EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000065457 (Gene tree)
Gene ID: 23536
Gene Symbol: ADAT1
Alias: N
Full Name: adenosine deaminase tRNA specific 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 26,343 bases
Position: chr16:75,596,981-75,623,323
Accession: 228
RBP type: canonical RBP
Summary: This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000310015	A_deamin	PF02137.18	1.1e-124	1	1
ENSP00000455108	A_deamin	PF02137.18	1.7e-41	1	1
ENSP00000457501	A_deamin	PF02137.18	6.2e-22	1	1
ENSP00000455121	A_deamin	PF02137.18	7.1e-16	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25630791	The origin of the ADAR gene family and animal RNA editing.	BMC Evol Biol	2015 Jan 29	Grice LF	doi: 10.1186/s12862-015-0279-3.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000565109	ADAT1-204	574	-	-	- (aa)	-	-
ENST00000568001	ADAT1-208	570	-	ENSP00000457999	91 (aa)	-	H3BV89
ENST00000564657	ADAT1-203	731	-	ENSP00000457501	109 (aa)	-	H3BU72
ENST00000567281	ADAT1-207	547	-	ENSP00000455108	160 (aa)	-	H3BP18
ENST00000568478	ADAT1-209	644	-	-	- (aa)	-	-
ENST00000568510	ADAT1-210	459	-	ENSP00000455000	18 (aa)	-	H3BNT8
ENST00000566445	ADAT1-205	2768	-	ENSP00000456768	103 (aa)	-	H3BSM1
ENST00000566450	ADAT1-206	501	-	ENSP00000455121	120 (aa)	-	H3BP27
ENST00000562374	ADAT1-202	582	-	ENSP00000456751	10 (aa)	-	A0A0G2JLA8
ENST00000307921	ADAT1-201	1869	-	ENSP00000310015	502 (aa)	-	Q9BUB4

Gene Model

Click here to download ENSG00000065457's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000065457	Child Development Disorders, Pervasive	1.9000000E-005	-
ENSG00000065457	Child Development Disorders, Pervasive	3.6000000E-005	-
ENSG00000065457	Child Development Disorders, Pervasive	2.4000000E-005	-
ENSG00000065457	Hypertension	5.6224452E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000065457	rs61078946	16	75606619	A	Educational attainment (MTAG)	30038396	[0.0079-0.0165] unit decrease	0.0122	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000065457's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000065457	ADAT1	63	32.579	ENSG00000160710	ADAR	68	32.432

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000065457	ADAT1	100	81.875	ENSAMEG00000005426	ADAT1	100	80.279	Ailuropoda_melanoleuca
ENSG00000065457	ADAT1	69	54.054	ENSACIG00000012000	adat1	93	46.104	Amphilophus_citrinellus
ENSG00000065457	ADAT1	98	43.002	ENSACIG00000011965	adat1	98	43.002	Amphilophus_citrinellus
ENSG00000065457	ADAT1	100	56.875	ENSAOCG00000012225	adat1	100	47.714	Amphiprion_ocellaris
ENSG00000065457	ADAT1	100	56.875	ENSAPEG00000007286	adat1	100	47.913	Amphiprion_percula
ENSG00000065457	ADAT1	100	58.716	ENSATEG00000007015	adat1	98	49.405	Anabas_testudineus
ENSG00000065457	ADAT1	100	70.642	ENSAPLG00000012379	ADAT1	99	58.218	Anas_platyrhynchos
ENSG00000065457	ADAT1	84	59.804	ENSACAG00000007555	ADAT1	93	48.624	Anolis_carolinensis
ENSG00000065457	ADAT1	100	93.750	ENSANAG00000027266	ADAT1	100	91.633	Aotus_nancymaae
ENSG00000065457	ADAT1	100	50.000	ENSACLG00000005857	adat1	98	45.565	Astatotilapia_calliptera
ENSG00000065457	ADAT1	100	55.000	ENSAMXG00000043589	adat1	94	46.094	Astyanax_mexicanus
ENSG00000065457	ADAT1	100	86.875	ENSBTAG00000015669	ADAT1	100	82.470	Bos_taurus
ENSG00000065457	ADAT1	100	95.625	ENSCJAG00000014241	ADAT1	100	91.235	Callithrix_jacchus
ENSG00000065457	ADAT1	100	86.250	ENSCAFG00000020071	ADAT1	98	83.068	Canis_familiaris
ENSG00000065457	ADAT1	100	86.250	ENSCAFG00020001703	ADAT1	98	83.068	Canis_lupus_dingo
ENSG00000065457	ADAT1	99	89.815	ENSCHIG00000022974	ADAT1	98	82.470	Capra_hircus
ENSG00000065457	ADAT1	100	89.375	ENSTSYG00000000811	ADAT1	100	86.255	Carlito_syrichta
ENSG00000065457	ADAT1	100	70.625	ENSCAPG00000014696	ADAT1	100	67.331	Cavia_aperea
ENSG00000065457	ADAT1	100	88.073	ENSCPOG00000012030	ADAT1	100	80.876	Cavia_porcellus
ENSG00000065457	ADAT1	100	95.413	ENSCCAG00000029724	ADAT1	100	92.032	Cebus_capucinus
ENSG00000065457	ADAT1	100	95.000	ENSCATG00000032587	ADAT1	100	94.422	Cercocebus_atys
ENSG00000065457	ADAT1	100	88.991	ENSCLAG00000006384	ADAT1	100	81.474	Chinchilla_lanigera
ENSG00000065457	ADAT1	100	95.000	ENSCSAG00000003669	ADAT1	100	94.821	Chlorocebus_sabaeus
ENSG00000065457	ADAT1	100	70.909	ENSCPBG00000026967	ADAT1	99	59.843	Chrysemys_picta_bellii
ENSG00000065457	ADAT1	95	50.000	ENSCING00000007695	-	99	34.901	Ciona_intestinalis
ENSG00000065457	ADAT1	92	52.000	ENSCSAVG00000001315	-	96	33.939	Ciona_savignyi
ENSG00000065457	ADAT1	100	95.625	ENSCANG00000033392	ADAT1	100	94.821	Colobus_angolensis_palliatus
ENSG00000065457	ADAT1	100	85.625	ENSCGRG00001018488	Adat1	100	79.722	Cricetulus_griseus_chok1gshd
ENSG00000065457	ADAT1	100	85.625	ENSCGRG00000015170	Adat1	100	79.722	Cricetulus_griseus_crigri
ENSG00000065457	ADAT1	100	53.211	ENSCSEG00000021708	adat1	98	45.090	Cynoglossus_semilaevis
ENSG00000065457	ADAT1	100	48.624	ENSCVAG00000004640	adat1	98	43.548	Cyprinodon_variegatus
ENSG00000065457	ADAT1	100	55.000	ENSDARG00000061348	adat1	98	46.869	Danio_rerio
ENSG00000065457	ADAT1	100	85.625	ENSDNOG00000039016	ADAT1	100	82.271	Dasypus_novemcinctus
ENSG00000065457	ADAT1	100	86.239	ENSDORG00000004779	Adat1	100	78.287	Dipodomys_ordii
ENSG00000065457	ADAT1	84	86.139	ENSETEG00000017916	ADAT1	100	75.955	Echinops_telfairi
ENSG00000065457	ADAT1	96	33.466	ENSEBUG00000000861	adat1	100	33.466	Eptatretus_burgeri
ENSG00000065457	ADAT1	100	87.500	ENSEASG00005013492	ADAT1	96	83.865	Equus_asinus_asinus
ENSG00000065457	ADAT1	100	87.500	ENSECAG00000009128	ADAT1	100	84.064	Equus_caballus
ENSG00000065457	ADAT1	100	69.375	ENSEEUG00000008801	ADAT1	84	70.504	Erinaceus_europaeus
ENSG00000065457	ADAT1	100	58.716	ENSELUG00000012492	adat1	99	48.221	Esox_lucius
ENSG00000065457	ADAT1	100	85.000	ENSFCAG00000031932	ADAT1	100	80.478	Felis_catus
ENSG00000065457	ADAT1	100	70.909	ENSFALG00000002524	ADAT1	99	57.115	Ficedula_albicollis
ENSG00000065457	ADAT1	100	88.991	ENSFDAG00000019304	ADAT1	100	82.271	Fukomys_damarensis
ENSG00000065457	ADAT1	100	55.046	ENSFHEG00000020413	adat1	98	47.379	Fundulus_heteroclitus
ENSG00000065457	ADAT1	100	68.807	ENSGALG00000000908	ADAT1	99	58.020	Gallus_gallus
ENSG00000065457	ADAT1	100	52.294	ENSGAFG00000021954	adat1	99	45.793	Gambusia_affinis
ENSG00000065457	ADAT1	98	53.271	ENSGACG00000002177	adat1	98	39.679	Gasterosteus_aculeatus
ENSG00000065457	ADAT1	100	70.909	ENSGAGG00000023840	ADAT1	99	60.236	Gopherus_agassizii
ENSG00000065457	ADAT1	100	100.000	ENSGGOG00000014665	ADAT1	100	98.606	Gorilla_gorilla
ENSG00000065457	ADAT1	98	56.075	ENSHBUG00000023160	adat1	95	47.879	Haplochromis_burtoni
ENSG00000065457	ADAT1	100	61.468	ENSHCOG00000006772	adat1	100	46.756	Hippocampus_comes
ENSG00000065457	ADAT1	98	56.481	ENSIPUG00000008416	adat1	99	48.111	Ictalurus_punctatus
ENSG00000065457	ADAT1	100	88.991	ENSSTOG00000022627	ADAT1	100	82.072	Ictidomys_tridecemlineatus
ENSG00000065457	ADAT1	100	55.963	ENSKMAG00000016307	adat1	98	47.590	Kryptolebias_marmoratus
ENSG00000065457	ADAT1	100	57.798	ENSLBEG00000027434	adat1	77	47.111	Labrus_bergylta
ENSG00000065457	ADAT1	100	57.798	ENSLBEG00000007725	-	97	49.353	Labrus_bergylta
ENSG00000065457	ADAT1	68	45.402	ENSLACG00000007761	ADAT1	100	45.402	Latimeria_chalumnae
ENSG00000065457	ADAT1	100	59.633	ENSLOCG00000003068	-	75	59.627	Lepisosteus_oculatus
ENSG00000065457	ADAT1	100	85.000	ENSLAFG00000000865	ADAT1	100	80.915	Loxodonta_africana
ENSG00000065457	ADAT1	100	95.625	ENSMFAG00000026786	ADAT1	100	95.020	Macaca_fascicularis
ENSG00000065457	ADAT1	100	95.000	ENSMMUG00000005751	ADAT1	100	94.622	Macaca_mulatta
ENSG00000065457	ADAT1	100	95.625	ENSMNEG00000032840	ADAT1	100	94.821	Macaca_nemestrina
ENSG00000065457	ADAT1	100	95.625	ENSMLEG00000041477	ADAT1	100	95.219	Mandrillus_leucophaeus
ENSG00000065457	ADAT1	100	56.881	ENSMAMG00000013028	adat1	99	45.507	Mastacembelus_armatus
ENSG00000065457	ADAT1	100	53.211	ENSMZEG00005015291	adat1	98	46.371	Maylandia_zebra
ENSG00000065457	ADAT1	100	86.875	ENSMAUG00000009647	Adat1	100	75.000	Mesocricetus_auratus
ENSG00000065457	ADAT1	100	91.743	ENSMICG00000011987	ADAT1	100	84.861	Microcebus_murinus
ENSG00000065457	ADAT1	100	86.875	ENSMOCG00000018424	Adat1	100	79.324	Microtus_ochrogaster
ENSG00000065457	ADAT1	100	54.128	ENSMMOG00000010638	adat1	99	45.743	Mola_mola
ENSG00000065457	ADAT1	100	75.776	ENSMODG00000002203	ADAT1	100	67.659	Monodelphis_domestica
ENSG00000065457	ADAT1	100	61.468	ENSMALG00000008062	adat1	99	46.850	Monopterus_albus
ENSG00000065457	ADAT1	100	85.000	MGP_CAROLIEiJ_G0031587	Adat1	100	77.579	Mus_caroli
ENSG00000065457	ADAT1	100	85.625	ENSMUSG00000031949	Adat1	100	77.381	Mus_musculus
ENSG00000065457	ADAT1	100	85.000	MGP_PahariEiJ_G0023185	Adat1	100	77.342	Mus_pahari
ENSG00000065457	ADAT1	100	86.250	MGP_SPRETEiJ_G0032705	Adat1	100	78.214	Mus_spretus
ENSG00000065457	ADAT1	100	86.875	ENSMPUG00000009882	ADAT1	98	79.681	Mustela_putorius_furo
ENSG00000065457	ADAT1	100	88.073	ENSMLUG00000015114	-	100	84.064	Myotis_lucifugus
ENSG00000065457	ADAT1	100	80.000	ENSMLUG00000024071	-	100	75.100	Myotis_lucifugus
ENSG00000065457	ADAT1	100	90.826	ENSNGAG00000019449	Adat1	100	80.080	Nannospalax_galili
ENSG00000065457	ADAT1	98	52.866	ENSNBRG00000003827	adat1	98	46.045	Neolamprologus_brichardi
ENSG00000065457	ADAT1	100	96.875	ENSNLEG00000013060	ADAT1	100	96.215	Nomascus_leucogenys
ENSG00000065457	ADAT1	100	60.625	ENSMEUG00000004823	ADAT1	100	59.046	Notamacropus_eugenii
ENSG00000065457	ADAT1	100	83.125	ENSOPRG00000012530	ADAT1	100	78.088	Ochotona_princeps
ENSG00000065457	ADAT1	100	85.321	ENSODEG00000014036	ADAT1	100	87.662	Octodon_degus
ENSG00000065457	ADAT1	58	38.796	ENSONIG00000010929	-	99	38.796	Oreochromis_niloticus
ENSG00000065457	ADAT1	99	74.684	ENSOANG00000008178	ADAT1	97	64.591	Ornithorhynchus_anatinus
ENSG00000065457	ADAT1	99	86.111	ENSOCUG00000015540	ADAT1	100	80.876	Oryctolagus_cuniculus
ENSG00000065457	ADAT1	98	56.075	ENSORLG00000015148	adat1	98	46.800	Oryzias_latipes
ENSG00000065457	ADAT1	98	56.075	ENSORLG00020013336	adat1	98	46.800	Oryzias_latipes_hni
ENSG00000065457	ADAT1	98	56.075	ENSORLG00015003577	adat1	98	46.800	Oryzias_latipes_hsok
ENSG00000065457	ADAT1	100	58.716	ENSOMEG00000019510	adat1	98	46.318	Oryzias_melastigma
ENSG00000065457	ADAT1	100	91.743	ENSOGAG00000005899	ADAT1	100	85.458	Otolemur_garnettii
ENSG00000065457	ADAT1	99	89.815	ENSOARG00000006898	ADAT1	100	81.873	Ovis_aries
ENSG00000065457	ADAT1	100	99.375	ENSPPAG00000035006	ADAT1	100	99.203	Pan_paniscus
ENSG00000065457	ADAT1	100	85.625	ENSPPRG00000002924	ADAT1	100	81.275	Panthera_pardus
ENSG00000065457	ADAT1	100	85.625	ENSPTIG00000008308	ADAT1	100	81.474	Panthera_tigris_altaica
ENSG00000065457	ADAT1	100	100.000	ENSPTRG00000008363	ADAT1	100	98.805	Pan_troglodytes
ENSG00000065457	ADAT1	100	95.625	ENSPANG00000015739	ADAT1	100	95.418	Papio_anubis
ENSG00000065457	ADAT1	100	60.550	ENSPKIG00000004925	adat1	73	55.906	Paramormyrops_kingsleyae
ENSG00000065457	ADAT1	100	68.142	ENSPSIG00000010286	ADAT1	99	58.661	Pelodiscus_sinensis
ENSG00000065457	ADAT1	92	55.000	ENSPMGG00000021265	adat1	94	43.750	Periophthalmus_magnuspinnatus
ENSG00000065457	ADAT1	99	86.164	ENSPEMG00000013185	Adat1	100	76.984	Peromyscus_maniculatus_bairdii
ENSG00000065457	ADAT1	96	56.190	ENSPMAG00000003955	adat1	99	43.504	Petromyzon_marinus
ENSG00000065457	ADAT1	100	75.625	ENSPCIG00000010759	ADAT1	100	68.390	Phascolarctos_cinereus
ENSG00000065457	ADAT1	100	53.211	ENSPFOG00000003012	adat1	100	46.230	Poecilia_formosa
ENSG00000065457	ADAT1	100	51.376	ENSPLAG00000019711	adat1	64	46.638	Poecilia_latipinna
ENSG00000065457	ADAT1	100	52.294	ENSPMEG00000001784	adat1	99	46.429	Poecilia_mexicana
ENSG00000065457	ADAT1	100	52.294	ENSPREG00000003181	adat1	100	45.618	Poecilia_reticulata
ENSG00000065457	ADAT1	100	98.750	ENSPPYG00000007566	ADAT1	100	97.821	Pongo_abelii
ENSG00000065457	ADAT1	100	80.734	ENSPCAG00000010651	ADAT1	85	80.142	Procavia_capensis
ENSG00000065457	ADAT1	100	90.000	ENSPCOG00000017311	ADAT1	100	86.056	Propithecus_coquereli
ENSG00000065457	ADAT1	100	85.000	ENSPVAG00000006747	ADAT1	100	80.080	Pteropus_vampyrus
ENSG00000065457	ADAT1	100	49.383	ENSPNYG00000003974	adat1	98	45.582	Pundamilia_nyererei
ENSG00000065457	ADAT1	100	55.625	ENSPNAG00000017166	adat1	96	48.104	Pygocentrus_nattereri
ENSG00000065457	ADAT1	99	86.111	ENSRNOG00000019434	Adat1	100	77.734	Rattus_norvegicus
ENSG00000065457	ADAT1	100	95.625	ENSRBIG00000035278	ADAT1	100	95.020	Rhinopithecus_bieti
ENSG00000065457	ADAT1	100	95.625	ENSRROG00000041834	ADAT1	100	95.219	Rhinopithecus_roxellana
ENSG00000065457	ADAT1	100	93.750	ENSSBOG00000017477	ADAT1	100	91.833	Saimiri_boliviensis_boliviensis
ENSG00000065457	ADAT1	84	72.277	ENSSHAG00000002356	ADAT1	100	65.217	Sarcophilus_harrisii
ENSG00000065457	ADAT1	100	61.468	ENSSDUG00000003575	adat1	99	48.521	Seriola_dumerili
ENSG00000065457	ADAT1	100	60.550	ENSSLDG00000003816	adat1	99	48.221	Seriola_lalandi_dorsalis
ENSG00000065457	ADAT1	99	60.377	ENSSPUG00000004954	ADAT1	99	56.189	Sphenodon_punctatus
ENSG00000065457	ADAT1	93	52.475	ENSSPAG00000004961	adat1	98	43.030	Stegastes_partitus
ENSG00000065457	ADAT1	100	88.073	ENSSSCG00000002706	ADAT1	100	81.275	Sus_scrofa
ENSG00000065457	ADAT1	100	70.909	ENSTGUG00000008449	ADAT1	99	56.917	Taeniopygia_guttata
ENSG00000065457	ADAT1	98	55.046	ENSTRUG00000003122	adat1	99	46.575	Takifugu_rubripes
ENSG00000065457	ADAT1	97	52.903	ENSTNIG00000008848	adat1	99	46.906	Tetraodon_nigroviridis
ENSG00000065457	ADAT1	98	57.944	ENSTNIG00000006547	-	99	54.375	Tetraodon_nigroviridis
ENSG00000065457	ADAT1	84	90.099	ENSTBEG00000015813	ADAT1	81	80.833	Tupaia_belangeri
ENSG00000065457	ADAT1	100	88.125	ENSTTRG00000001220	ADAT1	100	84.263	Tursiops_truncatus
ENSG00000065457	ADAT1	63	82.667	ENSUAMG00000017560	-	95	79.225	Ursus_americanus
ENSG00000065457	ADAT1	100	85.000	ENSUMAG00000014551	ADAT1	94	81.474	Ursus_maritimus
ENSG00000065457	ADAT1	100	88.750	ENSVPAG00000003715	ADAT1	100	76.693	Vicugna_pacos
ENSG00000065457	ADAT1	100	86.250	ENSVVUG00000024326	ADAT1	98	82.669	Vulpes_vulpes
ENSG00000065457	ADAT1	100	61.818	ENSXETG00000003571	adat1	99	51.389	Xenopus_tropicalis
ENSG00000065457	ADAT1	100	51.376	ENSXCOG00000020759	adat1	98	46.108	Xiphophorus_couchianus
ENSG00000065457	ADAT1	100	52.294	ENSXMAG00000016043	adat1	98	46.507	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	10430867.	IMP	Function
GO:0008033	tRNA processing	10430867.	IMP	Process
GO:0008251	tRNA-specific adenosine deaminase activity	10430867.	IMP	Function
GO:0046872	metal ion binding	-	IEA	Function