EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000070950 (Gene tree)
Gene ID: 56852
Gene Symbol: RAD18
Alias: RNF73
Full Name: RAD18 E3 ubiquitin protein ligase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 188,372 bases
Position: chr3:8,775,402-8,963,773
Accession: 18278
RBP type: canonical RBP
Summary: The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000264926	SAP	PF02037.27	1.4e-11	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29590477	RNA-splicing factor SART3 regulates translesion DNA synthesis.	Nucleic Acids Res	2018 May 18	Huang M	doi: 10.1093/nar/gky220.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000418463	RAD18-204	563	-	ENSP00000397852	53 (aa)	-	F8WAZ7
ENST00000495087	RAD18-210	593	-	-	- (aa)	-	-
ENST00000413832	RAD18-202	581	-	ENSP00000412261	91 (aa)	-	C9J0Q4
ENST00000469793	RAD18-208	592	-	-	- (aa)	-	-
ENST00000427329	RAD18-206	557	-	ENSP00000412054	131 (aa)	-	H7C3I2
ENST00000421052	RAD18-205	582	-	ENSP00000399620	126 (aa)	-	F8WFA6
ENST00000415439	RAD18-203	1550	-	ENSP00000402049	310 (aa)	-	F8WE49
ENST00000473069	RAD18-209	556	-	-	- (aa)	-	-
ENST00000429790	RAD18-207	516	-	ENSP00000393783	79 (aa)	-	H7C0A5
ENST00000264926	RAD18-201	5886	XM_017006873	ENSP00000264926	495 (aa)	XP_016862362	Q9NS91

Gene Model

Click here to download ENSG00000070950's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000070950	rs17049612	3	8822123	?	3-hydroxy-1-methylpropylmercapturic acid levels in smokers	26053186	[NR] unit decrease	0.3986	EFO_0004318\|EFO_0007015
ENSG00000070950	rs45449196	3	8880774	?	Colonoscopy-negative controls vs population controls	29228715	[NR]	2.28	EFO_0008460
ENSG00000070950	rs187941554	3	8945549	A	Clopidogrel active metabolite levels	28207573	[NR] unit increase	25.16	EFO_0007966
ENSG00000070950	rs34003290	3	8887207	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000070950	rs149611468	3	8775737	?	Morning person	30595370			EFO_0008328
ENSG00000070950	rs62243445	3	8843644	?	Alanine aminotransferase levels in low alcohol consumption	30589442	[0.075-0.181] unit increase	0.1282	EFO_0004735\|EFO_0007878
ENSG00000070950	rs149611468	3	8775737	T	Chronotype	30696823		1.1539606	EFO_0008328
ENSG00000070950	rs149611468	3	8775737	T	Morning person	30696823		1.146	EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000070950's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000070950	RAD18	96	57.471	ENSAPOG00000005260	rad18	77	45.103	Acanthochromis_polyacanthus
ENSG00000070950	RAD18	100	94.505	ENSAMEG00000012375	RAD18	100	72.456	Ailuropoda_melanoleuca
ENSG00000070950	RAD18	96	41.441	ENSACIG00000020655	rad18	86	40.642	Amphilophus_citrinellus
ENSG00000070950	RAD18	96	62.069	ENSAOCG00000004507	rad18	79	45.876	Amphiprion_ocellaris
ENSG00000070950	RAD18	96	62.069	ENSAPEG00000016837	rad18	57	59.574	Amphiprion_percula
ENSG00000070950	RAD18	71	84.615	ENSAPLG00000003138	RAD18	100	49.076	Anas_platyrhynchos
ENSG00000070950	RAD18	100	97.802	ENSANAG00000033360	RAD18	100	93.939	Aotus_nancymaae
ENSG00000070950	RAD18	95	58.140	ENSACLG00000023506	rad18	82	43.603	Astatotilapia_calliptera
ENSG00000070950	RAD18	99	60.000	ENSAMXG00000002534	rad18	92	41.032	Astyanax_mexicanus
ENSG00000070950	RAD18	100	92.308	ENSBTAG00000012142	RAD18	100	81.710	Bos_taurus
ENSG00000070950	RAD18	100	95.604	ENSCJAG00000040303	RAD18	100	92.323	Callithrix_jacchus
ENSG00000070950	RAD18	100	96.703	ENSCAFG00000005548	RAD18	100	82.540	Canis_familiaris
ENSG00000070950	RAD18	100	96.703	ENSCAFG00020009228	RAD18	100	82.540	Canis_lupus_dingo
ENSG00000070950	RAD18	99	93.333	ENSCHIG00000007965	RAD18	100	81.710	Capra_hircus
ENSG00000070950	RAD18	100	86.813	ENSTSYG00000012189	RAD18	100	83.300	Carlito_syrichta
ENSG00000070950	RAD18	89	76.173	ENSCAPG00000000356	RAD18	100	69.336	Cavia_aperea
ENSG00000070950	RAD18	100	90.110	ENSCPOG00000013890	RAD18	100	77.309	Cavia_porcellus
ENSG00000070950	RAD18	100	97.802	ENSCCAG00000022920	RAD18	100	92.929	Cebus_capucinus
ENSG00000070950	RAD18	100	97.802	ENSCATG00000039277	RAD18	100	95.766	Cercocebus_atys
ENSG00000070950	RAD18	100	90.110	ENSCLAG00000003652	RAD18	100	79.760	Chinchilla_lanigera
ENSG00000070950	RAD18	100	97.802	ENSCSAG00000010783	RAD18	100	94.059	Chlorocebus_sabaeus
ENSG00000070950	RAD18	98	79.775	ENSCPBG00000014787	RAD18	100	50.622	Chrysemys_picta_bellii
ENSG00000070950	RAD18	100	96.703	ENSCANG00000007308	RAD18	100	95.565	Colobus_angolensis_palliatus
ENSG00000070950	RAD18	98	84.783	ENSCGRG00001010209	-	100	73.956	Cricetulus_griseus_chok1gshd
ENSG00000070950	RAD18	98	89.888	ENSCGRG00001018154	-	100	76.342	Cricetulus_griseus_chok1gshd
ENSG00000070950	RAD18	98	89.888	ENSCGRG00000007283	-	100	76.342	Cricetulus_griseus_crigri
ENSG00000070950	RAD18	98	84.783	ENSCGRG00000019636	-	100	74.155	Cricetulus_griseus_crigri
ENSG00000070950	RAD18	100	59.341	ENSCSEG00000002516	rad18	88	43.672	Cynoglossus_semilaevis
ENSG00000070950	RAD18	98	59.551	ENSDARG00000027938	rad18	82	46.133	Danio_rerio
ENSG00000070950	RAD18	100	93.407	ENSDNOG00000040055	RAD18	100	80.677	Dasypus_novemcinctus
ENSG00000070950	RAD18	99	88.889	ENSDORG00000001099	Rad18	100	75.794	Dipodomys_ordii
ENSG00000070950	RAD18	97	64.238	ENSETEG00000002268	RAD18	97	67.599	Echinops_telfairi
ENSG00000070950	RAD18	100	97.802	ENSEASG00005013316	RAD18	94	85.857	Equus_asinus_asinus
ENSG00000070950	RAD18	100	97.802	ENSECAG00000010746	RAD18	94	85.857	Equus_caballus
ENSG00000070950	RAD18	98	91.011	ENSEEUG00000000236	-	97	57.209	Erinaceus_europaeus
ENSG00000070950	RAD18	89	58.025	ENSELUG00000000733	rad18	77	43.421	Esox_lucius
ENSG00000070950	RAD18	100	92.308	ENSFCAG00000025747	RAD18	100	82.470	Felis_catus
ENSG00000070950	RAD18	98	68.539	ENSFALG00000013625	RAD18	88	52.010	Ficedula_albicollis
ENSG00000070950	RAD18	100	87.912	ENSFDAG00000009907	RAD18	100	77.535	Fukomys_damarensis
ENSG00000070950	RAD18	98	74.157	ENSGALG00000008368	RAD18	78	55.980	Gallus_gallus
ENSG00000070950	RAD18	95	54.651	ENSGACG00000000920	rad18	86	43.814	Gasterosteus_aculeatus
ENSG00000070950	RAD18	62	89.286	ENSGAGG00000005184	RAD18	100	51.546	Gopherus_agassizii
ENSG00000070950	RAD18	100	100.000	ENSGGOG00000008391	RAD18	100	98.384	Gorilla_gorilla
ENSG00000070950	RAD18	83	44.867	ENSHBUG00000013322	rad18	81	46.082	Haplochromis_burtoni
ENSG00000070950	RAD18	100	91.209	ENSHGLG00000009196	-	100	83.226	Heterocephalus_glaber_female
ENSG00000070950	RAD18	100	91.209	ENSHGLG00100017675	-	100	83.226	Heterocephalus_glaber_male
ENSG00000070950	RAD18	100	53.846	ENSIPUG00000018681	rad18	83	42.520	Ictalurus_punctatus
ENSG00000070950	RAD18	100	95.604	ENSSTOG00000004870	-	100	83.548	Ictidomys_tridecemlineatus
ENSG00000070950	RAD18	99	91.111	ENSJJAG00000001484	Rad18	100	73.737	Jaculus_jaculus
ENSG00000070950	RAD18	95	59.302	ENSKMAG00000020725	rad18	75	44.010	Kryptolebias_marmoratus
ENSG00000070950	RAD18	85	73.750	ENSLACG00000018437	RAD18	96	53.247	Latimeria_chalumnae
ENSG00000070950	RAD18	98	57.303	ENSLOCG00000010629	rad18	83	50.133	Lepisosteus_oculatus
ENSG00000070950	RAD18	87	89.873	ENSLAFG00000004667	RAD18	95	72.786	Loxodonta_africana
ENSG00000070950	RAD18	100	97.802	ENSMFAG00000028864	RAD18	100	95.565	Macaca_fascicularis
ENSG00000070950	RAD18	100	97.802	ENSMMUG00000020013	RAD18	100	96.129	Macaca_mulatta
ENSG00000070950	RAD18	100	97.802	ENSMNEG00000013464	RAD18	100	95.766	Macaca_nemestrina
ENSG00000070950	RAD18	100	97.802	ENSMLEG00000014306	RAD18	100	95.565	Mandrillus_leucophaeus
ENSG00000070950	RAD18	85	41.639	ENSMAMG00000023936	rad18	76	44.475	Mastacembelus_armatus
ENSG00000070950	RAD18	95	58.140	ENSMZEG00005010577	rad18	70	43.342	Maylandia_zebra
ENSG00000070950	RAD18	73	81.818	ENSMGAG00000010131	RAD18	76	56.676	Meleagris_gallopavo
ENSG00000070950	RAD18	98	89.888	ENSMAUG00000020642	Rad18	100	70.707	Mesocricetus_auratus
ENSG00000070950	RAD18	98	83.231	ENSMICG00000013536	RAD18	99	83.231	Microcebus_murinus
ENSG00000070950	RAD18	98	88.764	ENSMOCG00000009114	Rad18	100	69.091	Microtus_ochrogaster
ENSG00000070950	RAD18	95	55.814	ENSMMOG00000021793	rad18	98	41.470	Mola_mola
ENSG00000070950	RAD18	100	83.516	ENSMODG00000004679	RAD18	94	59.919	Monodelphis_domestica
ENSG00000070950	RAD18	98	91.011	MGP_CAROLIEiJ_G0028712	Rad18	100	75.556	Mus_caroli
ENSG00000070950	RAD18	100	90.110	ENSMUSG00000030254	Rad18	100	77.346	Mus_musculus
ENSG00000070950	RAD18	98	91.011	MGP_PahariEiJ_G0022463	Rad18	100	77.023	Mus_pahari
ENSG00000070950	RAD18	100	90.110	MGP_SPRETEiJ_G0029740	Rad18	100	77.670	Mus_spretus
ENSG00000070950	RAD18	100	96.703	ENSMPUG00000017063	RAD18	100	82.669	Mustela_putorius_furo
ENSG00000070950	RAD18	100	93.407	ENSMLUG00000016494	RAD18	100	79.412	Myotis_lucifugus
ENSG00000070950	RAD18	98	88.764	ENSNGAG00000012464	Rad18	100	72.929	Nannospalax_galili
ENSG00000070950	RAD18	100	98.901	ENSNLEG00000003789	RAD18	100	97.576	Nomascus_leucogenys
ENSG00000070950	RAD18	81	66.142	ENSMEUG00000003444	-	82	54.094	Notamacropus_eugenii
ENSG00000070950	RAD18	99	88.889	ENSOPRG00000013856	RAD18	100	73.589	Ochotona_princeps
ENSG00000070950	RAD18	100	92.308	ENSODEG00000018158	RAD18	97	83.838	Octodon_degus
ENSG00000070950	RAD18	95	58.140	ENSONIG00000018979	rad18	81	45.879	Oreochromis_niloticus
ENSG00000070950	RAD18	100	93.407	ENSOCUG00000000013	RAD18	100	77.888	Oryctolagus_cuniculus
ENSG00000070950	RAD18	90	53.659	ENSORLG00000029026	rad18	95	39.024	Oryzias_latipes
ENSG00000070950	RAD18	99	96.667	ENSOGAG00000001410	RAD18	100	84.770	Otolemur_garnettii
ENSG00000070950	RAD18	99	93.333	ENSOARG00000007445	RAD18	100	81.065	Ovis_aries
ENSG00000070950	RAD18	100	98.990	ENSPPAG00000035797	RAD18	100	98.990	Pan_paniscus
ENSG00000070950	RAD18	100	92.308	ENSPPRG00000004021	RAD18	100	81.673	Panthera_pardus
ENSG00000070950	RAD18	100	92.308	ENSPTIG00000008602	RAD18	100	81.873	Panthera_tigris_altaica
ENSG00000070950	RAD18	100	98.901	ENSPTRG00000014583	RAD18	100	98.384	Pan_troglodytes
ENSG00000070950	RAD18	100	97.802	ENSPANG00000008855	RAD18	100	95.766	Papio_anubis
ENSG00000070950	RAD18	98	79.775	ENSPSIG00000006928	RAD18	99	51.731	Pelodiscus_sinensis
ENSG00000070950	RAD18	95	55.814	ENSPMGG00000013294	rad18	99	40.584	Periophthalmus_magnuspinnatus
ENSG00000070950	RAD18	98	89.888	ENSPEMG00000022129	Rad18	100	69.600	Peromyscus_maniculatus_bairdii
ENSG00000070950	RAD18	95	84.884	ENSPCIG00000024872	RAD18	93	61.521	Phascolarctos_cinereus
ENSG00000070950	RAD18	95	55.814	ENSPFOG00000002722	rad18	96	43.011	Poecilia_formosa
ENSG00000070950	RAD18	100	98.901	ENSPPYG00000013688	RAD18	100	98.182	Pongo_abelii
ENSG00000070950	RAD18	100	80.220	ENSPCAG00000008229	RAD18	100	65.368	Procavia_capensis
ENSG00000070950	RAD18	100	92.308	ENSPVAG00000012220	RAD18	100	84.848	Pteropus_vampyrus
ENSG00000070950	RAD18	95	58.140	ENSPNYG00000006815	rad18	76	43.377	Pundamilia_nyererei
ENSG00000070950	RAD18	95	60.465	ENSPNAG00000016082	rad18	82	43.236	Pygocentrus_nattereri
ENSG00000070950	RAD18	98	88.764	ENSRNOG00000005907	Rad18	100	75.800	Rattus_norvegicus
ENSG00000070950	RAD18	100	95.000	ENSRBIG00000044173	RAD18	100	93.964	Rhinopithecus_bieti
ENSG00000070950	RAD18	100	96.703	ENSRROG00000043948	RAD18	100	96.169	Rhinopithecus_roxellana
ENSG00000070950	RAD18	100	97.802	ENSSBOG00000008434	-	100	93.333	Saimiri_boliviensis_boliviensis
ENSG00000070950	RAD18	91	81.928	ENSSHAG00000012472	-	95	59.635	Sarcophilus_harrisii
ENSG00000070950	RAD18	99	60.000	ENSSFOG00015019264	rad18	76	46.791	Scleropages_formosus
ENSG00000070950	RAD18	96	82.759	ENSSPUG00000017486	RAD18	97	61.616	Sphenodon_punctatus
ENSG00000070950	RAD18	95	61.628	ENSSPAG00000007165	rad18	77	45.501	Stegastes_partitus
ENSG00000070950	RAD18	100	93.407	ENSSSCG00000026158	RAD18	100	82.704	Sus_scrofa
ENSG00000070950	RAD18	80	80.822	ENSTGUG00000010405	RAD18	86	53.627	Taeniopygia_guttata
ENSG00000070950	RAD18	90	54.878	ENSTRUG00000003517	rad18	97	44.318	Takifugu_rubripes
ENSG00000070950	RAD18	95	55.814	ENSTNIG00000014625	rad18	99	48.023	Tetraodon_nigroviridis
ENSG00000070950	RAD18	100	95.604	ENSTTRG00000005034	RAD18	100	85.657	Tursiops_truncatus
ENSG00000070950	RAD18	90	67.143	ENSUAMG00000009763	-	84	66.431	Ursus_americanus
ENSG00000070950	RAD18	100	94.505	ENSUMAG00000019279	RAD18	100	83.267	Ursus_maritimus
ENSG00000070950	RAD18	100	94.505	ENSVPAG00000002063	RAD18	100	77.489	Vicugna_pacos
ENSG00000070950	RAD18	100	96.703	ENSVVUG00000025318	RAD18	100	82.143	Vulpes_vulpes
ENSG00000070950	RAD18	98	70.330	ENSXETG00000033878	RAD18	99	53.723	Xenopus_tropicalis
ENSG00000070950	RAD18	95	41.860	ENSXCOG00000020018	rad18	94	39.084	Xiphophorus_couchianus
ENSG00000070950	RAD18	95	43.023	ENSXMAG00000001516	rad18	94	40.162	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000403	Y-form DNA binding	18363965.	IDA	Function
GO:0003684	damaged DNA binding	10884424.	NAS	Function
GO:0003697	single-stranded DNA binding	-	IEA	Function
GO:0005515	protein binding	18316726.18719106.19549727.21422291.21659603.22036607.22681887.25416956.25931565.26496610.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	15632077.22036607.25023518.	IDA	Component
GO:0005634	nucleus	10884424.	NAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005657	replication fork	18363965.	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0005813	centrosome	15632077.	IDA	Component
GO:0006281	DNA repair	10884424.	NAS	Process
GO:0006301	postreplication repair	21873635.	IBA	Process
GO:0006513	protein monoubiquitination	21873635.	IBA	Process
GO:0006974	cellular response to DNA damage stimulus	22036607.25023518.25931565.	IDA	Process
GO:0009411	response to UV	21873635.	IBA	Process
GO:0016567	protein ubiquitination	-	TAS	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0031593	polyubiquitin modification-dependent protein binding	22742833.	IDA	Function
GO:0031625	ubiquitin protein ligase binding	10908344.18363965.	IPI	Function
GO:0035861	site of double-strand break	25931565.	IDA	Component
GO:0042405	nuclear inclusion body	22036607.	IDA	Component
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	Process
GO:0042802	identical protein binding	25023518.	IDA	Function
GO:0043142	single-stranded DNA-dependent ATPase activity	21873635.	IBA	Function
GO:0044877	protein-containing complex binding	25931565.	IPI	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0051865	protein autoubiquitination	25023518.	IDA	Process
GO:0051984	positive regulation of chromosome segregation	25931565.	IMP	Process
GO:0060548	negative regulation of cell death	22036607.	IDA	Process
GO:0061630	ubiquitin protein ligase activity	21873635.	IBA	Function
GO:0097505	Rad6-Rad18 complex	21873635.	IBA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19630985	Mutation analysis of Rad18 in human cancer cell lines and non small cell lung cancer tissues.	J Exp Clin Cancer Res	2009 Jul 25	Nakamura T	doi: 10.1186/1756-9966-28-106.
17914568	Single nucleotide polymorphism in the RAD18 gene and risk of colorectal cancer in the Japanese population.	Oncol Rep	2007 Nov	Kanzaki H	-
17624554	The association between RAD18 Arg302Gln polymorphism and the risk of human non-small-cell lung cancer.	J Cancer Res Clin Oncol	2008 Feb	Kanzaki H	-
27377895	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.	Nat Commun	2016 Jul 5	Gao Y	doi: 10.1038/ncomms12105.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr3	8941741	Missense_Mutation	novel	K110N	0.41
BLCA	chr3	8947280	Missense_Mutation	NA	E69G	0.39
BRCA	chr3	8939605	Missense_Mutation	novel	K218T	0.07
BRCA	chr3	8881452	Missense_Mutation	NA	L465I	0.3
BRCA	chr3	8881354	3'UTR	novel		0.15
BRCA	chr3	8947275	Missense_Mutation	novel	D71N	0.1
BRCA	chr3	8913706	Nonsense_Mutation	rs536501018	R302*	0.35
BRCA	chr3	8902436	Frame_Shift_Ins	rs766463274	*T371Nfs9**	0.2
CESC	chr3	8941760	Missense_Mutation	novel	P104H	0.08
CESC	chr3	8881418	Missense_Mutation	rs140344625	R476H	0.47
COAD	chr3	8963381	Missense_Mutation	novel	D2V	0.28
COAD	chr3	8935922	Nonsense_Mutation	NA	E280*	0.23	SAP
COAD	chr3	8958921	Missense_Mutation	novel	N44K	0.26
COAD	chr3	8913641	Splice_Region	novel		0.4
COAD	chr3	8935952	Missense_Mutation	NA	N270H	0.29	SAP
COAD	chr3	8947221	Missense_Mutation	rs769975828	R89W	0.42
COAD	chr3	8902422	Missense_Mutation	NA	K376E	0.18
COAD	chr3	8902436	Frame_Shift_Ins	rs766463274	*T371Nfs9**	0.08
COAD	chr3	8890451	Splice_Region	NA	S441S	0.27
COAD	chr3	8881415	Missense_Mutation	rs149913355	R477H	0.23
COAD	chr3	8941759	In_Frame_Del	rs766404991	P104del	0.33
COAD	chr3	8941667	Missense_Mutation	novel	N135T	0.09
COAD	chr3	8939579	Missense_Mutation	rs781347031	E227K	0.27
COAD	chr3	8941536	Missense_Mutation	rs767423682	A179T	0.32
COAD	chr3	8939576	In_Frame_Ins	novel	E227_E228insQ	0.01
COAD	chr3	8963398	5'UTR	novel		0.28
HNSC	chr3	8913673	Missense_Mutation	rs369225742	R313C	0.15
HNSC	chr3	8948566	Silent	novel	C46C	0.11
HNSC	chr3	8941788	Nonsense_Mutation	novel	*F95Gfs2**	0.08
HNSC	chr3	8902409	Missense_Mutation	novel	S380C	0.53
HNSC	chr3	8898976	Nonsense_Mutation	novel	E414*	0.22
HNSC	chr3	8902505	Missense_Mutation	novel	S348I	0.27
KIRP	chr3	8913721	Splice_Site	novel	X297_splice	0.71
LIHC	chr3	8947282	Silent	novel	T68T	0.24
LUAD	chr3	8941640	Missense_Mutation	rs141788084	S144F	0.07
LUAD	chr3	8936005	Missense_Mutation	NA	S252C	0.07	SAP
LUAD	chr3	8898987	Missense_Mutation	novel	P410L	0.59
LUAD	chr3	8935892	Missense_Mutation	NA	D290H	0.18
LUSC	chr3	8899042	Frame_Shift_Del	novel	*E392Kfs4**	0.14
LUSC	chr3	8898994	Frame_Shift_Del	novel	*D408Tfs40**	0.18
LUSC	chr3	8941804	Splice_Region	novel	R89R	0.19
LUSC	chr3	8890443	Missense_Mutation	NA	S444L	0.3
LUSC	chr3	8881404	Missense_Mutation	novel	A481S	0.17
LUSC	chr3	8898909	Nonsense_Mutation	NA	S436*	0.07
LUSC	chr3	8963396	5'UTR	novel		0.11
MESO	chr3	8898937	Missense_Mutation	novel	I427V	0.36
OV	chr3	8936034	Nonsense_Mutation	novel	*L243Ifs7**	0.07
OV	chr3	8963341	Silent	NA	V15V	0.22
OV	chr3	8881379	Missense_Mutation	NA	R489T	0.21
PRAD	chr3	8958952	Missense_Mutation	rs775252068	I34T	0.13
PRAD	chr3	8902470	Missense_Mutation	rs773995781	G360R	0.08
PRAD	chr3	8939579	Missense_Mutation	rs781347031	E227K	0.13
PRAD	chr3	8947259	Missense_Mutation	rs377707311	R76H	0.37
READ	chr3	8947265	Missense_Mutation	novel	N74T	0.11
READ	chr3	8941741	Missense_Mutation	novel	K110N	0.38
SARC	chr3	8939558	Missense_Mutation	NA	R234G	0.32
SARC	chr3	8941475	Missense_Mutation	novel	V199A	0.22
SKCM	chr3	8941550	Missense_Mutation	novel	S174F	0.4
SKCM	chr3	8935963	Missense_Mutation	NA	S266F	0.61	SAP
SKCM	chr3	8936000	Missense_Mutation	NA	R254C	0.26	SAP
SKCM	chr3	8935955	Missense_Mutation	novel	G269R	0.31	SAP
SKCM	chr3	8941772	Missense_Mutation	NA	P100L	0.73
SKCM	chr3	8898903	Missense_Mutation	novel	S438L	0.41
SKCM	chr3	8936000	Missense_Mutation	NA	R254C	0.56	SAP
SKCM	chr3	8941665	Missense_Mutation	NA	F136I	0.15
SKCM	chr3	8899043	Silent	NA	Q391Q	0.53
STAD	chr3	8958946	Missense_Mutation	NA	M36T	0.04
STAD	chr3	8902445	Missense_Mutation	NA	S368L	0.2
STAD	chr3	8902437	Frame_Shift_Del	novel	*T371Qfs2**	0.38
STAD	chr3	8941617	Nonsense_Mutation	NA	E152*	0.36
STAD	chr3	8948549	Missense_Mutation	NA	K52T	0.36
STAD	chr3	8902437	Frame_Shift_Del	novel	*T371Qfs2**	0.32
STAD	chr3	8941723	Silent	novel	V116V	0.33
STAD	chr3	8958981	Silent	novel	R24R	0.13
STAD	chr3	8890443	Missense_Mutation	NA	S444L	0.67
STAD	chr3	8935907	Missense_Mutation	NA	Y285H	0.07
UCEC	chr3	8898931	Nonsense_Mutation	NA	E429*	0.32
UCEC	chr3	8880942	3'UTR	novel		0.43
UCEC	chr3	8881269	3'UTR	novel		0.09
UCEC	chr3	8902412	In_Frame_Del	NA	D378del	0.2
UCEC	chr3	8890431	Missense_Mutation	novel	R448I	0.4
UCEC	chr3	8913703	Nonsense_Mutation	novel	E303*	0.28
UCEC	chr3	8898982	Missense_Mutation	NA	E412K	0.23
UCEC	chr3	8890451	Splice_Region	NA	S441S	0.13
UCEC	chr3	8902474	In_Frame_Ins	novel	R358delinsSQHGETLSLL	0.08
UCEC	chr3	8912354	Frame_Shift_Ins	novel	*D329Ifs11**	0.05
UCEC	chr3	8898954	Missense_Mutation	novel	S421Y	0.29
UCEC	chr3	8935989	Missense_Mutation	novel	K257N	0.16	SAP
UCEC	chr3	8941653	Missense_Mutation	novel	E140K	0.41
UCEC	chr3	8881415	Missense_Mutation	rs149913355	R477H	0.3
UCEC	chr3	8881457	Missense_Mutation	novel	N463T	0.32
UCEC	chr3	8881313	3'UTR	rs372609640		0.18
UCEC	chr3	8881116	3'UTR	novel		0.47
UCEC	chr3	8941536	Missense_Mutation	rs767423682	A179T	0.09
UCEC	chr3	8941560	Nonsense_Mutation	novel	E171*	0.41
UCEC	chr3	8881255	3'UTR	novel		0.4
UCEC	chr3	8912317	Missense_Mutation	novel	K341T	0.47
UCEC	chr3	8935922	Nonsense_Mutation	NA	E280*	0.21	SAP
UCEC	chr3	8912311	Splice_Site	rs368820398	X343_splice	0.38
UCEC	chr3	8881240	3'UTR	rs45438900		0.31
UCEC	chr3	8881354	3'UTR	novel		0.39
UCEC	chr3	8890429	Missense_Mutation	novel	D449Y	0.3
UCEC	chr3	8941582	Silent	novel	A163A	0.5
UCEC	chr3	8912360	Frame_Shift_Ins	rs34098429	*T327Yfs11**	0.39
UCEC	chr3	8881415	Missense_Mutation	rs149913355	R477H	0.26
UCEC	chr3	8881370	Missense_Mutation	rs150411306	R492H	0.37
UCEC	chr3	8913672	Missense_Mutation	rs150523552	R313H	0.35
UCEC	chr3	8939654	Splice_Site	novel	X202_splice	0.23
UCEC	chr3	8941587	Nonsense_Mutation	NA	E162*	0.42
UCEC	chr3	8941606	Missense_Mutation	novel	S155R	0.09
UCEC	chr3	8948550	Missense_Mutation	NA	K52Q	0.34
UCEC	chr3	8958983	Missense_Mutation	novel	R24W	0.38
UCEC	chr3	8941558	Silent	novel	E171E	0.35
UCS	chr3	8939579	Missense_Mutation	rs781347031	E227K	0.23

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.75	0.02241
COAD	DEL	0.133	0.010931
KIRC	DEL	0.8428	2.8873e-53
LUAD	DEL	0.3062	0.068154
SKCM	DEL	0.158	0.13887
TGCT	DEL	0.2133	0.08422
THYM	DEL	0.0976	0.037527

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0016	Kaplan-Meier Survival Analysis
KIRC	0.018	Kaplan-Meier Survival Analysis
STAD	0.017	Kaplan-Meier Survival Analysis
SARC	0.0011	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.019	Kaplan-Meier Survival Analysis
PRAD	0.015	Kaplan-Meier Survival Analysis
KIRP	0.03	Kaplan-Meier Survival Analysis
PAAD	0.026	Kaplan-Meier Survival Analysis
PCPG	0.024	Kaplan-Meier Survival Analysis
READ	0.0051	Kaplan-Meier Survival Analysis
KICH	0.0015	Kaplan-Meier Survival Analysis
UCEC	0.0035	Kaplan-Meier Survival Analysis
LIHC	0.00026	Kaplan-Meier Survival Analysis
UVM	0.01	Kaplan-Meier Survival Analysis