EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000067704 (Gene tree)
Gene ID: 55699
Gene Symbol: IARS2
Alias: FLJ10326
Full Name: isoleucyl-tRNA synthetase 2, mitochondrial
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 53,940 bases
Position: chr1:220,094,102-220,148,041
Accession: 29685
RBP type: canonical RBP
Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. This gene encodes the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Dec 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000355889	tRNA-synt_1g	PF09334.11	9.2e-21	1	1
ENSP00000355889	Anticodon_1	PF08264.13	3e-26	1	1
ENSP00000355889	zf-FPG_IleRS	PF06827.14	0.00021	1	1
ENSP00000355889	tRNA-synt_1	PF00133.22	5.1e-165	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000490891	IARS2-204	447	-	-	- (aa)	-	-
ENST00000467924	IARS2-202	656	-	-	- (aa)	-	-
ENST00000488777	IARS2-203	570	-	-	- (aa)	-	-
ENST00000366922	IARS2-201	3560	-	ENSP00000355889	1012 (aa)	-	Q9NSE4

Gene Model

Click here to download ENSG00000067704's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000067704	Intelligence Tests	2.5117900E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000067704's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000067704	IARS2	95	61.674	ENSAPOG00000007331	iars2	95	61.674	Acanthochromis_polyacanthus
ENSG00000067704	IARS2	99	88.515	ENSAMEG00000010055	IARS2	99	88.515	Ailuropoda_melanoleuca
ENSG00000067704	IARS2	95	59.521	ENSACIG00000004676	iars2	94	59.521	Amphilophus_citrinellus
ENSG00000067704	IARS2	95	62.913	ENSAOCG00000011811	iars2	96	62.913	Amphiprion_ocellaris
ENSG00000067704	IARS2	95	62.707	ENSAPEG00000003588	iars2	96	62.707	Amphiprion_percula
ENSG00000067704	IARS2	99	60.178	ENSATEG00000012272	iars2	99	60.178	Anabas_testudineus
ENSG00000067704	IARS2	90	72.896	ENSAPLG00000004136	IARS2	99	72.896	Anas_platyrhynchos
ENSG00000067704	IARS2	91	71.676	ENSACAG00000001566	IARS2	100	71.676	Anolis_carolinensis
ENSG00000067704	IARS2	100	93.083	ENSANAG00000013146	IARS2	100	93.083	Aotus_nancymaae
ENSG00000067704	IARS2	99	60.651	ENSACLG00000006953	-	98	60.651	Astatotilapia_calliptera
ENSG00000067704	IARS2	99	57.409	ENSACLG00000014763	iars2	98	57.409	Astatotilapia_calliptera
ENSG00000067704	IARS2	94	61.675	ENSAMXG00000018899	iars2	94	61.675	Astyanax_mexicanus
ENSG00000067704	IARS2	100	88.933	ENSBTAG00000012582	IARS2	100	88.933	Bos_taurus
ENSG00000067704	IARS2	94	33.912	WBGene00002153	iars-2	98	33.730	Caenorhabditis_elegans
ENSG00000067704	IARS2	84	95.106	ENSCJAG00000036768	IARS2	99	95.106	Callithrix_jacchus
ENSG00000067704	IARS2	93	90.957	ENSCAFG00000010952	IARS2	100	90.957	Canis_familiaris
ENSG00000067704	IARS2	100	89.229	ENSCAFG00020004022	IARS2	100	89.229	Canis_lupus_dingo
ENSG00000067704	IARS2	100	88.933	ENSCHIG00000022986	IARS2	100	88.933	Capra_hircus
ENSG00000067704	IARS2	100	92.490	ENSTSYG00000007722	IARS2	100	92.490	Carlito_syrichta
ENSG00000067704	IARS2	83	77.712	ENSCAPG00000016129	IARS2	93	77.712	Cavia_aperea
ENSG00000067704	IARS2	99	78.656	ENSCPOG00000012942	IARS2	99	78.656	Cavia_porcellus
ENSG00000067704	IARS2	95	95.445	ENSCCAG00000021848	IARS2	99	95.445	Cebus_capucinus
ENSG00000067704	IARS2	100	93.775	ENSCATG00000043392	IARS2	100	93.775	Cercocebus_atys
ENSG00000067704	IARS2	91	85.374	ENSCLAG00000003537	IARS2	100	85.374	Chinchilla_lanigera
ENSG00000067704	IARS2	100	94.809	ENSCSAG00000015833	IARS2	100	94.809	Chlorocebus_sabaeus
ENSG00000067704	IARS2	99	83.647	ENSCHOG00000007208	IARS2	100	83.647	Choloepus_hoffmanni
ENSG00000067704	IARS2	97	74.108	ENSCPBG00000000463	IARS2	98	74.108	Chrysemys_picta_bellii
ENSG00000067704	IARS2	94	45.350	ENSCING00000008497	-	98	45.350	Ciona_intestinalis
ENSG00000067704	IARS2	94	42.229	ENSCSAVG00000004988	-	99	46.608	Ciona_savignyi
ENSG00000067704	IARS2	100	97.628	ENSCANG00000039390	IARS2	100	97.628	Colobus_angolensis_palliatus
ENSG00000067704	IARS2	100	84.684	ENSCGRG00001023111	Iars2	100	84.684	Cricetulus_griseus_chok1gshd
ENSG00000067704	IARS2	91	85.915	ENSCGRG00000014841	Iars2	100	85.915	Cricetulus_griseus_crigri
ENSG00000067704	IARS2	96	61.885	ENSCSEG00000000072	iars2	96	61.885	Cynoglossus_semilaevis
ENSG00000067704	IARS2	96	63.153	ENSCVAG00000006967	iars2	96	63.153	Cyprinodon_variegatus
ENSG00000067704	IARS2	94	62.381	ENSDARG00000044134	iars2	96	62.381	Danio_rerio
ENSG00000067704	IARS2	100	84.532	ENSDNOG00000001167	IARS2	100	84.532	Dasypus_novemcinctus
ENSG00000067704	IARS2	100	86.858	ENSDORG00000009975	Iars2	100	86.858	Dipodomys_ordii
ENSG00000067704	IARS2	94	39.566	FBgn0036569	IleRS-m	98	39.403	Drosophila_melanogaster
ENSG00000067704	IARS2	100	78.360	ENSETEG00000015309	IARS2	100	78.360	Echinops_telfairi
ENSG00000067704	IARS2	59	56.645	ENSEBUG00000014221	-	78	56.645	Eptatretus_burgeri
ENSG00000067704	IARS2	100	90.020	ENSEASG00005007698	IARS2	100	90.020	Equus_asinus_asinus
ENSG00000067704	IARS2	100	90.316	ENSECAG00000022576	IARS2	100	90.316	Equus_caballus
ENSG00000067704	IARS2	68	85.156	ENSEEUG00000014971	IARS2	89	85.156	Erinaceus_europaeus
ENSG00000067704	IARS2	96	60.722	ENSELUG00000002308	iars2	96	60.722	Esox_lucius
ENSG00000067704	IARS2	100	86.265	ENSFCAG00000002597	IARS2	99	86.265	Felis_catus
ENSG00000067704	IARS2	86	72.299	ENSFALG00000012124	IARS2	99	72.299	Ficedula_albicollis
ENSG00000067704	IARS2	91	82.646	ENSFDAG00000017577	IARS2	99	82.646	Fukomys_damarensis
ENSG00000067704	IARS2	99	60.159	ENSFHEG00000000205	iars2	98	60.159	Fundulus_heteroclitus
ENSG00000067704	IARS2	94	62.080	ENSGMOG00000016408	iars2	95	62.080	Gadus_morhua
ENSG00000067704	IARS2	96	72.119	ENSGALG00000009566	IARS2	97	72.119	Gallus_gallus
ENSG00000067704	IARS2	99	62.042	ENSGAFG00000019495	iars2	98	62.042	Gambusia_affinis
ENSG00000067704	IARS2	99	60.732	ENSGACG00000013305	iars2	98	60.732	Gasterosteus_aculeatus
ENSG00000067704	IARS2	91	75.866	ENSGAGG00000001959	IARS2	99	75.866	Gopherus_agassizii
ENSG00000067704	IARS2	100	99.407	ENSGGOG00000007340	IARS2	100	99.407	Gorilla_gorilla
ENSG00000067704	IARS2	99	59.763	ENSHBUG00000010898	iars2	98	59.763	Haplochromis_burtoni
ENSG00000067704	IARS2	99	80.473	ENSHGLG00000002201	IARS2	99	80.473	Heterocephalus_glaber_female
ENSG00000067704	IARS2	85	83.295	ENSHGLG00100011459	IARS2	99	83.295	Heterocephalus_glaber_male
ENSG00000067704	IARS2	95	62.087	ENSHCOG00000001452	iars2	96	62.087	Hippocampus_comes
ENSG00000067704	IARS2	95	61.850	ENSIPUG00000017082	iars2	96	61.850	Ictalurus_punctatus
ENSG00000067704	IARS2	100	89.723	ENSSTOG00000005879	IARS2	100	89.723	Ictidomys_tridecemlineatus
ENSG00000067704	IARS2	100	86.462	ENSJJAG00000017672	Iars2	100	86.462	Jaculus_jaculus
ENSG00000067704	IARS2	99	60.474	ENSKMAG00000002679	iars2	98	60.474	Kryptolebias_marmoratus
ENSG00000067704	IARS2	95	58.775	ENSLBEG00000003065	iars2	97	58.189	Labrus_bergylta
ENSG00000067704	IARS2	99	67.096	ENSLACG00000012668	IARS2	98	67.096	Latimeria_chalumnae
ENSG00000067704	IARS2	76	37.201	ENSLOCG00000017033	IARS2	99	37.201	Lepisosteus_oculatus
ENSG00000067704	IARS2	99	86.560	ENSLAFG00000011090	IARS2	100	86.560	Loxodonta_africana
ENSG00000067704	IARS2	100	97.925	ENSMFAG00000000345	IARS2	100	97.925	Macaca_fascicularis
ENSG00000067704	IARS2	100	97.727	ENSMMUG00000007783	IARS2	100	97.727	Macaca_mulatta
ENSG00000067704	IARS2	100	91.026	ENSMNEG00000038908	IARS2	100	91.026	Macaca_nemestrina
ENSG00000067704	IARS2	100	93.775	ENSMLEG00000002798	IARS2	100	93.775	Mandrillus_leucophaeus
ENSG00000067704	IARS2	99	60.852	ENSMAMG00000015306	iars2	98	60.852	Mastacembelus_armatus
ENSG00000067704	IARS2	99	60.651	ENSMZEG00005014151	iars2	98	60.651	Maylandia_zebra
ENSG00000067704	IARS2	91	73.485	ENSMGAG00000009158	IARS2	99	73.485	Meleagris_gallopavo
ENSG00000067704	IARS2	100	80.632	ENSMAUG00000012822	Iars2	100	80.632	Mesocricetus_auratus
ENSG00000067704	IARS2	100	91.107	ENSMICG00000017746	IARS2	100	91.107	Microcebus_murinus
ENSG00000067704	IARS2	100	84.783	ENSMOCG00000017822	Iars2	100	84.783	Microtus_ochrogaster
ENSG00000067704	IARS2	95	61.260	ENSMMOG00000005010	iars2	96	61.260	Mola_mola
ENSG00000067704	IARS2	99	74.260	ENSMODG00000004467	IARS2	99	74.458	Monodelphis_domestica
ENSG00000067704	IARS2	97	61.617	ENSMALG00000012599	iars2	97	61.617	Monopterus_albus
ENSG00000067704	IARS2	100	83.202	MGP_CAROLIEiJ_G0015021	Iars2	100	83.202	Mus_caroli
ENSG00000067704	IARS2	100	83.399	ENSMUSG00000026618	Iars2	100	83.399	Mus_musculus
ENSG00000067704	IARS2	100	83.202	MGP_PahariEiJ_G0028253	Iars2	99	83.202	Mus_pahari
ENSG00000067704	IARS2	100	83.498	MGP_SPRETEiJ_G0015821	Iars2	100	83.498	Mus_spretus
ENSG00000067704	IARS2	99	88.625	ENSMPUG00000004100	IARS2	94	88.625	Mustela_putorius_furo
ENSG00000067704	IARS2	97	82.437	ENSMLUG00000007322	IARS2	99	82.437	Myotis_lucifugus
ENSG00000067704	IARS2	100	85.968	ENSNGAG00000004930	Iars2	100	85.968	Nannospalax_galili
ENSG00000067704	IARS2	99	61.045	ENSNBRG00000024204	iars2	98	61.045	Neolamprologus_brichardi
ENSG00000067704	IARS2	100	98.814	ENSNLEG00000013853	IARS2	100	98.814	Nomascus_leucogenys
ENSG00000067704	IARS2	77	64.773	ENSMEUG00000007251	-	77	64.773	Notamacropus_eugenii
ENSG00000067704	IARS2	71	94.444	ENSOPRG00000014398	IARS2	71	94.444	Ochotona_princeps
ENSG00000067704	IARS2	100	79.368	ENSODEG00000014882	IARS2	100	79.368	Octodon_degus
ENSG00000067704	IARS2	99	60.848	ENSONIG00000012252	iars2	99	62.719	Oreochromis_niloticus
ENSG00000067704	IARS2	86	78.670	ENSOANG00000001426	IARS2	100	78.670	Ornithorhynchus_anatinus
ENSG00000067704	IARS2	91	90.065	ENSOCUG00000010419	IARS2	99	90.065	Oryctolagus_cuniculus
ENSG00000067704	IARS2	99	59.663	ENSORLG00000017813	iars2	98	59.663	Oryzias_latipes
ENSG00000067704	IARS2	95	61.314	ENSORLG00020014946	iars2	98	59.663	Oryzias_latipes_hni
ENSG00000067704	IARS2	97	60.101	ENSORLG00015011515	iars2	98	59.564	Oryzias_latipes_hsok
ENSG00000067704	IARS2	97	60.222	ENSOMEG00000019477	iars2	98	60.222	Oryzias_melastigma
ENSG00000067704	IARS2	100	75.984	ENSOGAG00000011364	IARS2	100	75.984	Otolemur_garnettii
ENSG00000067704	IARS2	92	89.485	ENSOARG00000012333	IARS2	100	89.679	Ovis_aries
ENSG00000067704	IARS2	100	99.308	ENSPPAG00000029870	IARS2	100	99.308	Pan_paniscus
ENSG00000067704	IARS2	100	89.427	ENSPPRG00000012244	IARS2	99	89.427	Panthera_pardus
ENSG00000067704	IARS2	92	89.741	ENSPTIG00000002279	IARS2	99	89.741	Panthera_tigris_altaica
ENSG00000067704	IARS2	100	99.605	ENSPTRG00000001997	IARS2	100	99.605	Pan_troglodytes
ENSG00000067704	IARS2	100	97.727	ENSPANG00000020678	IARS2	100	97.727	Papio_anubis
ENSG00000067704	IARS2	98	58.990	ENSPKIG00000022381	iars2	98	58.990	Paramormyrops_kingsleyae
ENSG00000067704	IARS2	86	74.771	ENSPSIG00000006220	IARS2	99	74.771	Pelodiscus_sinensis
ENSG00000067704	IARS2	100	84.783	ENSPEMG00000000136	Iars2	100	84.783	Peromyscus_maniculatus_bairdii
ENSG00000067704	IARS2	94	50.624	ENSPMAG00000001894	iars2	95	50.624	Petromyzon_marinus
ENSG00000067704	IARS2	97	75.101	ENSPCIG00000008692	IARS2	99	75.488	Phascolarctos_cinereus
ENSG00000067704	IARS2	99	61.249	ENSPFOG00000007310	iars2	99	61.089	Poecilia_formosa
ENSG00000067704	IARS2	99	61.348	ENSPLAG00000013833	iars2	98	61.348	Poecilia_latipinna
ENSG00000067704	IARS2	99	61.249	ENSPMEG00000023132	iars2	89	61.249	Poecilia_mexicana
ENSG00000067704	IARS2	99	59.653	ENSPREG00000003827	iars2	93	59.653	Poecilia_reticulata
ENSG00000067704	IARS2	100	98.518	ENSPPYG00000000208	IARS2	100	98.518	Pongo_abelii
ENSG00000067704	IARS2	77	89.655	ENSPCAG00000016006	IARS2	77	89.655	Procavia_capensis
ENSG00000067704	IARS2	99	92.582	ENSPCOG00000019722	IARS2	99	92.582	Propithecus_coquereli
ENSG00000067704	IARS2	100	82.312	ENSPVAG00000013149	IARS2	100	82.312	Pteropus_vampyrus
ENSG00000067704	IARS2	99	61.045	ENSPNYG00000018793	iars2	98	61.045	Pundamilia_nyererei
ENSG00000067704	IARS2	94	59.727	ENSPNAG00000025742	iars2	97	59.727	Pygocentrus_nattereri
ENSG00000067704	IARS2	100	82.016	ENSRNOG00000002368	Iars2	100	82.016	Rattus_norvegicus
ENSG00000067704	IARS2	100	98.123	ENSRBIG00000002958	IARS2	100	98.123	Rhinopithecus_bieti
ENSG00000067704	IARS2	100	98.221	ENSRROG00000013275	IARS2	100	98.221	Rhinopithecus_roxellana
ENSG00000067704	IARS2	94	36.462	YPL040C	ISM1	97	36.462	Saccharomyces_cerevisiae
ENSG00000067704	IARS2	100	95.850	ENSSBOG00000020069	IARS2	100	95.850	Saimiri_boliviensis_boliviensis
ENSG00000067704	IARS2	99	72.790	ENSSHAG00000004762	IARS2	100	75.638	Sarcophilus_harrisii
ENSG00000067704	IARS2	94	55.404	ENSSFOG00015007814	iars2	99	55.404	Scleropages_formosus
ENSG00000067704	IARS2	96	62.062	ENSSMAG00000014304	iars2	87	62.062	Scophthalmus_maximus
ENSG00000067704	IARS2	95	61.959	ENSSDUG00000020153	iars2	96	61.959	Seriola_dumerili
ENSG00000067704	IARS2	95	61.959	ENSSLDG00000014169	iars2	96	61.959	Seriola_lalandi_dorsalis
ENSG00000067704	IARS2	91	79.307	ENSSARG00000012575	IARS2	100	79.307	Sorex_araneus
ENSG00000067704	IARS2	100	66.207	ENSSPUG00000009468	IARS2	100	66.207	Sphenodon_punctatus
ENSG00000067704	IARS2	95	62.967	ENSSPAG00000001847	iars2	95	62.967	Stegastes_partitus
ENSG00000067704	IARS2	100	87.549	ENSSSCG00000010823	IARS2	100	87.549	Sus_scrofa
ENSG00000067704	IARS2	94	72.298	ENSTGUG00000002764	IARS2	96	72.298	Taeniopygia_guttata
ENSG00000067704	IARS2	94	60.271	ENSTRUG00000004465	iars2	95	60.271	Takifugu_rubripes
ENSG00000067704	IARS2	94	60.417	ENSTNIG00000005422	iars2	98	60.417	Tetraodon_nigroviridis
ENSG00000067704	IARS2	87	88.136	ENSTBEG00000002312	IARS2	87	88.136	Tupaia_belangeri
ENSG00000067704	IARS2	90	90.207	ENSTTRG00000013026	IARS2	90	90.207	Tursiops_truncatus
ENSG00000067704	IARS2	100	89.723	ENSUAMG00000020811	IARS2	100	89.723	Ursus_americanus
ENSG00000067704	IARS2	81	90.578	ENSUMAG00000022077	IARS2	100	90.578	Ursus_maritimus
ENSG00000067704	IARS2	91	87.866	ENSVPAG00000008913	IARS2	100	87.866	Vicugna_pacos
ENSG00000067704	IARS2	100	89.032	ENSVVUG00000012804	IARS2	100	89.032	Vulpes_vulpes
ENSG00000067704	IARS2	96	65.333	ENSXETG00000002726	iars2	98	65.333	Xenopus_tropicalis
ENSG00000067704	IARS2	99	61.943	ENSXCOG00000011279	iars2	98	61.943	Xiphophorus_couchianus
ENSG00000067704	IARS2	99	61.843	ENSXMAG00000018636	iars2	98	61.843	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	-	IEA	Function
GO:0002161	aminoacyl-tRNA editing activity	-	IEA	Function
GO:0004822	isoleucine-tRNA ligase activity	21873635.	IBA	Function
GO:0004822	isoleucine-tRNA ligase activity	-	TAS	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	Process
GO:0006428	isoleucyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0032543	mitochondrial translation	21873635.	IBA	Process
GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity	-	IEA	Process