EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000073712 (Gene tree)
Gene ID: 10979
Gene Symbol: FERMT2
Alias: mig-2|KIND2|UNC112B|PLEKHC1
Full Name: fermitin family member 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 95,168 bases
Position: chr14:52,857,268-52,952,435
Accession: 15767
RBP type: non-canonical RBP
Summary: (Fermitin Family Member 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Cell junction organization. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is FERMT1.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000557562	FERMT2-214	555	-	ENSP00000451085	65 (aa)	-	G3V379
ENST00000343279	FERMT2-202	3247	XM_006720008	ENSP00000342858	687 (aa)	XP_006720071	Q96AC1
ENST00000395631	FERMT2-203	3369	-	ENSP00000378993	680 (aa)	-	Q96AC1
ENST00000553663	FERMT2-206	655	-	ENSP00000451134	133 (aa)	-	H0YJB6
ENST00000557255	FERMT2-213	6001	-	-	- (aa)	-	-
ENST00000341590	FERMT2-201	3338	XM_005267285	ENSP00000340391	680 (aa)	XP_005267342	Q96AC1
ENST00000553768	FERMT2-207	791	-	-	- (aa)	-	-
ENST00000555546	FERMT2-211	2384	-	-	- (aa)	-	-
ENST00000554288	FERMT2-209	700	-	ENSP00000451268	155 (aa)	-	G3V3J0
ENST00000553373	FERMT2-205	2064	-	ENSP00000451084	687 (aa)	-	Q96AC1
ENST00000554712	FERMT2-210	587	-	ENSP00000450506	153 (aa)	-	G3V281
ENST00000554152	FERMT2-208	3029	-	ENSP00000450741	640 (aa)	-	H0YJ34
ENST00000399304	FERMT2-204	2082	-	ENSP00000382243	633 (aa)	-	Q96AC1
ENST00000555692	FERMT2-212	754	-	ENSP00000452472	133 (aa)	-	G3V5R2
ENST00000635305	FERMT2-215	2482	-	ENSP00000489609	545 (aa)	-	A0A0U1RRM8

Gene Model

Click here to download ENSG00000073712's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000073712	Blood Pressure	3.4538510E-005	-
ENSG00000073712	Blood Pressure	1.5866215E-005	-
ENSG00000073712	Blood Pressure	4.9068987E-005	-
ENSG00000073712	Blood Pressure	2.8678730E-005	-
ENSG00000073712	Blood Pressure	3.7978313E-006	-
ENSG00000073712	Blood Pressure	3.1925698E-006	-
ENSG00000073712	Blood Pressure	3.2355810E-005	-
ENSG00000073712	Blood Pressure	3.0310679E-006	-
ENSG00000073712	Prostatic Neoplasms	2E-14	23535732
ENSG00000073712	Bronchodilator Agents	5E-6	26634245
ENSG00000073712	Lung Volume Measurements	5E-6	26634245
ENSG00000073712	Glaucoma, Angle-Closure	3E-11	27064256
ENSG00000073712	Alzheimer Disease	8E-9	24162737
ENSG00000073712	Glaucoma, Angle-Closure	5E-9	27064256

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000073712	rs8009633	14	52920118	G	Intraocular pressure	29617998	[0.085-0.15] unit increase	0.1173	EFO_0004695
ENSG00000073712	rs79534246	14	52919724	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.17	GO_0097366\|EFO_0004713
ENSG00000073712	rs7494379	14	52944673	G	Glaucoma (primary angle closure)	27064256	[NR]	1.14	EFO_1001506
ENSG00000073712	rs7494379	14	52944673	G	Glaucoma (primary angle closure)	27064256	[NR]	1.13	EFO_1001506
ENSG00000073712	rs8008270	14	52905612	G	Prostate cancer	23535732	[1.08-1.16]	1.12	EFO_0001663
ENSG00000073712	rs17125944	14	52933911	C	Alzheimer's disease (late onset)	24162737	[1.09-1.19]	1.14	EFO_0000249
ENSG00000073712	rs12147852	14	52895157	?	Intraocular pressure	30054594	[0.091-0.151] unit decrease	0.1211	EFO_0004695
ENSG00000073712	rs17125924	14	52924962	?	Alzheimer's disease or family history of Alzheimer's disease	29777097			EFO_0000249\|EFO_0009268
ENSG00000073712	rs4901308	14	52913207	T	PR interval	30046033	[0.51-1.09] ms decrease	0.8	EFO_0004462
ENSG00000073712	rs9888615	14	52910822	T	Systolic blood pressure	28135244	[0.22-0.42] unit decrease	0.318	EFO_0006335
ENSG00000073712	rs8009633	14	52920118	G	Intraocular pressure	29785010	[0.081-0.139] unit increase	0.11	EFO_0004695
ENSG00000073712	rs12887631	14	52906681	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000073712	rs7161323	14	52899431	C	Diastolic blood pressure	27841878	unit decrease	0.147	EFO_0006336
ENSG00000073712	rs7161323	14	52899431	C	Systolic blood pressure	27841878	unit decrease	0.275	EFO_0006335
ENSG00000073712	rs7161323	14	52899431	C	Pulse pressure	27841878	unit decrease	0.132	EFO_0005763
ENSG00000073712	rs8008270	14	52905612	C	Prostate cancer	29892016	[1.07-1.11]	1.09	EFO_0001663

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000073712's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001725	stress fiber	-	IEA	Component
GO:0005515	protein binding	22699938.	IPI	Function
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	21325030.22030399.	IDA	Function
GO:0005634	nucleus	22699938.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	22699938.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	21325030.29162887.	IDA	Component
GO:0005938	cell cortex	-	IEA	Component
GO:0007160	cell-matrix adhesion	21325030.	IMP	Process
GO:0007160	cell-matrix adhesion	-	ISS	Process
GO:0007179	transforming growth factor beta receptor signaling pathway	21325030.	IMP	Process
GO:0007229	integrin-mediated signaling pathway	21325030.	IMP	Process
GO:0008360	regulation of cell shape	-	IEA	Process
GO:0009986	cell surface	-	IEA	Component
GO:0016055	Wnt signaling pathway	22699938.	IMP	Process
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	21325030.	IDA	Component
GO:0031258	lamellipodium membrane	-	IEA	Component
GO:0031674	I band	-	IEA	Component
GO:0033622	integrin activation	22030399.	IMP	Process
GO:0034329	cell junction assembly	-	TAS	Process
GO:0034446	substrate adhesion-dependent cell spreading	-	ISS	Process
GO:0048041	focal adhesion assembly	-	ISS	Process
GO:0051015	actin filament binding	-	IEA	Function
GO:0072657	protein localization to membrane	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23151599	The novel focal adhesion gene kindlin-2 promotes the invasion of gastric cancer cells mediated by tumor-associated macrophages.	Oncol Rep	2013 Feb	Shen Z	doi: 10.3892/or.2012.2137
21624607	Kindlin-2 expression in arsenite- and cadmium-transformed bladder cancer cell lines and in archival specimens of human bladder cancer.	Urology	2011 Jun	Talaat S	doi: 10.1016/j.urology.2011.02.040.
20127858	Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration.	Int J Cancer	2010 Nov 1	An Z	doi: 10.1002/ijc.25223.
22056622	Kindlin-2: a novel adhesion protein related to tumor invasion, lymph node metastasis, and patient outcome in gastric cancer.	Am J Surg	2012 Feb	Shen Z	doi: 10.1016/j.amjsurg.2011.06.050
30107706	[Kindlin-2 promotes gallbladder cancer metastasis and invasion by inducing epithelial-mesenchymal transition].	Zhonghua Wai Ke Za Zhi	2018 Aug 1	Lu X	doi: 10.3760/cma.j.issn.0529-5815.2018.08.013.
23857544	Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin β1 and β3.	J Surg Oncol	2013 Aug	Shen Z	doi: 10.1002/jso.23353.
23337877	A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells.	FEBS Lett	2013 Mar 18	Gao J	doi: 10.1016/j.febslet.2012.12.028
23483548	Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family.	Int J Cancer	2013 Sep 15	Yu Y	doi: 10.1002/ijc.28151
23211537	Kindlin-2 promotes genome instability in breast cancer cells.	Cancer Lett	2013 Apr 28	Zhao T	doi: 10.1016/j.canlet.2012.11.043
26551397	Kindlin-2 promotes invasiveness of prostate cancer cells via NF-??B-dependent upregulation of matrix metalloproteinases.	Gene	2016 Jan 15	Yang JR	doi: 10.1016/j.gene.2015.11.005
28687620	Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Activating CSF-1-Mediated Macrophage Infiltration.	Cancer Res	2017 Sep 15	Sossey-Alaoui K	doi: 10.1158/0008-5472.CAN-16-2337
28667517	Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology.	Sci China Life Sci	2017 Nov	Wang P	doi: 10.1007/s11427-016-9044-5

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr14	52919295	Silent	novel	L73L	0.34
BLCA	chr14	52919325	Silent	novel	L63L	0.4
BLCA	chr14	52919308	Missense_Mutation	novel	R69I	0.5
BLCA	chr14	52881099	Silent	novel	V264V	0.08
BLCA	chr14	52881353	Missense_Mutation	novel	E215K	0.35
BRCA	chr14	52872812	Missense_Mutation	novel	Q420H	0.03
BRCA	chr14	52950576	Splice_Site	novel		0.36
BRCA	chr14	52858541	Missense_Mutation	NA	E627Q	0.22
BRCA	chr14	52864490	Missense_Mutation	NA	P505S	0.1
CESC	chr14	52857815	3'UTR	novel		0.39
CESC	chr14	52875226	Missense_Mutation	NA	I365M	0.51
CESC	chr14	52858245	3'UTR	novel		0.51
CESC	chr14	52857625	3'UTR	novel		0.42
CESC	chr14	52858152	3'UTR	novel		0.28
CESC	chr14	52858267	3'UTR	novel		0.29
CESC	chr14	52875324	Missense_Mutation	NA	E333Q	0.42
COAD	chr14	52858439	Missense_Mutation	novel	K661Q	0.32
COAD	chr14	52860350	Missense_Mutation	novel	F573S	0.05
COAD	chr14	52950463	Missense_Mutation	novel	T36A	0.17
COAD	chr14	52864526	Missense_Mutation	rs752746667	L493I	0.23
COAD	chr14	52858444	Missense_Mutation	novel	R659H	0.32
COAD	chr14	52864811	Missense_Mutation	NA	F439C	0.39
COAD	chr14	52881276	Missense_Mutation	novel	Q240H	0.07
COAD	chr14	52859659	Missense_Mutation	rs751620780	R595W	0.08
COAD	chr14	52919169	Missense_Mutation	NA	F115L	0.1
COAD	chr14	52859659	Missense_Mutation	rs751620780	R595W	0.32
COAD	chr14	52859579	Silent	NA	I621I	0.35
COAD	chr14	52872821	Silent	novel	P417P	0.28
COAD	chr14	52859645	Silent	NA	S599S	0.32
COAD	chr14	52858259	3'UTR	novel		0.26
COAD	chr14	52858349	3'UTR	rs766246952		0.14
ESCA	chr14	52857815	3'UTR	novel		0.28
ESCA	chr14	52859539	Intron	novel		0.43
ESCA	chr14	52857726	3'UTR	novel		0.14
GBM	chr14	52864852	Frame_Shift_Ins	novel	*C426Mfs2**	0.18
GBM	chr14	52864404	Silent	novel	K533K	0.07
GBM	chr14	52858436	Missense_Mutation	novel	D662Y	0.27
GBM	chr14	52859562	Intron	novel		0.05
GBM	chr14	52864748	Missense_Mutation	novel	N460S	0.6
HNSC	chr14	52878594	Silent	novel	F317F	0.27
HNSC	chr14	52858373	3'UTR	novel		0.17
HNSC	chr14	52881268	Missense_Mutation	novel	L243P	0.15
KIRC	chr14	52919194	Frame_Shift_Del	novel	*K107Sfs3**	0.09
KIRC	chr14	52859564	Intron	rs537045234		0.21
KIRC	chr14	52950502	Missense_Mutation	rs147527926	H23Y	0.3
KIRC	chr14	52872880	Missense_Mutation	NA	T398S	0.29
KIRC	chr14	52919190	Silent	NA	Y108Y	0.27
KIRP	chr14	52919347	Missense_Mutation	NA	K56I	0.3
KIRP	chr14	52893334	Missense_Mutation	NA	E162G	0.4
KIRP	chr14	52919321	Missense_Mutation	novel	W65G	0.36
LAML	chr14	52872881	Silent	rs144924859	C397C	0.06
LGG	chr14	52919156	Missense_Mutation	NA	F120L	0.41
LIHC	chr14	52878673	Missense_Mutation	novel	I291S	0.49
LIHC	chr14	52864430	Missense_Mutation	rs747430958	R525C	0.45
LIHC	chr14	52893401	Missense_Mutation	novel	L140V	0.45
LUAD	chr14	52878683	Missense_Mutation	novel	A288S	0.29
LUAD	chr14	52864401	Missense_Mutation	novel	Q534H	0.17
LUAD	chr14	52864536	Silent	NA	V489V	0.16
LUAD	chr14	52858415	Missense_Mutation	NA	E669K	0.14
LUAD	chr14	52919215	Missense_Mutation	rs141887548	R100L	0.31
LUAD	chr14	52860362	Missense_Mutation	NA	G569D	0.11
LUAD	chr14	52858383	Missense_Mutation	NA	W679C	0.09
LUAD	chr14	52859659	Missense_Mutation	rs751620780	R595W	0.1
LUSC	chr14	52950570	5'UTR	novel		0.5
LUSC	chr14	52950470	Silent	novel	L33L	0.05
LUSC	chr14	52858402	Missense_Mutation	novel	Y673F	0.52
OV	chr14	52860444	Missense_Mutation	NA	A542S	0.15
OV	chr14	52919193	Missense_Mutation	novel	K107N	0.06
OV	chr14	52858044	3'UTR	novel		0.17
PAAD	chr14	52919313	Silent	rs567979465	K67K	0.13
PRAD	chr14	52864437	Silent	novel	V522V	0.49
PRAD	chr14	52858259	3'UTR	novel		0.45
READ	chr14	52858367	3'UTR	novel		0.24
READ	chr14	52860451	Silent	novel	I539I	0.05
READ	chr14	52881469	Missense_Mutation	NA	G176E	0.38
READ	chr14	52919169	Missense_Mutation	NA	F115L	0.39
READ	chr14	52919170	Missense_Mutation	novel	F115C	0.09
SKCM	chr14	52881398	Missense_Mutation	NA	P200S	0.54
SKCM	chr14	52881096	Silent	NA	K265K	0.54
SKCM	chr14	52950472	Silent	rs138988521	L33L	0.38
SKCM	chr14	52859704	Missense_Mutation	NA	G580S	0.19
SKCM	chr14	52860400	Missense_Mutation	NA	M556I	0.13
SKCM	chr14	52881094	Missense_Mutation	NA	E266G	0.27
SKCM	chr14	52881425	Missense_Mutation	novel	P191S	0.17
SKCM	chr14	52893399	Silent	NA	L140L	0.08
SKCM	chr14	52919124	Frame_Shift_Del	novel	*F130Lfs12**	0.18
SKCM	chr14	52950540	Missense_Mutation	novel	D10V	0.11
SKCM	chr14	52874187	Missense_Mutation	rs764477726	K380E	0.16
SKCM	chr14	52858337	3'UTR	rs768450230		0.25
SKCM	chr14	52864798	Silent	NA	L443L	0.36
STAD	chr14	52893364	Frame_Shift_Del	novel	*K152Rfs4**	0.42
STAD	chr14	52860398	Missense_Mutation	novel	R557K	0.63
STAD	chr14	52893364	Frame_Shift_Del	novel	*K152Rfs4**	0.21
STAD	chr14	52919346	Frame_Shift_Del	NA	*D57Ifs17**	0.23
STAD	chr14	52919346	Frame_Shift_Del	NA	*D57Ifs17**	0.41
STAD	chr14	52919346	Frame_Shift_Del	NA	*D57Ifs17**	0.36
STAD	chr14	52919313	Missense_Mutation	novel	K67N	0.23
STAD	chr14	52919304	Silent	rs745461975	T70T	0.19
STAD	chr14	52858351	3'UTR	novel		0.09
STAD	chr14	52893364	Frame_Shift_Del	novel	*K152Rfs4**	0.44
STAD	chr14	52881386	Missense_Mutation	novel	T204P	0.27
STAD	chr14	52864762	Nonsense_Mutation	NA	W455*	0.24
STAD	chr14	52950565	Missense_Mutation	NA	A2T	0.31
STAD	chr14	52858446	Silent	NA	T658T	0.23
STAD	chr14	52919345	Frame_Shift_Ins	novel	*D57Rfs4**	0.31
UCEC	chr14	52872914	Frame_Shift_Ins	novel	*L387Afs22**	0.34
UCEC	chr14	52950498	Missense_Mutation	NA	V24A	0.42
UCEC	chr14	52857538	3'UTR	rs570947682		0.25
UCEC	chr14	52875350	Missense_Mutation	novel	I324T	0.21
UCEC	chr14	52857545	3'UTR	novel		0.43
UCEC	chr14	52859646	Missense_Mutation	novel	S599N	0.27
UCEC	chr14	52864561	Missense_Mutation	novel	A481V	0.07
UCEC	chr14	52857861	3'UTR	novel		0.48
UCEC	chr14	52860378	Missense_Mutation	novel	S564P	0.22
UCEC	chr14	52857537	3'UTR	novel		0.26
UCEC	chr14	52858176	3'UTR	rs182640915		0.13
UCEC	chr14	52860395	Missense_Mutation	novel	F558C	0.23
UCEC	chr14	52858300	3'UTR	novel		0.42
UCEC	chr14	52858286	3'UTR	novel		0.39
UCEC	chr14	52893313	Missense_Mutation	novel	P169H	0.05
UCEC	chr14	52857683	3'UTR	novel		0.32
UCEC	chr14	52858307	3'UTR	novel		0.2
UCEC	chr14	52864778	Missense_Mutation	NA	G450D	0.39
UCEC	chr14	52881398	Missense_Mutation	NA	P200S	0.17
UCEC	chr14	52919128	Missense_Mutation	novel	T129I	0.21
UCEC	chr14	52878643	Missense_Mutation	novel	A301D	0.15
UCEC	chr14	52874208	Missense_Mutation	novel	P373S	0.06
UCEC	chr14	52857327	3'UTR	novel		0.06
UCEC	chr14	52857898	3'UTR	novel		0.44
UCEC	chr14	52881313	Missense_Mutation	rs369069013	T228M	0.38
UCEC	chr14	52893370	Missense_Mutation	novel	K150R	0.35
UCEC	chr14	52881048	Missense_Mutation	NA	D281E	0.36
UCEC	chr14	52859491	Intron	novel		0.28
UCEC	chr14	52919169	Missense_Mutation	NA	F115L	0.32
UCEC	chr14	52858259	3'UTR	novel		0.38
UCEC	chr14	52859566	Splice_Region	novel		0.29
UCEC	chr14	52872888	Missense_Mutation	novel	Y395F	0.33
UCEC	chr14	52878625	Missense_Mutation	rs367678207	I307T	0.14
UCEC	chr14	52857571	3'UTR	rs569846256		0.55
UCEC	chr14	52858216	3'UTR	novel		0.47
UCEC	chr14	52857558	3'UTR	novel		0.28
UCEC	chr14	52893372	Missense_Mutation	novel	K149N	0.52
UCEC	chr14	52919169	Missense_Mutation	NA	F115L	0.27
UCEC	chr14	52881300	Silent	novel	I232I	0.12
UCEC	chr14	52875278	Missense_Mutation	novel	A348D	0.28
UCEC	chr14	52859700	Missense_Mutation	NA	K581T	0.42
UCEC	chr14	52875281	Missense_Mutation	NA	D347G	0.25
UCEC	chr14	52881269	Missense_Mutation	NA	L243I	0.23
UCEC	chr14	52858177	3'UTR	novel		0.17
UCEC	chr14	52859620	Missense_Mutation	novel	R608C	0.38
UCEC	chr14	52893364	Frame_Shift_Del	novel	*K152Rfs4**	0.35
UCEC	chr14	52881319	Missense_Mutation	NA	P226L	0.37
UCEC	chr14	52857906	3'UTR	novel		0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1444	0.19769
CHOL	DEL	0.3889	0.00040262
KIRP	DEL	0.1563	0.085174
MESO	DEL	0.3908	0.088547
PAAD	DEL	0.0598	0.11332

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0015	Kaplan-Meier Survival Analysis
STAD	0.0011	Kaplan-Meier Survival Analysis
MESO	0.0027	Kaplan-Meier Survival Analysis
ACC	0.0051	Kaplan-Meier Survival Analysis
HNSC	0.016	Kaplan-Meier Survival Analysis
SKCM	0.049	Kaplan-Meier Survival Analysis
KIRP	0.012	Kaplan-Meier Survival Analysis
BLCA	0.00053	Kaplan-Meier Survival Analysis
LAML	0.026	Kaplan-Meier Survival Analysis
UCEC	0.044	Kaplan-Meier Survival Analysis
LGG	0.0084	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742