
ENSG00000065427	KARS	100	97.059	ENSSSCG00000002704	KARS	100	94.807	Sus_scrofa
ENSG00000065427	KARS	100	87.255	ENSTGUG00000008400	KARS	99	84.079	Taeniopygia_guttata
ENSG00000065427	KARS	100	89.216	ENSTRUG00000017551	kars	99	75.574	Takifugu_rubripes
ENSG00000065427	KARS	100	90.196	ENSTNIG00000009351	kars	96	80.354	Tetraodon_nigroviridis
ENSG00000065427	KARS	100	100.000	ENSTBEG00000004610	KARS	100	74.826	Tupaia_belangeri
ENSG00000065427	KARS	100	95.098	ENSTTRG00000001221	KARS	100	92.480	Tursiops_truncatus
ENSG00000065427	KARS	100	98.039	ENSUAMG00000017557	KARS	100	93.802	Ursus_americanus
ENSG00000065427	KARS	100	98.039	ENSUMAG00000014559	KARS	100	92.960	Ursus_maritimus
ENSG00000065427	KARS	100	100.000	ENSVPAG00000003716	KARS	100	93.440	Vicugna_pacos
ENSG00000065427	KARS	100	99.020	ENSVVUG00000024338	KARS	100	93.635	Vulpes_vulpes
ENSG00000065427	KARS	100	86.275	ENSXETG00000003569	kars	100	78.078	Xenopus_tropicalis
ENSG00000065427	KARS	100	88.235	ENSXCOG00000011313	kars	99	79.929	Xiphophorus_couchianus
ENSG00000065427	KARS	100	88.235	ENSXMAG00000003191	kars	99	79.518	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	21873635.	IBA	Function
GO:0000049	tRNA binding	10952987.	NAS	Function
GO:0000187	activation of MAPK activity	21873635.	IBA	Process
GO:0000187	activation of MAPK activity	15851690.	IDA	Process
GO:0002276	basophil activation involved in immune response	21873635.	IBA	Process
GO:0002276	basophil activation involved in immune response	19524539.	IGI	Process
GO:0002741	positive regulation of cytokine secretion involved in immune response	15851690.	IDA	Process
GO:0003877	ATP adenylyltransferase activity	21873635.	IBA	Function
GO:0003877	ATP adenylyltransferase activity	23159739.	IDA	Function
GO:0004824	lysine-tRNA ligase activity	21873635.	IBA	Function
GO:0004824	lysine-tRNA ligase activity	9278442.10952987.23159739.	IDA	Function
GO:0005515	protein binding	16189514.21220307.21536907.21900206.21988832.22386318.23159739.24212136.24312579.24983501.25416956.29997244.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005615	extracellular space	21873635.	IBA	Component
GO:0005615	extracellular space	15851690.	IDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	23159739.	IDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	10952987.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	19289464.23159739.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	Process
GO:0006430	lysyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0006430	lysyl-tRNA aminoacylation	9278442.10952987.23159739.	IDA	Process
GO:0008033	tRNA processing	10952987.	NAS	Process
GO:0008285	negative regulation of cell proliferation	15851690.	IDA	Process
GO:0010165	response to X-ray	-	IEA	Process
GO:0010759	positive regulation of macrophage chemotaxis	15851690.	IDA	Process
GO:0015966	diadenosine tetraphosphate biosynthetic process	21873635.	IBA	Process
GO:0015966	diadenosine tetraphosphate biosynthetic process	23159739.	IDA	Process
GO:0015966	diadenosine tetraphosphate biosynthetic process	19524539.	IGI	Process
GO:0016032	viral process	-	IEA	Process
GO:0016597	amino acid binding	-	IEA	Function
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	21873635.	IBA	Component
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	19131329.	IDA	Component
GO:0033209	tumor necrosis factor-mediated signaling pathway	21873635.	IBA	Process
GO:0033209	tumor necrosis factor-mediated signaling pathway	15851690.	IDA	Process
GO:0042802	identical protein binding	18272479.21536907.24212136.	IPI	Function
GO:0042803	protein homodimerization activity	23159739.	IPI	Function
GO:0043032	positive regulation of macrophage activation	21873635.	IBA	Process
GO:0043032	positive regulation of macrophage activation	15851690.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	19524539.	IGI	Process
GO:0070371	ERK1 and ERK2 cascade	19524539.	IGI	Process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	15851690.	IDA	Process
GO:1900017	positive regulation of cytokine production involved in inflammatory response	15851690.	IDA	Process
GO:1900745	positive regulation of p38MAPK cascade	15851690.	IDA	Process
GO:1905050	positive regulation of metallopeptidase activity	15851690.	IDA	Process