EuRBPDB

Description

Ensembl ID: ENSG00000068120 (Gene tree)
Gene ID: 80347
Gene Symbol: COASY
Alias: DPCK|NBP|CoASY|PPAT
Full Name: Coenzyme A synthase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 4,815 bases
Position: chr17:42,561,467-42,566,281
Accession: 29932
RBP type: non-canonical RBP
Summary: Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000590958	COASY-211	1976	XM_006722116	ENSP00000464814	593 (aa)	XP_006722179	Q13057
ENST00000393818	COASY-201	2458	-	ENSP00000377406	564 (aa)	-	Q13057
ENST00000587214	COASY-207	539	-	ENSP00000468583	147 (aa)	-	K7ES73
ENST00000588757	COASY-210	574	-	-	- (aa)	-	-
ENST00000587157	COASY-206	551	-	ENSP00000467322	96 (aa)	-	K7EPC2
ENST00000586771	COASY-205	742	-	ENSP00000466838	219 (aa)	-	K7EN91
ENST00000591779	COASY-214	994	-	ENSP00000467687	115 (aa)	-	K7EQ60
ENST00000587858	COASY-208	569	-	ENSP00000468755	128 (aa)	-	K7ESK6
ENST00000588353	COASY-209	387	-	-	- (aa)	-	-
ENST00000585811	COASY-203	625	-	ENSP00000467174	90 (aa)	-	K7EP09
ENST00000421097	COASY-202	2071	XM_011525300	ENSP00000393564	564 (aa)	XP_011523602	Q13057
ENST00000585909	COASY-204	570	-	ENSP00000467519	98 (aa)	-	K7EPT0
ENST00000591583	COASY-212	716	-	-	- (aa)	-	-
ENST00000591753	COASY-213	2225	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00770	Pantothenate and CoA biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000068120	rs668799	17	42564217	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004140	dephospho-CoA kinase activity	21873635.	IBA	Function
GO:0004140	dephospho-CoA kinase activity	11923312.11994049.	IDA	Function
GO:0004140	dephospho-CoA kinase activity	-	TAS	Function
GO:0004595	pantetheine-phosphate adenylyltransferase activity	21873635.	IBA	Function
GO:0004595	pantetheine-phosphate adenylyltransferase activity	11923312.11994049.	IDA	Function
GO:0004595	pantetheine-phosphate adenylyltransferase activity	-	TAS	Function
GO:0005515	protein binding	22982864.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005741	mitochondrial outer membrane	-	TAS	Component
GO:0005759	mitochondrial matrix	24360804.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0009108	coenzyme biosynthetic process	-	TAS	Process
GO:0015937	coenzyme A biosynthetic process	21873635.	IBA	Process
GO:0015937	coenzyme A biosynthetic process	11923312.	IDA	Process
GO:0015937	coenzyme A biosynthetic process	-	IEA	Process
GO:0015937	coenzyme A biosynthetic process	11994049.	TAS	Process
GO:0016310	phosphorylation	-	IEA	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component