EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000072682 (Gene tree)
Gene ID: 8974
Gene Symbol: P4HA2
Alias: C-P4Halpha(II)
Full Name: prolyl 4-hydroxylase subunit alpha 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 103,478 bases
Position: chr5:132,191,838-132,295,315
Accession: 8547
RBP type: canonical RBP
Summary: This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000166534	2OG-FeII_Oxy	PF03171.20	2e-05	1	1
ENSP00000368398	2OG-FeII_Oxy	PF03171.20	2e-05	1	1
ENSP00000384999	2OG-FeII_Oxy	PF03171.20	2e-05	1	1
ENSP00000353772	2OG-FeII_Oxy	PF03171.20	2.6e-05	1	1
ENSP00000368379	2OG-FeII_Oxy	PF03171.20	2.6e-05	1	1
ENSP00000368394	2OG-FeII_Oxy	PF03171.20	2.6e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000474628	P4HA2-218	743	-	-	- (aa)	-	-
ENST00000428369	P4HA2-211	751	-	ENSP00000396495	146 (aa)	-	C9JCP0
ENST00000379100	P4HA2-204	2563	-	ENSP00000368394	533 (aa)	-	O15460
ENST00000166534	P4HA2-201	2230	XM_005272116	ENSP00000166534	535 (aa)	XP_005272173	O15460
ENST00000439698	P4HA2-214	866	-	ENSP00000405406	184 (aa)	-	E7ERI1
ENST00000379104	P4HA2-205	2569	XM_005272118	ENSP00000368398	535 (aa)	XP_005272175	O15460
ENST00000418055	P4HA2-210	568	-	ENSP00000403883	114 (aa)	-	C9JIG4
ENST00000431054	P4HA2-213	724	-	ENSP00000391257	236 (aa)	-	E7EPI9
ENST00000467587	P4HA2-216	456	-	-	- (aa)	-	-
ENST00000395164	P4HA2-206	568	-	ENSP00000378593	167 (aa)	-	A8MXE0
ENST00000401867	P4HA2-207	3349	XM_005272119	ENSP00000384999	535 (aa)	XP_005272176	O15460
ENST00000416053	P4HA2-208	582	-	ENSP00000394953	101 (aa)	-	C9JN43
ENST00000360568	P4HA2-202	2313	XM_017010012	ENSP00000353772	533 (aa)	XP_016865501	O15460
ENST00000506807	P4HA2-221	463	-	-	- (aa)	-	-
ENST00000453286	P4HA2-215	819	-	ENSP00000413542	153 (aa)	-	C9JX45
ENST00000428841	P4HA2-212	427	-	ENSP00000395956	50 (aa)	-	C9JFJ1
ENST00000379086	P4HA2-203	2223	XM_006714729	ENSP00000368379	533 (aa)	XP_006714792	O15460
ENST00000478055	P4HA2-219	929	-	-	- (aa)	-	-
ENST00000417528	P4HA2-209	1023	-	ENSP00000389523	204 (aa)	-	E7ENX0
ENST00000471826	P4HA2-217	2508	-	-	- (aa)	-	-
ENST00000481636	P4HA2-220	496	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000072682's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00330	Arginine and proline metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000072682	Blood Pressure	2.3369131189499E-5	17903302
ENSG00000072682	Blood Pressure	4.2951713158379E-5	17903302
ENSG00000072682	Blood Pressure	4.0782724970212E-5	17903302
ENSG00000072682	Blood Pressure	8.28509725157023E-5	17903302
ENSG00000072682	Blood Pressure	9.7798852E-006	-
ENSG00000072682	Blood Pressure	7.8124131E-006	-
ENSG00000072682	Giant Cell Arteritis	5E-9	28041642

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000072682	rs185616	5	132208073	G	Intraocular pressure	29617998	[0.069-0.14] unit increase	0.1044	EFO_0004695
ENSG00000072682	rs11955347	5	132232231	A	Blood protein levels	29875488	[0.21-0.29] unit decrease	0.25	EFO_0007937
ENSG00000072682	rs128738	5	132205182	?	Giant cell arteritis	28041642	[1.20-1.45]	1.32	EFO_1001209
ENSG00000072682	rs7727544	5	132254841	T	Blood metabolite levels	24816252	[0.011-0.019] unit decrease	0.015	EFO_0005664
ENSG00000072682	rs199834894	5	132230266	?	Itch intensity from mosquito bite adjusted by bite size	28199695	[0.024-0.038] unit decrease	0.0311991	EFO_0008377\|EFO_0008378
ENSG00000072682	rs17516457	5	132254694	T	Itch intensity from mosquito bite adjusted by bite size	28199695	[0.026-0.04] unit decrease	0.0328262	EFO_0008377\|EFO_0008378
ENSG00000072682	rs17516457	5	132254694	T	Perceived unattractiveness to mosquitoes	28199695	[0.092-0.185] unit decrease	0.138285	EFO_0008380
ENSG00000072682	rs199834894	5	132230266	?	Itch intensity from mosquito bite	28199695	[0.038-0.052] unit decrease	0.0448161	EFO_0008377
ENSG00000072682	rs35260072	5	132295159	C	Itch intensity from mosquito bite	28199695	[0.041-0.056] unit increase	0.0482062	EFO_0008377
ENSG00000072682	rs55722650	5	132271607	T	Mosquito bite size	28199695	[0.039-0.06] unit decrease	0.0490999	EFO_0008378
ENSG00000072682	rs199834894	5	132230266	?	Itch intensity from mosquito bite adjusted by bite size	28199695	[0.023-0.035] unit decrease	0.0290066	EFO_0008377\|EFO_0008378
ENSG00000072682	rs199834894	5	132230266	?	Itch intensity from mosquito bite adjusted by bite size	28199695	[0.02-0.037] unit decrease	0.028714	EFO_0008377\|EFO_0008378
ENSG00000072682	rs12521097	5	132239645	G	Itch intensity from mosquito bite adjusted by bite size	28199695	[0.022-0.039] unit decrease	0.0305323	EFO_0008377\|EFO_0008378
ENSG00000072682	rs186675820	5	132223763	C	Sum eosinophil basophil counts	27863252	[0.16-0.27] unit increase	0.2121738	EFO_0005090\|EFO_0004842
ENSG00000072682	rs10479001	5	132272028	T	Red cell distribution width	28957414	[0.037-0.076] unit increase	0.0564112	EFO_0005192
ENSG00000072682	rs6864922	5	132280597	C	Blood protein levels	30072576	[0.58-0.77] unit increase	0.676	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000072682's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000072682	P4HA2	100	95.131	ENSAMEG00000017663	P4HA2	99	95.131	Ailuropoda_melanoleuca
ENSG00000072682	P4HA2	97	66.858	ENSACIG00000009196	p4ha2	99	66.858	Amphilophus_citrinellus
ENSG00000072682	P4HA2	89	71.399	ENSAOCG00000003785	p4ha2	94	71.399	Amphiprion_ocellaris
ENSG00000072682	P4HA2	98	70.802	ENSAPEG00000019437	p4ha2	98	70.802	Amphiprion_percula
ENSG00000072682	P4HA2	98	68.856	ENSATEG00000011722	p4ha2	98	68.856	Anabas_testudineus
ENSG00000072682	P4HA2	96	81.679	ENSAPLG00000003370	P4HA2	100	81.679	Anas_platyrhynchos
ENSG00000072682	P4HA2	100	77.020	ENSACAG00000012415	P4HA2	100	77.020	Anolis_carolinensis
ENSG00000072682	P4HA2	100	98.630	ENSANAG00000022840	P4HA2	100	97.936	Aotus_nancymaae
ENSG00000072682	P4HA2	99	68.051	ENSACLG00000012990	p4ha2	98	72.117	Astatotilapia_calliptera
ENSG00000072682	P4HA2	99	38.390	ENSAMXG00000036173	si:ch73-68b22.2	99	38.390	Astyanax_mexicanus
ENSG00000072682	P4HA2	100	94.934	ENSBTAG00000001116	P4HA2	100	94.934	Bos_taurus
ENSG00000072682	P4HA2	100	98.630	ENSCJAG00000012936	P4HA2	100	98.499	Callithrix_jacchus
ENSG00000072682	P4HA2	100	95.497	ENSCAFG00000000824	P4HA2	100	95.497	Canis_familiaris
ENSG00000072682	P4HA2	100	95.497	ENSCAFG00020014266	P4HA2	100	95.497	Canis_lupus_dingo
ENSG00000072682	P4HA2	100	94.559	ENSCHIG00000021007	P4HA2	100	94.559	Capra_hircus
ENSG00000072682	P4HA2	100	96.811	ENSTSYG00000003233	P4HA2	100	96.811	Carlito_syrichta
ENSG00000072682	P4HA2	100	87.477	ENSCAPG00000011398	P4HA2	100	87.477	Cavia_aperea
ENSG00000072682	P4HA2	100	92.871	ENSCPOG00000008411	P4HA2	100	92.150	Cavia_porcellus
ENSG00000072682	P4HA2	100	98.687	ENSCCAG00000030663	P4HA2	100	98.687	Cebus_capucinus
ENSG00000072682	P4HA2	100	100.000	ENSCATG00000037172	P4HA2	100	99.062	Cercocebus_atys
ENSG00000072682	P4HA2	100	92.495	ENSCLAG00000013749	P4HA2	100	92.495	Chinchilla_lanigera
ENSG00000072682	P4HA2	100	100.000	ENSCSAG00000013842	P4HA2	100	99.437	Chlorocebus_sabaeus
ENSG00000072682	P4HA2	100	87.129	ENSCHOG00000000025	P4HA2	100	80.597	Choloepus_hoffmanni
ENSG00000072682	P4HA2	100	83.178	ENSCPBG00000025117	P4HA2	100	83.178	Chrysemys_picta_bellii
ENSG00000072682	P4HA2	100	100.000	ENSCANG00000031458	P4HA2	100	99.250	Colobus_angolensis_palliatus
ENSG00000072682	P4HA2	100	93.996	ENSCGRG00001012916	P4ha2	100	93.996	Cricetulus_griseus_chok1gshd
ENSG00000072682	P4HA2	100	93.621	ENSCGRG00000008403	P4ha2	100	93.621	Cricetulus_griseus_crigri
ENSG00000072682	P4HA2	99	67.283	ENSCSEG00000013215	p4ha2	99	67.283	Cynoglossus_semilaevis
ENSG00000072682	P4HA2	99	70.998	ENSCVAG00000000703	p4ha2	99	70.998	Cyprinodon_variegatus
ENSG00000072682	P4HA2	95	40.583	ENSDARG00000094609	si:ch73-68b22.2	99	40.583	Danio_rerio
ENSG00000072682	P4HA2	99	71.241	ENSDARG00000010085	p4ha2	99	71.241	Danio_rerio
ENSG00000072682	P4HA2	100	93.996	ENSDORG00000013569	P4ha2	100	93.996	Dipodomys_ordii
ENSG00000072682	P4HA2	100	94.934	ENSEASG00005016292	P4HA2	100	94.934	Equus_asinus_asinus
ENSG00000072682	P4HA2	100	94.393	ENSECAG00000024817	P4HA2	100	94.393	Equus_caballus
ENSG00000072682	P4HA2	100	91.667	ENSEEUG00000013366	P4HA2	88	97.436	Erinaceus_europaeus
ENSG00000072682	P4HA2	100	69.944	ENSELUG00000021666	p4ha2	100	74.917	Esox_lucius
ENSG00000072682	P4HA2	100	94.934	ENSFCAG00000014013	P4HA2	100	94.934	Felis_catus
ENSG00000072682	P4HA2	100	93.058	ENSFDAG00000006739	P4HA2	100	93.058	Fukomys_damarensis
ENSG00000072682	P4HA2	97	66.667	ENSGMOG00000006035	p4ha2	98	66.667	Gadus_morhua
ENSG00000072682	P4HA2	100	80.261	ENSGALG00000006677	P4HA2	100	83.004	Gallus_gallus
ENSG00000072682	P4HA2	95	70.809	ENSGAFG00000005640	p4ha2	100	70.809	Gambusia_affinis
ENSG00000072682	P4HA2	97	66.226	ENSGACG00000020865	p4ha2	96	66.226	Gasterosteus_aculeatus
ENSG00000072682	P4HA2	100	100.000	ENSGGOG00000006366	P4HA2	100	99.813	Gorilla_gorilla
ENSG00000072682	P4HA2	99	70.599	ENSHBUG00000005250	p4ha2	98	70.599	Haplochromis_burtoni
ENSG00000072682	P4HA2	100	92.683	ENSHGLG00000013514	P4HA2	100	92.683	Heterocephalus_glaber_female
ENSG00000072682	P4HA2	100	92.683	ENSHGLG00100000246	P4HA2	100	92.683	Heterocephalus_glaber_male
ENSG00000072682	P4HA2	97	70.881	ENSHCOG00000017395	p4ha2	99	70.881	Hippocampus_comes
ENSG00000072682	P4HA2	99	71.375	ENSIPUG00000017927	p4ha2	99	71.375	Ictalurus_punctatus
ENSG00000072682	P4HA2	100	95.614	ENSSTOG00000007747	P4HA2	100	94.934	Ictidomys_tridecemlineatus
ENSG00000072682	P4HA2	100	93.058	ENSJJAG00000023004	P4ha2	100	93.058	Jaculus_jaculus
ENSG00000072682	P4HA2	99	69.811	ENSKMAG00000011787	p4ha2	99	69.811	Kryptolebias_marmoratus
ENSG00000072682	P4HA2	100	66.727	ENSLBEG00000016497	p4ha2	92	66.727	Labrus_bergylta
ENSG00000072682	P4HA2	100	74.861	ENSLACG00000010010	P4HA2	100	74.861	Latimeria_chalumnae
ENSG00000072682	P4HA2	100	66.481	ENSLOCG00000010375	P4HA2	100	66.481	Lepisosteus_oculatus
ENSG00000072682	P4HA2	100	93.669	ENSLAFG00000007412	P4HA2	100	93.797	Loxodonta_africana
ENSG00000072682	P4HA2	100	100.000	ENSMFAG00000040077	P4HA2	100	99.250	Macaca_fascicularis
ENSG00000072682	P4HA2	100	100.000	ENSMMUG00000010858	P4HA2	100	90.807	Macaca_mulatta
ENSG00000072682	P4HA2	100	99.315	ENSMNEG00000043295	P4HA2	100	99.062	Macaca_nemestrina
ENSG00000072682	P4HA2	100	100.000	ENSMLEG00000039335	P4HA2	100	99.062	Mandrillus_leucophaeus
ENSG00000072682	P4HA2	99	71.241	ENSMAMG00000021549	p4ha2	98	75.333	Mastacembelus_armatus
ENSG00000072682	P4HA2	99	70.787	ENSMZEG00005008207	p4ha2	98	70.787	Maylandia_zebra
ENSG00000072682	P4HA2	100	80.561	ENSMGAG00000008789	P4HA2	100	80.561	Meleagris_gallopavo
ENSG00000072682	P4HA2	99	91.000	ENSMAUG00000007802	P4ha2	100	87.337	Mesocricetus_auratus
ENSG00000072682	P4HA2	100	94.747	ENSMICG00000005666	P4HA2	100	94.747	Microcebus_murinus
ENSG00000072682	P4HA2	100	93.996	ENSMOCG00000010121	P4ha2	100	93.996	Microtus_ochrogaster
ENSG00000072682	P4HA2	100	69.403	ENSMMOG00000013676	p4ha2	100	69.403	Mola_mola
ENSG00000072682	P4HA2	100	80.150	ENSMODG00000014035	P4HA2	100	80.150	Monodelphis_domestica
ENSG00000072682	P4HA2	100	92.871	MGP_CAROLIEiJ_G0016353	P4ha2	100	92.871	Mus_caroli
ENSG00000072682	P4HA2	98	93.702	ENSMUSG00000018906	P4ha2	99	92.683	Mus_musculus
ENSG00000072682	P4HA2	100	92.308	MGP_PahariEiJ_G0017488	P4ha2	100	92.308	Mus_pahari
ENSG00000072682	P4HA2	100	93.246	MGP_SPRETEiJ_G0017195	P4ha2	100	93.246	Mus_spretus
ENSG00000072682	P4HA2	100	95.310	ENSMPUG00000010718	P4HA2	100	95.310	Mustela_putorius_furo
ENSG00000072682	P4HA2	100	92.537	ENSMLUG00000001634	P4HA2	100	92.537	Myotis_lucifugus
ENSG00000072682	P4HA2	100	94.371	ENSNGAG00000019060	P4ha2	100	94.371	Nannospalax_galili
ENSG00000072682	P4HA2	100	100.000	ENSNLEG00000012634	P4HA2	100	99.626	Nomascus_leucogenys
ENSG00000072682	P4HA2	100	79.452	ENSMEUG00000014251	-	77	90.857	Notamacropus_eugenii
ENSG00000072682	P4HA2	100	91.589	ENSOPRG00000011633	P4HA2	100	91.589	Ochotona_princeps
ENSG00000072682	P4HA2	100	89.726	ENSODEG00000009419	P4HA2	100	86.168	Octodon_degus
ENSG00000072682	P4HA2	97	72.674	ENSONIG00000008377	p4ha2	100	71.348	Oreochromis_niloticus
ENSG00000072682	P4HA2	99	70.245	ENSORLG00000019064	p4ha2	99	70.245	Oryzias_latipes
ENSG00000072682	P4HA2	99	70.433	ENSORLG00015005888	p4ha2	99	70.433	Oryzias_latipes_hsok
ENSG00000072682	P4HA2	97	71.429	ENSOMEG00000004357	p4ha2	97	71.429	Oryzias_melastigma
ENSG00000072682	P4HA2	100	93.843	ENSOARG00000015394	P4HA2	99	93.843	Ovis_aries
ENSG00000072682	P4HA2	100	100.000	ENSPPAG00000028815	P4HA2	100	99.626	Pan_paniscus
ENSG00000072682	P4HA2	100	94.559	ENSPPRG00000005209	P4HA2	100	94.559	Panthera_pardus
ENSG00000072682	P4HA2	100	94.747	ENSPTIG00000006055	P4HA2	100	94.747	Panthera_tigris_altaica
ENSG00000072682	P4HA2	100	100.000	ENSPTRG00000017213	P4HA2	100	99.626	Pan_troglodytes
ENSG00000072682	P4HA2	99	44.299	ENSPKIG00000003449	si:ch73-68b22.2	93	44.299	Paramormyrops_kingsleyae
ENSG00000072682	P4HA2	98	72.401	ENSPKIG00000003533	p4ha2	97	76.333	Paramormyrops_kingsleyae
ENSG00000072682	P4HA2	99	64.340	ENSPKIG00000001702	P4HA2	99	64.340	Paramormyrops_kingsleyae
ENSG00000072682	P4HA2	100	80.561	ENSPSIG00000012716	P4HA2	100	80.561	Pelodiscus_sinensis
ENSG00000072682	P4HA2	100	94.184	ENSPEMG00000004967	P4ha2	100	94.184	Peromyscus_maniculatus_bairdii
ENSG00000072682	P4HA2	100	84.142	ENSPCIG00000001023	P4HA2	100	84.142	Phascolarctos_cinereus
ENSG00000072682	P4HA2	99	69.303	ENSPFOG00000009942	p4ha2	99	69.303	Poecilia_formosa
ENSG00000072682	P4HA2	99	69.115	ENSPLAG00000003519	p4ha2	99	69.115	Poecilia_latipinna
ENSG00000072682	P4HA2	99	69.303	ENSPMEG00000002935	p4ha2	99	69.303	Poecilia_mexicana
ENSG00000072682	P4HA2	99	68.646	ENSPREG00000004360	p4ha2	98	71.260	Poecilia_reticulata
ENSG00000072682	P4HA2	100	100.000	ENSPPYG00000015755	P4HA2	100	99.812	Pongo_abelii
ENSG00000072682	P4HA2	100	95.310	ENSPCOG00000017003	P4HA2	100	95.310	Propithecus_coquereli
ENSG00000072682	P4HA2	97	71.374	ENSPNAG00000014592	p4ha2	100	71.937	Pygocentrus_nattereri
ENSG00000072682	P4HA2	100	93.433	ENSRNOG00000033663	P4ha2	100	93.433	Rattus_norvegicus
ENSG00000072682	P4HA2	100	100.000	ENSRBIG00000043030	P4HA2	100	99.065	Rhinopithecus_bieti
ENSG00000072682	P4HA2	100	100.000	ENSRROG00000041342	P4HA2	100	99.250	Rhinopithecus_roxellana
ENSG00000072682	P4HA2	100	98.687	ENSSBOG00000032486	P4HA2	100	98.687	Saimiri_boliviensis_boliviensis
ENSG00000072682	P4HA2	100	81.970	ENSSHAG00000002885	P4HA2	93	81.970	Sarcophilus_harrisii
ENSG00000072682	P4HA2	97	72.414	ENSSFOG00015001608	p4ha2	100	73.123	Scleropages_formosus
ENSG00000072682	P4HA2	99	70.599	ENSSMAG00000005843	p4ha2	99	70.599	Scophthalmus_maximus
ENSG00000072682	P4HA2	99	70.056	ENSSLDG00000008672	p4ha2	99	70.056	Seriola_lalandi_dorsalis
ENSG00000072682	P4HA2	95	80.550	ENSSPUG00000009999	P4HA2	99	80.550	Sphenodon_punctatus
ENSG00000072682	P4HA2	99	69.663	ENSSPAG00000012480	p4ha2	99	69.663	Stegastes_partitus
ENSG00000072682	P4HA2	100	95.122	ENSSSCG00000020915	P4HA2	100	95.122	Sus_scrofa
ENSG00000072682	P4HA2	96	81.801	ENSTGUG00000001347	P4HA2	100	82.184	Taeniopygia_guttata
ENSG00000072682	P4HA2	100	69.703	ENSTRUG00000000302	p4ha2	100	69.703	Takifugu_rubripes
ENSG00000072682	P4HA2	100	87.745	ENSTBEG00000010113	P4HA2	89	95.763	Tupaia_belangeri
ENSG00000072682	P4HA2	100	93.832	ENSTTRG00000002908	P4HA2	100	93.832	Tursiops_truncatus
ENSG00000072682	P4HA2	100	95.310	ENSUMAG00000018565	P4HA2	100	95.310	Ursus_maritimus
ENSG00000072682	P4HA2	100	95.310	ENSVVUG00000024626	P4HA2	100	95.310	Vulpes_vulpes
ENSG00000072682	P4HA2	97	74.374	ENSXETG00000006987	p4ha2	100	72.626	Xenopus_tropicalis
ENSG00000072682	P4HA2	99	69.623	ENSXMAG00000012283	p4ha2	99	69.623	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004656	procollagen-proline 4-dioxygenase activity	21873635.	IBA	Function
GO:0005506	iron ion binding	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005788	endoplasmic reticulum lumen	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0009055	electron transfer activity	9211872.	TAS	Function
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	-	IEA	Function
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	21873635.	IBA	Process
GO:0022900	electron transport chain	-	IEA	Process
GO:0031418	L-ascorbic acid binding	-	IEA	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22813596	Profiling and comparative analysis of glycoproteins in Hs578BST and Hs578T and investigation of prolyl 4-hydroxylase alpha polypeptide II expression and influence in breast cancer cells.	Biochemistry (Mosc)	2012 May	Pan PW	doi: 10.1134/S000629791205015X.
24383403	Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition.	BMC Cancer	2014 Jan 2	Xiong G	doi: 10.1186/1471-2407-14-1.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr5	132194966	Silent	NA	T499T	0.28
BRCA	chr5	132193011	Silent	novel	*536*	0.17
CESC	chr5	132217313	Missense_Mutation	rs200158840	S72L	0.35
CESC	chr5	132198237	Missense_Mutation	rs778443240	T447M	0.25	2OG-FeII_Oxy
CESC	chr5	132209328	Missense_Mutation	NA	P238R	0.4
CHOL	chr5	132194979	Frame_Shift_Del	novel	*G495Vfs32**	0.68	2OG-FeII_Oxy
COAD	chr5	132217259	Missense_Mutation	NA	V90A	0.27
COAD	chr5	132203848	Splice_Site	NA	X384_splice	0.37
COAD	chr5	132203844	Silent	novel	S385S	0.34
COAD	chr5	132210438	Silent	rs200709337	T185T	0.31
COAD	chr5	132198897	Silent	rs141851075	P429P	0.1
COAD	chr5	132198366	Intron	rs149818800		0.14
COAD	chr5	132198206	Splice_Region	rs759732903	Y457Y	0.15
COAD	chr5	132207737	Missense_Mutation	rs202201315	E351K	0.1
COAD	chr5	132218563	Missense_Mutation	NA	E22K	0.3
COAD	chr5	132192963	3'UTR	rs201413375		0.33
ESCA	chr5	132210301	Missense_Mutation	rs200355999	R231H	0.13
GBM	chr5	132198353	Intron	novel		0.39
GBM	chr5	132209240	Missense_Mutation	novel	E267D	0.15
GBM	chr5	132209180	Silent	NA	R287R	0.3
HNSC	chr5	132195014	Silent	novel	A483A	0.27
HNSC	chr5	132198211	Missense_Mutation	novel	N456Y	0.77	2OG-FeII_Oxy
HNSC	chr5	132195481	Splice_Site	novel	X458_splice	0.14
HNSC	chr5	132207794	Missense_Mutation	novel	E332Q	0.14
HNSC	chr5	132218638	5'UTR	novel		0.16
KIRC	chr5	132207872	Nonsense_Mutation	NA	Q306*	0.13
LAML	chr5	132198907	Missense_Mutation	novel	Q426L	0.04	2OG-FeII_Oxy
LGG	chr5	132192920	3'UTR	novel		0.15
LGG	chr5	132192864	3'UTR	novel		0.27
LIHC	chr5	132217254	Missense_Mutation	rs370556720	R92W	0.38
LUAD	chr5	132209306	Silent	NA	G245G	0.13
LUAD	chr5	132207790	Missense_Mutation	NA	W333S	0.38
LUAD	chr5	132204133	Missense_Mutation	novel	R367L	0.18
LUAD	chr5	132203807	Missense_Mutation	novel	V398L	0.5
LUAD	chr5	132207825	Missense_Mutation	novel	Q321H	0.06
LUAD	chr5	132210284	Missense_Mutation	NA	D237Y	0.39
LUAD	chr5	132210289	Missense_Mutation	novel	S235C	0.16
LUAD	chr5	132192962	3'UTR	rs777656754		0.17
LUAD	chr5	132210372	Silent	novel	S207S	0.2
LUAD	chr5	132198897	Silent	rs141851075	P429P	0.66
LUSC	chr5	132217783	Missense_Mutation	NA	V50L	0.6
LUSC	chr5	132195419	Missense_Mutation	rs772697844	P478L	0.19	2OG-FeII_Oxy
LUSC	chr5	132214040	Missense_Mutation	novel	N115K	0.58
LUSC	chr5	132194990	Silent	NA	R491R	0.24
LUSC	chr5	132192884	3'UTR	novel		0.48
LUSC	chr5	132217205	Nonsense_Mutation	NA	S108*	0.09
LUSC	chr5	132195441	Missense_Mutation	NA	D471H	0.09	2OG-FeII_Oxy
OV	chr5	132210437	Missense_Mutation	novel	V186L	0.09
OV	chr5	132210288	Silent	novel	S235S	0.18
OV	chr5	132210409	Missense_Mutation	novel	Q195R	0.05
PAAD	chr5	132210362	Missense_Mutation	novel	D211N	0.15
PCPG	chr5	132210473	Missense_Mutation	rs377044728	R174C	0.06
PRAD	chr5	132209205	Missense_Mutation	NA	R279M	0.05
PRAD	chr5	132195433	Silent	NA	G473G	0.31
PRAD	chr5	132194971	Nonsense_Mutation	rs200102278	R498*	0.4	2OG-FeII_Oxy
PRAD	chr5	132207835	Missense_Mutation	novel	R318M	0.3
SARC	chr5	132193053	Missense_Mutation	rs753260673	G522E	0.45
SKCM	chr5	132210469	Missense_Mutation	rs764954173	S175L	0.45
SKCM	chr5	132218637	5'UTR	novel		0.31
SKCM	chr5	132210363	Silent	NA	L210L	0.11
SKCM	chr5	132203801	Missense_Mutation	rs201043216	R400C	0.38
SKCM	chr5	132218558	Silent	NA	F23F	0.7
SKCM	chr5	132207782	Missense_Mutation	NA	P336S	0.11
SKCM	chr5	132210289	Missense_Mutation	rs267600343	S235F	0.31
SKCM	chr5	132207783	Silent	NA	S335S	0.29
SKCM	chr5	132192923	3'UTR	novel		0.83
SKCM	chr5	132193035	Missense_Mutation	novel	P528L	0.27
SKCM	chr5	132193036	Missense_Mutation	novel	P528S	0.27
STAD	chr5	132217834	Missense_Mutation	NA	L33M	0.27
STAD	chr5	132198227	Silent	novel	R450R	0.08
STAD	chr5	132207810	Silent	novel	P326P	0.12
STAD	chr5	132217232	Missense_Mutation	rs201860203	A99V	0.33
STAD	chr5	132210302	Missense_Mutation	rs149593706	R231C	0.33
STAD	chr5	132207773	Missense_Mutation	rs148040234	V339I	0.31
STAD	chr5	132195000	Missense_Mutation	rs200845342	N488S	0.11	2OG-FeII_Oxy
STAD	chr5	132204146	Nonsense_Mutation	rs201861932	R363*	0.23
STAD	chr5	132207773	Missense_Mutation	rs148040234	V339I	0.07
STAD	chr5	132194937	Frame_Shift_Del	novel	*G509Afs18**	0.13	2OG-FeII_Oxy
STAD	chr5	132198897	Silent	rs141851075	P429P	0.17
UCEC	chr5	132210500	Missense_Mutation	NA	S165R	0.25
UCEC	chr5	132204104	Missense_Mutation	rs147398523	A377T	0.27
UCEC	chr5	132218598	Missense_Mutation	novel	M10T	0.54
UCEC	chr5	132210298	Missense_Mutation	rs201223748	R232H	0.1
UCEC	chr5	132204133	Missense_Mutation	rs376347090	R367H	0.44
UCEC	chr5	132210298	Missense_Mutation	rs201223748	R232H	0.36
UCEC	chr5	132204145	Missense_Mutation	novel	R363Q	0.04
UCEC	chr5	132204104	Missense_Mutation	rs147398523	A377T	0.21
UCEC	chr5	132209171	Silent	rs778379528	Y290Y	0.14
UCEC	chr5	132214045	Missense_Mutation	rs201062782	A114T	0.25
UCEC	chr5	132210369	Missense_Mutation	novel	Q208H	0.17
UCEC	chr5	132207876	Silent	NA	R304R	0.45
UCEC	chr5	132217761	Missense_Mutation	novel	K57T	0.35
UCEC	chr5	132204127	Missense_Mutation	novel	P369L	0.19
UCEC	chr5	132213953	Silent	novel	R144R	0.2
UCEC	chr5	132213957	Missense_Mutation	novel	Y143C	0.33
UCEC	chr5	132210492	Silent	NA	D167D	0.3
UCEC	chr5	132203825	Missense_Mutation	novel	D392Y	0.32
UCEC	chr5	132207719	Missense_Mutation	rs769262955	A357T	0.42
UCEC	chr5	132218563	Missense_Mutation	NA	E22K	0.3
UCEC	chr5	132204143	Missense_Mutation	NA	A364T	0.27
UCEC	chr5	132217242	Missense_Mutation	NA	D96Y	0.34
UCEC	chr5	132207761	Missense_Mutation	novel	D343N	0.2
UCEC	chr5	132217224	Missense_Mutation	novel	D102N	0.25
UCEC	chr5	132198890	Missense_Mutation	NA	D432N	0.34	2OG-FeII_Oxy
UCEC	chr5	132207877	Missense_Mutation	rs202117062	R304H	0.46
UCEC	chr5	132207794	Missense_Mutation	rs780330769	E332K	0.41
UCEC	chr5	132194998	Missense_Mutation	NA	L489I	0.4	2OG-FeII_Oxy
UCEC	chr5	132195415	Silent	novel	K479K	0.14
UCEC	chr5	132210298	Missense_Mutation	rs201223748	R232H	0.4
UCEC	chr5	132213932	Silent	novel	S151S	0.07
UCEC	chr5	132209213	Silent	novel	I276I	0.53
UCEC	chr5	132207719	Missense_Mutation	rs769262955	A357T	0.27
UCEC	chr5	132198890	Missense_Mutation	NA	D432N	0.31	2OG-FeII_Oxy
UCEC	chr5	132217795	Nonsense_Mutation	NA	E46*	0.4
UCEC	chr5	132198269	Splice_Region	NA	N436N	0.34
UCEC	chr5	132195432	Missense_Mutation	novel	A474T	0.45	2OG-FeII_Oxy
UCEC	chr5	132195450	Missense_Mutation	rs766442821	V468I	0.24	2OG-FeII_Oxy
UCEC	chr5	132192962	3'UTR	rs777656754		0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0382	0.11554
LAML	DEL	0.0838	1.2971e-07
LUAD	DEL	0.3004	7.4776e-05
LUSC	DEL	0.6467	0.002071
MESO	DEL	0.1494	0.20184
PRAD	AMP	0.0264	0.16448
STAD	DEL	0.2721	2.8835e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
STAD	0.015	Kaplan-Meier Survival Analysis
HNSC	0.0069	Kaplan-Meier Survival Analysis
LUSC	0.011	Kaplan-Meier Survival Analysis
BRCA	0.0011	Kaplan-Meier Survival Analysis
KIRP	0.00064	Kaplan-Meier Survival Analysis
BLCA	0.00024	Kaplan-Meier Survival Analysis
CESC	0.00011	Kaplan-Meier Survival Analysis
KICH	0.011	Kaplan-Meier Survival Analysis
UCEC	0.0062	Kaplan-Meier Survival Analysis
GBM	0.00084	Kaplan-Meier Survival Analysis
LIHC	0.0097	Kaplan-Meier Survival Analysis
LGG	0.00013	Kaplan-Meier Survival Analysis
LUAD	0.026	Kaplan-Meier Survival Analysis
UVM	0.0001	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742