EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000067248 (Gene tree)
Gene ID: 54505
Gene Symbol: DHX29
Alias: DDX29
Full Name: DExH-box helicase 29
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 51,478 bases
Position: chr5:55,256,245-55,307,722
Accession: 15815
RBP type: canonical RBP
Summary: This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000251636	DEAD	PF00270.29	2.9e-10	1	1
ENSP00000481966	DEAD	PF00270.29	2.9e-10	1	1
ENSP00000251636	HA2	PF04408.23	1.2e-15	1	1
ENSP00000481966	HA2	PF04408.23	1.2e-15	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000504778	DHX29-202	4557	-	-	- (aa)	-	-
ENST00000513447	DHX29-204	844	-	-	- (aa)	-	-
ENST00000508346	DHX29-203	479	-	ENSP00000421435	160 (aa)	-	H0Y8L1
ENST00000251636	DHX29-201	4502	-	ENSP00000251636	1369 (aa)	-	Q7Z478
ENST00000621106	DHX29-205	4450	-	ENSP00000481966	1370 (aa)	-	A0A087WYN9

Gene Model

Click here to download ENSG00000067248's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000067248's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000067248	DHX29	52	40.796	ENSG00000067596	DHX8	50	40.196
ENSG00000067248	DHX29	61	40.521	ENSG00000174953	DHX36	98	46.789
ENSG00000067248	DHX29	53	49.282	ENSG00000047188	YTHDC2	55	46.930
ENSG00000067248	DHX29	60	39.636	ENSG00000163214	DHX57	99	36.903
ENSG00000067248	DHX29	57	34.496	ENSG00000132153	DHX30	65	33.455
ENSG00000067248	DHX29	65	33.148	ENSG00000135829	DHX9	63	33.839

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000067248	DHX29	98	61.960	ENSAPOG00000007731	dhx29	99	61.461	Acanthochromis_polyacanthus
ENSG00000067248	DHX29	100	93.864	ENSAMEG00000013838	DHX29	100	93.572	Ailuropoda_melanoleuca
ENSG00000067248	DHX29	86	66.851	ENSACIG00000015064	dhx29	99	67.318	Amphilophus_citrinellus
ENSG00000067248	DHX29	99	61.302	ENSAOCG00000011810	dhx29	99	67.073	Amphiprion_ocellaris
ENSG00000067248	DHX29	100	61.016	ENSAPEG00000019407	dhx29	99	67.623	Amphiprion_percula
ENSG00000067248	DHX29	94	62.625	ENSATEG00000015041	dhx29	99	60.317	Anabas_testudineus
ENSG00000067248	DHX29	95	79.119	ENSAPLG00000009145	DHX29	100	79.499	Anas_platyrhynchos
ENSG00000067248	DHX29	96	79.163	ENSACAG00000015328	DHX29	99	76.551	Anolis_carolinensis
ENSG00000067248	DHX29	100	97.955	ENSANAG00000005482	DHX29	100	97.955	Aotus_nancymaae
ENSG00000067248	DHX29	97	62.611	ENSACLG00000001805	dhx29	97	63.506	Astatotilapia_calliptera
ENSG00000067248	DHX29	95	58.496	ENSAMXG00000018788	dhx29	99	58.346	Astyanax_mexicanus
ENSG00000067248	DHX29	100	94.453	ENSBTAG00000010510	DHX29	100	94.015	Bos_taurus
ENSG00000067248	DHX29	100	97.516	ENSCJAG00000001692	DHX29	100	97.516	Callithrix_jacchus
ENSG00000067248	DHX29	100	94.891	ENSCAFG00000006710	DHX29	100	95.036	Canis_familiaris
ENSG00000067248	DHX29	100	94.891	ENSCAFG00020024395	DHX29	100	96.234	Canis_lupus_dingo
ENSG00000067248	DHX29	99	94.367	ENSCHIG00000013568	-	100	94.075	Capra_hircus
ENSG00000067248	DHX29	99	95.611	ENSTSYG00000003651	DHX29	100	95.538	Carlito_syrichta
ENSG00000067248	DHX29	72	92.982	ENSCAPG00000014688	DHX29	98	92.982	Cavia_aperea
ENSG00000067248	DHX29	100	90.504	ENSCPOG00000040097	DHX29	100	90.657	Cavia_porcellus
ENSG00000067248	DHX29	100	97.882	ENSCCAG00000026726	DHX29	100	97.882	Cebus_capucinus
ENSG00000067248	DHX29	100	98.101	ENSCATG00000036778	DHX29	100	98.101	Cercocebus_atys
ENSG00000067248	DHX29	100	93.791	ENSCLAG00000007178	DHX29	99	93.718	Chinchilla_lanigera
ENSG00000067248	DHX29	100	97.956	ENSCSAG00000016510	DHX29	100	97.956	Chlorocebus_sabaeus
ENSG00000067248	DHX29	97	81.729	ENSCPBG00000026552	DHX29	100	80.249	Chrysemys_picta_bellii
ENSG00000067248	DHX29	100	98.101	ENSCANG00000031806	DHX29	100	98.101	Colobus_angolensis_palliatus
ENSG00000067248	DHX29	100	92.487	ENSCGRG00001002444	Dhx29	100	92.560	Cricetulus_griseus_chok1gshd
ENSG00000067248	DHX29	100	92.487	ENSCGRG00000005333	DHX29	100	92.560	Cricetulus_griseus_crigri
ENSG00000067248	DHX29	96	59.467	ENSCSEG00000018670	dhx29	99	58.424	Cynoglossus_semilaevis
ENSG00000067248	DHX29	99	60.113	ENSCVAG00000004486	dhx29	93	67.737	Cyprinodon_variegatus
ENSG00000067248	DHX29	99	61.819	ENSDARG00000040326	dhx29	99	61.676	Danio_rerio
ENSG00000067248	DHX29	95	89.169	ENSDNOG00000015364	DHX29	99	89.169	Dasypus_novemcinctus
ENSG00000067248	DHX29	83	92.733	ENSDORG00000006778	Dhx29	100	90.044	Dipodomys_ordii
ENSG00000067248	DHX29	79	96.667	ENSETEG00000000721	DHX29	79	96.667	Echinops_telfairi
ENSG00000067248	DHX29	100	95.255	ENSEASG00005013287	DHX29	100	95.401	Equus_asinus_asinus
ENSG00000067248	DHX29	100	95.109	ENSECAG00000024365	DHX29	100	95.385	Equus_caballus
ENSG00000067248	DHX29	78	95.628	ENSEEUG00000000507	DHX29	82	95.628	Erinaceus_europaeus
ENSG00000067248	DHX29	99	61.489	ENSELUG00000004969	dhx29	93	69.697	Esox_lucius
ENSG00000067248	DHX29	100	94.526	ENSFCAG00000008182	DHX29	100	94.672	Felis_catus
ENSG00000067248	DHX29	92	79.428	ENSFALG00000010826	DHX29	100	79.825	Ficedula_albicollis
ENSG00000067248	DHX29	100	93.572	ENSFDAG00000019507	DHX29	100	93.499	Fukomys_damarensis
ENSG00000067248	DHX29	99	59.585	ENSFHEG00000022875	DHX29	99	59.871	Fundulus_heteroclitus
ENSG00000067248	DHX29	97	61.431	ENSGMOG00000014621	dhx29	100	60.445	Gadus_morhua
ENSG00000067248	DHX29	100	77.213	ENSGALG00000014700	DHX29	100	77.529	Gallus_gallus
ENSG00000067248	DHX29	95	61.688	ENSGAFG00000012487	dhx29	94	65.629	Gambusia_affinis
ENSG00000067248	DHX29	97	61.504	ENSGACG00000016244	dhx29	100	60.904	Gasterosteus_aculeatus
ENSG00000067248	DHX29	97	81.067	ENSGAGG00000020049	DHX29	99	79.768	Gopherus_agassizii
ENSG00000067248	DHX29	100	99.489	ENSGGOG00000001862	DHX29	100	99.489	Gorilla_gorilla
ENSG00000067248	DHX29	97	62.741	ENSHBUG00000006356	dhx29	97	63.431	Haplochromis_burtoni
ENSG00000067248	DHX29	99	93.197	ENSHGLG00000015591	DHX29	100	93.489	Heterocephalus_glaber_female
ENSG00000067248	DHX29	99	93.270	ENSHGLG00100013079	DHX29	100	93.563	Heterocephalus_glaber_male
ENSG00000067248	DHX29	69	65.010	ENSHCOG00000019967	dhx29	97	64.907	Hippocampus_comes
ENSG00000067248	DHX29	95	62.529	ENSIPUG00000024354	dhx29	95	67.598	Ictalurus_punctatus
ENSG00000067248	DHX29	100	94.887	ENSSTOG00000010789	DHX29	99	94.887	Ictidomys_tridecemlineatus
ENSG00000067248	DHX29	100	90.743	ENSJJAG00000024034	Dhx29	100	90.452	Jaculus_jaculus
ENSG00000067248	DHX29	99	61.191	ENSKMAG00000012503	dhx29	99	60.665	Kryptolebias_marmoratus
ENSG00000067248	DHX29	80	67.922	ENSLBEG00000019477	dhx29	97	67.922	Labrus_bergylta
ENSG00000067248	DHX29	99	67.777	ENSLACG00000011195	DHX29	100	67.656	Latimeria_chalumnae
ENSG00000067248	DHX29	99	66.300	ENSLOCG00000010159	dhx29	99	65.440	Lepisosteus_oculatus
ENSG00000067248	DHX29	100	92.044	ENSLAFG00000010492	DHX29	100	92.044	Loxodonta_africana
ENSG00000067248	DHX29	100	98.028	ENSMFAG00000003740	DHX29	100	98.028	Macaca_fascicularis
ENSG00000067248	DHX29	100	97.955	ENSMMUG00000010376	DHX29	100	97.955	Macaca_mulatta
ENSG00000067248	DHX29	100	98.101	ENSMNEG00000027210	DHX29	100	98.101	Macaca_nemestrina
ENSG00000067248	DHX29	100	97.809	ENSMLEG00000032837	DHX29	100	97.809	Mandrillus_leucophaeus
ENSG00000067248	DHX29	95	65.328	ENSMAMG00000016839	dhx29	99	65.328	Mastacembelus_armatus
ENSG00000067248	DHX29	97	62.463	ENSMZEG00005000550	dhx29	93	68.531	Maylandia_zebra
ENSG00000067248	DHX29	95	64.161	ENSMGAG00000003948	DHX29	99	63.967	Meleagris_gallopavo
ENSG00000067248	DHX29	100	92.341	ENSMAUG00000009094	Dhx29	100	92.414	Mesocricetus_auratus
ENSG00000067248	DHX29	100	95.773	ENSMICG00000012740	DHX29	100	95.773	Microcebus_murinus
ENSG00000067248	DHX29	100	91.454	ENSMOCG00000010302	Dhx29	100	91.339	Microtus_ochrogaster
ENSG00000067248	DHX29	79	68.106	ENSMMOG00000002478	dhx29	99	68.106	Mola_mola
ENSG00000067248	DHX29	99	87.721	ENSMODG00000019487	DHX29	99	88.015	Monodelphis_domestica
ENSG00000067248	DHX29	96	62.491	ENSMALG00000003169	dhx29	99	61.521	Monopterus_albus
ENSG00000067248	DHX29	100	90.226	MGP_CAROLIEiJ_G0018897	Dhx29	100	90.153	Mus_caroli
ENSG00000067248	DHX29	100	90.803	ENSMUSG00000042426	Dhx29	100	90.730	Mus_musculus
ENSG00000067248	DHX29	100	91.028	MGP_PahariEiJ_G0015968	Dhx29	100	90.956	Mus_pahari
ENSG00000067248	DHX29	100	90.306	MGP_SPRETEiJ_G0019776	Dhx29	100	90.233	Mus_spretus
ENSG00000067248	DHX29	100	94.380	ENSMPUG00000007636	DHX29	100	94.380	Mustela_putorius_furo
ENSG00000067248	DHX29	100	91.247	ENSMLUG00000001130	DHX29	100	91.174	Myotis_lucifugus
ENSG00000067248	DHX29	100	92.628	ENSNGAG00000018322	Dhx29	100	92.555	Nannospalax_galili
ENSG00000067248	DHX29	83	68.050	ENSNBRG00000011405	dhx29	99	68.531	Neolamprologus_brichardi
ENSG00000067248	DHX29	100	98.758	ENSNLEG00000001232	DHX29	100	98.758	Nomascus_leucogenys
ENSG00000067248	DHX29	69	92.432	ENSMEUG00000006454	-	81	92.432	Notamacropus_eugenii
ENSG00000067248	DHX29	88	94.172	ENSOPRG00000007959	DHX29	92	94.172	Ochotona_princeps
ENSG00000067248	DHX29	99	89.574	ENSODEG00000017600	DHX29	98	89.868	Octodon_degus
ENSG00000067248	DHX29	97	62.982	ENSONIG00000007583	dhx29	99	62.069	Oreochromis_niloticus
ENSG00000067248	DHX29	92	88.025	ENSOANG00000004883	-	100	88.184	Ornithorhynchus_anatinus
ENSG00000067248	DHX29	100	94.887	ENSOCUG00000004454	DHX29	100	95.179	Oryctolagus_cuniculus
ENSG00000067248	DHX29	96	62.144	ENSORLG00000005364	dhx29	99	66.985	Oryzias_latipes
ENSG00000067248	DHX29	81	66.803	ENSORLG00020006421	dhx29	94	66.712	Oryzias_latipes_hni
ENSG00000067248	DHX29	96	61.769	ENSORLG00015013087	dhx29	99	66.712	Oryzias_latipes_hsok
ENSG00000067248	DHX29	100	59.957	ENSOMEG00000008943	dhx29	99	60.628	Oryzias_melastigma
ENSG00000067248	DHX29	100	94.672	ENSOGAG00000002880	DHX29	100	94.891	Otolemur_garnettii
ENSG00000067248	DHX29	100	93.800	ENSOARG00000007827	DHX29	100	93.363	Ovis_aries
ENSG00000067248	DHX29	100	99.345	ENSPPAG00000041713	DHX29	100	99.345	Pan_paniscus
ENSG00000067248	DHX29	100	94.891	ENSPPRG00000024000	DHX29	100	94.891	Panthera_pardus
ENSG00000067248	DHX29	100	94.748	ENSPTIG00000009977	DHX29	100	94.894	Panthera_tigris_altaica
ENSG00000067248	DHX29	100	99.416	ENSPTRG00000016875	DHX29	100	99.416	Pan_troglodytes
ENSG00000067248	DHX29	100	97.955	ENSPANG00000013603	DHX29	100	97.955	Papio_anubis
ENSG00000067248	DHX29	99	62.591	ENSPKIG00000020627	dhx29	99	63.588	Paramormyrops_kingsleyae
ENSG00000067248	DHX29	97	81.142	ENSPSIG00000011702	DHX29	100	79.550	Pelodiscus_sinensis
ENSG00000067248	DHX29	86	64.982	ENSPMGG00000002597	dhx29	100	64.982	Periophthalmus_magnuspinnatus
ENSG00000067248	DHX29	100	91.977	ENSPEMG00000004741	Dhx29	100	91.831	Peromyscus_maniculatus_bairdii
ENSG00000067248	DHX29	88	88.779	ENSPCIG00000024988	DHX29	100	88.801	Phascolarctos_cinereus
ENSG00000067248	DHX29	96	55.928	ENSPFOG00000012697	dhx29	99	55.018	Poecilia_formosa
ENSG00000067248	DHX29	68	69.124	ENSPLAG00000000725	dhx29	90	68.421	Poecilia_latipinna
ENSG00000067248	DHX29	70	68.981	ENSPMEG00000010486	dhx29	91	68.276	Poecilia_mexicana
ENSG00000067248	DHX29	99	60.129	ENSPREG00000003029	dhx29	99	60.000	Poecilia_reticulata
ENSG00000067248	DHX29	81	99.549	ENSPPYG00000015468	DHX29	100	99.549	Pongo_abelii
ENSG00000067248	DHX29	66	95.833	ENSPCAG00000012957	DHX29	69	95.833	Procavia_capensis
ENSG00000067248	DHX29	100	89.690	ENSPCOG00000021937	DHX29	100	89.690	Propithecus_coquereli
ENSG00000067248	DHX29	100	93.212	ENSPVAG00000002444	DHX29	100	93.212	Pteropus_vampyrus
ENSG00000067248	DHX29	99	59.450	ENSPNYG00000006076	dhx29	94	61.986	Pundamilia_nyererei
ENSG00000067248	DHX29	99	62.818	ENSPNAG00000008720	dhx29	99	62.727	Pygocentrus_nattereri
ENSG00000067248	DHX29	100	90.664	ENSRNOG00000010369	Dhx29	100	90.518	Rattus_norvegicus
ENSG00000067248	DHX29	100	98.320	ENSRBIG00000032473	DHX29	100	98.320	Rhinopithecus_bieti
ENSG00000067248	DHX29	100	98.320	ENSRROG00000044066	DHX29	100	98.320	Rhinopithecus_roxellana
ENSG00000067248	DHX29	100	97.736	ENSSBOG00000026450	DHX29	100	97.736	Saimiri_boliviensis_boliviensis
ENSG00000067248	DHX29	96	89.076	ENSSHAG00000003003	DHX29	98	89.076	Sarcophilus_harrisii
ENSG00000067248	DHX29	99	61.349	ENSSFOG00015014445	dhx29	94	63.392	Scleropages_formosus
ENSG00000067248	DHX29	99	61.687	ENSSMAG00000007649	dhx29	99	68.994	Scophthalmus_maximus
ENSG00000067248	DHX29	99	61.544	ENSSDUG00000023790	dhx29	99	67.164	Seriola_dumerili
ENSG00000067248	DHX29	99	61.456	ENSSLDG00000006175	dhx29	99	67.571	Seriola_lalandi_dorsalis
ENSG00000067248	DHX29	99	86.623	ENSSARG00000008364	DHX29	100	86.404	Sorex_araneus
ENSG00000067248	DHX29	98	78.459	ENSSPUG00000006458	DHX29	100	83.983	Sphenodon_punctatus
ENSG00000067248	DHX29	94	63.733	ENSSPAG00000011500	dhx29	99	63.568	Stegastes_partitus
ENSG00000067248	DHX29	79	68.457	ENSSPAG00000011397	dhx29	99	69.359	Stegastes_partitus
ENSG00000067248	DHX29	100	94.088	ENSSSCG00000016907	DHX29	100	96.095	Sus_scrofa
ENSG00000067248	DHX29	95	77.557	ENSTGUG00000002464	DHX29	100	77.939	Taeniopygia_guttata
ENSG00000067248	DHX29	95	63.276	ENSTRUG00000014726	dhx29	99	65.848	Takifugu_rubripes
ENSG00000067248	DHX29	97	61.556	ENSTNIG00000007548	dhx29	99	61.211	Tetraodon_nigroviridis
ENSG00000067248	DHX29	95	92.857	ENSTTRG00000008675	DHX29	95	92.857	Tursiops_truncatus
ENSG00000067248	DHX29	100	94.745	ENSUAMG00000023080	DHX29	99	96.234	Ursus_americanus
ENSG00000067248	DHX29	91	95.813	ENSUMAG00000009971	DHX29	99	95.733	Ursus_maritimus
ENSG00000067248	DHX29	99	94.079	ENSVPAG00000011173	DHX29	99	94.225	Vicugna_pacos
ENSG00000067248	DHX29	100	94.818	ENSVVUG00000021328	DHX29	100	94.964	Vulpes_vulpes
ENSG00000067248	DHX29	99	67.473	ENSXETG00000000367	dhx29	99	67.653	Xenopus_tropicalis
ENSG00000067248	DHX29	95	62.033	ENSXMAG00000004847	dhx29	99	60.573	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003743	translation initiation factor activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0006413	translational initiation	-	IEA	Process
GO:0016282	eukaryotic 43S preinitiation complex	23706745.	IDA	Component
GO:0034459	ATP-dependent 3'-5' RNA helicase activity	21873635.	IBA	Function
GO:0043024	ribosomal small subunit binding	23706745.	IDA	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045948	positive regulation of translational initiation	-	IEA	Process