EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000068878 (Gene tree)
Gene ID: 23198
Gene Symbol: PSME4
Alias: PA200|KIAA0077
Full Name: proteasome activator subunit 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 106,774 bases
Position: chr2:53,864,067-53,970,840
Accession: 20635
RBP type: non-canonical RBP
Summary: (Proteasome Activator Subunit 4) is a Protein Coding gene. Among its related pathways are Developmental Biology and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include binding and peptidase activator activity.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000488687	PSME4-209	3073	-	-	- (aa)	-	-
ENST00000478731	PSME4-207	514	-	-	- (aa)	-	-
ENST00000461810	PSME4-203	562	-	-	- (aa)	-	-
ENST00000389993	PSME4-201	6581	-	ENSP00000374643	571 (aa)	-	F8WBH5
ENST00000476586	PSME4-206	1422	-	-	- (aa)	-	-
ENST00000466539	PSME4-204	548	-	-	- (aa)	-	-
ENST00000404125	PSME4-202	7099	XM_006711969	ENSP00000384211	1843 (aa)	XP_006712032	Q14997
ENST00000481518	PSME4-208	886	-	-	- (aa)	-	-
ENST00000475694	PSME4-205	547	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000068878's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03050	Proteasome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000068878	rs10208649	2	53934226	C	Body mass index	28892062	[0.08-0.142] kg/m2 decrease	0.111	EFO_0004340
ENSG00000068878	rs805343	2	53966056	T	Hand grip strength	29691431	[0.0014-0.0026] unit decrease	0.002	EFO_0006941
ENSG00000068878	rs11892759	2	53943202	?	Heel bone mineral density	30048462	[0.02-0.033] unit increase	0.0264782	EFO_0009270
ENSG00000068878	rs115660490	2	53949596	?	Heel bone mineral density	30048462	[0.034-0.051] unit increase	0.0425566	EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000068878's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	ISS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006281	DNA repair	-	ISS	Process
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0006974	cellular response to DNA damage stimulus	-	ISS	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	21873635.	IBA	Process
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	-	ISS	Process
GO:0010952	positive regulation of peptidase activity	-	IEA	Process
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016504	peptidase activator activity	21873635.	IBA	Function
GO:0016504	peptidase activator activity	-	ISS	Function
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0016607	nuclear speck	-	IEA	Component
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0035093	spermatogenesis, exchange of chromosomal proteins	21873635.	IBA	Process
GO:0035093	spermatogenesis, exchange of chromosomal proteins	-	ISS	Process
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0070577	lysine-acetylated histone binding	21873635.	IBA	Function
GO:0070577	lysine-acetylated histone binding	-	ISS	Function
GO:0070628	proteasome binding	21873635.	IBA	Function
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process
GO:1990111	spermatoproteasome complex	21873635.	IBA	Component
GO:1990111	spermatoproteasome complex	-	ISS	Component