EuRBPDB

Description

Ensembl ID: ENSG00000065613 (Gene tree)
Gene ID: 9748
Gene Symbol: SLK
Alias: STK2|se20-9|KIAA0204
Full Name: STE20 like kinase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 62,052 bases
Position: chr10:103,967,182-104,029,233
Accession: 11088
RBP type: non-canonical RBP
Summary: (STE20 Like Kinase) is a Protein Coding gene. Diseases associated with SLK include Autoimmune Glomerulonephritis and Robinow Syndrome, Autosomal Dominant 1. Among its related pathways are DNA Damage and Adhesion. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is STK10.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17003224	The 3'-untranslated region of the Ste20-like kinase SLK regulates SLK expression.	Am J Physiol Renal Physiol	2007 Feb	Cybulsky AV	-
26074452	Hypoxia induces miR-210, leading to anti-apoptosis in ovarian follicular cells of marine medaka Oryzias melastigma.	Aquat Toxicol	2015 Aug	Tse AC	doi: 10.1016/j.aquatox.2015.06.002
28984199	Roles of alternative splicing in modulating transcriptional regulation.	BMC Syst Biol	2017 Oct 3	Li J	doi: 10.1186/s12918-017-0465-6.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000474260	SLK-203	622	-	-	- (aa)	-	-
ENST00000369755	SLK-202	7766	XM_011540401	ENSP00000358770	1235 (aa)	XP_011538703	Q9H2G2
ENST00000335753	SLK-201	7673	-	ENSP00000336824	1204 (aa)	-	Q9H2G2

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04114	Oocyte meiosis	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	18239682.	IDA	Function
GO:0005515	protein binding	25882817.26094769.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	18287541.26094769.	IDA	Component
GO:0006915	apoptotic process	-	IEA	Process
GO:0023014	signal transduction by protein phosphorylation	21873635.	IBA	Process
GO:0030334	regulation of cell migration	26818812.	IMP	Process
GO:0030334	regulation of cell migration	-	ISS	Process
GO:0031098	stress-activated protein kinase signaling cascade	21873635.	IBA	Process
GO:0031122	cytoplasmic microtubule organization	18287541.	IMP	Process
GO:0031252	cell leading edge	-	ISS	Component
GO:0032147	activation of protein kinase activity	21873635.	IBA	Process
GO:0042802	identical protein binding	18239682.	IPI	Function
GO:0042803	protein homodimerization activity	18239682.22203681.	IDA	Function
GO:0042981	regulation of apoptotic process	22203681.	IDA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046777	protein autophosphorylation	18239682.	IDA	Process
GO:0048471	perinuclear region of cytoplasm	26094769.	IDA	Component
GO:0051893	regulation of focal adhesion assembly	23128389.	IDA	Process
GO:0070062	extracellular exosome	19056867.19199708.	HDA	Component