EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000070366 (Gene tree)
Gene ID: 23293
Gene Symbol: SMG6
Alias: KIAA0732|SMG-6|EST1A|C17orf31
Full Name: SMG6 nonsense mediated mRNA decay factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 243,975 bases
Position: chr17:2,059,839-2,303,813
Accession: 17809
RBP type: canonical RBP
Summary: This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000263073	EST1	PF10374.9	2.3e-14	1	1
ENSP00000263073	EST1_DNA_bind	PF10373.9	6.9e-60	1	1
ENSP00000346977	EST1_DNA_bind	PF10373.9	1.9e-17	1	1
ENSP00000440283	EST1_DNA_bind	PF10373.9	1.9e-17	1	1
ENSP00000459164	EST1_DNA_bind	PF10373.9	4.2e-13	1	1
ENSP00000460898	EST1_DNA_bind	PF10373.9	4.7e-13	1	1
ENSP00000458635	EST1_DNA_bind	PF10373.9	5.2e-13	1	1
ENSP00000465793	EST1_DNA_bind	PF10373.9	4.7e-09	1	1
ENSP00000460191	EST1_DNA_bind	PF10373.9	6.4e-08	1	1
ENSP00000466139	EST1_DNA_bind	PF10373.9	1.9e-07	1	1
ENSP00000460301	EST1_DNA_bind	PF10373.9	1.4e-06	1	1
ENSP00000466951	EST1_DNA_bind	PF10373.9	0.00013	1	1
ENSP00000346977	PIN_4	PF13638.6	3.4e-21	1	1
ENSP00000440283	PIN_4	PF13638.6	3.4e-21	1	1
ENSP00000263073	PIN_4	PF13638.6	5.9e-21	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27693585	Cleavage of influenza RNA by using a human PUF-based artificial RNA-binding protein-staphylococcal nuclease hybrid.	Biochem Biophys Res Commun	2016 Oct 28	Mori T	doi: 10.1016/j.bbrc.2016.09.142
17940095	Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase.	Nucleic Acids Res	2007	Redon S	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000572369	SMG6-211	689	-	ENSP00000465793	138 (aa)	-	K7EKV2
ENST00000573827	SMG6-214	601	-	-	- (aa)	-	-
ENST00000354901	SMG6-202	3473	XM_005256571	ENSP00000346977	511 (aa)	XP_005256628	Q86US8
ENST00000575338	SMG6-217	546	-	-	- (aa)	-	-
ENST00000536871	SMG6-203	1865	-	ENSP00000440283	511 (aa)	-	Q86US8
ENST00000570659	SMG6-205	592	-	ENSP00000460898	163 (aa)	-	I3L421
ENST00000576218	SMG6-220	902	-	-	- (aa)	-	-
ENST00000570606	SMG6-204	572	-	ENSP00000460191	123 (aa)	-	I3L355
ENST00000263073	SMG6-201	5960	XM_005256569	ENSP00000263073	1419 (aa)	XP_005256626	Q86US8
ENST00000575176	SMG6-216	557	-	ENSP00000466139	124 (aa)	-	K7ELM2
ENST00000575663	SMG6-219	574	-	ENSP00000458635	162 (aa)	-	I3L176
ENST00000570874	SMG6-208	533	-	-	- (aa)	-	-
ENST00000575454	SMG6-218	652	-	ENSP00000460273	208 (aa)	-	I3L390
ENST00000572205	SMG6-210	551	-	ENSP00000466951	115 (aa)	-	K7ENH7
ENST00000573153	SMG6-212	552	-	-	- (aa)	-	-
ENST00000570668	SMG6-206	547	-	ENSP00000460301	119 (aa)	-	I3L3A9
ENST00000571442	SMG6-209	588	-	ENSP00000459164	164 (aa)	-	I3L1W8
ENST00000574501	SMG6-215	2419	-	-	- (aa)	-	-
ENST00000570756	SMG6-207	2426	-	-	- (aa)	-	-
ENST00000573166	SMG6-213	4236	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000070366's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000070366	Body Mass Index	2E-8	25673413
ENSG00000070366	Body Mass Index	9E-8	25673413
ENSG00000070366	Myocardial Infarction	3E-6	26343387
ENSG00000070366	Schizophrenia	1E-9	26198764
ENSG00000070366	Hydroxyindoleacetic Acid	3E-6	23319000
ENSG00000070366	Coronary Disease	9E-10	21378990
ENSG00000070366	Schizophrenia	6E-8	23974872
ENSG00000070366	Schizophrenia	3E-10	25056061
ENSG00000070366	Bone Density	1E-18	22504420
ENSG00000070366	Mitral Valve Prolapse	2E-8	26301497
ENSG00000070366	Body Mass Index	8E-8	25673413
ENSG00000070366	Coronary Artery Disease	5E-7	26343387
ENSG00000070366	Coronary Disease	1E-9	21378990
ENSG00000070366	Aorta	2E-11	19584346
ENSG00000070366	Carcinoma, Squamous Cell	2E-11	22960999
ENSG00000070366	Esophageal Neoplasms	2E-11	22960999
ENSG00000070366	Schizophrenia	7E-6	26198764
ENSG00000070366	Coronary Disease	1E-7	24262325

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000070366	rs4061659	17	2094150	G	Intraocular pressure	29617998	[0.064-0.12] unit increase	0.0922	EFO_0004695
ENSG00000070366	rs216195	17	2299873	T	Intraocular pressure	29617998	[0.058-0.118] unit decrease	0.088	EFO_0004695
ENSG00000070366	rs7209460	17	2145419	T	Femoral neck bone mineral density	29499414	[0.038-0.068] unit increase	0.0529	EFO_0007785
ENSG00000070366	rs370221402	17	2171733	C	Monocyte count	27863252	[0.019-0.037] unit decrease	0.02797022	EFO_0005091
ENSG00000070366	rs4790312	17	2078186	T	Left atrial antero-posterior diameter	28394258	[0.012-0.028] unit decrease	0.0197	EFO_0008205
ENSG00000070366	rs4790881	17	2165638	A	Bone mineral density	22504420	[NR] unit increase	0.05	EFO_0003923
ENSG00000070366	rs2281727	17	2214651	G	Coronary artery disease	24262325	[1.04-1.10]	1.07	EFO_0001645
ENSG00000070366	rs216205	17	2292856	T	Mitral valve prolapse	26301497	[1.15-1.33]	1.24	HP_0001634
ENSG00000070366	rs216172	17	2223210	C	Coronary artery disease	26343387	[1.03- 1.07]	1.05	EFO_0000378
ENSG00000070366	rs9914266	17	2229956	C	Myocardial infarction	26343387	[1.03-1.07]	1.05	EFO_0000612
ENSG00000070366	rs2019872	17	2107024	C	Schizophrenia	26198764	[NR]	1.0752687	EFO_0000692
ENSG00000070366	rs17761864	17	2268343	A	Esophageal cancer (squamous cell)	22960999	[1.14-1.28]	1.21	EFO_0000707\|EFO_0002916
ENSG00000070366	rs10852932	17	2240166	T	Aortic root size	19584346	[0.02-0.04] cm increase	0.03	EFO_0005037
ENSG00000070366	rs11078884	17	2241899	C	Metabolite levels (5-HIAA)	23319000	unit increase	0.2234	EFO_0005132
ENSG00000070366	rs4790881	17	2165638	?	Intraocular pressure	29235454	[NR] unit increase	0.1	EFO_0004695
ENSG00000070366	rs35401268	17	2123124	GA	Heel bone mineral density	28869591	[0.044-0.066] unit decrease	0.0552294	EFO_0009270
ENSG00000070366	rs2281727	17	2214651	G	Body mass index	28892062	[0.054-0.066] kg/m2 increase	0.06	EFO_0004340
ENSG00000070366	rs35401268	17	2123124	GA	Heel bone mineral density	28869591	[0.05-0.064] unit decrease	0.0567881	EFO_0009270
ENSG00000070366	rs35401268	17	2123124	GA	Heel bone mineral density	28869591	[0.051-0.07] unit decrease	0.0603701	EFO_0009270
ENSG00000070366	rs2873195	17	2161408	A	Total body bone mineral density	29304378	unit decrease	0.0406	EFO_0003923
ENSG00000070366	rs4790323	17	2278364	A	Total body bone mineral density	29304378	unit decrease	0.0362	EFO_0003923
ENSG00000070366	rs7213347	17	2249963	C	Total body bone mineral density	29304378	unit increase	0.0393	EFO_0003923
ENSG00000070366	rs7209460	17	2145419	T	Total body bone mineral density	29304378	unit increase	0.0438	EFO_0003923
ENSG00000070366	rs62068034	17	2129018	A	Coronary artery disease	29212778	[0.071-0.165] unit decrease	0.118	EFO_0000378
ENSG00000070366	rs7209460	17	2145419	T	Coronary artery disease	29212778	[0.039-0.067] unit increase	0.053	EFO_0000378
ENSG00000070366	rs170041	17	2266922	T	Coronary artery disease	29212778	[0.036-0.058] unit decrease	0.0469	EFO_0000378
ENSG00000070366	rs216215	17	2237374	T	Forehead morphology	29921221	[NR] unit decrease	0.723	EFO_0007844
ENSG00000070366	rs216191	17	2285345	T	Platelet count	27863252	[0.03-0.044] unit increase	0.03702377	EFO_0004309
ENSG00000070366	rs7225843	17	2098531	C	White blood cell count	27863252	[0.023-0.041] unit decrease	0.03204602	EFO_0004308
ENSG00000070366	rs12943566	17	2254480	G	Plateletcrit	27863252	[0.038-0.053] unit increase	0.04590243	EFO_0007985
ENSG00000070366	rs216172	17	2223210	C	Coronary heart disease	21378990	[1.05-1.09]	1.07	EFO_0001645
ENSG00000070366	rs1231206	17	2222311	A	Coronary heart disease	21378990	[1.05-1.09]	1.07	EFO_0001645
ENSG00000070366	rs9914578	17	2101842	C	Body mass index	26426971	unit decrease	0.01795047	EFO_0004340
ENSG00000070366	rs7216638	17	2253159	?	Schizophrenia	29483656	[1.05-1.09]	1.067	EFO_0000692
ENSG00000070366	rs557139647	17	2142526	?	Heel bone mineral density	30048462	[0.054-0.083] unit decrease	0.068774	EFO_0009270
ENSG00000070366	rs216181	17	2269459	?	Heel bone mineral density	30048462	[0.049-0.072] unit increase	0.0601311	EFO_0009270
ENSG00000070366	rs9898390	17	2274190	?	Heel bone mineral density	30048462	[0.043-0.052] unit decrease	0.0471822	EFO_0009270
ENSG00000070366	rs35401268	17	2123124	?	Heel bone mineral density	30048462	[0.021-0.03] unit decrease	0.0253946	EFO_0009270
ENSG00000070366	rs17761723	17	2203796	T	Cannabis use	30150663	[0.029-0.065] unit increase	0.047	EFO_0007585
ENSG00000070366	rs8068234	17	2066975	G	Heel bone mineral density	30598549	[0.038-0.067] unit decrease	0.0527399	EFO_0009270
ENSG00000070366	rs140760578	17	2104316	G	Heel bone mineral density	30598549	[0.038-0.073] unit increase	0.0556689	EFO_0009270
ENSG00000070366	rs7209460	17	2145419	C	Heel bone mineral density	30598549	[0.048-0.056] unit decrease	0.0515381	EFO_0009270
ENSG00000070366	rs7213347	17	2249963	?	Balding type 1	30595370			EFO_0007825
ENSG00000070366	rs17834563	17	2269416	C	Male-pattern baldness	30573740	[0.023-0.036] unit decrease	0.0298148	EFO_0007825
ENSG00000070366	rs9896535	17	2229911	?	Body mass index	30595370			EFO_0004340
ENSG00000070366	rs4790870	17	2066907	A	Smoking status (ever vs never smokers)	30643258	[0.0089-0.017] unit increase	0.012981379	EFO_0004318
ENSG00000070366	rs3760231	17	2111690	?	White blood cell count	30595370			EFO_0004308
ENSG00000070366	rs3803809	17	2062958	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000070366	rs4790874	17	2091883	?	Smoking status	30595370			EFO_0006527
ENSG00000070366	rs216199	17	2297577	?	Eczema	30595370			HP_0000964
ENSG00000070366	rs12952051	17	2079496	T	Systolic blood pressure	30578418	[0.18-0.31] mmHg decrease	0.244	EFO_0006335
ENSG00000070366	rs9303241	17	2075669	T	Systolic blood pressure	27841878	unit increase	0.204	EFO_0006335
ENSG00000070366	rs35087650	17	2155056	ATT	Knee osteoarthritis	30664745	[1.05-1.1]	1.07	EFO_0004616
ENSG00000070366	rs9303241	17	2075669	T	Pulse pressure	27841878	unit increase	0.159	EFO_0005763
ENSG00000070366	rs2760751	17	2124812	?	Lung function (FEV1/FVC)	30595370			EFO_0004713
ENSG00000070366	rs11657636	17	2150626	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000070366	rs4790874	17	2091883	T	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0059-0.0102] unit increase	0.00802647	EFO_0006527
ENSG00000070366	rs4790874	17	2091883	T	Smoking initiation (ever regular vs never regular)	30643251	[0.012-0.022] unit increase	0.01744911	EFO_0006527
ENSG00000070366	rs16952006	17	2195889	T	Breast cancer	29059683	[0.031-0.074] unit decrease	0.0524	EFO_0000305
ENSG00000070366	rs1231207	17	2222156	?	Calcaneus stiffness index	30779856	[0.061-0.119] unit decrease	0.0901	EFO_0007772
ENSG00000070366	rs216195	17	2299873	G	Smoking initiation	30617275	[0.0017-0.0135] unit decrease (replication)	0.0076	EFO_0005670

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000070366's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000070366	SMG6	100	58.135	ENSAPOG00000019448	smg6	74	54.914	Acanthochromis_polyacanthus
ENSG00000070366	SMG6	100	97.260	ENSAMEG00000007632	SMG6	100	92.882	Ailuropoda_melanoleuca
ENSG00000070366	SMG6	100	60.526	ENSACIG00000012997	smg6	78	55.413	Amphilophus_citrinellus
ENSG00000070366	SMG6	100	57.770	ENSAOCG00000002630	smg6	74	55.078	Amphiprion_ocellaris
ENSG00000070366	SMG6	100	57.770	ENSAPEG00000019101	smg6	74	55.234	Amphiprion_percula
ENSG00000070366	SMG6	100	58.684	ENSATEG00000006483	smg6	73	55.547	Anabas_testudineus
ENSG00000070366	SMG6	100	73.381	ENSACAG00000011783	SMG6	99	57.704	Anolis_carolinensis
ENSG00000070366	SMG6	100	98.780	ENSANAG00000035760	SMG6	100	95.278	Aotus_nancymaae
ENSG00000070366	SMG6	100	58.640	ENSACLG00000005288	smg6	80	55.113	Astatotilapia_calliptera
ENSG00000070366	SMG6	100	62.405	ENSAMXG00000017326	smg6	99	50.448	Astyanax_mexicanus
ENSG00000070366	SMG6	100	96.869	ENSBTAG00000000267	SMG6	100	92.248	Bos_taurus
ENSG00000070366	SMG6	100	98.551	ENSCJAG00000001820	SMG6	100	94.785	Callithrix_jacchus
ENSG00000070366	SMG6	100	97.065	ENSCAFG00000019260	SMG6	100	92.741	Canis_familiaris
ENSG00000070366	SMG6	100	97.065	ENSCAFG00020009770	SMG6	100	92.741	Canis_lupus_dingo
ENSG00000070366	SMG6	100	97.260	ENSCHIG00000021998	SMG6	100	92.178	Capra_hircus
ENSG00000070366	SMG6	100	97.456	ENSTSYG00000003406	SMG6	100	97.456	Carlito_syrichta
ENSG00000070366	SMG6	89	93.496	ENSCAPG00000016197	SMG6	99	82.904	Cavia_aperea
ENSG00000070366	SMG6	100	97.065	ENSCPOG00000014878	SMG6	97	93.421	Cavia_porcellus
ENSG00000070366	SMG6	100	98.551	ENSCCAG00000035801	SMG6	100	95.560	Cebus_capucinus
ENSG00000070366	SMG6	100	98.630	ENSCATG00000031956	SMG6	100	96.688	Cercocebus_atys
ENSG00000070366	SMG6	100	98.374	ENSCLAG00000006748	SMG6	100	91.896	Chinchilla_lanigera
ENSG00000070366	SMG6	100	99.413	ENSCSAG00000013800	SMG6	100	97.040	Chlorocebus_sabaeus
ENSG00000070366	SMG6	57	98.507	ENSCHOG00000005024	-	73	98.507	Choloepus_hoffmanni
ENSG00000070366	SMG6	100	82.192	ENSCPBG00000020369	SMG6	100	72.203	Chrysemys_picta_bellii
ENSG00000070366	SMG6	99	34.951	ENSCING00000010099	-	99	35.305	Ciona_intestinalis
ENSG00000070366	SMG6	54	37.456	ENSCSAVG00000007638	-	99	37.943	Ciona_savignyi
ENSG00000070366	SMG6	100	99.217	ENSCANG00000031764	SMG6	100	99.217	Colobus_angolensis_palliatus
ENSG00000070366	SMG6	55	86.189	ENSCGRG00001019595	Smg6	98	86.189	Cricetulus_griseus_chok1gshd
ENSG00000070366	SMG6	88	96.154	ENSCGRG00000007782	Smg6	100	84.222	Cricetulus_griseus_crigri
ENSG00000070366	SMG6	100	61.017	ENSCSEG00000012757	smg6	80	53.569	Cynoglossus_semilaevis
ENSG00000070366	SMG6	100	57.559	ENSCVAG00000012789	smg6	74	53.678	Cyprinodon_variegatus
ENSG00000070366	SMG6	100	61.654	ENSDARG00000100481	smg6	76	56.672	Danio_rerio
ENSG00000070366	SMG6	100	97.065	ENSDNOG00000048283	SMG6	100	91.966	Dasypus_novemcinctus
ENSG00000070366	SMG6	100	99.187	ENSDORG00000016614	Smg6	94	98.198	Dipodomys_ordii
ENSG00000070366	SMG6	100	96.377	ENSETEG00000016790	SMG6	93	100.000	Echinops_telfairi
ENSG00000070366	SMG6	99	55.307	ENSEBUG00000005059	smg6	66	49.806	Eptatretus_burgeri
ENSG00000070366	SMG6	100	98.374	ENSEASG00005009318	SMG6	99	93.366	Equus_asinus_asinus
ENSG00000070366	SMG6	100	97.561	ENSECAG00000006519	SMG6	99	93.084	Equus_caballus
ENSG00000070366	SMG6	91	96.842	ENSEEUG00000003493	SMG6	100	81.536	Erinaceus_europaeus
ENSG00000070366	SMG6	100	61.654	ENSELUG00000005934	smg6	67	56.201	Esox_lucius
ENSG00000070366	SMG6	100	99.187	ENSFCAG00000028817	SMG6	100	93.939	Felis_catus
ENSG00000070366	SMG6	100	83.366	ENSFALG00000006538	SMG6	100	71.744	Ficedula_albicollis
ENSG00000070366	SMG6	100	97.065	ENSFDAG00000015106	SMG6	100	91.543	Fukomys_damarensis
ENSG00000070366	SMG6	100	56.307	ENSFHEG00000013282	smg6	75	53.230	Fundulus_heteroclitus
ENSG00000070366	SMG6	100	52.852	ENSGMOG00000019077	smg6	68	69.626	Gadus_morhua
ENSG00000070366	SMG6	100	83.398	ENSGALG00000003108	SMG6	98	71.062	Gallus_gallus
ENSG00000070366	SMG6	100	57.299	ENSGAFG00000000379	smg6	74	53.792	Gambusia_affinis
ENSG00000070366	SMG6	100	59.659	ENSGACG00000020521	smg6	100	53.664	Gasterosteus_aculeatus
ENSG00000070366	SMG6	100	82.387	ENSGAGG00000025617	SMG6	100	71.855	Gopherus_agassizii
ENSG00000070366	SMG6	100	99.804	ENSGGOG00000017156	SMG6	100	98.238	Gorilla_gorilla
ENSG00000070366	SMG6	100	58.640	ENSHBUG00000021311	smg6	74	55.556	Haplochromis_burtoni
ENSG00000070366	SMG6	100	97.456	ENSHGLG00000012882	SMG6	100	91.274	Heterocephalus_glaber_female
ENSG00000070366	SMG6	100	97.456	ENSHGLG00100017815	SMG6	100	91.274	Heterocephalus_glaber_male
ENSG00000070366	SMG6	100	59.134	ENSHCOG00000008761	smg6	96	53.485	Hippocampus_comes
ENSG00000070366	SMG6	100	61.860	ENSIPUG00000012493	smg6	75	54.424	Ictalurus_punctatus
ENSG00000070366	SMG6	100	99.187	ENSSTOG00000028127	SMG6	100	93.446	Ictidomys_tridecemlineatus
ENSG00000070366	SMG6	100	96.748	ENSJJAG00000015367	Smg6	95	86.395	Jaculus_jaculus
ENSG00000070366	SMG6	100	59.273	ENSKMAG00000000279	smg6	76	53.858	Kryptolebias_marmoratus
ENSG00000070366	SMG6	100	56.569	ENSLBEG00000002184	smg6	74	54.060	Labrus_bergylta
ENSG00000070366	SMG6	55	57.753	ENSLACG00000000806	-	98	58.824	Latimeria_chalumnae
ENSG00000070366	SMG6	100	76.087	ENSLACG00000003276	SMG6	100	80.000	Latimeria_chalumnae
ENSG00000070366	SMG6	100	67.823	ENSLOCG00000006448	smg6	100	55.261	Lepisosteus_oculatus
ENSG00000070366	SMG6	100	97.260	ENSLAFG00000001261	SMG6	100	92.319	Loxodonta_africana
ENSG00000070366	SMG6	100	99.217	ENSMFAG00000003394	SMG6	100	97.040	Macaca_fascicularis
ENSG00000070366	SMG6	100	99.217	ENSMMUG00000023161	SMG6	100	96.970	Macaca_mulatta
ENSG00000070366	SMG6	100	99.217	ENSMNEG00000044592	SMG6	100	91.989	Macaca_nemestrina
ENSG00000070366	SMG6	100	99.217	ENSMLEG00000029353	SMG6	99	94.521	Mandrillus_leucophaeus
ENSG00000070366	SMG6	100	59.347	ENSMAMG00000020119	smg6	79	55.956	Mastacembelus_armatus
ENSG00000070366	SMG6	100	58.640	ENSMZEG00005024736	smg6	74	55.294	Maylandia_zebra
ENSG00000070366	SMG6	100	73.171	ENSMGAG00000005401	-	99	65.468	Meleagris_gallopavo
ENSG00000070366	SMG6	91	85.789	ENSMGAG00000017200	-	100	85.014	Meleagris_gallopavo
ENSG00000070366	SMG6	100	94.928	ENSMAUG00000017203	-	98	93.363	Mesocricetus_auratus
ENSG00000070366	SMG6	100	99.275	ENSMICG00000012913	SMG6	100	94.503	Microcebus_murinus
ENSG00000070366	SMG6	100	97.101	ENSMOCG00000019924	-	99	92.641	Microtus_ochrogaster
ENSG00000070366	SMG6	100	60.646	ENSMMOG00000010883	smg6	100	49.018	Mola_mola
ENSG00000070366	SMG6	100	49.587	ENSMODG00000024463	-	99	42.074	Monodelphis_domestica
ENSG00000070366	SMG6	100	50.413	ENSMODG00000024410	-	99	41.683	Monodelphis_domestica
ENSG00000070366	SMG6	100	51.240	ENSMODG00000024395	-	98	52.790	Monodelphis_domestica
ENSG00000070366	SMG6	100	95.108	ENSMODG00000010622	SMG6	100	85.513	Monodelphis_domestica
ENSG00000070366	SMG6	100	47.934	ENSMODG00000024460	-	99	41.879	Monodelphis_domestica
ENSG00000070366	SMG6	100	57.664	ENSMALG00000001106	smg6	73	55.400	Monopterus_albus
ENSG00000070366	SMG6	100	97.652	MGP_CAROLIEiJ_G0016729	Smg6	100	90.909	Mus_caroli
ENSG00000070366	SMG6	100	97.652	ENSMUSG00000038290	Smg6	100	90.839	Mus_musculus
ENSG00000070366	SMG6	100	97.456	MGP_PahariEiJ_G0017866	Smg6	100	90.416	Mus_pahari
ENSG00000070366	SMG6	100	97.652	MGP_SPRETEiJ_G0017572	Smg6	100	90.839	Mus_spretus
ENSG00000070366	SMG6	100	97.260	ENSMPUG00000013046	SMG6	100	92.953	Mustela_putorius_furo
ENSG00000070366	SMG6	100	97.652	ENSMLUG00000005739	SMG6	100	92.248	Myotis_lucifugus
ENSG00000070366	SMG6	100	96.748	ENSNGAG00000007287	Smg6	100	90.137	Nannospalax_galili
ENSG00000070366	SMG6	100	58.659	ENSNBRG00000009511	smg6	81	54.667	Neolamprologus_brichardi
ENSG00000070366	SMG6	100	99.804	ENSNLEG00000017171	SMG6	100	99.804	Nomascus_leucogenys
ENSG00000070366	SMG6	100	94.129	ENSMEUG00000015804	SMG6	100	81.681	Notamacropus_eugenii
ENSG00000070366	SMG6	100	95.161	ENSOPRG00000000579	SMG6	85	97.368	Ochotona_princeps
ENSG00000070366	SMG6	100	97.070	ENSODEG00000008038	SMG6	100	83.978	Octodon_degus
ENSG00000070366	SMG6	100	58.824	ENSONIG00000005594	smg6	100	51.667	Oreochromis_niloticus
ENSG00000070366	SMG6	78	76.074	ENSOANG00000030166	-	90	84.333	Ornithorhynchus_anatinus
ENSG00000070366	SMG6	100	97.842	ENSOCUG00000013018	SMG6	100	92.752	Oryctolagus_cuniculus
ENSG00000070366	SMG6	100	57.091	ENSORLG00000003317	smg6	75	54.312	Oryzias_latipes
ENSG00000070366	SMG6	100	57.221	ENSORLG00020015343	smg6	75	53.930	Oryzias_latipes_hni
ENSG00000070366	SMG6	100	56.727	ENSORLG00015020454	smg6	75	54.115	Oryzias_latipes_hsok
ENSG00000070366	SMG6	100	56.679	ENSOMEG00000010838	smg6	75	53.695	Oryzias_melastigma
ENSG00000070366	SMG6	100	100.000	ENSOGAG00000004483	SMG6	100	93.944	Otolemur_garnettii
ENSG00000070366	SMG6	100	97.065	ENSOARG00000015076	SMG6	100	92.058	Ovis_aries
ENSG00000070366	SMG6	100	100.000	ENSPPAG00000043296	SMG6	100	98.168	Pan_paniscus
ENSG00000070366	SMG6	100	99.187	ENSPPRG00000014581	SMG6	100	94.010	Panthera_pardus
ENSG00000070366	SMG6	100	99.187	ENSPTIG00000008925	SMG6	100	98.043	Panthera_tigris_altaica
ENSG00000070366	SMG6	100	100.000	ENSPTRG00000008544	SMG6	100	100.000	Pan_troglodytes
ENSG00000070366	SMG6	100	99.217	ENSPANG00000024588	SMG6	100	96.899	Papio_anubis
ENSG00000070366	SMG6	93	84.021	ENSPSIG00000006660	SMG6	96	70.367	Pelodiscus_sinensis
ENSG00000070366	SMG6	100	59.626	ENSPMGG00000000844	smg6	100	60.742	Periophthalmus_magnuspinnatus
ENSG00000070366	SMG6	100	97.847	ENSPEMG00000020707	Smg6	97	94.690	Peromyscus_maniculatus_bairdii
ENSG00000070366	SMG6	100	59.590	ENSPFOG00000012035	smg6	100	51.239	Poecilia_formosa
ENSG00000070366	SMG6	100	57.299	ENSPLAG00000017660	smg6	74	53.768	Poecilia_latipinna
ENSG00000070366	SMG6	100	57.143	ENSPMEG00000000258	smg6	74	54.082	Poecilia_mexicana
ENSG00000070366	SMG6	100	57.299	ENSPREG00000010066	smg6	74	53.997	Poecilia_reticulata
ENSG00000070366	SMG6	100	98.374	ENSPPYG00000007790	SMG6	100	92.194	Pongo_abelii
ENSG00000070366	SMG6	93	95.876	ENSPCAG00000000552	SMG6	100	87.808	Procavia_capensis
ENSG00000070366	SMG6	100	98.551	ENSPCOG00000020925	SMG6	100	94.292	Propithecus_coquereli
ENSG00000070366	SMG6	100	97.065	ENSPVAG00000002159	SMG6	86	100.000	Pteropus_vampyrus
ENSG00000070366	SMG6	100	61.494	ENSPNYG00000024151	smg6	79	57.328	Pundamilia_nyererei
ENSG00000070366	SMG6	100	62.709	ENSPNAG00000015480	smg6	74	62.877	Pygocentrus_nattereri
ENSG00000070366	SMG6	100	97.456	ENSRNOG00000003041	Smg6	100	91.332	Rattus_norvegicus
ENSG00000070366	SMG6	100	98.826	ENSRBIG00000024746	SMG6	100	96.899	Rhinopithecus_bieti
ENSG00000070366	SMG6	100	98.826	ENSRROG00000030423	SMG6	100	98.826	Rhinopithecus_roxellana
ENSG00000070366	SMG6	100	98.551	ENSSBOG00000022518	SMG6	100	93.517	Saimiri_boliviensis_boliviensis
ENSG00000070366	SMG6	100	94.129	ENSSHAG00000010045	SMG6	98	84.935	Sarcophilus_harrisii
ENSG00000070366	SMG6	92	46.457	ENSSHAG00000000380	-	99	39.802	Sarcophilus_harrisii
ENSG00000070366	SMG6	100	63.738	ENSSFOG00015005436	smg6	70	56.525	Scleropages_formosus
ENSG00000070366	SMG6	100	57.169	ENSSMAG00000019777	smg6	73	53.852	Scophthalmus_maximus
ENSG00000070366	SMG6	100	58.106	ENSSDUG00000016412	smg6	74	54.992	Seriola_dumerili
ENSG00000070366	SMG6	100	52.353	ENSSLDG00000020747	smg6	77	54.045	Seriola_lalandi_dorsalis
ENSG00000070366	SMG6	100	81.518	ENSSPUG00000007152	SMG6	99	69.547	Sphenodon_punctatus
ENSG00000070366	SMG6	100	58.059	ENSSPAG00000015633	smg6	91	49.104	Stegastes_partitus
ENSG00000070366	SMG6	100	96.869	ENSSSCG00000017826	SMG6	100	91.831	Sus_scrofa
ENSG00000070366	SMG6	100	84.149	ENSTGUG00000005836	SMG6	100	71.950	Taeniopygia_guttata
ENSG00000070366	SMG6	100	58.835	ENSTRUG00000000358	smg6	100	47.879	Takifugu_rubripes
ENSG00000070366	SMG6	100	60.037	ENSTNIG00000016164	smg6	100	50.529	Tetraodon_nigroviridis
ENSG00000070366	SMG6	94	96.410	ENSTBEG00000011424	SMG6	100	88.795	Tupaia_belangeri
ENSG00000070366	SMG6	100	94.512	ENSTTRG00000001175	SMG6	91	91.667	Tursiops_truncatus
ENSG00000070366	SMG6	100	96.887	ENSUAMG00000025152	SMG6	100	93.012	Ursus_americanus
ENSG00000070366	SMG6	100	97.456	ENSUMAG00000009306	SMG6	100	93.357	Ursus_maritimus
ENSG00000070366	SMG6	100	95.122	ENSVPAG00000000225	SMG6	88	92.593	Vicugna_pacos
ENSG00000070366	SMG6	100	97.065	ENSVVUG00000021727	SMG6	100	92.600	Vulpes_vulpes
ENSG00000070366	SMG6	100	69.291	ENSXETG00000023799	SMG6	100	59.280	Xenopus_tropicalis
ENSG00000070366	SMG6	100	60.571	ENSXCOG00000009867	smg6	74	55.175	Xiphophorus_couchianus
ENSG00000070366	SMG6	100	57.482	ENSXMAG00000010321	smg6	74	54.105	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	21873635.	IBA	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	18974281.19060897.20930030.	IMP	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	16488880.	TAS	Process
GO:0000781	chromosome, telomeric region	-	IEA	Component
GO:0003723	RNA binding	17940095.	IPI	Function
GO:0004521	endoribonuclease activity	21873635.	IBA	Function
GO:0004521	endoribonuclease activity	19060897.	IDA	Function
GO:0004521	endoribonuclease activity	18974281.	IMP	Function
GO:0004521	endoribonuclease activity	-	TAS	Function
GO:0005515	protein binding	12699629.20930030.21145460.	IPI	Function
GO:0005634	nucleus	14636577.	IDA	Component
GO:0005697	telomerase holoenzyme complex	21873635.	IBA	Component
GO:0005697	telomerase holoenzyme complex	12699629.	TAS	Component
GO:0005730	nucleolus	12676087.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	14636577.	IDA	Component
GO:0005829	cytosol	19060897.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006406	mRNA export from nucleus	16488880.	TAS	Process
GO:0007004	telomere maintenance via telomerase	21873635.	IBA	Process
GO:0032204	regulation of telomere maintenance	12699629.17916692.	IMP	Process
GO:0032210	regulation of telomere maintenance via telomerase	21873635.	IBA	Process
GO:0032210	regulation of telomere maintenance via telomerase	22011238.	IC	Process
GO:0032210	regulation of telomere maintenance via telomerase	16507993.	TAS	Process
GO:0035145	exon-exon junction complex	20930030.	IDA	Component
GO:0035303	regulation of dephosphorylation	15721257.	TAS	Process
GO:0042162	telomeric DNA binding	21873635.	IBA	Function
GO:0042162	telomeric DNA binding	12699629.17916692.	IDA	Function
GO:0043021	ribonucleoprotein complex binding	21873635.	IBA	Function
GO:0043021	ribonucleoprotein complex binding	12676087.17940095.	IPI	Function
GO:0043487	regulation of RNA stability	21873635.	IBA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051972	regulation of telomerase activity	22011238.	IC	Process
GO:0070034	telomerase RNA binding	21873635.	IBA	Function
GO:0070034	telomerase RNA binding	15857955.17940095.	IPI	Function
GO:0070182	DNA polymerase binding	17940095.22011238.	IPI	Function
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process
GO:1904354	negative regulation of telomere capping	12676087.	IDA	Process