EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000070087 (Gene tree)
Gene ID: 5217
Gene Symbol: PFN2
Alias: N
Full Name: profilin 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 85,885 bases
Position: chr3:149,964,904-150,050,788
Accession: 8882
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000489155	PFN2-211	636	-	ENSP00000420504	91 (aa)	-	C9J712
ENST00000452853	PFN2-203	1780	-	ENSP00000410464	140 (aa)	-	P35080
ENST00000461930	PFN2-206	606	-	ENSP00000417912	45 (aa)	-	C9J5V8
ENST00000497148	PFN2-215	743	-	ENSP00000417817	91 (aa)	-	C9J712
ENST00000423691	PFN2-202	911	-	ENSP00000408283	188 (aa)	-	G5E9Q6
ENST00000461868	PFN2-205	613	-	ENSP00000420244	110 (aa)	-	C9JQ45
ENST00000239940	PFN2-201	2261	-	ENSP00000239940	140 (aa)	-	P35080
ENST00000475518	PFN2-208	637	-	ENSP00000418142	91 (aa)	-	C9J712
ENST00000649949	PFN2-218	2325	-	ENSP00000498146	91 (aa)	-	UPI00001EFD24
ENST00000494827	PFN2-213	793	-	ENSP00000418523	91 (aa)	-	C9J0J7
ENST00000497060	PFN2-214	764	-	-	- (aa)	-	-
ENST00000498307	PFN2-217	556	-	ENSP00000420202	91 (aa)	-	C9J712
ENST00000468323	PFN2-207	894	-	ENSP00000418494	55 (aa)	-	F2Z3G0
ENST00000481275	PFN2-209	560	-	ENSP00000418216	91 (aa)	-	C9J712
ENST00000490975	PFN2-212	858	-	ENSP00000417351	125 (aa)	-	C9J2N0
ENST00000460404	PFN2-204	942	-	ENSP00000417924	45 (aa)	-	C9J5V8
ENST00000498169	PFN2-216	662	-	ENSP00000418521	55 (aa)	-	F2Z3G0
ENST00000481767	PFN2-210	1620	-	ENSP00000420417	91 (aa)	-	C9J0J7

Gene Model

Click here to download ENSG00000070087's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04015	Rap1 signaling pathway	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05131	Shigellosis	KEGG
hsa05132	Salmonella infection	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000070087	rs1457546	3	149974810	?	Reaction time	29844566	[0.005-0.0118] unit increase	0.0083875	EFO_0008393
ENSG00000070087	rs9289798	3	150004607	G	Pulse pressure	30578418	[0.11-0.21] mmHg decrease	0.1595	EFO_0005763

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000070087's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000070087	PFN2	99	63.333	ENSG00000108518	PFN1	99	63.043	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003779	actin binding	21873635.	IBA	Function
GO:0003785	actin monomer binding	7758455.	IPI	Function
GO:0005515	protein binding	9822597.15383276.16169070.	IPI	Function
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	7758455.	IDA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005856	cytoskeleton	-	IEA	Component
GO:0010633	negative regulation of epithelial cell migration	23153535.	IMP	Process
GO:0016887	ATPase activity	7758455.	IDA	Function
GO:0030036	actin cytoskeleton organization	-	IEA	Process
GO:0030833	regulation of actin filament polymerization	21873635.	IBA	Process
GO:0030837	negative regulation of actin filament polymerization	7758455.	IDA	Process
GO:0030838	positive regulation of actin filament polymerization	23153535.	IGI	Process
GO:0032233	positive regulation of actin filament bundle assembly	21873635.	IBA	Process
GO:0032233	positive regulation of actin filament bundle assembly	23153535.	IMP	Process
GO:0032781	positive regulation of ATPase activity	7758455.	IDA	Process
GO:0033138	positive regulation of peptidyl-serine phosphorylation	23153535.	IMP	Process
GO:0050821	protein stabilization	18573880.	IDA	Process
GO:0051496	positive regulation of stress fiber assembly	23153535.	IMP	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0098685	Schaffer collateral - CA1 synapse	-	IEA	Component
GO:0098793	presynapse	-	IEA	Component
GO:0098794	postsynapse	-	IEA	Component
GO:0098885	modification of postsynaptic actin cytoskeleton	-	IEA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:1900028	negative regulation of ruffle assembly	23153535.	IMP	Process
GO:2000300	regulation of synaptic vesicle exocytosis	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23827010	Profilin-1 versus profilin-2: two faces of the same coin?	Breast Cancer Res	2013 Jun 27	Ding Z	doi: 10.1186/bcr3433.
28405690	MicroRNA-30a-5p suppresses epithelial-mesenchymal transition by targeting profilin-2 in high invasive non-small cell lung cancer cell lines.	Oncol Rep	2017 May	Yan J	doi: 10.3892/or.2017.5566
30015842	Loss of profilin2 contributes to enhanced epithelial-mesenchymal transition and metastasis of colorectal cancer.	Int J Oncol	2018 Sep	Zhang H	doi: 10.3892/ijo.2018.4475

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	149966324	3'UTR	novel		0.25
BLCA	chr3	149966499	Missense_Mutation	novel	S138C	0.16
BRCA	chr3	149966518	Missense_Mutation	novel	A132P	0.04
BRCA	chr3	149966519	Missense_Mutation	novel	M131I	0.04
CESC	chr3	149966185	3'UTR	novel		0.08
CESC	chr3	149964962	3'UTR	novel		0.58
CESC	chr3	149965726	3'UTR	novel		0.29
COAD	chr3	149966197	3'UTR	NA		0.32
COAD	chr3	149965864	3'UTR	novel		0.27
COAD	chr3	149966345	3'UTR	NA		0.36
COAD	chr3	149968496	Missense_Mutation	NA	G63S	0.34
COAD	chr3	149966310	3'UTR	rs557338547		0.4
COAD	chr3	149968481	Missense_Mutation	NA	A68T	0.22
COAD	chr3	149968480	Missense_Mutation	NA	A68V	0.21
ESCA	chr3	149965969	3'UTR	novel		0.15
ESCA	chr3	149965957	3'UTR	novel		0.38
HNSC	chr3	149968487	Missense_Mutation	novel	L66V	0.13
KIRC	chr3	149966220	3'UTR	novel		0.64
LAML	chr3	149966135	3'UTR	novel		0.1
LGG	chr3	149966302	3'UTR	novel		0.47
LUAD	chr3	149966051	3'UTR	novel		0.31
LUSC	chr3	149968506	Silent	novel	F59F	0.43
LUSC	chr3	149966311	3'UTR	rs776480347		0.2
OV	chr3	149966055	3'UTR	novel		0.43
OV	chr3	149966533	Missense_Mutation	novel	K127Q	0.05
OV	chr3	149965935	3'UTR	novel		0.21
OV	chr3	149968373	Missense_Mutation	NA	G104R	0.25
OV	chr3	149968460	Missense_Mutation	novel	R75G	0.53
PRAD	chr3	149968445	Missense_Mutation	NA	V80F	0.27
PRAD	chr3	149966545	Missense_Mutation	rs763130284	G123R	0.07
PRAD	chr3	149968481	Missense_Mutation	NA	A68T	0.43
READ	chr3	149968544	Nonsense_Mutation	NA	E47*	0.33
SARC	chr3	149966336	3'UTR	novel		0.25
SARC	chr3	149966337	3'UTR	novel		0.25
SKCM	chr3	149966458	3'UTR	novel		0.55
SKCM	chr3	149966460	3'UTR	novel		0.57
STAD	chr3	149966309	3'UTR	rs762210043		0.32
STAD	chr3	149966310	3'UTR	rs557338547		0.34
STAD	chr3	149966309	3'UTR	rs762210043		0.37
STAD	chr3	149968485	Silent	NA	L66L	0.05
STAD	chr3	149966287	3'UTR	novel		0.13
TGCT	chr3	149970919	5'UTR	novel		0.14
UCEC	chr3	149965726	3'UTR	novel		0.33
UCEC	chr3	149965899	3'UTR	novel		0.47
UCEC	chr3	149966043	3'UTR	novel		0.34
UCEC	chr3	149970736	Nonsense_Mutation	novel	Q41*	0.32
UCEC	chr3	149965145	3'UTR	novel		0.53
UCEC	chr3	149965302	3'UTR	novel		0.31
UCEC	chr3	149968544	Nonsense_Mutation	NA	E47*	0.56
UCEC	chr3	149966116	3'UTR	novel		0.38
UCEC	chr3	149965670	3'UTR	novel		0.33
UCEC	chr3	149966405	3'UTR	novel		0.27
UCEC	chr3	149966424	3'UTR	novel		0.22
UCEC	chr3	149966074	3'UTR	novel		0.63
UCEC	chr3	149965947	3'UTR	novel		0.52
UCEC	chr3	149966246	3'UTR	novel		0.35
UCEC	chr3	149964943	3'UTR	novel		0.49
UCEC	chr3	149964963	3'UTR	novel		0.5
UCEC	chr3	149965783	3'UTR	novel		0.29
UCEC	chr3	149966452	3'UTR	rs550532075		0.33
UCEC	chr3	149966555	Silent	novel	V119V	0.45
UCEC	chr3	149966063	3'UTR	novel		0.07
UCEC	chr3	149968356	Splice_Site	NA	X109_splice	0.33
UCEC	chr3	149966032	3'UTR	novel		0.44
UCEC	chr3	149965310	3'UTR	novel		0.33
UCEC	chr3	149965129	3'UTR	novel		0.29
UCEC	chr3	149968532	Missense_Mutation	novel	I51F	0.26
UCEC	chr3	149965930	3'UTR	novel		0.46
UCEC	chr3	149965040	3'UTR	novel		0.22
UCEC	chr3	149965127	3'UTR	novel		0.16
UCEC	chr3	149968446	Silent	NA	Y79Y	0.28
UCEC	chr3	149968544	Nonsense_Mutation	NA	E47*	0.32
UCEC	chr3	149966061	3'UTR	novel		0.34
UCEC	chr3	149966282	3'UTR	novel		0.2
UCEC	chr3	149968486	Missense_Mutation	novel	L66R	0.2
UCS	chr3	149966513	Silent	novel	K133K	0.45
UCS	chr3	149968506	Missense_Mutation	novel	F59L	0.06

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	DEL	0.1136	0.11092
KIRP	AMP	0.3125	0.15981
PAAD	AMP	0.0978	0.16151

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.036	Kaplan-Meier Survival Analysis
STAD	0.025	Kaplan-Meier Survival Analysis
SARC	0.00016	Kaplan-Meier Survival Analysis
ACC	0.037	Kaplan-Meier Survival Analysis
UCS	0.027	Kaplan-Meier Survival Analysis
HNSC	0.00083	Kaplan-Meier Survival Analysis
PRAD	0.025	Kaplan-Meier Survival Analysis
LUSC	0.014	Kaplan-Meier Survival Analysis
COAD	0.014	Kaplan-Meier Survival Analysis
PAAD	0.027	Kaplan-Meier Survival Analysis
READ	0.026	Kaplan-Meier Survival Analysis
UCEC	0.0056	Kaplan-Meier Survival Analysis
LIHC	0.00037	Kaplan-Meier Survival Analysis
LUAD	0.029	Kaplan-Meier Survival Analysis
UVM	0.021	Kaplan-Meier Survival Analysis
OV	0.038	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742