EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000072778 (Gene tree)
Gene ID: 37
Gene Symbol: ACADVL
Alias: VLCAD|LCACD|ACAD6
Full Name: acyl-CoA dehydrogenase very long chain
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 8,149 bases
Position: chr17:7,217,125-7,225,273
Accession: 92
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is targeted to the inner mitochondrial membrane where it catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. This acyl-Coenzyme A dehydrogenase is specific to long-chain and very-long-chain fatty acids. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000322910	ACADVL-201	2352	-	ENSP00000325395	39 (aa)	-	J9JID6
ENST00000356839	ACADVL-203	2323	XM_006721516	ENSP00000349297	655 (aa)	XP_006721579	P49748
ENST00000584103	ACADVL-238	555	-	ENSP00000465353	157 (aa)	-	K7EJW8
ENST00000582056	ACADVL-227	738	-	-	- (aa)	-	-
ENST00000582356	ACADVL-229	633	-	-	- (aa)	-	-
ENST00000585203	ACADVL-239	947	-	-	- (aa)	-	-
ENST00000578269	ACADVL-210	724	-	-	- (aa)	-	-
ENST00000583312	ACADVL-233	799	-	ENSP00000467920	224 (aa)	-	K7EQP4
ENST00000577433	ACADVL-207	803	-	-	- (aa)	-	-
ENST00000579391	ACADVL-218	341	-	-	- (aa)	-	-
ENST00000582379	ACADVL-230	833	-	-	- (aa)	-	-
ENST00000583760	ACADVL-234	599	-	-	- (aa)	-	-
ENST00000578579	ACADVL-213	458	-	-	- (aa)	-	-
ENST00000577191	ACADVL-206	1212	-	-	- (aa)	-	-
ENST00000580365	ACADVL-224	494	-	-	- (aa)	-	-
ENST00000579886	ACADVL-221	502	-	ENSP00000463246	155 (aa)	-	J3QKU9
ENST00000581378	ACADVL-225	752	-	ENSP00000462366	76 (aa)	-	J3KS89
ENST00000578824	ACADVL-216	720	-	-	- (aa)	-	-
ENST00000578809	ACADVL-215	709	-	-	- (aa)	-	-
ENST00000580263	ACADVL-223	545	-	-	- (aa)	-	-
ENST00000543245	ACADVL-205	2227	-	ENSP00000438689	678 (aa)	-	P49748
ENST00000350303	ACADVL-202	2191	-	ENSP00000344152	633 (aa)	-	P49748
ENST00000583848	ACADVL-235	503	-	ENSP00000466487	45 (aa)	-	K7EMF8
ENST00000577857	ACADVL-208	566	-	-	- (aa)	-	-
ENST00000582166	ACADVL-228	550	-	-	- (aa)	-	-
ENST00000579546	ACADVL-220	582	-	ENSP00000464254	194 (aa)	-	J3QRJ8
ENST00000578319	ACADVL-211	718	-	-	- (aa)	-	-
ENST00000579286	ACADVL-217	933	-	-	- (aa)	-	-
ENST00000582450	ACADVL-231	294	-	-	- (aa)	-	-
ENST00000583074	ACADVL-232	410	-	-	- (aa)	-	-
ENST00000581562	ACADVL-226	571	-	-	- (aa)	-	-
ENST00000578033	ACADVL-209	562	-	-	- (aa)	-	-
ENST00000542255	ACADVL-204	1016	-	ENSP00000442082	282 (aa)	-	G3V1M7
ENST00000579894	ACADVL-222	429	-	-	- (aa)	-	-
ENST00000578421	ACADVL-212	548	-	-	- (aa)	-	-
ENST00000583850	ACADVL-236	903	-	-	- (aa)	-	-
ENST00000579425	ACADVL-219	1234	-	-	- (aa)	-	-
ENST00000583858	ACADVL-237	1015	-	ENSP00000462611	204 (aa)	-	J3KSR4
ENST00000578711	ACADVL-214	1732	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000072778's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00071	Fatty acid degradation	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01212	Fatty acid metabolism	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000072778's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000072778	ACADVL	93	57.751	FBgn0034432	CG7461	94	56.471	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000062	fatty-acyl-CoA binding	21873635.	IBA	Function
GO:0001659	temperature homeostasis	-	ISS	Process
GO:0004466	long-chain-acyl-CoA dehydrogenase activity	7668252.	IDA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005739	mitochondrion	-	ISS	Component
GO:0005743	mitochondrial inner membrane	-	IEA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006635	fatty acid beta-oxidation	-	TAS	Process
GO:0009409	response to cold	-	IEA	Process
GO:0015980	energy derivation by oxidation of organic compounds	7479827.	TAS	Process
GO:0017099	very-long-chain-acyl-CoA dehydrogenase activity	21873635.	IBA	Function
GO:0030855	epithelial cell differentiation	21492153.	IEP	Process
GO:0031966	mitochondrial membrane	16020546.	IDA	Component
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	7668252.	IDA	Process
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	-	ISS	Process
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0042645	mitochondrial nucleoid	18063578.	IDA	Component
GO:0045717	negative regulation of fatty acid biosynthetic process	-	ISS	Process
GO:0046322	negative regulation of fatty acid oxidation	-	ISS	Process
GO:0050660	flavin adenine dinucleotide binding	-	IEA	Function
GO:0090181	regulation of cholesterol metabolic process	-	ISS	Process