EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000069329 (Gene tree)
Gene ID: 55737
Gene Symbol: VPS35
Alias: FLJ10752|MEM3|PARK17
Full Name: VPS35 retromer complex component
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 33,387 bases
Position: chr16:46,656,132-46,689,518
Accession: 13487
RBP type: non-canonical RBP
Summary: This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000568784	VPS35-209	4017	-	ENSP00000456274	48 (aa)	-	H3BRJ7
ENST00000569950	VPS35-210	1096	-	-	- (aa)	-	-
ENST00000647959	VPS35-212	5054	-	ENSP00000497702	47 (aa)	-	I3L4P4
ENST00000568642	VPS35-208	447	-	-	- (aa)	-	-
ENST00000568612	VPS35-207	697	-	ENSP00000461469	41 (aa)	-	I3L4S0
ENST00000568191	VPS35-206	520	-	-	- (aa)	-	-
ENST00000565228	VPS35-205	487	-	-	- (aa)	-	-
ENST00000563984	VPS35-204	775	-	-	- (aa)	-	-
ENST00000563884	VPS35-203	759	-	-	- (aa)	-	-
ENST00000640313	VPS35-211	141	-	ENSP00000491212	46 (aa)	-	A0A1W2PP10
ENST00000562420	VPS35-202	740	-	-	- (aa)	-	-
ENST00000299138	VPS35-201	6790	XM_005256045	ENSP00000299138	796 (aa)	XP_005256102	Q96QK1

Gene Model

Click here to download ENSG00000069329's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000069329's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000069329	VPS35	100	99.372	ENSMUSG00000031696	Vps35	100	99.372	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	11102511.15078903.16732284.17616579.17891154.18160348.19553991.19619496.20923837.21725319.22719997.23331060.23452853.24344282.24747528.25278552.25416956.26496610.26618722.27385586.27460146.28892079.	IPI	Function
GO:0005739	mitochondrion	26618722.	IDA	Component
GO:0005764	lysosome	-	IDA	Component
GO:0005765	lysosomal membrane	17897319.	HDA	Component
GO:0005768	endosome	15078903.28892079.	IDA	Component
GO:0005769	early endosome	18160348.20164305.27385586.	IDA	Component
GO:0005770	late endosome	21873635.	IBA	Component
GO:0005829	cytosol	11102511.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0007040	lysosome organization	-	IEA	Process
GO:0007416	synapse assembly	-	IEA	Process
GO:0008565	protein transporter activity	21873635.	IBA	Function
GO:0010008	endosome membrane	27385586.	IDA	Component
GO:0010628	positive regulation of gene expression	26618722.	IDA	Process
GO:0010629	negative regulation of gene expression	-	IEA	Process
GO:0010821	regulation of mitochondrion organization	26618722.	IGI	Process
GO:0014069	postsynaptic density	-	IEA	Component
GO:0016032	viral process	-	IEA	Process
GO:0016055	Wnt signaling pathway	24115276.	NAS	Process
GO:0016055	Wnt signaling pathway	-	TAS	Process
GO:0016241	regulation of macroautophagy	26172538.	TAS	Process
GO:0030904	retromer complex	21873635.	IBA	Component
GO:0030904	retromer complex	11102511.28892079.	IDA	Component
GO:0030904	retromer complex	18193037.	NAS	Component
GO:0030904	retromer complex	17239604.24115276.	TAS	Component
GO:0030906	retromer, cargo-selective complex	20164305.27385586.	IDA	Component
GO:0030906	retromer, cargo-selective complex	26220253.	NAS	Component
GO:0031647	regulation of protein stability	18193037.	IMP	Process
GO:0031648	protein destabilization	-	IEA	Process
GO:0031748	D1 dopamine receptor binding	27460146.	IPI	Function
GO:0032268	regulation of cellular protein metabolic process	26618722.	IDA	Process
GO:0032268	regulation of cellular protein metabolic process	25533483.	IGI	Process
GO:0032463	negative regulation of protein homooligomerization	-	IEA	Process
GO:0036010	protein localization to endosome	28892079.	IMP	Process
GO:0042147	retrograde transport, endosome to Golgi	21873635.	IBA	Process
GO:0042147	retrograde transport, endosome to Golgi	15078903.26618722.27385586.	IMP	Process
GO:0042147	retrograde transport, endosome to Golgi	11102511.18193037.26220253.	NAS	Process
GO:0043005	neuron projection	-	IEA	Component
GO:0043025	neuronal cell body	-	IEA	Component
GO:0043653	mitochondrial fragmentation involved in apoptotic process	26618722.	IMP	Process
GO:0045056	transcytosis	15247922.	IDA	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0050728	negative regulation of inflammatory response	25533483.	IGI	Process
GO:0050882	voluntary musculoskeletal movement	-	IEA	Process
GO:0060161	positive regulation of dopamine receptor signaling pathway	27460146.	IDA	Process
GO:0060548	negative regulation of cell death	25533483.	IGI	Process
GO:0061357	positive regulation of Wnt protein secretion	-	IEA	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0090141	positive regulation of mitochondrial fission	26618722.	IMP	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	IEA	Process
GO:0090326	positive regulation of locomotion involved in locomotory behavior	-	IEA	Process
GO:0097422	tubular endosome	15078903.	IDA	Component
GO:0098793	presynapse	-	IEA	Component
GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane	-	IEA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099003	vesicle-mediated transport in synapse	-	IEA	Process
GO:0099073	mitochondrion-derived vesicle	26618722.	IDA	Component
GO:0099074	mitochondrion to lysosome transport	26618722.	IMP	Process
GO:0099639	neurotransmitter receptor transport, endosome to plasma membrane	27460146.	IDA	Process
GO:1901215	negative regulation of neuron death	25533483.	IGI	Process
GO:1902823	negative regulation of late endosome to lysosome transport	23563491.	IMP	Process
GO:1902950	regulation of dendritic spine maintenance	26618722.	IMP	Process
GO:1903181	positive regulation of dopamine biosynthetic process	-	IEA	Process
GO:1903364	positive regulation of cellular protein catabolic process	25533483.	IGI	Process
GO:1903828	negative regulation of cellular protein localization	-	IEA	Process
GO:1905166	negative regulation of lysosomal protein catabolic process	-	IEA	Process
GO:1905606	regulation of presynapse assembly	25533483.	ISS	Process
GO:1990126	retrograde transport, endosome to plasma membrane	20164305.21602791.	IMP	Process
GO:2000331	regulation of terminal button organization	26618722.	IMP	Process