EuRBPDB

Description

Ensembl ID: ENSG00000070047 (Gene tree)
Gene ID: 57661
Gene Symbol: PHRF1
Alias: KIAA1542|PPP1R125|RNF221
Full Name: PHD and ring finger domains 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 36,003 bases
Position: chr11:576,220-612,222
Accession: 24351
RBP type: non-canonical RBP
Summary: (PHD And Ring Finger Domains 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and RNA polymerase binding. An important paralog of this gene is SCAF11.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000413872	PHRF1-202	5224	-	ENSP00000388589	1647 (aa)	-	F8WEF5
ENST00000416188	PHRF1-203	5227	-	ENSP00000410626	1648 (aa)	-	Q9P1Y6
ENST00000534320	PHRF1-206	5178	-	ENSP00000435360	1494 (aa)	-	Q9P1Y6
ENST00000533464	PHRF1-205	5218	XM_005253027	ENSP00000431870	1645 (aa)	XP_005253084	E9PJ24
ENST00000532550	PHRF1-204	748	-	-	- (aa)	-	-
ENST00000264555	PHRF1-201	5523	XM_005253025	ENSP00000264555	1649 (aa)	XP_005253082	Q9P1Y6

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000070047	Arteries	9.3330000E-005	-
ENSG00000070047	Lupus Erythematosus, Systemic	4E-6	21408207
ENSG00000070047	Lupus Erythematosus, Systemic	3E-10	18204446
ENSG00000070047	Lupus Erythematosus, Systemic	8E-6	23740937
ENSG00000070047	Scleroderma, Systemic	8E-6	23740937

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000070047	rs2396545	11	601785	?	Systemic lupus erythematosus and Systemic sclerosis	23740937	[NR]	1.19	EFO_0000717\|EFO_0002690
ENSG00000070047	rs4963128	11	589564	?	Systemic lupus erythematosus	18204446	[1.18-1.37]	1.28	EFO_0002690
ENSG00000070047	rs4963128	11	589564	?	Systemic lupus erythematosus	21408207	[1.18-1.49]	1.33	EFO_0002690
ENSG00000070047	rs7936397	11	577534	?	Hypothyroidism	30595370			EFO_0004705

Protein-Protein Interaction (PPI)

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0006366	transcription by RNA polymerase II	-	IEA	Process
GO:0006397	mRNA processing	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0070063	RNA polymerase binding	-	ISS	Function