EuRBPDB

Description

Ensembl ID: ENSG00000066084 (Gene tree)
Gene ID: 57609
Gene Symbol: DIP2B
Alias: KIAA1463|FLJ34278
Full Name: disco interacting protein 2 homolog B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 243,683 bases
Position: chr12:50,504,985-50,748,667
Accession: 29284
RBP type: non-canonical RBP
Summary: This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000549620	DIP2B-204	2676	-	-	- (aa)	-	-
ENST00000301180	DIP2B-201	8593	-	ENSP00000301180	1576 (aa)	-	Q9P265
ENST00000546732	DIP2B-203	3514	-	ENSP00000450181	64 (aa)	-	H0YIU5
ENST00000552328	DIP2B-205	429	-	-	- (aa)	-	-
ENST00000546719	DIP2B-202	2297	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000066084	Intelligence Tests	2.0275200E-005	-
ENSG00000066084	Intelligence Tests	1.0570700E-005	-
ENSG00000066084	Child Development Disorders, Pervasive	8.4276200E-006	-
ENSG00000066084	Child Development Disorders, Pervasive	2.9785900E-005	-
ENSG00000066084	Alopecia	2E-9	27182965
ENSG00000066084	Fibrinogen	9E-12	26561523
ENSG00000066084	Colorectal Neoplasms	2E-10	20972440
ENSG00000066084	Colorectal Neoplasms	4E-8	25990418
ENSG00000066084	Fibrinogen	3E-11	28107422
ENSG00000066084	Fibrinogen	3E-8	23969696

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000066084	rs7968440	12	50740958	A	Fibrinogen	23969696	[0.004-0.008] unit increase	0.006	EFO_0004623
ENSG00000066084	rs2731439	12	50666567	T	Fibrinogen levels	26561523	NR unit decrease	0.0064	EFO_0004623
ENSG00000066084	rs4768903	12	50651666	A	Colorectal cancer	25990418	[NR]	1.1	EFO_0005842
ENSG00000066084	rs71086466	12	50657224	C	Red cell distribution width	27863252	[0.019-0.035] unit decrease	0.027194	EFO_0005192
ENSG00000066084	rs11390181	12	50536868	AT	Plateletcrit	27863252	[0.022-0.037] unit decrease	0.0295376	EFO_0007985
ENSG00000066084	rs1521516	12	50661925	?	Fibrinogen levels	28107422	unit increase	0.0072	EFO_0004623
ENSG00000066084	rs35173156	12	50574547	C	Red cell distribution width	28957414	[0.023-0.043] unit increase	0.0330374	EFO_0005192
ENSG00000066084	rs7308872	12	50726391	?	Balding type 1	30595370			EFO_0007825
ENSG00000066084	rs1047912	12	50745079	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000066084	rs1047912	12	50745079	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000066084	rs10876041	12	50508099	?	Lipid traits (pleiotropy) (HIPO component 2)	30289880			EFO_0004574\|EFO_0004530\|EFO_0004611\|EFO_0004612
ENSG00000066084	rs17210898	12	50662728	G	Diastolic blood pressure	27841878	unit increase	0.351	EFO_0006336
ENSG00000066084	rs17210898	12	50662728	G	Systolic blood pressure	27841878	unit increase	0.556	EFO_0006335

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003674	molecular_function	-	ND	Function
GO:0003824	catalytic activity	-	IEA	Function
GO:0005634	nucleus	15531550.	IDA	Component
GO:0005737	cytoplasm	15531550.	IDA	Component
GO:0008150	biological_process	-	ND	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0070062	extracellular exosome	20458337.	HDA	Component