EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000068784 (Gene tree)
Gene ID: 55133
Gene Symbol: SRBD1
Alias: FLJ10379
Full Name: S1 RNA binding domain 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 223,486 bases
Position: chr2:45,388,680-45,612,165
Accession: 25521
RBP type: canonical RBP
Summary: (S1 RNA Binding Domain 1) is a Protein Coding gene. Diseases associated with SRBD1 include Glaucoma, Primary Open Angle. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity, acting on ester bonds.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000263736	S1	PF00575.23	1.5e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22605921	Genome-wide association study of primary open angle glaucoma risk and quantitative traits.	Mol Vis	2012	Gibson J	-
21508110	Association between SRBD1 and ELOVL5 gene polymorphisms and primary open-angle glaucoma.	Invest Ophthalmol Vis Sci	2011 Jun 28	Mabuchi F	doi: 10.1167/iovs.11-7382.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000475073	SRBD1-203	567	-	-	- (aa)	-	-
ENST00000461805	SRBD1-202	555	-	-	- (aa)	-	-
ENST00000493649	SRBD1-205	655	-	-	- (aa)	-	-
ENST00000490133	SRBD1-204	2419	-	-	- (aa)	-	-
ENST00000263736	SRBD1-201	3681	XM_011532946	ENSP00000263736	995 (aa)	XP_011531248	Q8N5C6

Gene Model

Click here to download ENSG00000068784's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000068784	Body Height	2.28055469801691E-6	17903300
ENSG00000068784	Body Height	2.68001278876743E-6	17903300
ENSG00000068784	Body Height	2.96477948849444E-7	17903300
ENSG00000068784	Body Height	1.88117129488261E-6	17903300
ENSG00000068784	Alcoholism	4.02E-05	-
ENSG00000068784	Platelet Function Tests	1.0840600E-005	-
ENSG00000068784	Glaucoma	3E-9	20363506
ENSG00000068784	Diabetes Mellitus, Type 2	1E-6	25760438

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000068784	rs7591446	2	45606937	C	Squamous cell lung carcinoma	28604730	[1.06-1.17]	1.1134666	EFO_0000708
ENSG00000068784	rs34669198	2	45521138	?	Type 2 diabetes	25760438	[0.18-0.42] unit increase	0.3	EFO_0001360
ENSG00000068784	rs3213787	2	45419685	A	Glaucoma	20363506	[1.96-3.99]	2.8	EFO_0000516
ENSG00000068784	rs114076575	2	45535468	T	Osteoarthritis (self-reported)	29559693	[1.38-1.25]	1.2485719	EFO_0002506

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000068784's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000068784	SRBD1	100	51.610	ENSAPOG00000005103	si:ch211-117n7.8	94	53.163	Acanthochromis_polyacanthus
ENSG00000068784	SRBD1	100	90.653	ENSAMEG00000005993	SRBD1	100	90.653	Ailuropoda_melanoleuca
ENSG00000068784	SRBD1	94	52.899	ENSACIG00000009875	si:ch211-117n7.8	97	52.911	Amphilophus_citrinellus
ENSG00000068784	SRBD1	98	51.992	ENSAOCG00000024718	si:ch211-117n7.8	84	57.851	Amphiprion_ocellaris
ENSG00000068784	SRBD1	83	57.851	ENSAPEG00000002645	si:ch211-117n7.8	87	57.851	Amphiprion_percula
ENSG00000068784	SRBD1	98	52.048	ENSATEG00000010844	si:ch211-117n7.8	97	52.376	Anabas_testudineus
ENSG00000068784	SRBD1	100	70.189	ENSAPLG00000006313	SRBD1	100	70.289	Anas_platyrhynchos
ENSG00000068784	SRBD1	100	94.171	ENSANAG00000025573	SRBD1	100	94.171	Aotus_nancymaae
ENSG00000068784	SRBD1	94	52.905	ENSACLG00000024219	si:ch211-117n7.8	94	52.615	Astatotilapia_calliptera
ENSG00000068784	SRBD1	89	58.509	ENSAMXG00000004294	SRBD1	93	56.184	Astyanax_mexicanus
ENSG00000068784	SRBD1	100	88.353	ENSBTAG00000007508	SRBD1	97	89.056	Bos_taurus
ENSG00000068784	SRBD1	73	30.106	WBGene00022830	ZK973.1	91	30.504	Caenorhabditis_elegans
ENSG00000068784	SRBD1	100	93.166	ENSCJAG00000000727	SRBD1	100	93.166	Callithrix_jacchus
ENSG00000068784	SRBD1	100	89.870	ENSCAFG00000002554	SRBD1	100	89.870	Canis_familiaris
ENSG00000068784	SRBD1	100	86.948	ENSCAFG00020026284	SRBD1	99	89.895	Canis_lupus_dingo
ENSG00000068784	SRBD1	100	88.554	ENSCHIG00000016535	SRBD1	98	89.257	Capra_hircus
ENSG00000068784	SRBD1	100	91.082	ENSTSYG00000012797	SRBD1	100	91.082	Carlito_syrichta
ENSG00000068784	SRBD1	100	87.249	ENSCPOG00000004773	SRBD1	100	87.249	Cavia_porcellus
ENSG00000068784	SRBD1	100	94.070	ENSCCAG00000025589	SRBD1	100	94.070	Cebus_capucinus
ENSG00000068784	SRBD1	100	96.583	ENSCATG00000039530	SRBD1	100	96.583	Cercocebus_atys
ENSG00000068784	SRBD1	100	88.377	ENSCLAG00000008623	SRBD1	100	88.377	Chinchilla_lanigera
ENSG00000068784	SRBD1	100	96.683	ENSCSAG00000013350	SRBD1	100	96.683	Chlorocebus_sabaeus
ENSG00000068784	SRBD1	93	75.878	ENSCHOG00000003805	SRBD1	93	75.878	Choloepus_hoffmanni
ENSG00000068784	SRBD1	100	73.400	ENSCPBG00000005677	SRBD1	100	73.173	Chrysemys_picta_bellii
ENSG00000068784	SRBD1	79	42.420	ENSCING00000005950	-	99	42.420	Ciona_intestinalis
ENSG00000068784	SRBD1	79	42.947	ENSCSAVG00000000861	-	99	42.947	Ciona_savignyi
ENSG00000068784	SRBD1	99	96.073	ENSCANG00000016307	SRBD1	99	96.073	Colobus_angolensis_palliatus
ENSG00000068784	SRBD1	100	84.469	ENSCGRG00001000513	Srbd1	100	84.469	Cricetulus_griseus_chok1gshd
ENSG00000068784	SRBD1	100	84.469	ENSCGRG00000002283	Srbd1	100	84.469	Cricetulus_griseus_crigri
ENSG00000068784	SRBD1	99	50.639	ENSCSEG00000000856	si:ch211-117n7.8	87	55.305	Cynoglossus_semilaevis
ENSG00000068784	SRBD1	83	56.368	ENSCVAG00000020212	si:ch211-117n7.8	89	56.368	Cyprinodon_variegatus
ENSG00000068784	SRBD1	100	89.590	ENSDNOG00000018686	SRBD1	100	89.590	Dasypus_novemcinctus
ENSG00000068784	SRBD1	100	85.930	ENSDORG00000010468	Srbd1	100	85.930	Dipodomys_ordii
ENSG00000068784	SRBD1	94	34.144	FBgn0051156	CG31156	98	34.347	Drosophila_melanogaster
ENSG00000068784	SRBD1	89	82.500	ENSETEG00000000739	SRBD1	91	82.500	Echinops_telfairi
ENSG00000068784	SRBD1	73	48.571	ENSEBUG00000008902	si:ch211-117n7.8	96	48.571	Eptatretus_burgeri
ENSG00000068784	SRBD1	100	88.253	ENSEASG00005003132	SRBD1	97	94.268	Equus_asinus_asinus
ENSG00000068784	SRBD1	100	91.365	ENSECAG00000013865	SRBD1	98	91.365	Equus_caballus
ENSG00000068784	SRBD1	97	54.582	ENSELUG00000012592	si:ch211-117n7.8	92	54.582	Esox_lucius
ENSG00000068784	SRBD1	100	90.964	ENSFCAG00000005101	SRBD1	100	90.964	Felis_catus
ENSG00000068784	SRBD1	100	67.659	ENSFALG00000012966	SRBD1	100	68.000	Ficedula_albicollis
ENSG00000068784	SRBD1	98	86.742	ENSFDAG00000016670	SRBD1	98	87.006	Fukomys_damarensis
ENSG00000068784	SRBD1	95	53.148	ENSFHEG00000019480	si:ch211-117n7.8	93	53.148	Fundulus_heteroclitus
ENSG00000068784	SRBD1	50	52.027	ENSGMOG00000018010	-	100	52.027	Gadus_morhua
ENSG00000068784	SRBD1	100	69.860	ENSGALG00000009990	SRBD1	100	69.431	Gallus_gallus
ENSG00000068784	SRBD1	98	50.849	ENSGAFG00000019664	si:ch211-117n7.8	97	51.160	Gambusia_affinis
ENSG00000068784	SRBD1	62	60.320	ENSGACG00000010794	si:ch211-117n7.8	100	60.480	Gasterosteus_aculeatus
ENSG00000068784	SRBD1	83	81.205	ENSGAGG00000006166	SRBD1	99	81.205	Gopherus_agassizii
ENSG00000068784	SRBD1	97	98.968	ENSGGOG00000005910	SRBD1	100	98.967	Gorilla_gorilla
ENSG00000068784	SRBD1	90	47.879	ENSHBUG00000013207	si:ch211-117n7.8	96	46.414	Haplochromis_burtoni
ENSG00000068784	SRBD1	99	88.016	ENSHGLG00000018153	-	99	88.016	Heterocephalus_glaber_female
ENSG00000068784	SRBD1	99	87.915	ENSHGLG00100015183	-	99	87.915	Heterocephalus_glaber_male
ENSG00000068784	SRBD1	85	60.915	ENSIPUG00000009661	srbd1	95	56.128	Ictalurus_punctatus
ENSG00000068784	SRBD1	100	90.553	ENSSTOG00000005898	SRBD1	100	90.553	Ictidomys_tridecemlineatus
ENSG00000068784	SRBD1	100	80.642	ENSJJAG00000022244	Srbd1	100	80.642	Jaculus_jaculus
ENSG00000068784	SRBD1	98	51.796	ENSKMAG00000003473	si:ch211-117n7.8	84	56.593	Kryptolebias_marmoratus
ENSG00000068784	SRBD1	98	51.734	ENSLBEG00000027518	si:ch211-117n7.8	97	51.600	Labrus_bergylta
ENSG00000068784	SRBD1	85	70.449	ENSLACG00000009790	SRBD1	100	70.449	Latimeria_chalumnae
ENSG00000068784	SRBD1	100	57.382	ENSLOCG00000016360	si:ch211-117n7.8	99	57.382	Lepisosteus_oculatus
ENSG00000068784	SRBD1	100	96.884	ENSMFAG00000042026	SRBD1	100	96.884	Macaca_fascicularis
ENSG00000068784	SRBD1	100	96.583	ENSMMUG00000003490	SRBD1	100	96.583	Macaca_mulatta
ENSG00000068784	SRBD1	100	94.271	ENSMNEG00000034701	SRBD1	100	94.271	Macaca_nemestrina
ENSG00000068784	SRBD1	100	96.482	ENSMLEG00000000745	SRBD1	100	96.482	Mandrillus_leucophaeus
ENSG00000068784	SRBD1	82	56.250	ENSMAMG00000021921	si:ch211-117n7.8	99	50.346	Mastacembelus_armatus
ENSG00000068784	SRBD1	94	53.002	ENSMZEG00005027369	si:ch211-117n7.8	94	52.615	Maylandia_zebra
ENSG00000068784	SRBD1	80	75.063	ENSMGAG00000010273	SRBD1	100	75.063	Meleagris_gallopavo
ENSG00000068784	SRBD1	79	86.347	ENSMAUG00000013916	Srbd1	99	83.886	Mesocricetus_auratus
ENSG00000068784	SRBD1	100	92.068	ENSMICG00000007835	SRBD1	100	92.068	Microcebus_murinus
ENSG00000068784	SRBD1	100	83.635	ENSMOCG00000018716	Srbd1	100	83.635	Microtus_ochrogaster
ENSG00000068784	SRBD1	84	55.934	ENSMMOG00000007507	si:ch211-117n7.8	87	55.934	Mola_mola
ENSG00000068784	SRBD1	99	50.290	ENSMALG00000001562	si:ch211-117n7.8	86	55.227	Monopterus_albus
ENSG00000068784	SRBD1	100	81.709	MGP_CAROLIEiJ_G0021934	Srbd1	99	84.026	Mus_caroli
ENSG00000068784	SRBD1	100	81.910	ENSMUSG00000024135	Srbd1	100	81.910	Mus_musculus
ENSG00000068784	SRBD1	100	81.005	MGP_PahariEiJ_G0020924	Srbd1	100	81.005	Mus_pahari
ENSG00000068784	SRBD1	100	82.010	MGP_SPRETEiJ_G0022850	Srbd1	100	82.010	Mus_spretus
ENSG00000068784	SRBD1	100	87.349	ENSMLUG00000007039	SRBD1	100	87.349	Myotis_lucifugus
ENSG00000068784	SRBD1	100	82.796	ENSNGAG00000011893	Srbd1	100	82.405	Nannospalax_galili
ENSG00000068784	SRBD1	98	50.199	ENSNBRG00000012873	si:ch211-117n7.8	96	51.559	Neolamprologus_brichardi
ENSG00000068784	SRBD1	100	98.191	ENSNLEG00000016877	SRBD1	100	98.191	Nomascus_leucogenys
ENSG00000068784	SRBD1	100	84.523	ENSODEG00000012095	SRBD1	100	84.523	Octodon_degus
ENSG00000068784	SRBD1	99	50.921	ENSONIG00000000945	si:ch211-117n7.8	100	58.343	Oreochromis_niloticus
ENSG00000068784	SRBD1	100	91.265	ENSOCUG00000015385	SRBD1	100	91.265	Oryctolagus_cuniculus
ENSG00000068784	SRBD1	85	53.617	ENSORLG00000004427	si:ch211-117n7.8	84	53.617	Oryzias_latipes
ENSG00000068784	SRBD1	99	50.476	ENSORLG00020012792	si:ch211-117n7.8	84	56.766	Oryzias_latipes_hni
ENSG00000068784	SRBD1	86	56.128	ENSORLG00015018598	si:ch211-117n7.8	84	56.128	Oryzias_latipes_hsok
ENSG00000068784	SRBD1	98	49.559	ENSOMEG00000012229	si:ch211-117n7.8	83	55.427	Oryzias_melastigma
ENSG00000068784	SRBD1	100	84.839	ENSOGAG00000001076	SRBD1	100	84.839	Otolemur_garnettii
ENSG00000068784	SRBD1	100	83.996	ENSOARG00000005958	SRBD1	100	84.675	Ovis_aries
ENSG00000068784	SRBD1	100	98.995	ENSPPAG00000038442	SRBD1	100	98.995	Pan_paniscus
ENSG00000068784	SRBD1	100	90.955	ENSPPRG00000003449	SRBD1	100	90.955	Panthera_pardus
ENSG00000068784	SRBD1	100	91.055	ENSPTIG00000012495	SRBD1	100	91.055	Panthera_tigris_altaica
ENSG00000068784	SRBD1	100	98.995	ENSPTRG00000011889	SRBD1	100	98.995	Pan_troglodytes
ENSG00000068784	SRBD1	100	96.482	ENSPANG00000008063	SRBD1	100	96.482	Papio_anubis
ENSG00000068784	SRBD1	96	54.849	ENSPKIG00000021973	si:ch211-117n7.8	97	54.668	Paramormyrops_kingsleyae
ENSG00000068784	SRBD1	100	72.445	ENSPSIG00000008992	SRBD1	100	73.046	Pelodiscus_sinensis
ENSG00000068784	SRBD1	89	53.231	ENSPMGG00000013348	si:ch211-117n7.8	98	50.806	Periophthalmus_magnuspinnatus
ENSG00000068784	SRBD1	100	82.336	ENSPEMG00000020684	Srbd1	100	82.336	Peromyscus_maniculatus_bairdii
ENSG00000068784	SRBD1	98	51.241	ENSPFOG00000010650	si:ch211-117n7.8	97	51.564	Poecilia_formosa
ENSG00000068784	SRBD1	98	51.639	ENSPLAG00000002141	si:ch211-117n7.8	97	51.968	Poecilia_latipinna
ENSG00000068784	SRBD1	98	51.341	ENSPMEG00000018537	si:ch211-117n7.8	97	51.665	Poecilia_mexicana
ENSG00000068784	SRBD1	85	56.286	ENSPREG00000003258	si:ch211-117n7.8	87	56.286	Poecilia_reticulata
ENSG00000068784	SRBD1	100	90.047	ENSPPYG00000012444	SRBD1	99	90.047	Pongo_abelii
ENSG00000068784	SRBD1	82	81.830	ENSPCAG00000005629	SRBD1	85	81.830	Procavia_capensis
ENSG00000068784	SRBD1	100	79.680	ENSPCOG00000017669	SRBD1	100	79.680	Propithecus_coquereli
ENSG00000068784	SRBD1	100	80.704	ENSPVAG00000001782	SRBD1	100	80.704	Pteropus_vampyrus
ENSG00000068784	SRBD1	90	51.717	ENSPNYG00000000508	si:ch211-117n7.8	96	50.157	Pundamilia_nyererei
ENSG00000068784	SRBD1	96	57.364	ENSPNAG00000013492	SRBD1	95	57.364	Pygocentrus_nattereri
ENSG00000068784	SRBD1	100	80.622	ENSRNOG00000014720	Srbd1	99	81.325	Rattus_norvegicus
ENSG00000068784	SRBD1	99	96.274	ENSRBIG00000033486	SRBD1	99	96.274	Rhinopithecus_bieti
ENSG00000068784	SRBD1	99	96.274	ENSRROG00000041599	SRBD1	99	96.274	Rhinopithecus_roxellana
ENSG00000068784	SRBD1	100	94.070	ENSSBOG00000024982	SRBD1	100	94.070	Saimiri_boliviensis_boliviensis
ENSG00000068784	SRBD1	87	58.087	ENSSFOG00015001128	si:ch211-117n7.8	93	58.087	Scleropages_formosus
ENSG00000068784	SRBD1	98	51.378	ENSSMAG00000018256	si:ch211-117n7.8	83	56.927	Scophthalmus_maximus
ENSG00000068784	SRBD1	85	56.387	ENSSLDG00000023189	si:ch211-117n7.8	84	56.387	Seriola_lalandi_dorsalis
ENSG00000068784	SRBD1	100	78.291	ENSSARG00000009740	SRBD1	100	78.291	Sorex_araneus
ENSG00000068784	SRBD1	89	73.991	ENSSPUG00000010475	SRBD1	98	74.831	Sphenodon_punctatus
ENSG00000068784	SRBD1	84	54.759	ENSSPAG00000008092	-	95	51.431	Stegastes_partitus
ENSG00000068784	SRBD1	100	89.659	ENSSSCG00000008445	SRBD1	98	90.261	Sus_scrofa
ENSG00000068784	SRBD1	83	76.627	ENSTGUG00000003878	SRBD1	100	76.627	Taeniopygia_guttata
ENSG00000068784	SRBD1	99	51.062	ENSTRUG00000007080	si:ch211-117n7.8	96	56.032	Takifugu_rubripes
ENSG00000068784	SRBD1	99	50.245	ENSTNIG00000007464	si:ch211-117n7.8	99	49.902	Tetraodon_nigroviridis
ENSG00000068784	SRBD1	83	98.936	ENSTBEG00000004556	SRBD1	82	98.936	Tupaia_belangeri
ENSG00000068784	SRBD1	94	91.705	ENSTTRG00000011871	SRBD1	94	91.705	Tursiops_truncatus
ENSG00000068784	SRBD1	100	90.462	ENSUAMG00000008126	SRBD1	97	95.290	Ursus_americanus
ENSG00000068784	SRBD1	100	90.462	ENSUMAG00000012902	SRBD1	98	90.462	Ursus_maritimus
ENSG00000068784	SRBD1	91	91.290	ENSVPAG00000006825	SRBD1	100	91.290	Vicugna_pacos
ENSG00000068784	SRBD1	100	89.458	ENSVVUG00000005389	SRBD1	100	90.060	Vulpes_vulpes
ENSG00000068784	SRBD1	100	52.802	ENSXETG00000002760	srbd1	100	53.003	Xenopus_tropicalis
ENSG00000068784	SRBD1	98	50.844	ENSXMAG00000016861	si:ch211-117n7.8	97	51.160	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0006139	nucleobase-containing compound metabolic process	-	IEA	Process
GO:0006412	translation	21873635.	IBA	Process