EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000071894 (Gene tree)
Gene ID: 29894
Gene Symbol: CPSF1
Alias: CPSF160
Full Name: cleavage and polyadenylation specific factor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 16,172 bases
Position: chr8:144,393,229-144,409,400
Accession: 2324
RBP type: canonical RBP
Summary: Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000478145	CPSF_A	PF03178.15	2.7e-91	1	1
ENSP00000484669	CPSF_A	PF03178.15	2.7e-91	1	1
ENSP00000478161	CPSF_A	PF03178.15	6.2e-39	1	2
ENSP00000478161	CPSF_A	PF03178.15	6.2e-39	2	2
ENSP00000483775	CPSF_A	PF03178.15	2.1e-33	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31267064	Alternative cleavage and polyadenylation in health and disease.	Nat Rev Genet	2019 Jul 2	Gruber AJ	doi: 10.1038/s41576-019-0145-z
9224719	The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins.	Genes Dev	1997 Jul 1	Barabino SM	-
19573236	Distinctive interactions of the Arabidopsis homolog of the 30 kD subunit of the cleavage and polyadenylation specificity factor (AtCPSF30) with other polyadenylation factor subunits.	BMC Cell Biol	2009 Jul 2	Rao S	doi: 10.1186/1471-2121-10-51.
25546057	Integration of developmental and environmental signals via a polyadenylation factor in Arabidopsis.	PLoS One	2014 Dec 29	Liu M	doi: 10.1371/journal.pone.0115779
27071088	Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe-2S cluster.	Proc Natl Acad Sci U S A	2016 Apr 26	Shimberg GD	doi: 10.1073/pnas.1517620113
29746237	Iron-Sulfur Clusters in Zinc Finger Proteins.	Methods Enzymol	2018	Shimberg GD	doi: 10.1016/bs.mie.2017.09.005
7852352	Poly(A) tail length control is caused by termination of processive synthesis.	J Biol Chem	1995 Feb 10	Wahle E	doi: 10.1074/jbc.270.6.2800.
9048562	Probing the 3' UTR structure of U1A mRNA and footprinting analysis of its complex with U1A protein.	Biochemistry	1997 Feb 18	Teunissen SW	-
20926573	Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response.	J Virol	2010 Dec	Steidle S	doi: 10.1128/JVI.00701-10

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000529288	CPSF1-204	588	-	-	- (aa)	-	-
ENST00000532560	CPSF1-208	701	-	-	- (aa)	-	-
ENST00000531480	CPSF1-206	789	-	-	- (aa)	-	-
ENST00000622776	CPSF1-214	1029	-	-	- (aa)	-	-
ENST00000527827	CPSF1-202	619	-	-	- (aa)	-	-
ENST00000620219	CPSF1-213	4462	XM_024447140	ENSP00000478145	1443 (aa)	XP_024302908	Q10570
ENST00000532935	CPSF1-210	506	-	ENSP00000478161	169 (aa)	-	A0A087WTV4
ENST00000531727	CPSF1-207	704	-	ENSP00000483775	204 (aa)	-	A0A087X101
ENST00000527916	CPSF1-203	506	-	-	- (aa)	-	-
ENST00000533492	CPSF1-211	510	-	-	- (aa)	-	-
ENST00000532725	CPSF1-209	597	-	-	- (aa)	-	-
ENST00000531042	CPSF1-205	580	-	ENSP00000435761	148 (aa)	-	E9PIM1
ENST00000616140	CPSF1-212	4494	XM_006716548	ENSP00000484669	1443 (aa)	XP_006716611	Q10570
ENST00000526271	CPSF1-201	697	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000071894's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000071894's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000071894	CPSF1	100	80.556	ENSAPOG00000019621	cpsf1	100	77.973	Acanthochromis_polyacanthus
ENSG00000071894	CPSF1	97	94.857	ENSAMEG00000005557	CPSF1	100	94.857	Ailuropoda_melanoleuca
ENSG00000071894	CPSF1	100	80.093	ENSACIG00000006112	cpsf1	100	77.870	Amphilophus_citrinellus
ENSG00000071894	CPSF1	100	80.556	ENSAOCG00000007120	cpsf1	100	79.187	Amphiprion_ocellaris
ENSG00000071894	CPSF1	100	80.556	ENSAPEG00000005755	cpsf1	100	79.574	Amphiprion_percula
ENSG00000071894	CPSF1	100	80.093	ENSATEG00000011097	cpsf1	100	77.815	Anabas_testudineus
ENSG00000071894	CPSF1	99	83.511	ENSACAG00000009655	CPSF1	100	81.561	Anolis_carolinensis
ENSG00000071894	CPSF1	100	98.960	ENSANAG00000036514	CPSF1	100	98.960	Aotus_nancymaae
ENSG00000071894	CPSF1	100	79.167	ENSACLG00000012231	cpsf1	99	78.536	Astatotilapia_calliptera
ENSG00000071894	CPSF1	100	79.630	ENSAMXG00000008485	cpsf1	100	73.964	Astyanax_mexicanus
ENSG00000071894	CPSF1	100	94.426	ENSBTAG00000008355	CPSF1	100	94.604	Bos_taurus
ENSG00000071894	CPSF1	100	32.260	WBGene00022301	cpsf-1	100	40.282	Caenorhabditis_elegans
ENSG00000071894	CPSF1	100	98.753	ENSCJAG00000021421	CPSF1	100	98.753	Callithrix_jacchus
ENSG00000071894	CPSF1	97	96.286	ENSCAFG00000001600	CPSF1	100	96.573	Canis_familiaris
ENSG00000071894	CPSF1	100	96.542	ENSCAFG00020020821	CPSF1	100	96.542	Canis_lupus_dingo
ENSG00000071894	CPSF1	100	90.771	ENSCHIG00000015833	CPSF1	100	90.771	Capra_hircus
ENSG00000071894	CPSF1	100	97.852	ENSTSYG00000028560	CPSF1	99	99.123	Carlito_syrichta
ENSG00000071894	CPSF1	97	95.272	ENSCAPG00000014921	CPSF1	99	95.272	Cavia_aperea
ENSG00000071894	CPSF1	100	94.945	ENSCPOG00000011448	CPSF1	100	94.945	Cavia_porcellus
ENSG00000071894	CPSF1	100	98.822	ENSCCAG00000037658	CPSF1	100	98.822	Cebus_capucinus
ENSG00000071894	CPSF1	100	99.168	ENSCATG00000037234	CPSF1	100	99.168	Cercocebus_atys
ENSG00000071894	CPSF1	100	96.604	ENSCLAG00000012166	CPSF1	100	96.604	Chinchilla_lanigera
ENSG00000071894	CPSF1	100	99.099	ENSCSAG00000008502	CPSF1	100	99.099	Chlorocebus_sabaeus
ENSG00000071894	CPSF1	99	87.343	ENSCPBG00000018910	CPSF1	96	87.413	Chrysemys_picta_bellii
ENSG00000071894	CPSF1	96	48.387	ENSCING00000000514	-	100	48.315	Ciona_intestinalis
ENSG00000071894	CPSF1	99	47.802	ENSCSAVG00000002293	-	98	49.765	Ciona_savignyi
ENSG00000071894	CPSF1	100	98.039	ENSCANG00000032760	CPSF1	100	98.039	Colobus_angolensis_palliatus
ENSG00000071894	CPSF1	100	96.535	ENSCGRG00001016344	Cpsf1	100	96.535	Cricetulus_griseus_chok1gshd
ENSG00000071894	CPSF1	100	94.456	ENSCGRG00000003118	Cpsf1	100	94.456	Cricetulus_griseus_crigri
ENSG00000071894	CPSF1	100	77.455	ENSCSEG00000013464	cpsf1	100	77.178	Cynoglossus_semilaevis
ENSG00000071894	CPSF1	100	81.463	ENSCVAG00000014059	cpsf1	100	81.463	Cyprinodon_variegatus
ENSG00000071894	CPSF1	100	79.477	ENSDARG00000034178	cpsf1	100	79.545	Danio_rerio
ENSG00000071894	CPSF1	57	95.942	ENSDNOG00000043654	CPSF1	94	95.942	Dasypus_novemcinctus
ENSG00000071894	CPSF1	97	95.989	ENSDORG00000006278	Cpsf1	99	95.989	Dipodomys_ordii
ENSG00000071894	CPSF1	99	50.794	FBgn0024698	Cpsf160	100	45.528	Drosophila_melanogaster
ENSG00000071894	CPSF1	88	90.299	ENSETEG00000006022	CPSF1	83	97.315	Echinops_telfairi
ENSG00000071894	CPSF1	99	68.617	ENSEBUG00000006844	-	97	74.541	Eptatretus_burgeri
ENSG00000071894	CPSF1	100	97.165	ENSEASG00005010774	CPSF1	100	97.165	Equus_asinus_asinus
ENSG00000071894	CPSF1	100	97.165	ENSECAG00000022209	CPSF1	100	97.165	Equus_caballus
ENSG00000071894	CPSF1	100	94.467	ENSEEUG00000000471	CPSF1	100	94.467	Erinaceus_europaeus
ENSG00000071894	CPSF1	100	79.630	ENSELUG00000012271	cpsf1	100	78.645	Esox_lucius
ENSG00000071894	CPSF1	100	96.674	ENSFDAG00000016060	CPSF1	100	96.674	Fukomys_damarensis
ENSG00000071894	CPSF1	100	76.875	ENSFHEG00000016801	cpsf1	100	76.738	Fundulus_heteroclitus
ENSG00000071894	CPSF1	100	78.704	ENSGMOG00000000796	cpsf1	100	77.793	Gadus_morhua
ENSG00000071894	CPSF1	95	85.714	ENSGAFG00000018890	cpsf1	100	85.714	Gambusia_affinis
ENSG00000071894	CPSF1	100	78.748	ENSGACG00000008703	cpsf1	100	78.611	Gasterosteus_aculeatus
ENSG00000071894	CPSF1	100	83.621	ENSGAGG00000004276	CPSF1	98	87.259	Gopherus_agassizii
ENSG00000071894	CPSF1	100	63.592	ENSGGOG00000040487	-	100	70.833	Gorilla_gorilla
ENSG00000071894	CPSF1	100	99.653	ENSGGOG00000016185	CPSF1	100	99.653	Gorilla_gorilla
ENSG00000071894	CPSF1	100	79.599	ENSHBUG00000018900	cpsf1	100	79.322	Haplochromis_burtoni
ENSG00000071894	CPSF1	100	96.535	ENSHGLG00000016139	CPSF1	100	96.535	Heterocephalus_glaber_female
ENSG00000071894	CPSF1	100	96.466	ENSHGLG00100009750	CPSF1	100	96.466	Heterocephalus_glaber_male
ENSG00000071894	CPSF1	100	77.778	ENSHCOG00000018509	cpsf1	100	76.746	Hippocampus_comes
ENSG00000071894	CPSF1	100	80.093	ENSIPUG00000011259	cpsf1	100	76.701	Ictalurus_punctatus
ENSG00000071894	CPSF1	97	96.717	ENSSTOG00000009957	CPSF1	99	96.717	Ictidomys_tridecemlineatus
ENSG00000071894	CPSF1	100	96.258	ENSJJAG00000023002	Cpsf1	100	96.258	Jaculus_jaculus
ENSG00000071894	CPSF1	91	85.893	ENSKMAG00000001940	cpsf1	99	85.893	Kryptolebias_marmoratus
ENSG00000071894	CPSF1	100	79.167	ENSLBEG00000003601	cpsf1	100	77.590	Labrus_bergylta
ENSG00000071894	CPSF1	100	82.407	ENSLACG00000000233	CPSF1	92	81.490	Latimeria_chalumnae
ENSG00000071894	CPSF1	100	81.651	ENSLOCG00000008484	cpsf1	100	78.360	Lepisosteus_oculatus
ENSG00000071894	CPSF1	97	95.497	ENSLAFG00000022601	CPSF1	100	95.497	Loxodonta_africana
ENSG00000071894	CPSF1	100	99.168	ENSMFAG00000037013	CPSF1	100	99.168	Macaca_fascicularis
ENSG00000071894	CPSF1	100	99.238	ENSMMUG00000007380	CPSF1	100	99.238	Macaca_mulatta
ENSG00000071894	CPSF1	100	98.529	ENSMNEG00000043564	CPSF1	100	99.355	Macaca_nemestrina
ENSG00000071894	CPSF1	100	99.168	ENSMLEG00000043010	CPSF1	100	99.168	Mandrillus_leucophaeus
ENSG00000071894	CPSF1	100	80.093	ENSMAMG00000003803	cpsf1	100	78.176	Mastacembelus_armatus
ENSG00000071894	CPSF1	100	79.167	ENSMZEG00005001168	cpsf1	100	77.178	Maylandia_zebra
ENSG00000071894	CPSF1	100	96.258	ENSMAUG00000003601	Cpsf1	100	96.258	Mesocricetus_auratus
ENSG00000071894	CPSF1	100	97.505	ENSMICG00000015767	CPSF1	100	97.505	Microcebus_murinus
ENSG00000071894	CPSF1	100	96.396	ENSMOCG00000022758	Cpsf1	100	96.396	Microtus_ochrogaster
ENSG00000071894	CPSF1	100	78.645	ENSMMOG00000021245	cpsf1	100	78.645	Mola_mola
ENSG00000071894	CPSF1	100	92.901	ENSMODG00000010755	CPSF1	100	92.901	Monodelphis_domestica
ENSG00000071894	CPSF1	100	79.167	ENSMALG00000020545	cpsf1	100	77.673	Monopterus_albus
ENSG00000071894	CPSF1	100	96.604	MGP_CAROLIEiJ_G0019936	Cpsf1	100	96.604	Mus_caroli
ENSG00000071894	CPSF1	100	96.535	ENSMUSG00000034022	Cpsf1	100	96.535	Mus_musculus
ENSG00000071894	CPSF1	100	96.466	MGP_PahariEiJ_G0019946	Cpsf1	100	96.466	Mus_pahari
ENSG00000071894	CPSF1	100	96.535	MGP_SPRETEiJ_G0020839	Cpsf1	100	96.535	Mus_spretus
ENSG00000071894	CPSF1	94	95.707	ENSMPUG00000006419	CPSF1	93	95.707	Mustela_putorius_furo
ENSG00000071894	CPSF1	78	97.484	ENSMLUG00000000667	-	100	96.667	Myotis_lucifugus
ENSG00000071894	CPSF1	100	96.258	ENSNGAG00000022460	Cpsf1	100	96.258	Nannospalax_galili
ENSG00000071894	CPSF1	100	79.167	ENSNBRG00000000813	cpsf1	100	74.845	Neolamprologus_brichardi
ENSG00000071894	CPSF1	100	98.039	ENSNLEG00000010633	-	100	98.039	Nomascus_leucogenys
ENSG00000071894	CPSF1	84	96.512	ENSMEUG00000014922	CPSF1	85	96.512	Notamacropus_eugenii
ENSG00000071894	CPSF1	61	96.939	ENSOPRG00000004693	-	71	96.939	Ochotona_princeps
ENSG00000071894	CPSF1	100	96.674	ENSODEG00000013995	CPSF1	100	96.674	Octodon_degus
ENSG00000071894	CPSF1	100	79.806	ENSONIG00000007676	cpsf1	100	79.599	Oreochromis_niloticus
ENSG00000071894	CPSF1	77	91.538	ENSOANG00000010716	CPSF1	88	91.429	Ornithorhynchus_anatinus
ENSG00000071894	CPSF1	100	77.778	ENSORLG00000013544	cpsf1	92	87.243	Oryzias_latipes
ENSG00000071894	CPSF1	100	77.778	ENSORLG00020021693	cpsf1	92	87.243	Oryzias_latipes_hni
ENSG00000071894	CPSF1	100	77.778	ENSORLG00015009979	cpsf1	100	77.362	Oryzias_latipes_hsok
ENSG00000071894	CPSF1	100	77.778	ENSOMEG00000011849	cpsf1	100	77.263	Oryzias_melastigma
ENSG00000071894	CPSF1	100	97.436	ENSOGAG00000000315	CPSF1	100	97.436	Otolemur_garnettii
ENSG00000071894	CPSF1	69	93.333	ENSOARG00000013594	-	89	92.063	Ovis_aries
ENSG00000071894	CPSF1	100	99.792	ENSPPAG00000019280	CPSF1	100	99.792	Pan_paniscus
ENSG00000071894	CPSF1	92	56.173	ENSPPAG00000042686	-	74	66.807	Pan_paniscus
ENSG00000071894	CPSF1	100	99.510	ENSPTRG00000051253	-	100	99.510	Pan_troglodytes
ENSG00000071894	CPSF1	100	61.765	ENSPTRG00000052516	-	100	69.444	Pan_troglodytes
ENSG00000071894	CPSF1	100	99.792	ENSPTRG00000049288	-	100	99.792	Pan_troglodytes
ENSG00000071894	CPSF1	100	99.020	ENSPANG00000015005	CPSF1	100	99.211	Papio_anubis
ENSG00000071894	CPSF1	100	81.481	ENSPKIG00000002582	cpsf1	100	80.862	Paramormyrops_kingsleyae
ENSG00000071894	CPSF1	100	75.926	ENSPMGG00000022177	-	100	84.259	Periophthalmus_magnuspinnatus
ENSG00000071894	CPSF1	100	92.833	ENSPCIG00000009035	CPSF1	100	92.833	Phascolarctos_cinereus
ENSG00000071894	CPSF1	100	76.389	ENSPFOG00000012870	cpsf1	100	76.387	Poecilia_formosa
ENSG00000071894	CPSF1	69	78.102	ENSPLAG00000022739	-	95	88.655	Poecilia_latipinna
ENSG00000071894	CPSF1	69	78.102	ENSPMEG00000019534	-	94	88.655	Poecilia_mexicana
ENSG00000071894	CPSF1	100	76.133	ENSPREG00000016307	cpsf1	100	76.065	Poecilia_reticulata
ENSG00000071894	CPSF1	100	91.199	ENSPPYG00000018973	CPSF1	100	91.199	Pongo_abelii
ENSG00000071894	CPSF1	91	94.886	ENSPCAG00000011541	CPSF1	94	94.886	Procavia_capensis
ENSG00000071894	CPSF1	100	94.608	ENSPCOG00000020001	CPSF1	100	94.608	Propithecus_coquereli
ENSG00000071894	CPSF1	91	98.571	ENSPVAG00000006761	CPSF1	91	98.571	Pteropus_vampyrus
ENSG00000071894	CPSF1	100	79.167	ENSPNYG00000004906	cpsf1	100	78.294	Pundamilia_nyererei
ENSG00000071894	CPSF1	99	78.723	ENSPNAG00000024395	cpsf1	100	75.362	Pygocentrus_nattereri
ENSG00000071894	CPSF1	100	96.535	ENSRNOG00000030705	Cpsf1	100	96.535	Rattus_norvegicus
ENSG00000071894	CPSF1	100	99.168	ENSRBIG00000044907	CPSF1	100	99.168	Rhinopithecus_bieti
ENSG00000071894	CPSF1	100	99.099	ENSRROG00000044861	CPSF1	100	99.099	Rhinopithecus_roxellana
ENSG00000071894	CPSF1	97	98.853	ENSSBOG00000027177	CPSF1	100	98.853	Saimiri_boliviensis_boliviensis
ENSG00000071894	CPSF1	100	92.695	ENSSHAG00000006500	CPSF1	100	92.695	Sarcophilus_harrisii
ENSG00000071894	CPSF1	100	81.944	ENSSFOG00015004606	cpsf1	100	81.323	Scleropages_formosus
ENSG00000071894	CPSF1	100	80.556	ENSSMAG00000020547	cpsf1	100	78.011	Scophthalmus_maximus
ENSG00000071894	CPSF1	100	80.093	ENSSDUG00000001100	cpsf1	100	79.006	Seriola_dumerili
ENSG00000071894	CPSF1	100	80.093	ENSSLDG00000003619	cpsf1	100	79.060	Seriola_lalandi_dorsalis
ENSG00000071894	CPSF1	89	97.917	ENSSARG00000003643	CPSF1	92	97.917	Sorex_araneus
ENSG00000071894	CPSF1	100	89.216	ENSSPUG00000014396	CPSF1	100	89.216	Sphenodon_punctatus
ENSG00000071894	CPSF1	100	80.093	ENSSPAG00000005349	cpsf1	100	78.093	Stegastes_partitus
ENSG00000071894	CPSF1	100	95.920	ENSSSCG00000005906	CPSF1	100	95.920	Sus_scrofa
ENSG00000071894	CPSF1	100	76.852	ENSTRUG00000013134	cpsf1	99	77.638	Takifugu_rubripes
ENSG00000071894	CPSF1	100	78.832	ENSTNIG00000014027	cpsf1	100	78.488	Tetraodon_nigroviridis
ENSG00000071894	CPSF1	77	88.812	ENSTBEG00000001756	CPSF1	91	88.812	Tupaia_belangeri
ENSG00000071894	CPSF1	100	88.426	ENSTTRG00000001937	CPSF1	90	96.718	Tursiops_truncatus
ENSG00000071894	CPSF1	97	96.571	ENSUAMG00000006476	CPSF1	98	96.571	Ursus_americanus
ENSG00000071894	CPSF1	90	58.580	ENSVPAG00000000157	-	50	94.949	Vicugna_pacos
ENSG00000071894	CPSF1	100	94.118	ENSVVUG00000005940	-	100	94.118	Vulpes_vulpes
ENSG00000071894	CPSF1	100	77.402	ENSXCOG00000003608	cpsf1	100	77.263	Xiphophorus_couchianus
ENSG00000071894	CPSF1	100	76.881	ENSXMAG00000005798	cpsf1	100	76.881	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0005515	protein binding	7590244.21102410.21822216.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	21873635.	IBA	Component
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	7590244.21102410.	IDA	Component
GO:0006369	termination of RNA polymerase II transcription	-	TAS	Process
GO:0006378	mRNA polyadenylation	21873635.	IBA	Process
GO:0006378	mRNA polyadenylation	7590244.	IMP	Process
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0019899	enzyme binding	7590244.	IPI	Function
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0035925	mRNA 3'-UTR AU-rich region binding	7590244.	IDA	Function
GO:0098789	pre-mRNA cleavage required for polyadenylation	7590244.	IC	Process