EuRBPDB

Description

RBDs

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000068394 (Gene tree)
Gene ID: 27238
Gene Symbol: GPKOW
Alias: T54|GPATC5|GPATCH5|Spp2
Full Name: G-patch domain and KOW motifs
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 10,417 bases
Position: chrX:49,113,385-49,123,801
Accession: 30677
RBP type: canonical RBP
Summary: This gene encodes a putative RNA-binding protein containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. The encoded protein interacts directly with protein kinase A and protein kinase X and is also found associated with the spliceosome. [provided by RefSeq, Aug 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000156109	KOW	PF00467.29	4.1e-12	1	1
ENSP00000156109	G-patch	PF01585.23	0.00017	1	1

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21880142	G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A.	J Mol Signal	2011 Aug 31	Aksaas AK	doi: 10.1186/1750-2187-6-10.
15542821	Interaction between a G-patch protein and a spliceosomal DEXD/H-box ATPase that is critical for splicing.	Mol Cell Biol	2004 Dec	Silverman EJ	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000156109	GPKOW-201	1742	XM_017029415	ENSP00000156109	476 (aa)	XP_016884904	Q92917

Gene Model

Click here to download ENSG00000068394's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000068394	Child Development Disorders, Pervasive	4.5573000E-005	-
ENSG00000068394	Child Development Disorders, Pervasive	1.9075000E-005	-
ENSG00000068394	Child Development Disorders, Pervasive	1.1092000E-005	-
ENSG00000068394	Child Development Disorders, Pervasive	1.0427000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000068394's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000068394	GPKOW	95	45.161	ENSAPOG00000004970	gpkow	95	45.363	Acanthochromis_polyacanthus
ENSG00000068394	GPKOW	100	79.794	ENSAMEG00000012303	GPKOW	100	79.794	Ailuropoda_melanoleuca
ENSG00000068394	GPKOW	95	44.919	ENSACIG00000010755	gpkow	94	44.919	Amphilophus_citrinellus
ENSG00000068394	GPKOW	96	44.828	ENSAOCG00000022818	gpkow	94	45.102	Amphiprion_ocellaris
ENSG00000068394	GPKOW	96	44.848	ENSAPEG00000021416	gpkow	95	45.122	Amphiprion_percula
ENSG00000068394	GPKOW	95	43.775	ENSATEG00000023744	gpkow	94	44.177	Anabas_testudineus
ENSG00000068394	GPKOW	99	51.423	ENSACAG00000016598	GPKOW	98	51.423	Anolis_carolinensis
ENSG00000068394	GPKOW	100	84.454	ENSANAG00000033498	-	100	84.454	Aotus_nancymaae
ENSG00000068394	GPKOW	100	93.067	ENSANAG00000030473	-	100	93.067	Aotus_nancymaae
ENSG00000068394	GPKOW	84	89.250	ENSANAG00000036571	-	95	91.406	Aotus_nancymaae
ENSG00000068394	GPKOW	61	42.857	ENSAMXG00000039266	gpkow	87	42.857	Astyanax_mexicanus
ENSG00000068394	GPKOW	100	79.630	ENSBTAG00000002568	GPKOW	100	79.630	Bos_taurus
ENSG00000068394	GPKOW	100	91.176	ENSCJAG00000002656	GPKOW	100	91.176	Callithrix_jacchus
ENSG00000068394	GPKOW	100	80.785	ENSCAFG00000015794	GPKOW	100	80.785	Canis_familiaris
ENSG00000068394	GPKOW	100	80.785	ENSCAFG00020020258	GPKOW	100	80.785	Canis_lupus_dingo
ENSG00000068394	GPKOW	100	80.372	ENSCHIG00000013277	GPKOW	100	80.372	Capra_hircus
ENSG00000068394	GPKOW	100	81.513	ENSTSYG00000029374	-	100	81.513	Carlito_syrichta
ENSG00000068394	GPKOW	100	88.025	ENSTSYG00000033182	-	100	88.025	Carlito_syrichta
ENSG00000068394	GPKOW	79	80.315	ENSCAPG00000011329	GPKOW	100	80.315	Cavia_aperea
ENSG00000068394	GPKOW	100	78.261	ENSCPOG00000013270	GPKOW	100	78.261	Cavia_porcellus
ENSG00000068394	GPKOW	100	90.546	ENSCCAG00000034660	-	100	90.546	Cebus_capucinus
ENSG00000068394	GPKOW	99	83.158	ENSCCAG00000022161	-	99	83.158	Cebus_capucinus
ENSG00000068394	GPKOW	100	96.639	ENSCATG00000041433	GPKOW	100	96.639	Cercocebus_atys
ENSG00000068394	GPKOW	100	76.653	ENSCLAG00000002220	-	100	76.653	Chinchilla_lanigera
ENSG00000068394	GPKOW	100	69.815	ENSCLAG00000007117	-	95	69.815	Chinchilla_lanigera
ENSG00000068394	GPKOW	100	96.008	ENSCSAG00000012926	GPKOW	100	96.008	Chlorocebus_sabaeus
ENSG00000068394	GPKOW	96	49.482	ENSCPBG00000016609	GPKOW	95	49.383	Chrysemys_picta_bellii
ENSG00000068394	GPKOW	61	36.455	ENSCING00000020813	-	96	33.333	Ciona_intestinalis
ENSG00000068394	GPKOW	100	96.008	ENSCANG00000037595	GPKOW	100	96.008	Colobus_angolensis_palliatus
ENSG00000068394	GPKOW	100	73.265	ENSCGRG00001016210	Gpkow	100	73.265	Cricetulus_griseus_chok1gshd
ENSG00000068394	GPKOW	100	73.265	ENSCGRG00000013835	Gpkow	100	73.265	Cricetulus_griseus_crigri
ENSG00000068394	GPKOW	96	43.461	ENSCSEG00000020569	gpkow	96	44.467	Cynoglossus_semilaevis
ENSG00000068394	GPKOW	96	44.033	ENSCVAG00000017066	gpkow	95	44.033	Cyprinodon_variegatus
ENSG00000068394	GPKOW	96	45.808	ENSDARG00000029612	gpkow	95	45.808	Danio_rerio
ENSG00000068394	GPKOW	100	78.926	ENSDNOG00000016647	GPKOW	99	79.953	Dasypus_novemcinctus
ENSG00000068394	GPKOW	100	70.954	ENSDORG00000013663	Gpkow	100	70.954	Dipodomys_ordii
ENSG00000068394	GPKOW	80	38.732	ENSEBUG00000001912	gpkow	95	38.732	Eptatretus_burgeri
ENSG00000068394	GPKOW	100	80.252	ENSEASG00005019852	GPKOW	100	80.252	Equus_asinus_asinus
ENSG00000068394	GPKOW	100	84.917	ENSECAG00000018251	GPKOW	100	84.917	Equus_caballus
ENSG00000068394	GPKOW	100	69.118	ENSEEUG00000008839	GPKOW	100	69.118	Erinaceus_europaeus
ENSG00000068394	GPKOW	95	44.467	ENSELUG00000022223	gpkow	94	44.266	Esox_lucius
ENSG00000068394	GPKOW	100	82.983	ENSFCAG00000003818	GPKOW	100	82.983	Felis_catus
ENSG00000068394	GPKOW	100	79.959	ENSFDAG00000001669	GPKOW	100	79.959	Fukomys_damarensis
ENSG00000068394	GPKOW	96	44.286	ENSFHEG00000022349	gpkow	93	44.286	Fundulus_heteroclitus
ENSG00000068394	GPKOW	96	44.444	ENSGMOG00000019661	gpkow	95	44.444	Gadus_morhua
ENSG00000068394	GPKOW	95	42.137	ENSGACG00000012127	gpkow	95	42.540	Gasterosteus_aculeatus
ENSG00000068394	GPKOW	86	49.395	ENSGAGG00000006302	GPKOW	100	49.395	Gopherus_agassizii
ENSG00000068394	GPKOW	100	98.739	ENSGGOG00000013685	GPKOW	100	98.739	Gorilla_gorilla
ENSG00000068394	GPKOW	95	44.737	ENSHBUG00000010655	gpkow	87	44.939	Haplochromis_burtoni
ENSG00000068394	GPKOW	100	80.331	ENSHGLG00000002746	GPKOW	100	80.331	Heterocephalus_glaber_female
ENSG00000068394	GPKOW	100	80.124	ENSHGLG00100014283	GPKOW	100	80.124	Heterocephalus_glaber_male
ENSG00000068394	GPKOW	95	44.533	ENSIPUG00000008342	gpkow	94	44.334	Ictalurus_punctatus
ENSG00000068394	GPKOW	100	80.992	ENSSTOG00000014593	GPKOW	100	80.992	Ictidomys_tridecemlineatus
ENSG00000068394	GPKOW	100	76.721	ENSJJAG00000013397	Gpkow	100	76.721	Jaculus_jaculus
ENSG00000068394	GPKOW	96	44.400	ENSKMAG00000006241	gpkow	96	44.600	Kryptolebias_marmoratus
ENSG00000068394	GPKOW	95	44.355	ENSLBEG00000013238	gpkow	98	43.945	Labrus_bergylta
ENSG00000068394	GPKOW	53	52.590	ENSLACG00000003399	gpkow	91	52.590	Latimeria_chalumnae
ENSG00000068394	GPKOW	97	45.618	ENSLOCG00000014776	gpkow	95	45.618	Lepisosteus_oculatus
ENSG00000068394	GPKOW	100	79.381	ENSLAFG00000005896	GPKOW	100	79.381	Loxodonta_africana
ENSG00000068394	GPKOW	100	96.429	ENSMFAG00000035346	GPKOW	100	96.429	Macaca_fascicularis
ENSG00000068394	GPKOW	100	96.218	ENSMMUG00000020557	GPKOW	96	96.218	Macaca_mulatta
ENSG00000068394	GPKOW	100	96.218	ENSMNEG00000004803	GPKOW	100	96.218	Macaca_nemestrina
ENSG00000068394	GPKOW	100	96.218	ENSMLEG00000033293	GPKOW	100	96.218	Mandrillus_leucophaeus
ENSG00000068394	GPKOW	96	44.064	ENSMAMG00000024235	gpkow	95	44.266	Mastacembelus_armatus
ENSG00000068394	GPKOW	95	44.332	ENSMZEG00005026357	gpkow	87	44.534	Maylandia_zebra
ENSG00000068394	GPKOW	100	86.345	ENSMICG00000045083	GPKOW	100	86.345	Microcebus_murinus
ENSG00000068394	GPKOW	100	75.714	ENSMOCG00000019251	Gpkow	100	75.714	Microtus_ochrogaster
ENSG00000068394	GPKOW	90	53.456	ENSMODG00000011443	-	100	53.687	Monodelphis_domestica
ENSG00000068394	GPKOW	99	51.230	ENSMODG00000023705	-	100	51.230	Monodelphis_domestica
ENSG00000068394	GPKOW	96	41.189	ENSMALG00000015148	gpkow	95	42.008	Monopterus_albus
ENSG00000068394	GPKOW	83	74.083	MGP_CAROLIEiJ_G0032893	Gpkow	100	66.471	Mus_caroli
ENSG00000068394	GPKOW	96	75.000	ENSMUSG00000031148	Gpkow	99	74.636	Mus_musculus
ENSG00000068394	GPKOW	96	75.424	MGP_PahariEiJ_G0031441	Gpkow	99	75.052	Mus_pahari
ENSG00000068394	GPKOW	100	77.526	ENSMPUG00000013808	GPKOW	100	77.526	Mustela_putorius_furo
ENSG00000068394	GPKOW	63	70.470	ENSMLUG00000009281	-	96	70.470	Myotis_lucifugus
ENSG00000068394	GPKOW	100	75.203	ENSNGAG00000005382	Gpkow	100	75.203	Nannospalax_galili
ENSG00000068394	GPKOW	95	44.130	ENSNBRG00000008941	gpkow	94	44.332	Neolamprologus_brichardi
ENSG00000068394	GPKOW	100	96.639	ENSNLEG00000007998	GPKOW	100	96.639	Nomascus_leucogenys
ENSG00000068394	GPKOW	51	58.848	ENSMEUG00000007467	-	79	58.848	Notamacropus_eugenii
ENSG00000068394	GPKOW	80	68.615	ENSOPRG00000016412	-	80	69.018	Ochotona_princeps
ENSG00000068394	GPKOW	95	44.355	ENSONIG00000016834	gpkow	87	44.556	Oreochromis_niloticus
ENSG00000068394	GPKOW	100	69.672	ENSOCUG00000010422	GPKOW	100	69.877	Oryctolagus_cuniculus
ENSG00000068394	GPKOW	96	43.173	ENSORLG00000014442	gpkow	95	43.574	Oryzias_latipes
ENSG00000068394	GPKOW	96	43.173	ENSORLG00020012795	gpkow	95	43.574	Oryzias_latipes_hni
ENSG00000068394	GPKOW	96	43.373	ENSORLG00015006852	gpkow	95	43.775	Oryzias_latipes_hsok
ENSG00000068394	GPKOW	96	45.090	ENSOMEG00000003236	gpkow	95	45.090	Oryzias_melastigma
ENSG00000068394	GPKOW	100	71.849	ENSOGAG00000003644	GPKOW	100	71.849	Otolemur_garnettii
ENSG00000068394	GPKOW	100	80.372	ENSOARG00000010927	GPKOW	100	80.372	Ovis_aries
ENSG00000068394	GPKOW	100	98.529	ENSPPAG00000040116	GPKOW	100	98.529	Pan_paniscus
ENSG00000068394	GPKOW	100	82.983	ENSPPRG00000016972	GPKOW	100	82.983	Panthera_pardus
ENSG00000068394	GPKOW	100	80.579	ENSPTIG00000008398	GPKOW	100	80.579	Panthera_tigris_altaica
ENSG00000068394	GPKOW	100	98.739	ENSPTRG00000047603	GPKOW	100	98.739	Pan_troglodytes
ENSG00000068394	GPKOW	100	96.218	ENSPANG00000013477	GPKOW	100	96.218	Papio_anubis
ENSG00000068394	GPKOW	95	45.702	ENSPKIG00000008382	gpkow	93	45.493	Paramormyrops_kingsleyae
ENSG00000068394	GPKOW	95	43.878	ENSPMGG00000010880	gpkow	94	43.878	Periophthalmus_magnuspinnatus
ENSG00000068394	GPKOW	100	73.620	ENSPEMG00000009966	Gpkow	100	73.620	Peromyscus_maniculatus_bairdii
ENSG00000068394	GPKOW	97	42.412	ENSPMAG00000003497	gpkow	96	41.992	Petromyzon_marinus
ENSG00000068394	GPKOW	96	44.990	ENSPFOG00000003065	gpkow	93	44.990	Poecilia_formosa
ENSG00000068394	GPKOW	96	44.990	ENSPLAG00000023097	gpkow	93	44.990	Poecilia_latipinna
ENSG00000068394	GPKOW	96	45.194	ENSPMEG00000002762	gpkow	93	45.194	Poecilia_mexicana
ENSG00000068394	GPKOW	63	46.462	ENSPREG00000002671	gpkow	99	46.462	Poecilia_reticulata
ENSG00000068394	GPKOW	79	98.611	ENSPPYG00000020334	-	99	98.611	Pongo_abelii
ENSG00000068394	GPKOW	100	87.185	ENSPCOG00000008505	GPKOW	100	87.185	Propithecus_coquereli
ENSG00000068394	GPKOW	95	44.737	ENSPNYG00000014523	gpkow	94	44.939	Pundamilia_nyererei
ENSG00000068394	GPKOW	95	44.246	ENSPNAG00000008360	gpkow	94	44.643	Pygocentrus_nattereri
ENSG00000068394	GPKOW	96	75.796	ENSRNOG00000022939	Gpkow	99	75.833	Rattus_norvegicus
ENSG00000068394	GPKOW	95	96.000	ENSRBIG00000027885	GPKOW	99	96.000	Rhinopithecus_bieti
ENSG00000068394	GPKOW	100	95.588	ENSRROG00000037604	GPKOW	100	95.588	Rhinopithecus_roxellana
ENSG00000068394	GPKOW	100	92.227	ENSSBOG00000032042	-	100	92.227	Saimiri_boliviensis_boliviensis
ENSG00000068394	GPKOW	99	78.737	ENSSBOG00000024861	-	98	78.737	Saimiri_boliviensis_boliviensis
ENSG00000068394	GPKOW	54	52.896	ENSSHAG00000004719	-	100	52.896	Sarcophilus_harrisii
ENSG00000068394	GPKOW	96	46.667	ENSSFOG00015009901	gpkow	94	46.667	Scleropages_formosus
ENSG00000068394	GPKOW	95	44.444	ENSSMAG00000013323	gpkow	94	45.082	Scophthalmus_maximus
ENSG00000068394	GPKOW	96	45.079	ENSSDUG00000023134	gpkow	96	45.309	Seriola_dumerili
ENSG00000068394	GPKOW	96	45.276	ENSSLDG00000024756	gpkow	96	45.509	Seriola_lalandi_dorsalis
ENSG00000068394	GPKOW	88	77.088	ENSSARG00000003351	GPKOW	100	77.088	Sorex_araneus
ENSG00000068394	GPKOW	95	46.281	ENSSPAG00000015503	gpkow	97	46.694	Stegastes_partitus
ENSG00000068394	GPKOW	100	82.099	ENSSSCG00000012291	GPKOW	100	82.099	Sus_scrofa
ENSG00000068394	GPKOW	99	41.502	ENSTRUG00000000616	gpkow	98	41.502	Takifugu_rubripes
ENSG00000068394	GPKOW	99	41.870	ENSTNIG00000012502	gpkow	99	41.870	Tetraodon_nigroviridis
ENSG00000068394	GPKOW	80	81.173	ENSTBEG00000004087	GPKOW	80	81.173	Tupaia_belangeri
ENSG00000068394	GPKOW	99	82.737	ENSTTRG00000008579	GPKOW	100	82.737	Tursiops_truncatus
ENSG00000068394	GPKOW	90	80.778	ENSUAMG00000026502	GPKOW	100	80.778	Ursus_americanus
ENSG00000068394	GPKOW	83	81.683	ENSUMAG00000007072	GPKOW	80	81.683	Ursus_maritimus
ENSG00000068394	GPKOW	100	80.372	ENSVVUG00000017815	GPKOW	100	80.372	Vulpes_vulpes
ENSG00000068394	GPKOW	97	46.708	ENSXETG00000007727	gpkow	99	46.708	Xenopus_tropicalis
ENSG00000068394	GPKOW	96	45.399	ENSXCOG00000014306	gpkow	94	45.399	Xiphophorus_couchianus
ENSG00000068394	GPKOW	96	45.214	ENSXMAG00000018216	gpkow	93	45.214	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	25296192.	IMP	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	21880142.	IDA	Function
GO:0003723	RNA binding	25296192.	IMP	Function
GO:0005515	protein binding	16491121.21044950.21516116.21880142.22365833.25296192.25416956.	IPI	Function
GO:0005634	nucleus	21880142.25296192.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	25296192.	IDA	Component