EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000071127 (Gene tree)
Gene ID: 9948
Gene Symbol: WDR1
Alias: N
Full Name: WD repeat domain 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 42,611 bases
Position: chr4:10,074,339-10,116,949
Accession: 12754
RBP type: non-canonical RBP
Summary: This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20631256	The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation.	Mol Biol Cell	2010 Sep 1	Doukhanine E	doi: 10.1091/mbc.E10-04-0305
29328377	Feature genes in metastatic breast cancer identified by MetaDE and SVM classifier methods.	Mol Med Rep	2018 Mar	Tuo Y	doi: 10.3892/mmr.2018.8398

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000382452	WDR1-203	3142	-	ENSP00000371890	606 (aa)	-	O75083
ENST00000499869	WDR1-204	3054	XM_017008880	ENSP00000427687	606 (aa)	XP_016864369	O75083
ENST00000509695	WDR1-214	467	-	-	- (aa)	-	-
ENST00000514319	WDR1-216	719	-	-	- (aa)	-	-
ENST00000509600	WDR1-213	559	-	-	- (aa)	-	-
ENST00000502962	WDR1-206	1411	-	-	- (aa)	-	-
ENST00000505543	WDR1-208	687	-	-	- (aa)	-	-
ENST00000502702	WDR1-205	1691	-	ENSP00000426725	466 (aa)	-	O75083
ENST00000382451	WDR1-202	2722	-	ENSP00000371889	466 (aa)	-	O75083
ENST00000506246	WDR1-210	572	-	-	- (aa)	-	-
ENST00000264785	WDR1-201	549	-	-	- (aa)	-	-
ENST00000515743	WDR1-218	4482	-	-	- (aa)	-	-
ENST00000510848	WDR1-215	554	-	-	- (aa)	-	-
ENST00000508949	WDR1-212	552	-	-	- (aa)	-	-
ENST00000515018	WDR1-217	274	-	-	- (aa)	-	-
ENST00000508079	WDR1-211	812	-	ENSP00000425481	245 (aa)	-	D6RD66
ENST00000505851	WDR1-209	715	-	-	- (aa)	-	-
ENST00000504739	WDR1-207	555	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000071127's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000071127	Uric Acid	6.606e-005	-
ENSG00000071127	Uric Acid	6.708e-006	-
ENSG00000071127	Uric Acid	6.708e-006	-
ENSG00000071127	Uric Acid	4.512e-005	-
ENSG00000071127	Uric Acid	6.708e-006	-
ENSG00000071127	Uric Acid	1.045e-005	-
ENSG00000071127	Uric Acid	8.681e-006	-
ENSG00000071127	Uric Acid	5.666e-006	-
ENSG00000071127	Coronary Artery Disease	9.4310000E-005	-
ENSG00000071127	Neuroticism	9E-6	27089181

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000071127	rs2278121	4	10094510	A	Neuroticism	27089181	[0.0086-0.0221] unit increase	0.015303924	EFO_0007660
ENSG00000071127	rs3796822	4	10092027	A	Pulse pressure	30224653	[0.092-0.166] unit increase	0.1293	EFO_0005763
ENSG00000071127	rs3822241	4	10093307	A	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0045-0.0088] unit increase	0.00666617	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000071127's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000071127	WDR1	100	95.215	ENSMUSG00000005103	Wdr1	100	95.215	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002102	podosome	-	IEA	Component
GO:0002446	neutrophil mediated immunity	-	IEA	Process
GO:0002576	platelet degranulation	-	TAS	Process
GO:0005576	extracellular region	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005911	cell-cell junction	25792565.	IDA	Component
GO:0007605	sensory perception of sound	10036186.	TAS	Process
GO:0008360	regulation of cell shape	-	IEA	Process
GO:0030042	actin filament depolymerization	21873635.	IBA	Process
GO:0030043	actin filament fragmentation	-	IEA	Process
GO:0030054	cell junction	-	IDA	Component
GO:0030220	platelet formation	-	IEA	Process
GO:0030834	regulation of actin filament depolymerization	15629458.	IDA	Process
GO:0030836	positive regulation of actin filament depolymerization	21873635.	IBA	Process
GO:0030864	cortical actin cytoskeleton	21873635.	IBA	Component
GO:0030865	cortical cytoskeleton organization	-	IEA	Process
GO:0040011	locomotion	21873635.	IBA	Process
GO:0042247	establishment of planar polarity of follicular epithelium	-	IEA	Process
GO:0042643	actomyosin, actin portion	21873635.	IBA	Component
GO:0042995	cell projection	-	IEA	Component
GO:0043297	apical junction assembly	25792565.	IDA	Process
GO:0045199	maintenance of epithelial cell apical/basal polarity	25792565.	IDA	Process
GO:0045214	sarcomere organization	21873635.	IBA	Process
GO:0048713	regulation of oligodendrocyte differentiation	-	IEA	Process
GO:0051015	actin filament binding	21873635.	IBA	Function
GO:0051015	actin filament binding	-	ISS	Function
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	-	IEA	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:1990266	neutrophil migration	-	IEA	Process