EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000072756 (Gene tree)
Gene ID: 51095
Gene Symbol: TRNT1
Alias: MtCCA|CGI-47|CCA1
Full Name: tRNA nucleotidyl transferase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 25,588 bases
Position: chr3:3,126,916-3,152,503
Accession: 17341
RBP type: canonical RBP
Summary: The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000280591	PolyA_pol	PF01743.20	3.1e-33	1	1
ENSP00000251607	PolyA_pol	PF01743.20	3.2e-33	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24130456	An RNA-binding complex involved in ribosome biogenesis contains a protein with homology to tRNA CCA-adding enzyme.	PLoS Biol	2013 Oct	Lin J	doi: 10.1371/journal.pbio.1001669

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000397779	TRNT1-204	374	-	ENSP00000380881	65 (aa)	-	F8W8C3
ENST00000251607	TRNT1-201	2276	XM_011533776	ENSP00000251607	434 (aa)	XP_011532078	Q96Q11
ENST00000482311	TRNT1-211	447	-	-	- (aa)	-	-
ENST00000420393	TRNT1-207	854	-	ENSP00000400394	57 (aa)	-	Q96Q11
ENST00000402675	TRNT1-205	1935	-	ENSP00000385745	57 (aa)	-	Q96Q11
ENST00000465998	TRNT1-209	520	-	-	- (aa)	-	-
ENST00000280591	TRNT1-202	2180	-	ENSP00000280591	414 (aa)	-	Q96Q11
ENST00000434583	TRNT1-208	1871	-	ENSP00000415100	434 (aa)	-	Q96Q11
ENST00000469632	TRNT1-210	867	-	-	- (aa)	-	-
ENST00000339437	TRNT1-203	976	-	ENSP00000342985	57 (aa)	-	Q96Q11
ENST00000413000	TRNT1-206	483	-	ENSP00000388615	62 (aa)	-	C9JRS7

Gene Model

Click here to download ENSG00000072756's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000072756	Platelet Function Tests	2.5300000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000072756's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000072756	TRNT1	96	66.981	ENSAPOG00000013687	trnt1	99	66.981	Acanthochromis_polyacanthus
ENSG00000072756	TRNT1	100	92.431	ENSAMEG00000014520	TRNT1	100	92.431	Ailuropoda_melanoleuca
ENSG00000072756	TRNT1	96	67.925	ENSACIG00000021706	trnt1	99	67.925	Amphilophus_citrinellus
ENSG00000072756	TRNT1	96	68.000	ENSAOCG00000024612	trnt1	99	68.000	Amphiprion_ocellaris
ENSG00000072756	TRNT1	96	60.911	ENSAPEG00000022627	trnt1	97	60.911	Amphiprion_percula
ENSG00000072756	TRNT1	93	70.968	ENSATEG00000008928	trnt1	99	70.968	Anabas_testudineus
ENSG00000072756	TRNT1	89	76.227	ENSAPLG00000004258	TRNT1	96	76.227	Anas_platyrhynchos
ENSG00000072756	TRNT1	98	75.116	ENSACAG00000005657	TRNT1	98	75.116	Anolis_carolinensis
ENSG00000072756	TRNT1	100	97.005	ENSANAG00000024802	TRNT1	100	97.005	Aotus_nancymaae
ENSG00000072756	TRNT1	98	67.294	ENSACLG00000022227	trnt1	99	67.294	Astatotilapia_calliptera
ENSG00000072756	TRNT1	98	68.065	ENSAMXG00000003960	trnt1	99	68.065	Astyanax_mexicanus
ENSG00000072756	TRNT1	100	90.783	ENSBTAG00000019534	TRNT1	100	90.783	Bos_taurus
ENSG00000072756	TRNT1	94	43.705	WBGene00010089	hpo-31	94	43.705	Caenorhabditis_elegans
ENSG00000072756	TRNT1	100	96.544	ENSCJAG00000015466	TRNT1	100	96.544	Callithrix_jacchus
ENSG00000072756	TRNT1	100	92.166	ENSCAFG00000005985	TRNT1	99	92.166	Canis_familiaris
ENSG00000072756	TRNT1	100	92.166	ENSCAFG00020014746	TRNT1	99	92.166	Canis_lupus_dingo
ENSG00000072756	TRNT1	100	90.783	ENSCHIG00000007030	TRNT1	99	90.783	Capra_hircus
ENSG00000072756	TRNT1	100	94.700	ENSTSYG00000013390	TRNT1	100	94.700	Carlito_syrichta
ENSG00000072756	TRNT1	86	77.322	ENSCAPG00000006891	TRNT1	100	77.322	Cavia_aperea
ENSG00000072756	TRNT1	99	92.148	ENSCPOG00000007849	TRNT1	99	92.148	Cavia_porcellus
ENSG00000072756	TRNT1	95	92.788	ENSCCAG00000002919	TRNT1	100	95.012	Cebus_capucinus
ENSG00000072756	TRNT1	99	97.229	ENSCATG00000031985	TRNT1	99	97.229	Cercocebus_atys
ENSG00000072756	TRNT1	99	92.841	ENSCLAG00000005186	TRNT1	99	92.841	Chinchilla_lanigera
ENSG00000072756	TRNT1	100	97.696	ENSCSAG00000011052	TRNT1	100	97.696	Chlorocebus_sabaeus
ENSG00000072756	TRNT1	100	83.871	ENSCHOG00000005712	TRNT1	85	90.594	Choloepus_hoffmanni
ENSG00000072756	TRNT1	99	79.167	ENSCPBG00000017636	TRNT1	98	79.167	Chrysemys_picta_bellii
ENSG00000072756	TRNT1	93	44.444	ENSCING00000007069	-	99	44.444	Ciona_intestinalis
ENSG00000072756	TRNT1	95	45.652	ENSCSAVG00000007494	-	97	45.652	Ciona_savignyi
ENSG00000072756	TRNT1	100	97.235	ENSCANG00000039030	TRNT1	100	97.235	Colobus_angolensis_palliatus
ENSG00000072756	TRNT1	100	91.935	ENSCGRG00001009998	Trnt1	100	91.935	Cricetulus_griseus_chok1gshd
ENSG00000072756	TRNT1	100	91.935	ENSCGRG00000013410	Trnt1	100	91.935	Cricetulus_griseus_crigri
ENSG00000072756	TRNT1	94	68.473	ENSCSEG00000008157	trnt1	95	68.473	Cynoglossus_semilaevis
ENSG00000072756	TRNT1	96	67.849	ENSCVAG00000019770	trnt1	99	67.849	Cyprinodon_variegatus
ENSG00000072756	TRNT1	94	70.343	ENSDARG00000075297	trnt1	95	70.343	Danio_rerio
ENSG00000072756	TRNT1	100	92.396	ENSDNOG00000008837	TRNT1	100	92.396	Dasypus_novemcinctus
ENSG00000072756	TRNT1	100	90.323	ENSDORG00000014035	Trnt1	100	90.323	Dipodomys_ordii
ENSG00000072756	TRNT1	92	49.752	FBgn0037369	CG2100	83	49.752	Drosophila_melanogaster
ENSG00000072756	TRNT1	71	90.909	ENSETEG00000018177	TRNT1	100	91.566	Echinops_telfairi
ENSG00000072756	TRNT1	93	62.283	ENSEBUG00000012779	-	95	62.283	Eptatretus_burgeri
ENSG00000072756	TRNT1	100	94.470	ENSEASG00005003577	TRNT1	100	94.470	Equus_asinus_asinus
ENSG00000072756	TRNT1	100	94.700	ENSECAG00000014420	TRNT1	100	94.700	Equus_caballus
ENSG00000072756	TRNT1	100	88.940	ENSEEUG00000009567	TRNT1	100	88.940	Erinaceus_europaeus
ENSG00000072756	TRNT1	97	68.558	ENSELUG00000003802	trnt1	97	68.558	Esox_lucius
ENSG00000072756	TRNT1	100	91.705	ENSFCAG00000026805	TRNT1	99	91.705	Felis_catus
ENSG00000072756	TRNT1	89	74.545	ENSFALG00000013539	TRNT1	100	74.545	Ficedula_albicollis
ENSG00000072756	TRNT1	99	92.841	ENSFDAG00000018412	TRNT1	99	92.841	Fukomys_damarensis
ENSG00000072756	TRNT1	96	68.085	ENSFHEG00000019294	trnt1	99	68.085	Fundulus_heteroclitus
ENSG00000072756	TRNT1	97	65.882	ENSGMOG00000007460	trnt1	98	65.882	Gadus_morhua
ENSG00000072756	TRNT1	94	74.384	ENSGALG00000017368	TRNT1	94	74.384	Gallus_gallus
ENSG00000072756	TRNT1	96	67.612	ENSGAFG00000008647	trnt1	99	67.612	Gambusia_affinis
ENSG00000072756	TRNT1	96	65.647	ENSGACG00000011903	trnt1	99	65.647	Gasterosteus_aculeatus
ENSG00000072756	TRNT1	99	79.630	ENSGAGG00000020942	TRNT1	98	79.630	Gopherus_agassizii
ENSG00000072756	TRNT1	100	99.309	ENSGGOG00000015286	TRNT1	100	99.309	Gorilla_gorilla
ENSG00000072756	TRNT1	98	67.294	ENSHBUG00000002797	trnt1	99	67.294	Haplochromis_burtoni
ENSG00000072756	TRNT1	99	86.866	ENSHGLG00000000221	-	99	86.866	Heterocephalus_glaber_female
ENSG00000072756	TRNT1	99	92.379	ENSHGLG00000003649	TRNT1	99	92.379	Heterocephalus_glaber_female
ENSG00000072756	TRNT1	99	91.224	ENSHGLG00100016421	TRNT1	99	91.224	Heterocephalus_glaber_male
ENSG00000072756	TRNT1	94	67.241	ENSHCOG00000010618	trnt1	95	67.241	Hippocampus_comes
ENSG00000072756	TRNT1	96	68.029	ENSIPUG00000000971	trnt1	97	68.029	Ictalurus_punctatus
ENSG00000072756	TRNT1	100	87.788	ENSSTOG00000000150	TRNT1	98	90.594	Ictidomys_tridecemlineatus
ENSG00000072756	TRNT1	100	92.166	ENSJJAG00000018561	Trnt1	99	92.166	Jaculus_jaculus
ENSG00000072756	TRNT1	98	68.075	ENSKMAG00000011307	trnt1	99	68.075	Kryptolebias_marmoratus
ENSG00000072756	TRNT1	94	62.927	ENSLBEG00000019457	trnt1	97	62.927	Labrus_bergylta
ENSG00000072756	TRNT1	96	73.735	ENSLACG00000013227	TRNT1	96	73.735	Latimeria_chalumnae
ENSG00000072756	TRNT1	99	69.037	ENSLOCG00000011105	trnt1	99	69.037	Lepisosteus_oculatus
ENSG00000072756	TRNT1	100	94.009	ENSLAFG00000023191	TRNT1	100	94.009	Loxodonta_africana
ENSG00000072756	TRNT1	99	97.460	ENSMFAG00000045113	TRNT1	99	97.460	Macaca_fascicularis
ENSG00000072756	TRNT1	99	97.460	ENSMMUG00000017983	TRNT1	99	97.460	Macaca_mulatta
ENSG00000072756	TRNT1	99	97.460	ENSMNEG00000037805	TRNT1	99	97.460	Macaca_nemestrina
ENSG00000072756	TRNT1	88	98.429	ENSMLEG00000033671	TRNT1	99	98.429	Mandrillus_leucophaeus
ENSG00000072756	TRNT1	98	67.765	ENSMAMG00000023401	trnt1	99	67.765	Mastacembelus_armatus
ENSG00000072756	TRNT1	98	67.294	ENSMZEG00005009141	trnt1	99	67.294	Maylandia_zebra
ENSG00000072756	TRNT1	74	74.766	ENSMGAG00000009971	TRNT1	100	74.766	Meleagris_gallopavo
ENSG00000072756	TRNT1	100	92.396	ENSMAUG00000020707	Trnt1	100	92.396	Mesocricetus_auratus
ENSG00000072756	TRNT1	100	92.627	ENSMICG00000016615	TRNT1	100	92.627	Microcebus_murinus
ENSG00000072756	TRNT1	100	92.396	ENSMOCG00000004539	Trnt1	100	92.396	Microtus_ochrogaster
ENSG00000072756	TRNT1	96	66.903	ENSMMOG00000010742	trnt1	99	66.903	Mola_mola
ENSG00000072756	TRNT1	100	83.410	ENSMODG00000004368	TRNT1	100	83.410	Monodelphis_domestica
ENSG00000072756	TRNT1	98	66.353	ENSMALG00000008376	trnt1	99	66.353	Monopterus_albus
ENSG00000072756	TRNT1	100	92.627	MGP_CAROLIEiJ_G0028698	Trnt1	100	92.627	Mus_caroli
ENSG00000072756	TRNT1	100	92.627	ENSMUSG00000013736	Trnt1	100	92.627	Mus_musculus
ENSG00000072756	TRNT1	100	91.935	MGP_PahariEiJ_G0022449	Trnt1	100	91.935	Mus_pahari
ENSG00000072756	TRNT1	100	92.627	MGP_SPRETEiJ_G0029726	Trnt1	100	92.627	Mus_spretus
ENSG00000072756	TRNT1	100	92.627	ENSMPUG00000017017	TRNT1	99	92.627	Mustela_putorius_furo
ENSG00000072756	TRNT1	89	88.083	ENSMLUG00000011864	TRNT1	100	88.083	Myotis_lucifugus
ENSG00000072756	TRNT1	100	91.014	ENSNGAG00000000537	Trnt1	100	91.014	Nannospalax_galili
ENSG00000072756	TRNT1	79	66.957	ENSNBRG00000023606	trnt1	99	66.957	Neolamprologus_brichardi
ENSG00000072756	TRNT1	100	98.387	ENSNLEG00000003226	TRNT1	100	98.387	Nomascus_leucogenys
ENSG00000072756	TRNT1	100	83.641	ENSMEUG00000004684	TRNT1	100	83.641	Notamacropus_eugenii
ENSG00000072756	TRNT1	88	79.896	ENSOPRG00000015067	TRNT1	99	79.896	Ochotona_princeps
ENSG00000072756	TRNT1	99	92.610	ENSODEG00000007597	TRNT1	99	92.610	Octodon_degus
ENSG00000072756	TRNT1	96	67.765	ENSONIG00000020273	trnt1	98	67.765	Oreochromis_niloticus
ENSG00000072756	TRNT1	99	75.231	ENSOANG00000007514	TRNT1	99	75.231	Ornithorhynchus_anatinus
ENSG00000072756	TRNT1	100	84.562	ENSOCUG00000008580	TRNT1	99	84.562	Oryctolagus_cuniculus
ENSG00000072756	TRNT1	96	66.906	ENSORLG00000003165	trnt1	98	66.906	Oryzias_latipes
ENSG00000072756	TRNT1	96	67.146	ENSORLG00020022060	trnt1	98	67.146	Oryzias_latipes_hni
ENSG00000072756	TRNT1	98	65.412	ENSORLG00015018915	trnt1	99	65.412	Oryzias_latipes_hsok
ENSG00000072756	TRNT1	95	66.019	ENSOMEG00000003331	trnt1	97	66.019	Oryzias_melastigma
ENSG00000072756	TRNT1	100	90.553	ENSOARG00000008631	TRNT1	99	90.553	Ovis_aries
ENSG00000072756	TRNT1	100	99.309	ENSPPAG00000043566	TRNT1	100	99.309	Pan_paniscus
ENSG00000072756	TRNT1	99	92.148	ENSPPRG00000001327	TRNT1	99	92.148	Panthera_pardus
ENSG00000072756	TRNT1	100	91.705	ENSPTIG00000011448	TRNT1	99	91.705	Panthera_tigris_altaica
ENSG00000072756	TRNT1	100	99.309	ENSPTRG00000014564	TRNT1	100	99.309	Pan_troglodytes
ENSG00000072756	TRNT1	99	97.229	ENSPANG00000025944	TRNT1	99	97.229	Papio_anubis
ENSG00000072756	TRNT1	98	68.941	ENSPKIG00000020015	trnt1	98	68.941	Paramormyrops_kingsleyae
ENSG00000072756	TRNT1	91	81.360	ENSPSIG00000017356	TRNT1	99	83.056	Pelodiscus_sinensis
ENSG00000072756	TRNT1	96	67.470	ENSPMGG00000008888	trnt1	96	67.470	Periophthalmus_magnuspinnatus
ENSG00000072756	TRNT1	100	92.857	ENSPEMG00000019845	Trnt1	100	92.857	Peromyscus_maniculatus_bairdii
ENSG00000072756	TRNT1	100	83.641	ENSPCIG00000030436	TRNT1	100	83.641	Phascolarctos_cinereus
ENSG00000072756	TRNT1	94	69.212	ENSPFOG00000006194	trnt1	95	69.212	Poecilia_formosa
ENSG00000072756	TRNT1	94	69.212	ENSPLAG00000015623	trnt1	99	68.983	Poecilia_latipinna
ENSG00000072756	TRNT1	96	67.376	ENSPMEG00000012216	trnt1	99	68.983	Poecilia_mexicana
ENSG00000072756	TRNT1	96	67.139	ENSPREG00000021470	trnt1	99	67.139	Poecilia_reticulata
ENSG00000072756	TRNT1	100	98.157	ENSPPYG00000013702	TRNT1	100	98.157	Pongo_abelii
ENSG00000072756	TRNT1	88	93.211	ENSPCAG00000001951	TRNT1	100	93.211	Procavia_capensis
ENSG00000072756	TRNT1	100	94.240	ENSPCOG00000022228	TRNT1	100	94.240	Propithecus_coquereli
ENSG00000072756	TRNT1	88	92.448	ENSPVAG00000008784	TRNT1	100	92.448	Pteropus_vampyrus
ENSG00000072756	TRNT1	98	67.294	ENSPNYG00000003120	trnt1	99	67.294	Pundamilia_nyererei
ENSG00000072756	TRNT1	96	68.675	ENSPNAG00000000565	trnt1	96	68.675	Pygocentrus_nattereri
ENSG00000072756	TRNT1	100	92.166	ENSRNOG00000006432	Trnt1	100	92.166	Rattus_norvegicus
ENSG00000072756	TRNT1	100	94.931	ENSRBIG00000042632	TRNT1	100	94.931	Rhinopithecus_bieti
ENSG00000072756	TRNT1	100	97.005	ENSRROG00000036866	TRNT1	100	97.005	Rhinopithecus_roxellana
ENSG00000072756	TRNT1	100	96.544	ENSSBOG00000021208	TRNT1	100	96.544	Saimiri_boliviensis_boliviensis
ENSG00000072756	TRNT1	100	83.410	ENSSHAG00000018861	TRNT1	100	83.410	Sarcophilus_harrisii
ENSG00000072756	TRNT1	99	67.742	ENSSFOG00015020844	trnt1	94	70.864	Scleropages_formosus
ENSG00000072756	TRNT1	98	66.824	ENSSMAG00000015432	trnt1	97	66.824	Scophthalmus_maximus
ENSG00000072756	TRNT1	96	66.824	ENSSDUG00000012320	trnt1	99	66.824	Seriola_dumerili
ENSG00000072756	TRNT1	56	64.730	ENSSLDG00000016463	-	96	62.451	Seriola_lalandi_dorsalis
ENSG00000072756	TRNT1	96	66.824	ENSSLDG00000009325	trnt1	99	66.824	Seriola_lalandi_dorsalis
ENSG00000072756	TRNT1	88	81.510	ENSSPUG00000014153	TRNT1	100	81.510	Sphenodon_punctatus
ENSG00000072756	TRNT1	96	66.824	ENSSPAG00000021005	trnt1	99	66.824	Stegastes_partitus
ENSG00000072756	TRNT1	100	92.627	ENSSSCG00000011529	TRNT1	100	92.627	Sus_scrofa
ENSG00000072756	TRNT1	93	74.815	ENSTGUG00000010192	TRNT1	99	74.815	Taeniopygia_guttata
ENSG00000072756	TRNT1	94	69.951	ENSTRUG00000001088	trnt1	95	69.951	Takifugu_rubripes
ENSG00000072756	TRNT1	94	69.951	ENSTNIG00000007363	trnt1	94	69.951	Tetraodon_nigroviridis
ENSG00000072756	TRNT1	100	85.484	ENSTBEG00000006367	TRNT1	100	78.277	Tupaia_belangeri
ENSG00000072756	TRNT1	100	91.014	ENSTTRG00000007803	TRNT1	100	91.014	Tursiops_truncatus
ENSG00000072756	TRNT1	100	91.935	ENSUAMG00000022574	TRNT1	99	91.935	Ursus_americanus
ENSG00000072756	TRNT1	100	92.396	ENSUMAG00000024092	TRNT1	99	92.396	Ursus_maritimus
ENSG00000072756	TRNT1	100	92.396	ENSVVUG00000012810	TRNT1	99	92.396	Vulpes_vulpes
ENSG00000072756	TRNT1	96	63.962	ENSXETG00000025091	trnt1	99	65.423	Xenopus_tropicalis
ENSG00000072756	TRNT1	96	67.612	ENSXCOG00000010150	trnt1	99	67.612	Xiphophorus_couchianus
ENSG00000072756	TRNT1	96	67.139	ENSXMAG00000002227	trnt1	99	67.139	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	11504732.	IDA	Function
GO:0001680	tRNA 3'-terminal CCA addition	25193871.	IDA	Process
GO:0005524	ATP binding	11504732.	TAS	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005739	mitochondrion	11504732.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0034062	5'-3' RNA polymerase activity	-	TAS	Function
GO:0042780	tRNA 3'-end processing	-	TAS	Process
GO:0052927	CTP:tRNA cytidylyltransferase activity	-	IEA	Function
GO:0052928	CTP:3'-cytidine-tRNA cytidylyltransferase activity	-	IEA	Function
GO:0052929	ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity	11504732.	IDA	Function
GO:1990180	mitochondrial tRNA 3'-end processing	11504732.	IDA	Process
GO:1990180	mitochondrial tRNA 3'-end processing	-	TAS	Process