EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000072506 (Gene tree)
Gene ID: 3028
Gene Symbol: HSD17B10
Alias: ERAB|MHBD|17b-HSD10|ABAD|SDR5C1|MRPP2|CAMR|HADH2|MRXS10
Full Name: hydroxysteroid 17-beta dehydrogenase 10
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 3,119 bases
Position: chrX:53,431,258-53,434,376
Accession: 4800
RBP type: non-canonical RBP
Summary: This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26632259	The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs.	Nat Commun	2015 Dec 3	Beckmann BM	doi: 10.1038/ncomms10127.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000477706	HSD17B10-204	556	-	-	- (aa)	-	-
ENST00000375304	HSD17B10-203	916	-	ENSP00000364453	252 (aa)	-	Q99714
ENST00000495986	HSD17B10-205	666	-	-	- (aa)	-	-
ENST00000375298	HSD17B10-202	823	-	ENSP00000364447	169 (aa)	-	Q5H928
ENST00000168216	HSD17B10-201	960	-	ENSP00000168216	261 (aa)	-	Q99714

Gene Model

Click here to download ENSG00000072506's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00280	Valine, leucine and isoleucine degradation	KEGG
hsa01100	Metabolic pathways	KEGG
hsa05010	Alzheimer disease	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000072506's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000072506	HSD17B10	97	68.898	FBgn0021765	scu	100	75.397	Drosophila_melanogaster
ENSG00000072506	HSD17B10	100	87.739	ENSMUSG00000025260	Hsd17b10	100	87.739	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	29040705.	IDA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	23042678.25925575.28888424.	IDA	Function
GO:0005515	protein binding	9338779.18984158.23042678.29040705.29128334.	IPI	Function
GO:0005737	cytoplasm	9338779.	TAS	Component
GO:0005739	mitochondrion	23042678.	IDA	Component
GO:0005739	mitochondrion	-	ISS	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005886	plasma membrane	9338779.	TAS	Component
GO:0006629	lipid metabolic process	9338779.	TAS	Process
GO:0007005	mitochondrion organization	20077426.	IMP	Process
GO:0008709	cholate 7-alpha-dehydrogenase activity	9338779.	TAS	Function
GO:0009083	branched-chain amino acid catabolic process	-	TAS	Process
GO:0030283	testosterone dehydrogenase [NAD(P)] activity	28888424.	IDA	Function
GO:0030678	mitochondrial ribonuclease P complex	25925575.28888424.	IDA	Component
GO:0030678	mitochondrial ribonuclease P complex	23042678.	TAS	Component
GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity	-	IEA	Function
GO:0047015	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity	-	IEA	Function
GO:0051289	protein homotetramerization	25925575.	IDA	Process
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0070901	mitochondrial tRNA methylation	25925575.28888424.	IDA	Process
GO:0070901	mitochondrial tRNA methylation	-	TAS	Process
GO:0090646	mitochondrial tRNA processing	-	TAS	Process
GO:0097745	mitochondrial tRNA 5'-end processing	24549042.25925575.28888424.29040705.	IDA	Process
GO:1990180	mitochondrial tRNA 3'-end processing	29040705.	IDA	Process