EuRBPDB

Description

Ensembl ID: ENSG00000070061 (Gene tree)
Gene ID: 8518
Gene Symbol: ELP1
Alias: IKAP|TOT1|IKI3|DYS|IKBKAP
Full Name: elongator complex protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 66,812 bases
Position: chr9:108,867,517-108,934,328
Accession: 5959
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000495759	ELP1-203	2840	-	ENSP00000433514	346 (aa)	-	H0YDF3
ENST00000467959	ELP1-202	437	-	-	- (aa)	-	-
ENST00000374647	ELP1-201	5905	XM_011519136	ENSP00000363779	1332 (aa)	XP_011517438	O95163
ENST00000537196	ELP1-204	3823	-	ENSP00000439367	983 (aa)	-	F5H2T0

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000070061	Body Weight	9.54011576599356E-5	17903300
ENSG00000070061	Personality Inventory	8.61e-005	-
ENSG00000070061	Personality Inventory	8.61e-005	-
ENSG00000070061	Platelet Function Tests	1.7869700E-005	-
ENSG00000070061	Myocardial Infarction	2.2530000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000070061	rs12353209	9	108890800	?	Myringotomy	28928442	[0.5-6.96] unit decrease	3.7323	EFO_0007904
ENSG00000070061	rs2275641	9	108934109	C	Educational attainment (MTAG)	30038396	[0.0093-0.0147] unit increase	0.012	EFO_0004784
ENSG00000070061	rs2275641	9	108934109	C	Highest math class taken (MTAG)	30038396	[0.0091-0.0157] unit increase	0.0124	EFO_0004875
ENSG00000070061	rs10979613	9	108925304	T	Educational attainment (years of education)	30038396	[0.0088-0.0146] unit decrease	0.0117	EFO_0004784

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000070061	ELP1	100	80.899	ENSMUSG00000028431	Elp1	100	80.899	Mus_musculus
ENSG00000070061	ELP1	75	35.000	YLR384C	IKI3	76	35.000	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000993	RNA polymerase II complex binding	11714725.	IDA	Function
GO:0002098	tRNA wobble uridine modification	-	IEA	Process
GO:0005515	protein binding	11714725.15383276.19185337.21903422.22854966.	IPI	Function
GO:0005730	nucleolus	11714725.	IDA	Component
GO:0005737	cytoplasm	11714725.22854966.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006357	regulation of transcription by RNA polymerase II	11818576.	IDA	Process
GO:0006357	regulation of transcription by RNA polymerase II	11714725.	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	11714725.	TAS	Process
GO:0006468	protein phosphorylation	9751059.	TAS	Process
GO:0006955	immune response	9751059.	TAS	Process
GO:0008023	transcription elongation factor complex	11714725.	IDA	Component
GO:0008607	phosphorylase kinase regulator activity	11818576.	IDA	Function
GO:0030335	positive regulation of cell migration	-	ISS	Process
GO:0033588	Elongator holoenzyme complex	22854966.	IDA	Component
GO:0045859	regulation of protein kinase activity	-	IEA	Process
GO:0065003	protein-containing complex assembly	9751059.	TAS	Process